Traditional Chinese medicine composition for treating rhinitis and nasosinusitis

Abstract

The invention discloses a traditional Chinese medicine composition for treating rhinitis and nasosinusitis, relates to the technical field of traditional Chinese medicine compositions, and is technically characterized in that the traditional Chinese medicine composition is prepared from 5-15 g of fructus chebulae, 1-5 g of herba asari, 5-15 g of herba schizonepetae, 5-15 g of radix platycodonis, 3-10 g of ramulus cinnamomi, 3-10 g of flos magnoliae, 5-15 g of radix angelicae and 5-15 g of radix codonopsis. The traditional Chinese medicine composition can effectively help to regulate lung functions and relieve symptoms caused by lung qi deficiency or cold evil invasion in rhinitis and nasosinusitis, and is especially suitable for patient groups with symptoms such as nasal obstruction, running nose and cough caused by wind-cold invasion.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating rhinitis and sinusitis. Background Art

[0002] Rhinitis and sinusitis are common respiratory diseases that affect a large number of people worldwide. Rhinitis usually refers to inflammation of the nasal mucosa. It can be divided into allergic rhinitis and non-allergic rhinitis according to the cause, and is often manifested by symptoms such as nasal congestion, sneezing, runny nose, and nasal itching. Allergic rhinitis is often caused by allergens such as pollen, dust mites, and pet dander, and is more common during seasonal changes.

[0003] Sinusitis refers to inflammation of the mucous membranes in the sinuses, often caused by infection, allergies or abnormalities in the structure of the nasal cavity. Acute sinusitis is usually caused by colds, bacterial or viral infections, and manifests as persistent nasal congestion, facial pain, headaches, purulent discharge, etc. Chronic sinusitis is a condition in which symptoms persist for more than 12 weeks and are often accompanied by loss of smell, postnasal drip, etc.

[0004] These two diseases not only affect the quality of life of patients, but may also lead to complications such as otitis media and asthma. Although modern medicine has a variety of drugs and surgical methods to relieve symptoms, they are prone to relapse during treatment. Traditional Chinese medicine has become an auxiliary treatment option for many patients in terms of conditioning the body, relieving symptoms and reducing recurrence. Summary of the invention

[0005] The purpose of the present invention is to solve the above problems and provide a Chinese medicine composition for treating rhinitis and sinusitis. The medicinal materials in the composition can comprehensively improve the symptoms of patients with rhinitis and sinusitis through the multiple effects of warming the lungs, dispelling wind and cold, anti-inflammatory and antibacterial, and enhancing immunity. It can not only relieve nasal congestion, runny nose, headache, facial pain, etc. during the acute attack period, but also achieve the effect of treating both the symptoms and the root causes by regulating lung qi and enhancing immunity for a long time, thereby reducing the risk of recurrence of the disease.

[0006] In order to achieve the above purpose, the technical scheme of the present invention is as follows: a traditional Chinese medicine composition for treating rhinitis and sinusitis, the traditional Chinese medicine composition is composed of 5-15 grams of Terminalia chebula fruit, 1-5 grams of Asarum, 5-15 grams of Schizonepeta tenuifolia, 5-15 grams of Platycodon grandiflorum, 3-10 grams of cinnamon twig, 3-10 grams of magnolia, 5-15 grams of Angelica dahurica, and 5-15 grams of Codonopsis pilosula.

[0007] Preferably, the weight ratio of Terminalia chebula, Asarum, Schizonepeta tenuifolia, Platycodon grandiflorum, Cinnamomum cassia, Magnolia officinalis, Angelica dahurica and Codonopsis pilosula in the traditional Chinese medicine composition is 1:0.5:0.3:1:1:0.5:0.5:1:1.

[0008] Preferably, the ratio of the traditional Chinese medicine composition is 10 grams of Terminalia chebula fruit, 3 grams of Asarum, 10 grams of Schizonepeta tenuifolia, 10 grams of Platycodon grandiflorum, 5 grams of Cinnamon twig, 5 grams of Magnolia officinalis, 10 grams of Angelica dahurica, and 10 grams of Codonopsis pilosula.

[0009] The present invention also provides a method for preparing a traditional Chinese medicine composition for treating rhinitis and sinusitis: take each of the medicinal materials of Terminalia chebula, Asarum, Nepeta tenuifolia, Platycodon grandiflorum, Cinnamomum cassia, Flos magnoliae, Angelica dahurica and Codonopsis pilosula respectively, put them into a clean container, add 10 times the amount of water, soak for 30 minutes, so that the medicinal materials can fully absorb water; after the soaking, put the medicinal materials together with the soaking water into a medicine decocting pot, boil them with high heat, then change to low heat, and decoct for 30-40 minutes; after the decoction is completed, filter the medicinal liquid with gauze, retain the medicinal liquid, add an appropriate amount of clean water to the medicinal residue, repeat the decoction once, mix the two medicinal liquids and let them stand, separate the upper clear liquid, and the prepared medicinal liquid can be packaged and stored after cooling, and placed in a refrigerator for refrigeration to obtain the traditional Chinese medicine composition.

[0010] Preferably, the Chinese medicine composition is used for the preparation of medicine for treating rhinitis and sinusitis.

[0011] Compared with the prior art, this solution has the following beneficial effects:

[0012] Warming the lungs and dispelling cold, clearing the nasal passages: The herbs in the formula, such as cinnamon twig, asarum, magnolia, and angelica root, are warm in nature and can warm the lungs and dispel cold, and are particularly suitable for rhinitis and sinusitis symptoms caused by wind-cold invasion or insufficient lung qi. These medicines help regulate the flow of lung qi and relieve symptoms such as nasal congestion, runny nose, and cough caused by cold evil in the lungs.

[0013] Inducing sweating and dispelling external pathogens: Cinnamon twigs can induce sweating and dispel external pathogens, which can help patients with rhinitis and sinusitis to dispel cold pathogens through sweating, and relieve symptoms such as nasal congestion, increased nasal discharge, and general fatigue caused by wind and cold. When combined with Schizonepeta tenuifolia, the effect of dispelling wind and dispelling external pathogens is better, especially for acute rhinitis and sinusitis caused by wind and cold.

[0014] Anti-inflammatory and detumescent: Terminalia chebula and Platycodon grandiflorum have anti-inflammatory and detoxifying effects, which can reduce inflammation of the nasal and sinus mucosa, relieve swelling, and reduce the production of secretions.

[0015] Relieving pain and removing dampness: Angelica dahurica, Magnolia officinalis, etc. have the effect of clearing the orifices and relieving pain. They can relieve headaches and facial pain caused by sinusitis, while helping to clear nasal fluid and relieve nasal discomfort.

[0016] Enhance immunity and prevent recurrence: Codonopsis pilosula replenishes Qi and strengthens the spleen, enhances the body's immunity, helps resist the invasion of external pathogens, and reduces the chance of recurrence of rhinitis and sinusitis. DETAILED DESCRIPTION

[0017] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0018] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0019] Example:

[0020] A traditional Chinese medicine composition for treating rhinitis and sinusitis comprises 10 grams of terminalia chebula pulp, 3 grams of asarum, 10 grams of schizonepeta, 10 grams of platycodon, 5 grams of cassia twig, 5 grams of magnolia, 10 grams of angelica dahurica and 10 grams of codonopsis pilosula.

[0021] The preparation method of the traditional Chinese medicine composition is as follows: taking each of the medicinal materials of terminalia chebula, asarum, schizonepeta, platycodon, cassia twig, magnolia, angelica dahurica and codonopsis pilosula respectively and putting them into a clean container, adding 10 times the amount of water, soaking for 30 minutes, so that the medicinal materials can fully absorb water; after the soaking, putting the medicinal materials together with the soaking water into a decoction pot, boiling with high heat, then changing to low heat, and decocting for 30-40 minutes; after the decoction is completed, filtering the medicinal liquid with fine gauze, retaining the medicinal liquid, adding an appropriate amount of clear water to the medicinal residue, repeating the decoction once, mixing the two medicinal liquids and standing them, separating the upper clear liquid, and cooling the prepared medicinal liquid and storing it in subpackages, and storing it in a refrigerator to obtain the traditional Chinese medicine composition.

[0022] The various ingredients in this formula have the following pharmacological effects, and can work together to treat the symptoms of rhinitis and sinusitis, and play the role of warming the lungs and dispelling cold, clearing the nasal passages, sweating, expelling external pathogens, and reducing swelling and relieving pain:

[0023] Terminalia chebula flesh: It has the effect of astringing lung qi, relieving cough and asthma, and can help relieve breathing difficulties caused by rhinitis.

[0024] Asarum: warms and dispels cold evil, opens the orifices and relieves pain. It is suitable for rhinitis symptoms such as nasal congestion and headache.

[0025] Schizonepeta: It can dispel wind and relieve exterior symptoms, has good anti-allergic and anti-inflammatory effects, and can relieve nasal itching and runny nose caused by rhinitis.

[0026] Platycodon: It can clear the lungs and relieve sore throat, expel phlegm and clear away heat, and can relieve sore throat and excessive phlegm symptoms caused by rhinitis.

[0027] Cinnamon twig: Cinnamon twig is warm in nature and has a strong effect of warming yang and dispelling cold. It is suitable for colds, rhinitis and sinusitis caused by wind and cold. It can warm the yang in the body, dispel the cold evil in the body, and help relieve symptoms such as nasal congestion, runny nose, and fever caused by cold evil.

[0028] Magnolia: Dispels wind and cold, clears the nasal passages, and is especially effective for symptoms such as nasal congestion, runny nose, and headache.

[0029] Angelica dahurica: It is pungent and warm in nature and can dispel wind and cold, and clear the nasal passages. It is often used to treat symptoms such as rhinitis, nasal congestion, and headache.

[0030] Codonopsis: It replenishes the middle and replenishes Qi, strengthens the spleen and lungs, enhances immunity, and can help relieve symptoms of physical weakness caused by rhinitis and sinusitis.

[0031] Medication and conditioning methods

[0032] In addition to the commonly used oral administration, the Chinese medicine composition also has a second administration method: leave the liquid medicine in a thermos cup (simmer the granules for half an hour), fumigate the nose with the liquid medicine steam for 10 to 15 minutes, and inhale the steam containing the medicine, twice a day. (It is best to be able to tolerate it without being too hot);

[0033] Advantages: On the one hand, it has physical effects on the nasal cavity such as cleaning, warming and humidification. On the other hand, the medicinal steam directly acts on the nasal mucosa and takes effect locally in the nasal cavity, stabilizing the nasal and sinus mucosa and improving the function of the nasal and sinus cavities.

[0034] Conditioning method: During the medication process, be careful not to eat raw or cold food, and get more sun exposure to stimulate Yang energy.

[0035] The following experiments demonstrate that the Chinese medicine composition provided by the present invention can be used to prepare medicines for treating rhinitis and sinusitis.

[0036] (I) 70 patients with chronic rhinosinusitis of lung qi deficiency and cold type were enrolled as research subjects and randomly divided into an experimental group (taking this Chinese medicine combination) and a control group (using budesonide nasal spray hormone). The intervention lasted for 4 weeks. The results showed that (1) the severity of the disease VAS score: both groups improved compared with before treatment (P < 0.05), and there was no difference between the groups; (2) the total score of TCM syndrome: the TCM syndrome score of the experimental group improved compared with before treatment (P < 0.05), while the control group did not show significant improvement (P > 0.05). (3) clinical efficacy: no significant statistical difference was found in the clinical efficacy between the experimental group and the control group. (4) During the 4-week treatment, 3 patients in the control group experienced adverse reactions such as dry nose and epistaxis, while no adverse reactions were found in the experimental group.

[0037] Table 1 Comparison of VAS scores of disease severity after treatment

[0038]

[0039] Table 2 TCM syndrome scores before and after treatment

[0040]

[0041] Table 3 Clinical efficacy of different groups

[0042]

[0043] (II) Examples

[0044] (1) Case 1

[0045] Li, female, 27 years old.

[0046] Initial diagnosis (March 20, 2009): Complaints of repeated nasal itching, sneezing, runny nose, and nasal congestion for 5 years, aggravated for 7 days. Reported that after getting up 7 days ago, there was no obvious cause for sudden nasal itching, sneezing, runny nose, accompanied by nasal congestion, which was intermittent, obvious when getting up in the morning, and the symptoms were significantly relieved 2-3 hours after getting up. The whole body was short of breath and lazy to speak, and the limbs were tired and weak; the tongue was pale, fat, with teeth marks on the edges of the tongue, thin white fur, and weak pulse. After catching a cold 5 years ago, the symptoms of nasal itching, sneezing, and runny nose appeared, which had been delayed and unhealed. The symptoms were particularly prominent when the weather suddenly changed. In the past 2 years, the nasal itching, sneezing, and runny nose gradually appeared after getting up. No smoking or drinking habits, no special history of entertainment. No other special medical history. Specialist examination showed that the inferior turbinate was enlarged and smooth, the mucosa was pale, the nasal septum was S-shaped, and there was a lot of watery secretions in the nasal passages. Subjective olfactory examination showed mild bilateral hyposmia. Auxiliary examinations: blood and urine routine tests showed no obvious abnormalities; liver and kidney functions were normal. Chest X-ray showed no abnormalities.

[0047] Syndrome differentiation and analysis: Lung-Qi deficiency and cold, nasal orifices are not nourished, wind-cold and foreign air take advantage of the opportunity to attack, and the healthy Qi drives the evil out, resulting in itchy nose and frequent sneezing; lung-Qi deficiency, water and moisture cannot be transported, stagnating in the nasal orifices, so there is nasal congestion, clear nasal discharge, swollen inferior turbinate, and pale mucosa; shortness of breath and laziness to speak, fatigue and weakness in the limbs, pale tongue, fat tongue, teeth marks on the edges of the tongue, and weak pulse, all of which are signs of Qi deficiency.

[0048] Diagnosis: Allergic rhinitis.

[0049] Syndrome differentiation: Lung qi deficiency and cold syndrome.

[0050] Treatment method: Warm the lungs and dispel cold, open the orifices and stop nosebleeds.

[0051] Prescription: 10g of Terminalia chebula, 3g of Asarum, 10g of Nepeta tenuifolia, 10g of Platycodon grandiflorum, 5g of Cinnamon twig, 5g of Magnolia officinalis, 10g of Angelica dahurica, 10g of Codonopsis pilosula

[0052] Second visit (March 28, 2009): After taking 7 doses of the above prescription, sneezing, clear nasal discharge, and nasal congestion were alleviated. If the effect is not improved, the prescription is not changed, and the original treatment is still followed. After taking 5 more doses of the above prescription, the symptoms were further alleviated.

[0053] (2) Case 2

[0054] Chen, male, 33 years old.

[0055] Initial diagnosis (October 1998): The patient came to the hospital with long-term alternating nasal obstruction, purulent mucus, and purulent pharyngeal sputum. The patient had been taking oral antibiotics and nasal sprays for a long time, but the effect was not good. Surgery was recommended, but the patient refused. He often felt weak and cold, had a tasteless mouth, pale and fat tongue, white and greasy coating, weak and slow pulse, especially the right radial pulse. Specialist examination showed edema and pale white nasal mucosa, swollen and less smooth lower nail, pale and edema middle nail, mild polypoid changes, pus in the middle tract and olfactory fissure, and pale red pharyngeal mucosa.

[0056] Syndrome analysis: The patient often feels weak and cold, has a dull taste in the mouth, has a pale and fat tongue, a white and greasy coating, a thin and slow pulse, and the right radial pulse is particularly weak. Spleen deficiency, dysfunction of healthy movement, failure of lung qi to spread, dampness and turbidity attack, stagnation in the nasal cavity, resulting in nasal congestion, excessive mucus, decreased sense of smell, and swollen nasal concha; lung qi deficiency and cold, abnormal ascending and descending, resulting in dizziness or head distension; pale and fat tongue, white and greasy coating, thin and slow pulse, and the right radial pulse is particularly weak, all of which are signs of lung qi deficiency and cold.

[0057] Diagnosis: chronic sinusitis (chronic purulent sinusitis).

[0058] Syndrome differentiation: Lung qi deficiency and cold syndrome.

[0059] Treatment method: Warm the lungs and dispel cold, open the orifices and stop nosebleeds.

[0060] Prescription: 10 grams of Terminalia chebula, 3 grams of Asarum, 10 grams of Schizonepeta tenuifolia, 10 grams of Platycodon grandiflorum, 5 grams of cinnamon twig, 5 grams of Magnolia officinalis, 10 grams of Angelica dahurica, and 10 grams of Codonopsis pilosula.

[0061] Second visit (14 doses): The patient took the medicine for more than half a month and the symptoms were significantly relieved. After taking the original prescription for 7 and a half months, there was no obvious obstruction to nasal ventilation, the purulent discharge basically disappeared, the systemic symptoms were significantly alleviated, and the physical strength gradually recovered. After more than half a year of treatment with the prescription, the symptoms basically disappeared. Although the symptoms of nasal obstruction and a small amount of purulent discharge may reappear due to cold, the symptoms are mild and can be cured by the prescription again.

[0062] The above specific embodiments are merely explanations of the present invention and are not limitations of the present invention. After reading this specification, those skilled in the art may make modifications to the embodiments without any creative contribution as needed. However, such modifications are protected by the patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A Chinese medicine composition for treating rhinitis and sinusitis, characterized in that: The Chinese medicine composition consists of 5-15 grams of Terminalia chebula fruit, 1-5 grams of Asarum, 5-15 grams of Schizonepeta tenuifolia, 5-15 grams of Platycodon grandiflorum, 3-10 grams of Cinnamomum cassia, 3-10 grams of Magnolia officinalis, 5-15 grams of Angelica dahurica and 5-15 grams of Codonopsis pilosula.

2. A Chinese medicine composition for treating rhinitis and sinusitis according to claim 1, characterized in that: The weight ratio of Terminalia chebula, Asarum, Schizonepeta tenuifolia, Platycodon grandiflorum, Cinnamomum cassia, Magnolia officinalis, Angelica dahurica and Codonopsis pilosula in the traditional Chinese medicine composition is 1:0.5:0.3:1:1:0.5:0.5:1:

1.

3. A Chinese medicine composition for treating rhinitis and sinusitis according to claim 1, characterized in that: The proportion of the Chinese medicine composition is 10 grams of Terminalia chebula fruit, 3 grams of Asarum, 10 grams of Schizonepeta, 10 grams of Platycodon grandiflorum, 5 grams of Cinnamomum cassia, 5 grams of Magnolia officinalis, 10 grams of Angelica dahurica and 10 grams of Codonopsis pilosula.

4. A method for preparing a Chinese medicine composition for treating rhinitis and sinusitis according to claim 1, characterized in that: The preparation method comprises the following steps: taking each of Terminalia chebula, Asarum, Nepeta tenuifolia, Platycodon grandiflorum, Cinnamomum cassia, Flos Magnoliae, Angelica dahurica and Codonopsis pilosula respectively and putting them into a clean container, adding 10 times the amount of water, soaking for 30 minutes to allow the medicinal materials to fully absorb water, and after soaking, putting the medicinal materials together with the soaking water into a decoction pot, boiling over high heat and then changing to low heat, decocting for 30-40 minutes, and after decocting, filtering the medicinal liquid with gauze, retaining the medicinal liquid, adding an appropriate amount of clean water to the medicinal residue, repeating the decocting once, mixing the two medicinal liquids and standing them to separate the upper clear liquid, and the prepared medicinal liquid can be packaged and stored after cooling, and placed in a refrigerator for refrigeration to obtain a Chinese medicine composition.

5. The use of the Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is used for preparing medicine for treating rhinitis and sinusitis.

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