116 results about "Allergic transfusion reaction" patented technology

The invention relates to a class of CpG immunostimulatory oligonucleotides containing a CpG immunostimulatory motif and a second motif which is capable of forming secondary structure, including duplex and higher order structures, in vitro and in vivo. The oligonucleotides of the invention are useful as adjuvants in vaccination. The oligonucleotides are also useful for inducing an immune response, inducing expression of a type I interferon (IFN), inducing expression of gamma interferon (IFN-gamma), and for treating a variety of conditions, including allergy, asthma, infection, and cancer.

Invented is a method of inhibiting the activity/function of PI3 kinases using naphthyridine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of naphthyridine derivatives.

The invention relates to the use of human lysozyme in pharmaceutical industry, in particular the use in preparing medicines for treating dermatosis, infection and ulceration caused by bacteria, fungus, viruses, allergic reaction, and occupational diseases, physical diseases, nerve dysfunctional diseases, and immunity diseases. The invention exploits the novel use of human lysozyme in medical treatment, the gene recombination lysozyme has rich source, the invention also features simple process for manufacturing, and ease in use.

The invention relates to a medicine for treating allergic rhinitis, which takes radix astragali, divaricate saposhnikovia root, atractylodes rhizome, grass leaf sweelflag rhizome, cocklebur fruit, angelica root, Chinese angelica, szechuan lovage rhizome, cassia twig, radix paeoniae alba, gizzard-membrane of chicken, large-leaved gentian, rhizoma atractylodis, amur corktree bark, tuckahoe, chrysanthemum and liquorice as raw materials; the raw materials are added with water and decocted to be concentrated into thick paste; after that, the thick paste is dried and ground, and then is filled intocapsules; finally, after being sterilized, the capsule product can be prepared. The medicine has the functions of warming lung and tonifying spleen, eliminating evils and activating organs as well asactivating blood circulation to dissipate blood stasis, is used for treating the allergic rhinitis with reliable, rapid and convenient treating effect, is safe to take, and has the total effective rate of 96.9% through clinical observation.

The invention belongs to the field of immunodetection and provides a method for diagnosing bovine tuberculosis mediated by a recombinant protein mixture and a regent for diagnosing bovine tuberculosis mediated by the recombinant protein mixture; the reagent comprises the recombinant protein mixture used as specific irritant; animals infected by mycobacterium bovis can be simulated by the recombinant protein mixture so as to generate a DTH (delayed type hypersensitivity) reaction; compared with a PPD (purified protein derivative) intradermal allergic reaction test, a intradermal allergic reaction test established by regent provided by the invention has higher specificity; mycobacterium bovis infection can be distinguished from environmental mycobacteria infection; and therefore, the method and the reagent can be effectively used for clinical detection of the bovine tuberculosis.

The invention discloses a stable granular medicine composition containing epinastine or hydrochloride thereof. The stable granular medicine composition also comprises a binding agent which has a stabilizing effect on the epinastine or the hydrochloride thereof. Meanwhile, the invention also discloses a preparation method of the stable granular medicine composition. The granular medicine composition disclosed by the invention can also be used as a medicament which urgently needs to be developed in clinic and has an excellent effect on allergic reaction diseases of children.

The invention discloses a pseudolaric acid B and the application of derivative thereof in the preparation of immunity inhibitor. Experiments prove that the pseudolaric acid B and the derivative thereof have excellent immunity inhibiting effect and lower toxicity, so that the pseudolaric acid B and the derivative thereof or pseudolaric acetate and salt of the derivative of the pseudolaric acid B can be taken as medicine for preventing or treating exclusive reaction, autoimmune disease, inflammatory disease, allergic disease and the like which are related to immunity and caused by organ or skin grafting of mammal (especially human beings).

The invention relates to a pharmaceutical composition for treating asthma, allergic reaction and inflammation. The composition comprises a leukotriene antagonist, antihistaminics and medicinal carriers, wherein the leukotriene antagonist is Montelukast and salts thereof, and the antihistaminics is olopatadine hydrochloride and salts thereof. The composition is suitable for preventing and long-term treating of asthma for children and adults, and can treat asthma patients sensitive to aspirin, prevent bronchoconstriction induced by movement, treat pruritus concomitant with allergic rhinitis, urticaria and skin diseases, and the like. The composition has better curative effect compared with that the two medicines are used independently.

The present invention provides allergy and allergic reaction inhibitors, specifically the compound of the present invention as described in the following chemical formula I. The method for treating allergic reaction or allergic reaction disease or disorder comprises administering to a subject in need thereof for treatment An effective amount of a composition comprising a compound of formula I or a pharmaceutically acceptable salt, solvate or prodrug thereof and a pharmaceutically acceptable carrier, vehicle or excipient.

The invention discloses an oral compound traditional Chinese medicine preparation for preventing poultry chill cold and flu. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight through even mixing: 120-200 parts of schizonepeta, 50-80 parts of ox horn wire, 15-35 parts of taurine, 20-60 parts of shikimic acid, 80-150 parts of gypsum, 1-3 parts of borneol, 80-150 parts of mint, 80-150 parts of herba violae, 30-80 parts of rhizoma phragmitis, and 10-50 parts of isatis root. The compound preparation is compounded by adopting traditional Chinese medicine extracts and traditional Chinese medicine powder with unique effects, has the effects of diminishing inflammation, killing bacteria, resisting virus, strengthening heart, relieving cough, resisting allergic reaction, improving poultry disease resisting immunity, repairing damaged mucous membranes and effectively controlling secondary infection, and has efficient treating effect on the poultry influenza and flu. The oral compound traditional Chinese medicine preparation has the advantages of reasonable and scientific formula, simple preparation, prominent effect and wide application, and can be used as the priority drug for preventing and treating the poultry influenza and flu.

The invention relates to a water-containing liquid bacterin preparation and the purpose thereof for treating and preventing allergic reaction. The preparation contains an allergen extract which exists in water-containing liquid or suspension containing a protein stabilizer and derives from one or more kinds of artemisia plant pollen.

The invention relates to the technical field of cosmetics, and discloses a plant extract composition with an anti-allergy effect and a preparation method. The composition comprises, in percentage by weight, 1%-50% of the extract of radix stephaniae tetrandrae, 1%-50% of the extract of radix gentianae and 1%-50% of the extract of liquorice roots. The composition formed by compounding the plant extracts can inhibit allergic reaction from multiple ways and reduce inflammation, and the composition can more effectively exert anti-allergy effect; the plant extract composition with the anti-allergy effect is extracted by taking a deep eutectic solvent as an extraction solvent; and the method has the characteristic of high extraction efficiency compared with a traditional water extraction method or a simple water-alcohol combined extraction method, and the anti-allergy effect of the extract is more remarkable.

The invention relates to extract of the steroid saponin produced from the yam or the yam with the guilder leaf which has the character of containing the 80%-90% the steroid saponin in the percentage by weight. The intravenous fluid produced from the extract of the steroid saponin can not only dilate the coronary, depress the myocardial oxygen consumption, melt the thrombus, improve the myocardial ischemia and the microcirculation, amend the function of the vas endothelial cell, increase the blood stream of the brain, prevent the ischemia brain cell injury, but also drop the blood pressure, the blood fat, the blood sugar; at the same time, it has the function of resisting inflammation, ease pain, codein, preventing asthma, dispelling the myospasm, improving the immunity and resisting the allergy. So it can cure the cerebrovascular, the rheumatism and the disease of the respiratory system. The invention has the good clinic extended value because of the low dosage of the active ingredient, the efficacy, the effecting quick and the high bioavailability.

The invention discloses compound levofloxacin hydrochloride soluble powder for treating respiratory diseases of poultry. The soluble powder is prepared by uniformly mixing the following components in percentage by weight: 2-10 percent of levofloxacin hydrochloride, 2-10 percent of azithromycin, 2-6 percent of venenum bufonis, 10-30 percent of liquorice extract, 3-9 percent of Kameiding, 1-5 percent of trimethoprim lactate, and the balance of pharmaceutically applicable auxiliaries. The compound preparation is compounded by latest market medicines, traditional Chinese medicinal extracts, novel antiasthmatic drugs and medicinal synergistic agents, and fatal factors are comprehensively taken, so that the compound levofloxacin hydrochloride soluble powder has the effects of anti-inflammation, sterilization, anti-virus, heart strengthening, cough relieving and allergic reaction resistance, can be used for improving the anti-disease immunity of poultry, repairing injured mucous membrane and effectively controlling secondary infection, and has an effective treatment effect to respiratory diseases of poultry.

The invention discloses an application of honokiol in inhibiting streptococcus suis or a biofilm of the streptococcus suis. The inventors find that the honokiol or a pharmaceutically acceptable salt of the honokiol has the effect of inhibiting the formation of the streptococcus suis and the biofilm or killing the streptococcus suis in the mature biofilm; the inventors use a standard micro-dilutionmethod to measure the MIC value of the honokiol against the streptococcus suis, and results show that the MIC value of the honokiol against the streptococcus suis is close to the MIC value of antibiotics; and the inventors use a high-throughput static biofilm system method to construct an in-vitro biofilm model, and find that the subinhibitory-concentration honokiol can reduce the formation of the streptococcus suis biofilm and destroy the three-dimensional structure of the streptococcus suis biofilm through research results of a crystal violet method and scanning electron microscopy. The invention discloses a pharmaceutical composition for inhibiting the streptococcus suis or the biofilm by using the honokiol as a main active ingredient, and the pharmaceutical composition has good safety, and does not have the problems of drug residues, bacterial drug resistance, allergic reactions and gastrointestinal bleeding.

The present invention relates to specific skin reagent for diagnosing tuberculous infection and active tuberculosis, and belongs to the field of medical immunological diagnosis technology. The specific skin reagent consists of diluent liquid and dissolved tuberculous allergen, and the tuberculous allergen is tuberculous mycobacterium ESAT6 protein. The present invention also proposes applying tuberculous mycobacterium ESAT6 protein for human skin test as tuberculous allergen to detect tuberculous infecting person and tuberculosis patient and identify the specific reaction of inoculated Calmette-Guerin bacillus vaccine. The present invention can induce the immune response of tuberculous infecting person. The reagent can induce delayed allergic reaction of tuberculous infecting person and can identify BCG inoculation from the allergic reaction of non-tuberculous mycobacterium and tuberculous mycobacterium infection.

The present invention provides methods and devices for inducing, stimulating, blocking and reducing the immune response of a mammal to an antigen, using an implantable device which exposes the antigen in a controlled fashion to cells of the immune system. The device comprises a porous matrix contained within a perforated, impermeable container. By manipulating the bioavailability of antigen within the device, and the timing of introduction of antigen into the device relative to the time of implantation of the device within the mammal, a robust and long-term response can be induced against an antigen, or an existing or potential immune response can be down regulated or blocked. The methods and devices can be used for therapeutic vaccination, and in non-exposed mammals for prophylactic vaccination. Immunity can be cellular, humoral, or mucosal. Suppression of the immune response is useful for the treatment or prophylaxis of such conditions as allergies, autoimmune disease, and in tolerizing mammals to suppress an immune response to transplant antigens. The device can also be used for harvesting immune cells for later reintroduction into the mammal, and for preparing immune serum and hybridomas.