System and method including analytical units

A technology for storage units and reagent packs, applied in chemical instruments and methods, biochemical equipment and methods, analytical materials, etc., can solve the problems of reducing repeatability, limiting answer report turnover, processing flexibility, and lack of processing flexibility

Inactive Publication Date: 2013-05-22
BECKMAN COULTER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, multiple sources of contamination continue to risk erroneous results
Furthermore, the complexity of multiple steps of processing requiring complete nucleic acid analysis can create processing bottlenecks and reduce reproducibility, limiting answer reporting turnaround and processing flexibility
Limited answer reporting turnaround may increase time to initiate appropriate clinical treatment
For a broad and expandable test menu, lack of processing flexibility limits support for changes in assay protocols
Lack of processing flexibility can also force laboratories to sequence or batch samples and reagents in ways inconsistent with clinical needs

Method used

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  • System and method including analytical units
  • System and method including analytical units
  • System and method including analytical units

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0893] Example 1: Gram-positive DNA: Group B Streptococcus test

[0894]

[0895]

[0896] In order to combine the use of cassette warming channels, a series of assay cassette processing is alternated. Within a given movement time (X), approximately 50 seconds after moving to the CLU presentation channel and receiving a sample aliquot, the test cartridge (N) is moved to one of the two positions of the transfer shuttle. The shuttle moves to the cassette heating channel, and retrieves the previous test cassette (N-1) in the series from the cassette heater to the open position, and then transmits the current test cassette (N) to the cassette heater. Then the previous test box (N-1) passes through the end of the exercise time (X) and returns to the CLU presentation channel through the 60-second symbol of the exercise time (X) for further processing. After that, in the exercise time (X) +1) When starting, move to the next channel designated for the test box (N-1) in the procedure. ...

example 2

[0897] Example 2: DNA: CT-NG test

[0898]

[0899]

[0900]

[0901] In order to combine the use of cassette warming channels, a series of assay cassette processing is alternated. Within a given movement time (X), approximately 50 seconds after moving into the CLU presentation channel and receiving a sample aliquot, the test cartridge (N) is moved to one of the two positions of the transfer shuttle. The shuttle moves to the cartridge heating channel, and the previous test cartridge (N-1) in the series is retrieved from the cartridge heater to the still open position, and then the current test cartridge (N) is transferred to the cartridge heater. Then the previous test box (N-1) passes the end of the exercise time (X) and returns to the CLU presentation channel through the 60-second symbol of the exercise time (X) for further processing. After that, the test box (N-1) When the exercise time (X+1) starts, it moves to the next channel designated for the test box (N-1) in the proce...

example 3

[0902] Example 3: RNA: Hepatitis C virus test

[0903]

[0904]

[0905]

[0906] In order to combine the use of cassette warming channels, a series of assay cassette processing is alternated. Within a given movement time (X), approximately 50 seconds after moving into the CLU presentation channel and receiving a sample aliquot, the test cartridge (N) is moved to one of the two positions of the transfer shuttle. The shuttle moves to the cassette heating channel, and retrieves the previous test cassette (N-1) in the series from the cassette heater to the still open position, and then transfers the current test cassette (N) to the cassette heater. Then the end of the previous test box (N-1) after the exercise time (X) is returned to the CLU presentation channel through the 60-second symbol of the exercise time (X) for further processing. After this, the test box (N-1) is When the exercise time (X+1) starts, it moves to the next channel designated for the test box (N-1) in the pr...

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Abstract

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

Description

[0001] Cross references to related applications [0002] This application claims the priority rights of U.S. Provisional Application 61 / 367,343 filed on July 23, 2010, and the entire content of the provisional application is hereby incorporated for all purposes. Background technique [0003] Many nucleic acid sequences have clinical relevance. For example, nucleic acid sequences related to infectious organisms provide an indication of the presence of infection through the organism. Generally, nucleic acid sequences not expressed in patient samples can indicate the activation of pathways related to diseases or other symptoms. Other nucleic acid sequences can still indicate differences in the patient's possible response to recommended therapy. [0004] The determination of clinically relevant nucleic acids usually depends on the amplification of specific nucleic acid sequences under control and the detection of amplified products. For the determination of readiness, amplification im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/10G01N35/04G01N35/00
CPCB01L2300/022B01L2200/0668B01L2300/0654B01L7/52B01L3/545B01L2300/1822B01L2200/0642C12Q1/686C12M41/12G01N2035/1076G01N2035/1025C12Q3/00G01N1/38B01L3/50825G01N2035/0415B01L2300/046G01N2035/1051G01N2035/00435B01L2300/045G01N2035/1013B01L3/021G01N2035/0465B01L2200/12G01N35/1002B01L2300/1827B01L2200/147G01N2035/0413B01L3/0275G01F23/26G01F23/24B01L2400/043B01L2200/025G01N35/1009C12Q1/68G01N2035/1048B01L2300/042B01L3/50851B01L2300/044G05B13/02G01N2035/0475G01N35/0098B01L2300/024G01N1/31G06F19/10G01N35/04B01L3/52B01L3/5085B01L2300/123B01L2300/0851G01N35/1016B01L2300/021G01N2035/0436G16B25/20Y10T436/113332C12M1/16C12M1/34C12M1/38G01N35/10B01L2300/18C12P19/34G01N35/00732G01N35/0092G01N35/1011G01N35/1081G01N2035/00752G01N2035/00851G05B13/0205G16B99/00
Inventor 布赖恩·D·威尔逊萨米·D·艾拉路里大卫·L·安德森马太·S·大卫马太·D·埃里克森罗伯特·B·格温艾伦·N·约翰逊查尔斯·S·克赖汗泽尔盖瑞克·A·莫勒迈克尔·J·罗斯马克·F·赛尔布格丹尼尔·R·舒密特里德·B·瓦格纳约书亚·D·威尔斯托马斯·M·斯塔奇莱克大卫·L·杨
Owner BECKMAN COULTER INC
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