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The present application relates to the field of pharmaceutical preparation and nanomedicine, and particularly relates to a kind of nano-drug composition, its combined drug delivery system and application.The nano-drug composition comprises alpha 1-AR blocker and amphiphilic nano-carrier;The alpha 1-AR blocker is loaded in the hydrophobic core formed by amphiphilic nano-carrier;The alpha 1-AR blocker is selected from one or more of prazosin, terazosin, doxazosin;The average particle size of the nano-drug composition is 220-260 nm, the polydispersity index is less than 0.3, and the encapsulation efficiency is greater than 50%.The nano-drug composition of the present application has dual functions of anti-tumor proliferation and immune microenvironment remodeling, improves the dispersion stability of the drug in physiological medium, effectively reduces the in vivo clearance rate, prolongs the circulation time, and realizes the efficient in vivo delivery of the drug.The preparation process of the nano-preparation is stable and can be produced on a large scale.

The present application relates to the technical field of green prevention and control of rice diseases and pests, and specifically discloses a compound traditional Chinese medicine preparation for preventing and treating apple snails, and a preparation method and application thereof. The compound traditional Chinese medicine preparation comprises the following components in parts by weight: radix veratri 15-25 parts, monkshood 10-20 parts, Chinese toona fruit 15-20 parts, capsicum 18-28 parts, kopsia 8-15 parts, mint 5-10 parts, and rhizoma haemorrhoidalis 3-8 parts. The present application uses natural traditional Chinese medicine materials, has no chemical pesticide components, and can be completely degraded naturally without destroying the ecological balance of the rice field. The present application has the advantages of fast and complete killing speed, long egg inhibition duration, high overall killing rate of apple snails, wide source and low price of traditional Chinese medicine materials, simple preparation process, convenient field operation, multiple target points, no drug resistance of apple snails, continuous use for years, stable and non-declining prevention and control effect, improvement of the water and soil environment of the rice field, inhibition of the occurrence of diseases and pests in the field, promotion of the growth of rice roots, and improvement of the seedling emergence rate and seed setting rate of rice.