7 results about "Allergic transfusion reaction" patented technology

The present invention relates to a composition comprising human milk oligosaccharides for use in infants or young children for the prevention or treatment of allergies, said composition comprising at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide, the invention relates to a composition for preventing and / or treating allergy symptoms in an infant or a young child by increasing propionate production in the body of the infant or the young child.

The invention discloses a multilayer nanofiber oral paste loaded with an allergen-immunologic adjuvant composition as well as a preparation method and application of the multilayer nanofiber oral paste. The multilayer nanofiber oral paste has an adhesion function. The multilayer nanofiber oral paste is prepared by adopting a continuous electrostatic spinning technology, the adhesion layer is prepared from a polymer material, and the backing layer is prepared from a hydrophobic polymer material. The invention relates to an allergen-immunologic adjuvant composition, and the allergen-immunologic adjuvant composition or a composition nanoparticle is loaded by an adhesive layer. The multi-layer nanofiber oral paste is applied to an oral mucosa area of a patient within a treatment course, so that long-acting release of allergens is realized. After the multi-layer nanofiber oral paste is repeatedly used by a patient, the prevention or treatment of allergic diseases (allergic diseases) can be realized.

Relates to an application of an anti-TSLP antibody or an antigen-binding fragment thereof and a nucleic acid molecule encoding the antibody in preparation of drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases, the antibody or the antigen-binding fragment thereof has high affinity to TSLP, can effectively bind to TSLP and block the proliferation effect of TSLP on Ba / F3-hTSLPR-hIL7R alpha cells, and can be used for preparing drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases. And the TSLP is capable of blocking the activation of PBMC (peripheral blood mononuclear cells) and secreting cytokines.

The present invention relates to a pharmaceutical composition for preventing, suppressing, or treating a symptom associated with a pseudo-allergic reaction, the pharmaceutical composition including a compound having a P2X4 receptor antagonizing action, or a pharmaceutically acceptable salt thereof, as an active ingredient.

The invention discloses a preparation method of dendrophenol-glycyrrhizic acid self-assembled gel spray as well as a product and application thereof, and belongs to the field of new medical application of active ingredients of traditional Chinese medicinal materials. The preparation method comprises the following steps: preparing dendrophenol-glycyrrhizic acid self-assembled nanoparticles by taking dendrophenol and glycyrrhizic acid as raw materials, mixing the nanoparticles with chitosan, adding a cross-linking agent, and further preparing into a gel spray dosage form. Experimental results show that the gel spray has good biocompatibility and remarkable antibacterial performance, inflammatory response and epidermis thickening of a mouse allergic skin disease model induced by 2, 4-dinitrochlorobenzene can be effectively inhibited, scratching behaviors are reduced, skin tissue inflammation and oxidative stress injury are relieved, and the gel spray has a good application prospect. The infiltration of eosinophilic granulocytes and mast cells at the affected part is reduced, and the immune balance is regulated. The product obtained by the invention has various effects of resisting allergic reaction, diminishing swelling, relieving itching and the like, and has a good application prospect in the aspect of treatment of allergic skin diseases.

Relates to an application of an anti-TSLP antibody or an antigen-binding fragment thereof and a nucleic acid molecule encoding the antibody in preparation of drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases, the antibody or the antigen-binding fragment thereof has high affinity to TSLP, can effectively bind to TSLP and block the proliferation effect of TSLP on Ba / F3-hTSLPR-hIL7R alpha cells, and can be used for preparing drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases. And the TSLP is capable of blocking the activation of PBMC (peripheral blood mononuclear cells) and secreting cytokines.

The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine preparation for treating allergic rhinitis and a preparation method thereof.The traditional Chinese medicine preparation is prepared from, by weight, 10-60 g of platycodon grandiflorum, 40-70 g of rhizoma zingiberis, 15-65 g of Chinese yam and 25-95 g of honey-fried licorice root. The traditional Chinese medicine composition is used for treating allergic rhinitis and has the advantages of being convenient to use, quick in effect taking, convenient to take, low in price, exact in anti-allergic effect, free of toxic and side effects and safe in medication.