Sanguisorba officinalis ointment for treating psoriasis and preparation method thereof

Abstract

The invention discloses a garden burnet cream for treating psoriasis and a preparation method thereof. The garden burnet cream is prepared from garden burnet, golden cypress, scutellaria baicalensis, rheum officinale, coptis chinensis, liquorice, lithospermum, schizonepeta, folium artemisiae argyi and borneol. The radix sanguisorbae paste is prepared from 15 g to 30 g of radix sanguisorbae, 7 g to 16 g of cortex phellodendri, 8 g to 13 g of radix scutellariae, 7 g to 16 g of radix et rhizoma rhei, 8 g to 10 g of rhizoma coptidis, 9 g to 13 g of radix glycyrrhizae, 2 g to 16 g of radix arnebiae seu lithospermi, 14 g to 21 g of herba schizonepetae, 11 g to 22 g of folium artemisiae argyi and 15 g to 26 g of borneol according to the formula proportion, the medicines are prepared into the radix sanguisorbae paste, and therefore the treatment effect can be better achieved. Sanguisorba officinalis in the formula has the effects of cooling blood, detoxifying and healing sores, can resist inflammation and bacteria and promote healing of sore surfaces, and can enhance the effects of resisting inflammation and allergy by cooperating with golden cypress capable of clearing heat, drying dampness, purging fire and detoxifying, so that psoriasis can be treated more effectively.

Description

Technical Field

[0001] The present invention relates to the technical field of psoriasis treatment, and in particular to a sanguisorba decoction for psoriasis treatment and its preparation method. Background Art

[0002] Psoriasis is a common erythematous and scaly skin disease, mainly manifested by erythema, papules, and plaques with white scales covering the surface, which are distributed locally or widely. This disease is an immune response mediated mainly by T lymphocytes induced by various internal and external environmental factors on the basis of genetic susceptibility, causing infiltration of inflammatory factors and excessive proliferation of epidermal keratinocytes. The course of this disease is long, stubborn and difficult to cure, and it is extremely easy to relapse, seriously affecting the quality of life and physical and mental health of patients.

[0003] After retrieval, the invention patent with the Chinese patent number 202411202012.2 discloses a traditional Chinese medicine composition for treating psoriasis and its preparation method and application. Its raw material composition includes, by mass: 10 - 30 parts of schizonepeta, 10 - 30 parts of mugwort leaf, and 10 - 30 parts of acorus tatarinowii. Animal experiments show that the traditional Chinese medicine composition of the present invention can repair the skin barrier function and relieve the skin lesion symptoms of psoriasis-like mice. Thus, it is indicated that the traditional Chinese medicine composition of the present invention has a good therapeutic effect on psoriasis.

[0004] Compared with the prior art, by promoting the repair of the skin barrier function, the skin lesion symptoms of psoriasis-like mice are relieved. Thus, it is indicated that the traditional Chinese medicine composition of the present invention has a good therapeutic effect on psoriasis. Schizonepeta, mugwort leaf, and acorus tatarinowii cooperate with each other, having the efficacy of relieving exterior syndrome, promoting eruption, and removing dampness, being able to effectively repair the skin barrier function, having a significant therapeutic effect on psoriasis, and being safe without toxic and side effects.

[0005] However, in the actual use process of the above formula, the extraction of the effective components of the medicinal materials is not sufficient, and the medicinal effect of the medicinal material extract is low; making the medicinal materials into a sanguisorba decoction can also better exert its therapeutic effect on psoriasis. Therefore, a sanguisorba decoction for psoriasis treatment and its preparation method are needed. Summary of the Invention

[0006] The purpose of the present invention is to solve the disadvantages in the prior art that the extraction of the effective components of the medicinal materials is not sufficient and the effect on the affected area is poor, and to propose a sanguisorba decoction for psoriasis treatment and its preparation method.

[0007] To achieve the above purpose, the present invention adopts the following technical scheme:

[0008] A sanguisorba decoction for psoriasis treatment, the formula of the sanguisorba decoction consists of sanguisorba, phellodendron, scutellaria, rhubarb, coptis, licorice, lithospermum, schizonepeta, mugwort leaf, and borneol;

[0009] The formula ratio of Sanguisorba officinalis paste is 15g - 30g of Sanguisorba officinalis, 7g - 16g of Phellodendron amurense, 8g - 13g of Scutellaria baicalensis, 7g - 16g of Rheum palmatum, 8g - 10g of Coptis chinensis, 9g - 13g of Glycyrrhiza uralensis, 2g - 16g of Lithospermum erythrorhizon, 14g - 21g of Schizonepeta tenuifolia, 11g - 22g of Artemisia argyi, and 15g - 26g of Borneol.

[0010] The above technical solution further includes:

[0011] The best formula ratio of the Sanguisorba officinalis paste formula is 20g of Sanguisorba officinalis, 10g of Phellodendron amurense, 10g of Scutellaria baicalensis, 10g of Rheum palmatum, 10g of Coptis chinensis, 10g of Glycyrrhiza uralensis, 10g of Lithospermum erythrorhizon, 17g of Schizonepeta tenuifolia, 20g of Artemisia argyi, and 23g of Borneol.

[0012] A preparation method of a Sanguisorba officinalis paste formula is as follows:

[0013] Step 1: Weigh Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, Artemisia argyi, and Borneol according to the ratio;

[0014] Step 2: Clean and crush the weighed Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, and Artemisia argyi in sequence;

[0015] Step 3: Place the crushed and mixed medicinal materials in sesame oil for soaking;

[0016] Step 4: Boil the soaked sesame oil. First, bring it to a boil over high heat, and then turn to low heat for boiling;

[0017] Step 5: After boiling, filter the medicinal residues to obtain traditional Chinese medicine oil, and put the ground Borneol into the traditional Chinese medicine oil and cool it to room temperature.

[0018] During the crushing process, put Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, and Artemisia argyi into the crusher for crushing in sequence, and the crushing time is 3.5 min - 4.0 min.

[0019] Before the traditional Chinese medicine in Step 2 is crushed, it is pretreated, and the pretreatment steps are as follows:

[0020] First step: Wash the weighed Chinese medicinal materials with clean water for 50s - 70s, and then rinse them with alcohol for 20s;

[0021] Second step: Rinse the medicinal materials after alcohol washing with pure water again for 50s - 70s;

[0022] Third step: Naturally dry the washed medicinal materials at room temperature.

[0023] The ratio between the sesame oil and the medicinal materials is 2:1;

[0024] The time for the crushed medicinal materials to be soaked in sesame oil is 15h - 20h, and they are stirred once every 1h during the soaking process;

[0025] In step four, the time for low-temperature boiling is 30min - 45min, and continuous stirring is carried out during this process;

[0026] In step five, borneol is ground into extremely fine powder and put into the traditional Chinese medicine oil, then beeswax is added and stirred evenly, and left to cool to room temperature.

[0027] The present invention has the following beneficial effects:

[0028] In the present invention, by making the medicine into Sanguisorba officinalis paste, the therapeutic effect can be better exerted. Sanguisorba officinalis in the formula has the effects of cooling blood, detoxifying and astringing sores, can anti-inflammatory, antibacterial and promote the healing of sore surfaces. Combined with Phellodendron amurense which can clear heat and dry dampness, purge fire and detoxify, it can strengthen the anti-inflammatory and anti-allergic effects, and can more effectively treat the skin lesions of psoriasis. Other traditional Chinese medicinal materials in the formula have the effects of clearing heat and cooling blood, drying dampness and detoxifying, dispelling wind and relieving itching. The combination of various herbs conforms to the pathogenesis of "blood heat" in traditional Chinese medicine for psoriasis and the basic treatment principle of treating from blood. In addition, borneol in the formula can promote the percutaneous penetration of the medicine and reach the affected area directly, thus improving the clinical efficacy. Specific embodiments

[0029] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0030] Example 1

[0031] Step 1: Weigh Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, Artemisia argyi and borneol according to the proportion. The specific proportion is 20g of Sanguisorba officinalis, 10g of Phellodendron amurense, 10g of Scutellaria baicalensis, 10g of Rheum palmatum, 10g of Coptis chinensis, 10g of Glycyrrhiza uralensis, 10g of Lithospermum erythrorhizon, 17g of Schizonepeta tenuifolia, 20g of Artemisia argyi, and 23g of borneol;

[0032] Step 2: Clean and crush the symmetrically taken Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia and Artemisia argyi in sequence. During the crushing process, put Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia and Artemisia argyi into the crusher for crushing in sequence. The crushing time is 3.5min - 4.0min. Pretreatment is carried out before crushing the traditional Chinese medicine. The steps of the pretreatment are as follows:

[0033] The first step: Wash the weighed traditional Chinese medicinal materials with clean water for 50s - 70s, and then rinse with alcohol for 20s;

[0034] Step 2: Rinse the medicinal materials after alcohol cleaning with pure water again for 50s - 70s;

[0035] Step 3: Naturally dry the medicinal materials after cleaning at room temperature;

[0036] Step 3: Place the crushed and mixed medicinal materials in sesame oil for soaking, where the ratio between sesame oil and the medicinal materials is 2:1;

[0037] Step 4: Boil the soaked sesame oil. First, bring it to a boil over high heat, then turn to low heat for boiling. The soaking time of the crushed medicinal materials in sesame oil is 15h - 20h, and stir once every 1h during the soaking process. The low-temperature boiling time in Step 4 is 30min - 45min, and keep stirring continuously during this process;

[0038] Step 5: Filter the medicinal residues after boiling to obtain Chinese medicinal oil. Grind borneol into extremely fine powder, put it into the Chinese medicinal oil, then add beeswax and stir evenly, and let it stand and cool to room temperature to obtain Sanguisorba officinalis Ointment A.

[0039] Example 2

[0040] Step 1: Weigh Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, Artemisia argyi, and borneol according to the ratio. The specific ratio is 20g of Sanguisorba officinalis, 10g of Phellodendron amurense, 10g of Scutellaria baicalensis, 10g of Rheum palmatum, 10g of Coptis chinensis, 10g of Glycyrrhiza uralensis, 10g of Lithospermum erythrorhizon, 17g of Schizonepeta tenuifolia, 20g of Artemisia argyi, and 23g of borneol;

[0041] Step 2: Clean and crush the weighed Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, and Artemisia argyi in sequence. During the crushing process, put Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Schizonepeta tenuifolia, and Artemisia argyi into the crusher for crushing in sequence. The crushing time is 3.5min - 4.0min. Pretreatment is carried out before crushing the Chinese medicine. The steps of the pretreatment are as follows:

[0042] Step 1: Wash the weighed Chinese medicinal materials with clean water for 50s - 70s, and then rinse with alcohol for 20s;

[0043] Step 2: Rinse the medicinal materials after alcohol cleaning with pure water again for 50s - 70s;

[0044] Step 3: Naturally dry the medicinal materials after cleaning at room temperature;

[0045] Step 3: Put the crushed traditional Chinese medicine into sesame oil and boil it. When boiling, first bring it to a boil over high heat, and then turn to low heat for boiling. The soaking time of the crushed medicinal materials in sesame oil is 15h - 20h, and stir them every 1h during the soaking process. The low-temperature boiling time in Step 4 is 30min - 45min, and keep stirring continuously during this process;

[0046] Step 4: After boiling, filter out the medicinal residues to obtain traditional Chinese medicine oil. Grind borneol into extremely fine powder and put it into the traditional Chinese medicine oil, then add beeswax and stir evenly, and let it stand and cool to room temperature to obtain Sanguisorba officinalis Ointment B.

[0047] Example 3

[0048] Step 1: Weigh Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, and Lithospermum erythrorhizon according to the ratio. The specific ratio is 20g of Sanguisorba officinalis, 10g of Phellodendron amurense, 10g of Scutellaria baicalensis, 10g of Rheum palmatum, 10g of Coptis chinensis, 10g of Glycyrrhiza uralensis, and 10g of Lithospermum erythrorhizon;

[0049] Step 2: Clean and crush the weighed Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, and Lithospermum erythrorhizon in sequence. During the crushing process, put the traditional Chinese medicines of Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rheum palmatum, Coptis chinensis, Glycyrrhiza uralensis, and Lithospermum erythrorhizon into the crusher for crushing in sequence. The crushing time is 3.5min - 4.0min. Pretreatment is carried out before crushing the traditional Chinese medicine. The steps of pretreatment are as follows:

[0050] First step: Wash the weighed Chinese medicinal materials with clean water for 50s - 70s, and then rinse them with alcohol for 20s;

[0051] Second step: Rinse the medicinal materials after alcohol washing with pure water again for 50s - 70s;

[0052] Third step: Let the washed medicinal materials dry naturally at room temperature;

[0053] Step 3: Put the crushed and mixed medicinal materials into sesame oil for soaking, and the ratio between sesame oil and the medicinal materials is 2:1;

[0054] Step 4: Boil the soaked sesame oil. When boiling, first bring it to a boil over high heat, and then turn to low heat for boiling. The soaking time of the crushed medicinal materials in sesame oil is 15h - 20h, and stir them every 1h during the soaking process. The low-temperature boiling time in Step 4 is 30min - 45min, and keep stirring continuously during this process;

[0055] Step 5: After boiling, filter out the medicinal residues to obtain traditional Chinese medicine oil, add beeswax and stir evenly, and let it stand and cool to room temperature to obtain Sanguisorba officinalis Ointment C.

[0056] Control Example 1

[0057] Step 1: Weigh Cortex Phellodendri, Radix Scutellariae, Radix et Rhizoma Rhei, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Arnebiae / Lithospermi, Herba Schizonepetae, Folium Artemisiae Argyi and Borneolum Syntheticum according to a ratio. The specific ratio is 20 g of Radix Sanguisorbae, 10 g of Cortex Phellodendri, 10 g of Radix Scutellariae, 10 g of Radix et Rhizoma Rhei, 10 g of Rhizoma Coptidis, 10 g of Radix Glycyrrhizae, 10 g of Radix Arnebiae / Lithospermi, 17 g of Herba Schizonepetae, 20 g of Folium Artemisiae Argyi, and 23 g of Borneolum Syntheticum;

[0058] Step 2: Clean and pulverize the symmetrically taken Cortex Phellodendri, Radix Scutellariae, Radix et Rhizoma Rhei, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Arnebiae / Lithospermi, Herba Schizonepetae and Folium Artemisiae Argyi in sequence. During the pulverization process, put Cortex Phellodendri, Radix Scutellariae, Radix et Rhizoma Rhei, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Arnebiae / Lithospermi, Herba Schizonepetae and Folium Artemisiae Argyi into the pulverizer for pulverization in sequence. The pulverization time is 3.5 min - 4.0 min. The traditional Chinese medicine is pretreated before pulverization. The pretreatment steps are as follows:

[0059] First step: Wash the weighed traditional Chinese medicine with clear water for 50 s - 70 s, and then rinse it with alcohol for 20 s;

[0060] Second step: Rinse the medicine after alcohol washing with pure water again for 50 s - 70 s;

[0061] Third step: Naturally dry the washed medicine at room temperature;

[0062] Step 3: Place the pulverized and mixed medicine in Sesame Oil for soaking. The ratio between Sesame Oil and the medicine is 2:1;

[0063] Step 4: Boil the soaked Sesame Oil. First, bring it to a boil over high heat, and then turn to low heat for boiling. The time for the pulverized medicine to be soaked in Sesame Oil is 15 h - 20 h, and stir it once every 1 h during the soaking process. The time for low-temperature boiling in Step 4 is 30 min - 45 min, and keep stirring during this process;

[0064] Step 5: Filter the medicinal residues after boiling to obtain traditional Chinese medicine oil. Grind Borneolum Syntheticum into extremely fine powder, put it into the traditional Chinese medicine oil, add beeswax and stir evenly, and let it stand and cool to room temperature to obtain Ointment A.

[0065] Apply the Sanguisorba Ointment prepared in Examples 1 - 3 and the ointment prepared in Comparative Example 1 to 10 psoriasis patients respectively, continuously apply for 30 days, and record the situation after 30 days. The specific data are shown in the following table:

[0066]

[0067]

[0068] It can be seen from the above table that the sanguisorba decoction prepared by this formula can better play a therapeutic role. Sanguisorba in the formula has the effects of cooling blood, detoxifying and astringing sores, can anti-inflammatory, antibacterial and promote the healing of sore surfaces. Combined with phellodendron amurense, which can clear heat and dry dampness, purge fire and detoxify, it can strengthen the anti-inflammatory and anti-allergic effects, and can more effectively treat psoriasis skin lesions. Other Chinese medicinal materials in the formula have the effects of clearing heat and cooling blood, drying dampness and detoxifying, dispelling wind and relieving itching. The combination of various herbs conforms to the pathogenesis of "blood heat" in traditional Chinese medicine for psoriasis and the basic treatment principle of treating from blood. In addition, borneol in the formula can promote the percutaneous penetration of drugs and reach the affected area directly, thus improving the clinical efficacy.

[0069] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made in these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Sanguisorba officinalis ointment for treating psoriasis, characterized in that: The formula of the burdock ointment is composed of burdock, phellodendron, scutellaria, rhubarb, coptis, liquorice, lithospermum, schizonepeta, wormwood and borneol; The formula ratio of Sanguisorba officinalis paste is 15g-30g of Sanguisorba officinalis, 7g-16g of Phellodendron chinense, 8g-13g of Scutellaria baicalensis, 7g-16g of Rhubarb, 8g-10g of Coptis chinensis, 9g-13g of Lithospermum officinale, 2g-16g of Lithospermum officinale, 14g-21g of Schizonepeta tenuifolia, 11g-22g of Artemisia argyi, and 15g-26g of Borneol.

2. The Sanguisorba officinalis ointment for treating psoriasis according to claim 1, characterized in that: The optimal formula ratio of the Sanguisorba officinalis paste is 20g of Sanguisorba officinalis, 10g of Phellodendron chinense, 10g of Scutellaria baicalensis, 10g of Rhubarb, 10g of Coptis chinensis, 10g of Lithospermum officinale, 17g of Schizonepeta tenuifolia, 20g of Artemisia argyi, and 23g of Borneol.

3. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 2, characterized in that: The following steps are involved: Step 1: Weigh sanguisorba officinalis, phellodendron amurense, scutellaria baicalensis, rhubarb, coptis chinensis, liquorice, lithospermum officinale, schizonepeta tenuifolia, wormwood leaf and borneol according to the proportion; Step 2: Clean and crush the symmetrically taken Radix Sanguisorbae, Cortex Phellodendri, Radix Scutellariae, Radix Rhei, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Lithospermi, Herba Schizonepetae and Folium Artemisiae Argyi in turn; Step 3: Soak the crushed and mixed medicinal materials in sesame oil; Step 4: Boil the soaked sesame oil. First boil it over high heat, then switch to low heat. Step 5: After boiling, filter the residue to obtain the Chinese medicine oil. Put the ground borneol into the Chinese medicine oil and cool it to room temperature.

4. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 3, characterized in that: During the crushing process, the Chinese medicinal materials of Sanguisorba officinalis, Phellodendron amurense, Scutellaria baicalensis, Rhubarb, Coptis chinensis, Licorice, Lithospermum officinale, Schizonepeta tenuifolia and Artemisia argyi are put into the crusher in turn for crushing, and the crushing time is 3.5min-4.0min.

5. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 3, characterized in that: The Chinese medicine in step 2 is pre-treated before being crushed, and the steps of the pre-treatment are as follows: Step 1: Wash the weighed Chinese medicinal materials with clean water for 50s-70s, and then rinse with alcohol for 20s; Step 2: Rinse the medicinal materials after alcohol cleaning again with pure water for 50s-70s; Step 3: Dry the cleaned medicinal materials naturally at room temperature.

6. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 3, characterized in that: The ratio between sesame oil and medicinal materials is 2:

1.

7. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 3, characterized in that: The crushed medicinal materials are soaked in sesame oil for 15-20 hours, and are stirred every hour during the soaking process.

8. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 3, characterized in that: The time for low-temperature boiling in step 4 is 30 minutes to 45 minutes, and the mixture is stirred continuously during the process.

9. The method for preparing the Sanguisorba officinalis ointment for treating psoriasis according to claim 3, characterized in that: In step 5, grind the borneol into extremely fine powder and put it into the traditional Chinese medicine oil, then add beeswax and stir evenly, and let it stand to cool to room temperature.

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