Preparation method of dendrophenol-glycyrrhizic acid self-assembled gel spray as well as product and application of dendrophenol-glycyrrhizic acid self-assembled gel spray

The preparation of dendrobium phenol-glycyrrhizic acid self-assembled gel solved the problems of low drug delivery efficiency and large side effects in the treatment of allergic skin diseases, and achieved efficient drug loading and multi-functional synergistic therapeutic effects, significantly improving the symptoms and histopathological characteristics of allergic skin diseases.

CN121754473APending Publication Date: 2026-03-31HEFEI NORMAL UNIV
0 Cites 0 Cited by

Patent Information

Application Number
CN202511809628.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-03
Publication Date
2026-03-31

AI Technical Summary

Technical Problem

Existing drugs for treating allergic skin diseases have significant side effects with long-term use, low drug delivery efficiency, and safety issues. Traditional hydrogel carriers have low encapsulation rates and drug burst release when encapsulating hydrophobic drugs, making it difficult to meet the needs of multi-pathway synergistic therapy.

Method used

A method for preparing dendrobium-glycyrrhizic acid self-assembled gel was adopted. Dendrobium and glycyrrhizic acid self-assembled nanoparticles were mixed with chitosan, and a crosslinking agent was added to form a dendrobium-glycyrrhizic acid nanoparticle/chitosan/dextran hydrogel. The dynamic bond network was used to achieve pH-responsive release and multiple functional synergistic effects.

Benefits of technology

It achieves efficient drug delivery, pH-responsive release, and synergistic antibacterial, antioxidant, and immunomodulatory functions, significantly improving the symptoms and histopathological features of allergic skin diseases, reducing drug side effects, and improving the safety and cost-effectiveness of treatment.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a preparation method of dendrophenol-glycyrrhizic acid self-assembled gel spray as well as a product and application thereof, and belongs to the field of new medical application of active ingredients of traditional Chinese medicinal materials. The preparation method comprises the following steps: preparing dendrophenol-glycyrrhizic acid self-assembled nanoparticles by taking dendrophenol and glycyrrhizic acid as raw materials, mixing the nanoparticles with chitosan, adding a cross-linking agent, and further preparing into a gel spray dosage form. Experimental results show that the gel spray has good biocompatibility and remarkable antibacterial performance, inflammatory response and epidermis thickening of a mouse allergic skin disease model induced by 2, 4-dinitrochlorobenzene can be effectively inhibited, scratching behaviors are reduced, skin tissue inflammation and oxidative stress injury are relieved, and the gel spray has a good application prospect. The infiltration of eosinophilic granulocytes and mast cells at the affected part is reduced, and the immune balance is regulated. The product obtained by the invention has various effects of resisting allergic reaction, diminishing swelling, relieving itching and the like, and has a good application prospect in the aspect of treatment of allergic skin diseases.
Need to check novelty before this filing date? Find Prior Art