Hydroxyapatite-chitosan compound gel and preparation process and application thereof

The technology of hydroxyapatite and composite gel is applied in the fields of biomedicine and daily necessities, and can solve the problems of difficult biodegradation, adsorption and remineralization, unsuitable for clinical medical treatment, etc. The effect of improving the symptoms of bleeding gums

Active Publication Date: 2014-12-31
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, due to the shortcomings of simple HA, which is not easy to biodegrade, absorb and remineralize, even if it forms a complex, it still has the problem that it is not suitable for clinical treatment.

Method used

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  • Hydroxyapatite-chitosan compound gel and preparation process and application thereof
  • Hydroxyapatite-chitosan compound gel and preparation process and application thereof
  • Hydroxyapatite-chitosan compound gel and preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] The preparation method of modified hydroxyapatite described in this embodiment comprises the following steps:

[0137] (a) Weigh 200 kg of hydroxyapatite and 2 kg of aluminum hydroxide, add 2.5 times by weight of concentrated nitric acid (commercially available) with a mass concentration of about 68%, stir to dissolve completely, and obtain liquid C;

[0138] (b) Weigh 45 kg of sodium chloride, 6 kg of potassium chloride, and 45 kg of magnesium chloride and mix evenly, add 3 times the amount of purified water by weight, stir to completely dissolve, filter to obtain liquid D;

[0139] (c) Mix the above liquid C and liquid D, add 10% sodium hydroxide solution to adjust its pH value to ≥10, and form a white suspension;

[0140] (d) After continuously stirring the suspension at 30 rpm for 3 hours, stop stirring, leave the material to stand and age at room temperature for 24 hours, filter under pressure filtration, take the precipitate and wash it with deionized water until ...

Embodiment 2

[0142] The preparation method of modified hydroxyapatite described in this embodiment comprises the following steps:

[0143] (a) Weigh 100 kg of hydroxyapatite and 5 kg of aluminum hydroxide, add 4 times by weight of concentrated nitric acid (commercially available) with a mass concentration of about 68%, stir to dissolve completely, and obtain liquid C;

[0144] (b) Take by weighing 20 kg of sodium chloride, 2 kg of potassium chloride, and 20 kg of magnesium chloride, add 5 times the amount of purified water by weight, stir to completely dissolve, filter to obtain liquid D;

[0145] (c) Mix the above liquid C and liquid D, add 25% sodium hydroxide solution to adjust its pH value to ≥10, and form a white suspension;

[0146] (d) After the suspension was continuously stirred at 50rpm for 2 hours, the stirring was stopped, and the material was left to age at room temperature for 48 hours, filtered by pressure filtration, and the precipitate was washed with deionized water until...

Embodiment 3

[0148] The preparation method of modified hydroxyapatite described in this embodiment comprises the following steps:

[0149] (a) Weigh 100 kg of hydroxyapatite and 1 kg of aluminum hydroxide, add 2 times by weight of concentrated nitric acid (commercially available) with a mass concentration of about 68%, stir to dissolve completely, and obtain liquid C;

[0150] (b) Weigh 70 kg of sodium chloride, 10 kg of potassium chloride, and 70 kg of magnesium chloride, add 2 times the amount of purified water by weight, stir to completely dissolve, filter to obtain liquid D;

[0151] (c) Mix the above liquid C and liquid D, add 5% sodium hydroxide solution to adjust its pH value to ≥10, and form a white suspension;

[0152] (d) After the suspension was continuously stirred at 20 rpm for 6 hours, the stirring was stopped, and the material was left to age at room temperature for 12 hours, filtered by pressure filtration, and the precipitate was washed with deionized water until the filtr...

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Abstract

The invention belongs to the technical field of biomedicines and daily necessities and in particular relates to hydroxyapatite-chitosan compound gel and a preparation process of the compound gel and application of the compound gel to preparation of drug preparations or oral care products with effects of improving gingivitis. Toothpaste prepared from the compound gel has a relatively good improvement effect on red and swollen gums and bleeding gums caused by the gingivitis, has a certain relieving effect on halitosis, does not have remarkable adverse reaction, and has a certain improvement and treatment effect on oral mucosa ulcer.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and daily necessities, and in particular relates to a hydroxyapatite-chitosan composite gel and its preparation process and application. Background technique [0002] Vertebrate hard tissues (such as bones and teeth) are composites composed of organic and inorganic nano-hybrids, in which the inorganic matter is mainly nano-sized hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , Hydroxyapatite, referred to as HA], the content of hydroxyapatite in human tooth enamel is more than 95%. Synthetic hydroxyapatite has excellent biocompatibility and has a certain inducing effect on new bone growth. Therefore, it stands out among many synthetic bone substitutes and has attracted much attention. In addition, hydroxyapatite has certain remineralization, desensitization and whitening effects on oral health care. There have been many reports on its application in toothpaste, and products have been put on the mar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61K9/70A61K8/73A61Q11/00A61P1/02
Inventor 林艺青洪绯潘裕添沈育松
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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