19 results about "Allergic transfusion reaction" patented technology

The present invention relates to a composition for infants or young children comprising at least one probiotic strain and a prebiotic mixture of human milk oligosaccharides, said probiotic strain being Bifidobacteria, the present invention relates to a composition comprising a prebiotic mixture of human milk oligosaccharides consisting of 2 '-fucosyllactose (2FL), milk difucosyltetraose / difucosyllactose (DFL), milk-N-tetraose (LNT), 6'-sialyllactose (6SL), 3 '-sialyllactose (3SL) and optionally 3-fucosyllactose (3FL), which composition is useful for (i) preventing and / or treating a bacterial infection in an infant or a young child; (ii) modulate the microbiota in the infant or young child; and / or iii) preventing and / or treating allergies in infants or young children.

The invention discloses a method for establishing indirect ELISA (enzyme-linked immunosorbent assay) for detecting mycobacterium bovis Lprl, which comprises the following steps: preparing mycobacterium bovis Lprl protein, taking the purified protein as an antigen, and determining conditions such as optimal antigen coating concentration, serum dilution, serum incubation time, secondary antibody dilution concentration, incubation time and the like. The established indirect ELISA detection method does not have cross reaction with other bovine pathogens, the specificity is good, the detection accuracy is high, and the total coincidence rate of test results of intradermal allergy with bovine tubercle bacillus is 95.8%; the intra-batch variation coefficient of the detected samples is 2.43%-3.61%, the inter-batch variation coefficient is 2.83%-3.96%, and the intra-batch variation coefficient and the inter-batch variation coefficient are both smaller than 10%. A new diagnosis target is developed, the established indirect ELISA method has the characteristics of high sensitivity, strong specificity, good repeatability and the like, the operation is easy, and a new method is provided for the detection work of the mycobacterium bovis.

The present invention relates to a pharmaceutical composition for preventing, suppressing, or treating a symptom associated with a pseudo-allergic reaction, the pharmaceutical composition including a compound having a P2X4 receptor antagonizing action or a pharmaceutically acceptable salt thereof as an active ingredient.

The present invention relates to a composition comprising human milk oligosaccharides for use in infants or young children for the prevention or treatment of allergies, said composition comprising at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide, the invention relates to a composition for preventing and / or treating allergy symptoms in an infant or a young child by increasing propionate production in the body of the infant or the young child.

The invention discloses a multilayer nanofiber oral paste loaded with an allergen-immunologic adjuvant composition as well as a preparation method and application of the multilayer nanofiber oral paste. The multilayer nanofiber oral paste has an adhesion function. The multilayer nanofiber oral paste is prepared by adopting a continuous electrostatic spinning technology, the adhesion layer is prepared from a polymer material, and the backing layer is prepared from a hydrophobic polymer material. The invention relates to an allergen-immunologic adjuvant composition, and the allergen-immunologic adjuvant composition or a composition nanoparticle is loaded by an adhesive layer. The multi-layer nanofiber oral paste is applied to an oral mucosa area of a patient within a treatment course, so that long-acting release of allergens is realized. After the multi-layer nanofiber oral paste is repeatedly used by a patient, the prevention or treatment of allergic diseases (allergic diseases) can be realized.

The invention relates to a monoclonal antibody preparation targeting TSLP. A pharmaceutical composition containing a TSLP (thymic stromal lymphopoietin) antibody or an antigen binding fragment thereof comprises 50-400 mg / mL of the TSLP antibody or the antigen binding fragment thereof, and auxiliary materials. The invention also relates to a preparation and a kit containing the pharmaceutical composition, and application of the preparation and the kit in treatment of allergic inflammation or autoimmune diseases.

The present application belongs to the field of biological testing. Disclosed are a multi-joint test quantum dot quantitative test cassette, a preparation method and device therefor, and a use method therefor. The multi-joint test quantum dot quantitative test cassette comprises a multi-joint-row cassette shell and test strips, wherein a plurality of reaction cavities are provided in the multi-joint-row cassette shell and are used for the placement of the test strips; the multi-joint-row cassette shell further comprises a plurality of sample-adding holes and a plurality of observation windows, the sample-adding holes and the observation windows corresponding to the reaction cavities on a one-to-one basis; and each test strip comprises a binding pad, which is coated with an antibody marked by quantum dots, the antibody marked by the quantum dots serving as a chromogenic substance. The present application provides a multi-joint test quantum dot quantitative test cassette, which uses quantum-dot-marked quantitative testing, a nitrocellulose membrane with a plurality of test lines, and the form of the multi-joint-row cassette shell. Thus, the problems of quantitative testing and multi-joint testing are both solved, and the test efficiency and accuracy are improved; furthermore, the present application achieves the aim of rapidly diagnosing various allergic diseases of a human body that are caused by the inhalation and ingestion of allergens.

Relates to an application of an anti-TSLP antibody or an antigen-binding fragment thereof and a nucleic acid molecule encoding the antibody in preparation of drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases, the antibody or the antigen-binding fragment thereof has high affinity to TSLP, can effectively bind to TSLP and block the proliferation effect of TSLP on Ba / F3-hTSLPR-hIL7R alpha cells, and can be used for preparing drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases. And the TSLP is capable of blocking the activation of PBMC (peripheral blood mononuclear cells) and secreting cytokines.

The present invention relates to a pharmaceutical composition for preventing, suppressing, or treating a symptom associated with a pseudo-allergic reaction, the pharmaceutical composition including a compound having a P2X4 receptor antagonizing action, or a pharmaceutically acceptable salt thereof, as an active ingredient.

The utility model relates to a skull repairing mesh plate which comprises a mesh plate body, a plurality of drainage holes are formed in the middle of the mesh plate body, a diversion trench is formed in the back face of the mesh plate body, the two ends of the diversion trench are connected with the drainage holes respectively, and an outer periphery is arranged on the face, opposite to the back face of the mesh plate body, of the mesh plate body along the periphery of the mesh plate body. The mesh plate is excellent in mechanical property, integrally stable, non-heat-conducting and non-conductive, does not damage skin soft tissues, does not limit the application of later-stage MRI (Magnetic Resonance Imaging) examination of a patient, has no artifact interference in postoperative imaging, does not stimulate tissue allergy and bone autolysis after being implanted into a body for a long time, can be trimmed, and is convenient for intraoperative shaping; the drainage hole is matched with the flow guide groove, so that liquid can be effectively guided to be discharged, and postoperative epidural effusion is reduced; the fixing pieces are arranged on the outer periphery of the screen plate body, so that the stability of the screen plate at the skull defect part can be ensured; the outer peripheral edge adopts a low incisura design, and seamless attachment of the outer peripheral edge of the screen plate and a bone seam is achieved through gradual change of the thickness of the outer peripheral edge.

The utility model discloses an allergic reaction detection device which is characterized in that an operation table is connected with a platform through an operation table slide way, an arm placing through groove is formed in the operation table, a support frame is arranged at the upper part of the operation table, and a test module is arranged on the support frame; the pricking module is arranged at the front end of the lifting beam and connected with the lifting beam through the pricking module dip angle adjusting device. The sliding block mechanism is connected with a rack, the rack is connected with a gear in a matched mode, and translation of detection, pricking, liquid dropping and heating links is achieved; the gear is connected with a speed reduction driving mechanism installed on the platform, a main control device is arranged in the main frame, and the speed reduction driving mechanism is connected with the main control device. The device has the advantages that the height of the pricking needle is adjusted and locked by detecting the position of the skin of the arm of the human body, so that the depth of pricking the pricking needle into the skin is consistent. In the liquid dropping link, the positions of the liquid dropping units are stable, the liquid dropping amount is controllable, and liquid can be accurately dropped to the skin puncturing position. The detection accuracy is improved, and physical exhaustion of medical staff is saved.

The invention discloses a preparation method of dendrophenol-glycyrrhizic acid self-assembled gel spray as well as a product and application thereof, and belongs to the field of new medical application of active ingredients of traditional Chinese medicinal materials. The preparation method comprises the following steps: preparing dendrophenol-glycyrrhizic acid self-assembled nanoparticles by taking dendrophenol and glycyrrhizic acid as raw materials, mixing the nanoparticles with chitosan, adding a cross-linking agent, and further preparing into a gel spray dosage form. Experimental results show that the gel spray has good biocompatibility and remarkable antibacterial performance, inflammatory response and epidermis thickening of a mouse allergic skin disease model induced by 2, 4-dinitrochlorobenzene can be effectively inhibited, scratching behaviors are reduced, skin tissue inflammation and oxidative stress injury are relieved, and the gel spray has a good application prospect. The infiltration of eosinophilic granulocytes and mast cells at the affected part is reduced, and the immune balance is regulated. The product obtained by the invention has various effects of resisting allergic reaction, diminishing swelling, relieving itching and the like, and has a good application prospect in the aspect of treatment of allergic skin diseases.

The invention discloses a radix gentianae anti-allergy soothing repairing agent and a preparation method thereof. In the invention, the cortex dictamni extract has an anti-allergic reaction effect, and can effectively inhibit mast cell degranulation and reduce release of inflammatory mediators such as histamine, so that symptoms such as pruritus, red and swollen, pain and the like caused by allergic reaction are relieved. The fructus kochiae extract, the radix scutellariae extract, the dandelion extract and the honeysuckle flower extract also have the effects of resisting inflammation, resisting allergy and the like, and allergy symptoms can be further relieved. The radix gentianae extract has the effects of clearing heat, drying dampness, purging fire and removing toxin and can improve the damp-heat state of skin and relieve allergy symptoms, and the multiple medicinal material extracts in the repairing agent all have a good relieving effect and can effectively relieve discomfort such as red and swollen skin and pruritus, so that the skin feels fresh, cool and comfortable. Meanwhile, the repairing agent also has the effect of repairing damaged skin, and can promote skin cell regeneration, repair damaged skin barrier, improve skin resistance and prevent repeated attack of allergic symptoms.

The invention discloses a novel compound traditional Chinese medicine asthma-relieving aerosol which is prepared from the following raw materials in parts by weight: 10-60 parts of agastache rugosus, 10-60 parts of pericarpium citri reticulatae, 10-60 parts of mangnolia officinalis and 10-60 parts of perilla leaves. The invention further discloses a preparation method of the novel compound traditional Chinese medicine asthma-relieving aerosol. The invention provides an efficient and safe traditional Chinese medicine asthma-relieving aerosol capable of treating acute attack of asthma and a preparation method thereof, the aerosol is convenient to dose, can be inhaled through atomization, is convenient to use, has a unique treatment effect, can effectively prevent and treat asthma patients after being continuously used twice a day for 5-7 days, treats both symptoms and root causes, and is short in treatment period, quick in effect taking, reliable in effect and free of toxic and side effects. The traditional Chinese medicine composition has the effects of spasmolysis, anti-inflammation, anti-allergic reaction and the like.

The present invention discloses a PLK1 inhibitor and its application, belonging to the field of biomedicine technology. The present invention discloses the application of a PLK1 inhibitor in the preparation of a drug for treating pseudoallergic reactions, wherein the inhibitor includes volasertib. The present invention has confirmed through in vitro and in vivo cell experiments that the PLK1 inhibitor Volasertib can improve the morphological changes during degranulation of RBL-2H3 cells induced by C48 / 80, reduce cell apoptosis, and reduce the release of HA and β-HEX, and has a significant improvement effect on pseudoallergic reactions; in vivo experiments on a mouse PCA model also show that inhibiting PLK1 activity can alleviate local allergic reaction symptoms. The results show that PLK1 has a significant regulatory effect on pseudoallergic reactions, providing a theoretical basis and experimental basis for exploring the potential mechanism and treatment methods of pseudoallergic reactions.

Relates to an application of an anti-TSLP antibody or an antigen-binding fragment thereof and a nucleic acid molecule encoding the antibody in preparation of drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases, the antibody or the antigen-binding fragment thereof has high affinity to TSLP, can effectively bind to TSLP and block the proliferation effect of TSLP on Ba / F3-hTSLPR-hIL7R alpha cells, and can be used for preparing drugs for preventing and / or treating asthma, allergic inflammation, anaphylaxis or autoimmune diseases. And the TSLP is capable of blocking the activation of PBMC (peripheral blood mononuclear cells) and secreting cytokines.

The invention discloses a garden burnet cream for treating psoriasis and a preparation method thereof. The garden burnet cream is prepared from garden burnet, golden cypress, scutellaria baicalensis, rheum officinale, coptis chinensis, liquorice, lithospermum, schizonepeta, folium artemisiae argyi and borneol. The radix sanguisorbae paste is prepared from 15 g to 30 g of radix sanguisorbae, 7 g to 16 g of cortex phellodendri, 8 g to 13 g of radix scutellariae, 7 g to 16 g of radix et rhizoma rhei, 8 g to 10 g of rhizoma coptidis, 9 g to 13 g of radix glycyrrhizae, 2 g to 16 g of radix arnebiae seu lithospermi, 14 g to 21 g of herba schizonepetae, 11 g to 22 g of folium artemisiae argyi and 15 g to 26 g of borneol according to the formula proportion, the medicines are prepared into the radix sanguisorbae paste, and therefore the treatment effect can be better achieved. Sanguisorba officinalis in the formula has the effects of cooling blood, detoxifying and healing sores, can resist inflammation and bacteria and promote healing of sore surfaces, and can enhance the effects of resisting inflammation and allergy by cooperating with golden cypress capable of clearing heat, drying dampness, purging fire and detoxifying, so that psoriasis can be treated more effectively.

Provided are thiophene derivatives of formula (I) and pharmaceutically acceptable salts thereof. These compounds can be used to treat or prevent diseases caused by IgE, such as allergies, type 1 hypersensitivity reactions, or common sinus inflammation. #imgabs0#

The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine preparation for treating allergic rhinitis and a preparation method thereof.The traditional Chinese medicine preparation is prepared from, by weight, 10-60 g of platycodon grandiflorum, 40-70 g of rhizoma zingiberis, 15-65 g of Chinese yam and 25-95 g of honey-fried licorice root. The traditional Chinese medicine composition is used for treating allergic rhinitis and has the advantages of being convenient to use, quick in effect taking, convenient to take, low in price, exact in anti-allergic effect, free of toxic and side effects and safe in medication.