Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Test box

A test box and reaction well technology, applied in the field of test boxes, can solve problems such as lack of processing flexibility, support for limited changes, and reduced repeatability

Inactive Publication Date: 2014-01-29
BECKMAN COULTER INC
View PDF7 Cites 78 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, multiple sources of contamination continue to risk erroneous results
Furthermore, the complexity of multiple steps of processing requiring complete nucleic acid analysis can create processing bottlenecks and reduce reproducibility, limiting answer reporting turnaround and processing flexibility
Limited answer reporting turnaround may increase time to initiate appropriate clinical treatment
For a broad and expandable test menu, lack of processing flexibility limits support for changes in assay protocols
Lack of processing flexibility can also force laboratories to sequence or batch samples and reagents in ways inconsistent with clinical needs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Test box
  • Test box
  • Test box

Examples

Experimental program
Comparison scheme
Effect test

example

[0820] Each of the following examples outlines the processing steps in the protocol. Processing steps include extraction and isolation of nucleic acids, arrangement of the amplification mixture, delivery of the amplification mixture to a thermal cycler, amplification and detection, and waste removal.

example 1

[0821] Example 1: Gram Positive DNA: Group B Strep Assay

[0822]

[0823]

[0824]To incorporate the use of the cartridge warming lane, the processing of a series of assay cartridges is alternated. Within a given motion time (X), approximately 50 seconds after moving to the CLU presentation lane and receiving a sample aliquot, the assay cartridge (N) is moved to one of two positions on the shuttle. The shuttle moves to the cartridge warming lane and retrieves the previous assay cartridge (N-1) in the series from the cartridge heater to the hold open position, then delivers the current assay cartridge (N) to the cartridge heater. The preceding assay cartridge (N-1) is then passed back to the CLU presentation lane for further processing by the end of the exercise time (X) at the end of the exercise time (X) for further processing, after which, at the end of the exercise time (X) +1) On start, move to the next lane specified for the assay cartridge (N-1) in the protocol...

example 2

[0825] Example 2: DNA:CT-NG Assay

[0826]

[0827]

[0828]

[0829] To incorporate the use of the cartridge warming lane, the processing of a series of assay cartridges is alternated. Within a given motion time (X), approximately 50 seconds after moving into the CLU presentation lane and receiving a sample aliquot, the assay cartridge (N) is moved to one of two positions on the shuttle. The shuttle moves to the cartridge warming lane and the previous assay cartridge (N-1) in the series is retrieved from the cartridge heater to the still on position, then the current assay cartridge (N) is delivered to the cartridge heater. Then the previous assay box (N-1) passes the end of the movement time (X), returns to the CLU presentation lane for further processing by the 60 second sign of the movement time (X), after which, the assay box (N-1) Moves to the next lane assigned to assay cartridge (N-1) in the protocol when motion time (X+1) starts. This leaves the shuttle emp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is a test box, comprising a reaction hole including a first side wall for receiving reaction mixture, a second side wall, a first end wall, a second end wall and a hole base plate, wherein the first side wall, the second side wall, the first end wall and the second end wall form an opening end. The first end wall comprises a first segment and a second segment, which are jointed through a bending part. At least one of the first segment and the second segment is formed into taper shape, so that the closer the cross section of the reaction hole is to the hole base plate, the more the cross section can be reduced.

Description

[0001] This application is a divisional application of the following application: [0002] Filing date of the original application: July 22, 2011 [0003] Application number of the original application: 201180045939.4 (PCT / US2011 / 045107) [0004] Title of Invention of Original Application: System and Method Containing Analysis Unit [0005] Cross References to Related Applications [0006] This application claims the benefit of priority to US Provisional Application 61 / 367,343, filed July 23, 2010, the entire contents of which are hereby incorporated for all purposes. Background technique [0007] Many nucleic acid sequences are of clinical relevance. For example, nucleic acid sequences associated with an infectious organism provide an indication of the presence of an infection by the organism. Nucleic acid sequences that are not normally expressed in patient samples can be indicative of activation of pathways associated with disease or other conditions. Still other nucle...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00
CPCB01L2300/022B01L2200/0668B01L2300/0654B01L7/52B01L3/545B01L2300/1822B01L2200/0642C12Q1/686C12M41/12G01N2035/1076G01N2035/1025C12Q3/00G01N1/38B01L3/50825G01N2035/0415B01L2300/046G01N2035/1051G01N2035/00435B01L2300/045G01N2035/1013B01L3/021G01N2035/0465B01L2200/12G01N35/1002B01L2300/1827B01L2200/147G01N2035/0413B01L3/0275G01F23/26G01F23/24B01L2400/043B01L2200/025C12Q1/68G01N2035/1048B01L2300/042B01L3/50851B01L2300/044G05B13/02G01N2035/0475G01N35/0098B01L2300/024G01N1/31G06F19/10G01N35/04B01L3/52B01L3/5085B01L2300/123B01L2300/0851G01N35/1016B01L2300/021G01N2035/0436G16B25/20Y10T436/113332C12M1/16C12M1/34C12M1/38G01N35/10B01L2300/18C12P19/34G01N35/00732G01N35/0092G01N35/1011G01N35/1081G01N2035/00752G01N2035/00851G05B13/0205G16B99/00
Inventor 布赖恩·D·威尔逊大卫·L·安德森马太·S·大卫马太·D·埃里克森艾伦·N·约翰逊盖瑞克·A·莫勒迈克尔·J·罗斯丹尼尔·R·舒密特马克·F·赛尔布格约书亚·D·威尔斯
Owner BECKMAN COULTER INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com