123 results about "Sinus inflammation" patented technology

Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also generally relates to pharmaceutical compositions comprising one or more active pharmaceutical ingredients, such as azelastine or pharmaceutically acceptable salts or esters thereof including azelastine hydrochloride, particularly wherein the compositions are provided in unit dosage form. In certain embodiments, the invention provides such unit dosage pharmaceutical compositions comprising azelastine hydrochloride formulated for use as nasal sprays and / or ocular solutions or drops. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of a variety of allergic and non-allergic conditions, particularly conjunctivitis, sinusitis, rhinitis and rhinosinusitis. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention relates to a compound represented by the formula (I),wherein all symbols are as defined in the description,a salt thereof, a solvate thereof, or a prodrug thereof, which has a leukotriene receptor antagonistic activity which is expected to be more effective than those of the leukotriene receptor antagonists currently used in clinical trials. Therefore, it is useful as an agent for the prevention and / or treatment of a leukotriene-mediated disease such as a respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, pulmonary emphysema, chronic bronchitis, pneumonia (e.g. interstitial pneumonia etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g. acute sinusitis, chronic sinusitis, etc.), or the like, or as an expectorant or an antiitussive.

The invention discloses a traditional Chinese medicine decoction for treating chronic paranasal sinusitis and a preparation method thereof. The traditional Chinese medicine decoction mainly consists of honeysuckle, platycodon grandiflorus, angelica dahurica, radix paeoniae rubra, lotus rhizome node, siberian cocklour fruit, divaricate saposhnikovia root, acorus gramineus, gardenia, liquorice, wrinkled gianthyssop herb, magnolia flower and mint. The traditional Chinese medicine composition has the effects of stopping pain and smoothening the nose, has the effect of well relieving various pain symptoms and stuffy noses and running noses caused by the chronic paranasal sinusitis and has the obvious effect of treating the chronic paranasal sinusitis.

The invention discloses a traditional Chinese herbal preparation for treating chronic nasosinusitis, which consists of gypsum, honeysuckle, chrysanthemum, ligusticum wallichii, radix angelicae, mint, dried tangerine, figwort root, spina gleditsiae, radices sileris, radix rehmanniae, angelica sinensis, pollen, magnolia flower, Siberian cocklour fruit, platycodon grandiflorum, radix bupleuri, radixscutellariae, herba pogostemonis, radix puerariae, bighead atractylodes rhizome and liquorice, the medicines are composited to generate a synergistic effect of all the medicine efficacies, and the preparation has the effects of opening the inhibited lung-energy, dispelling pathogenic wind, clearing liver fire, cooling and activating blood, eliminating stagnation and discharging pus. The traditional Chinese herbal preparation adopts the pharmacological basis on treating chronic nasosinusitis that: by aiming at the etiological pathology of the chronic nasosinusitis, the traditional Chinese herbal preparation prevents bacteria, diminish inflammation, avoid allergic reaction, improve immunity of the organism and microcirculation, and promote tissue cell repair. The preparation of the invention not only is in accordance with the principle of medicine and health syndrome differentiation and treatment in China, but also is supported by modern pharmological study, so the curative effect is obvious; and the preparation has no toxic or side effect, stable long-term effect and convenience for taking, and is worth being popularized.

The present invention relates to new medicament combinations which contain in addition to one or more PDE4-inhibitors (1) at least one EP4 receptor antagonist (2), as well as the use thereof for the treatment of preferably respiratory complaints such as particularly COPD, chronic sinusitis and asthma.The invention relates in particular to those medicament combinations which contain, in addition to one or more, preferably one, PDE4 inhibitor of general formula 1wherein X is SO or SO2, but preferably SO, and whereinR1, R2, R3 and R4 have the meanings given in claim 1, at least one EP4 receptor antagonist (2), the preparation thereof and the use thereof for the treatment of respiratory complaints.

A nasal solution and method for treating nasal and sinus inflammation. The nasal solution includes vitamin C, an extract of scutellaria radix, an extract of eleutherococcus radix, an extract of chamomile, and a pharmaceutically acceptable carrier which is suitable for administering the vitamin C, the scutellaria radix extract; the eleutherococcus radix extract; and the chamomile to the nose of a patient. The method includes administering the nasal solution which suppresses early phase and late phase mediators of allergic mucosal disease in order to maintain long-term inhibition of nasal and sinus inflammation.

The invention relates to a traditional Chinese medicine for treating sinusitis. The traditional Chinese medicine is characterized by being prepared from the following active pharmaceutical ingredients in parts by weight: 12 parts of olibanum, 12 parts of myrrha, 16 parts of bulbus fritillariae thunbergii, 12 parts of radix curcumae, 10 parts of radix saposhnikoviae, 20 parts of rhizoma anemarrhenae, 10 parts of pericarpium citri reticulatae, 20 parts of radix astragali, 20 parts of cortex phyllodendri stirred with yellow rice wine, 10 parts of fructus forsythiae, 10 parts of platycodon grandiflorus, 8 parts of saussurea costus, 16 parts of semen pharbitidis, 10 parts of flos lonicerae and 6 parts of radix glycyrrhizae. Experiments prove that the traditional Chinese medicine can safely and effectively treat sinusitis.

The present invention relates to the field of salt soda water processing and specifically discloses low salt type lemon flavored salt soda water. In a preparation of the salt soda water, the following raw material ingredients are used: soft white sugar, a salicornia europaea extract, edible salt, edible essence, citric acids, an amino acid additive, sodium citrate, sorbitol, vitamins, carbon dioxide and the balanced being purified water. The edible salt is not singly used and the salicornia europaea extract is used to replace a part of sodium chloride, so that a problem that traditional salt soda water is bitter and salty, and does not quench thirsty is solved. The contained trace elements of calcium, potassium, magnesium, ferrum, iodine, etc., enzymes, fibers, alkaloid ingredients, etc. have significant effects on cancers, sinusitis, arthritis, high blood pressure, low blood pressure, low back pain, obesity, hemorrhoids, diabetes, thyroiditis, asthma and bronchitis and the salt soda water is in a low salt type and has a lemon flavor.