The invention relates to a protective separating agent for high-nickel steel wide sheet rolling and a rolling method. The protective separating agent is formed by mixing a protective separating agentadhesive and a protective separating agent powder, wherein the protective separating agent adhesive is composed of silicon dioxide and ionized water, and the protective separating agent powder is composed of nano silicon dioxide, silicon nitride, zirconium dioxide and aluminum silicate. The process route of the high-nickel steel wide sheet rolling comprises the following steps of selecting materials, normalizing, cutting, beveling, edge milling, cleaning, preparing a protective separating agent, spraying the protective separating agent, assembling, presetting air holes, welding, spraying a high-temperature anti-oxidation paint, heating, rolling, separating and measuring thickness. The protective separating agent can play a role in preventing the rolled steel plate from being oxidized in ahigh-temperature process, and the effect that the steel plates are easy to separate after rolling is ensured; and the protective separating agent can be applied to the high-nickel steel wide sheet rolling, the rolling difficulty can be reduced, the flatness of the steel plate is improved, the rolling success rate is improved, and the yield is improved.