122 results about "Mesitylene" patented technology

The invention relates to a pyrimidyl full-conjugated structure covalent organic framework material, a catalyst containing the pyrimidyl full-conjugated structure covalent organic framework material and a preparation method and application thereof. The preparation method of the pyrimidyl full-conjugated structure covalent organic framework material comprises the following steps: (1) dissolving an aldehyde precursor and a methyl precursor containing a bipyrimidine structure in an organic mixed solvent, fully dispersing, and adding a catalyst to obtain a mixed solution; the organic mixed solvent is composed of mesitylene, 1, 4-dioxane and acetonitrile, and the catalyst is trifluoroacetic acid; (2) sequentially carrying out liquid nitrogen freezing-vacuumizing-unfreezing cyclic operation, vacuum sealing and secondary unfreezing on the obtained mixed solution to room temperature, and reacting at the temperature of 120-150 DEG C to obtain a crude product; and (3) deblocking the reaction system of the obtained crude product, and then carrying out solid-liquid separation, washing, Soxhlet extraction and drying to obtain the pyrimidyl covalent organic framework material with the fully conjugated structure.

The invention relates to a method for synthesizing mesitylene by gas-phase non-hydroisomerization of unsym-trimethylbenzene, which comprises the following step of: contacting the unsym-trimethylbenzene with a catalyst under a gas-phase non-hydroisomerization reaction condition in the presence of the catalyst, wherein the catalyst is an EWT structure molecular sieve, the total pore volume of the EWT structure molecular sieve is 0.20-0.51 cm < 3 >. G <-1 >, and the mesoporous volume is 0.11-0.37 cm < 3 >. G <-1 >. According to the method disclosed by the invention, the EWT structure molecular sieve with an ultra-large pore channel structure is adopted as the catalyst, and when the catalyst is used for synthesizing mesitylene through unsym-trimethylbenzene gas-phase non-hydroisomerization, the distribution conditions of raw materials and products are improved, the conversion rate of unsym-trimethylbenzene and the selectivity and the mass yield of mesitylene are improved, heavy component carbon deposition is slowed down, and the yield of mesitylene is improved. The service life of the catalyst is prolonged.

The invention relates to the technical field of C9 heavy aromatics, in particular to a method and device for producing mesitylene from C9 heavy aromatics, and the method comprises the following steps: firstly, in the presence of a catalyst, mixing the C9 heavy aromatics with hydrogen, performing dealkylation isomerization reaction and dehydrogenation separation to obtain a liquid-phase product, and then performing two-stage separation on the liquid-phase product to obtain mesitylene. And mesitylene is produced to the maximum extent. The C9 heavy aromatics are subjected to selective dealkylation and trimethylbenzene isomerization reaction, and the obtained product does not contain propylbenzene, and the content of methyl-ethylbenzene is 1t; the method has the advantages that the yield of mesitylene is more than or equal to 0.2%, the interference of methyl ethyl benzene on the separation of the mesitylene is eliminated, the loss of the mesitylene is small, the one-way yield of the mesitylene is more than or equal to 12%, the reaction process is simple, the mesitylene and unsym-trimethylbenzene products are high in purity, the unsym-trimethylbenzene can be recycled to further increase the yield of the mesitylene, the process is flexible, byproducts are few, the product value is high, and the utilization value of C9 heavy aromatic hydrocarbon resources is obviously improved.

The invention belongs to the technical field of medical nano-materials, and particularly relates to a preparation method of a nano-metal covalent organic framework material for enhancing cell ferroptosis by consuming glutathione as well as an obtained product and application of the nano-metal covalent organic framework material. The material is prepared by the following steps: firstly, preparing a metal organic ligand Cu3-PyCA3; the preparation method comprises the following steps: firstly, preparing a metal organic ligand Cu3-PyCA3, then mixing the metal organic ligand Cu3-PyCA3, 2, 5-diethoxybenzene-1, 4-bis (formylhydrazine), mesitylene, 1, 4-dioxane and a trifluoroacetic acid solution, and then reacting to obtain a nano metal covalent organic framework Cu3-MCOF; and finally, uniformly mixing the activated hyaluronic acid solution and the Cu3-MCOF, and intensely stirring to obtain the Cu3-MCOF-coated HA. The nano-metal covalent organic framework provided by the invention can consume glutathione to enhance cell ferroptosis, and the nano-metal covalent organic framework Cu3-MCOF can quickly react with glutathione, so that the framework structure of the Cu3-MCOF is seriously damaged, the crystalline state disappears, a large number of ribbons are further assembled and generated, glutathione is consumed, and the ferroptosis of cells is enhanced. The ferroptosis tumor treatment enhancer has an application prospect.

According to the method, a heteroatom EWT structure molecular sieve with a framework containing aluminum atoms and heteroatoms is adopted as a catalyst, the molecular sieve has the advantage of improving the utilization rate of an acid center, and when the molecular sieve is used for a gas-phase non-hydroisomerization reaction of the unsym-trimethylbenzene, the utilization rate of the acid center is increased; according to the present invention, the activity, the selectivity and the stability are high, the catalytic performance is significantly improved, the mesitylene selectivity and the mesitylene yield are higher than the heteroatom-free [Si, Al]-EWT structure molecular sieve, and the by-products such as tetratoluene and xylene are significantly reduced.

The present invention relates to a preparation method and application of a catalyst for catalyzing the production of mesitylene from trimethylbenzene. The method comprises the following steps: firstly preparing a multi-level pore Hβ zeolite molecular sieve, then mixing the multi-level pore Hβ zeolite molecular sieve with a hydrogen-type mordenite molecular sieve and a binder, adding a nitric acid solution and water, extruding the zeolite molecular sieve into strips, drying the strips and then calcining the strips at 500-750°C to obtain an unmodified catalyst I; performing impregnation modification on the unmodified catalyst I, then drying and calcining the strips to obtain a modified catalyst; and reducing the modified catalyst in a hydrogen atmosphere at 0.3-1MPa and 350-450°C to obtain a catalyst for isomerization of trimethylbenzene to mesitylene. The present invention utilizes a multi-level pore Hβ zeolite molecular sieve and a hydrogen-type mordenite molecular sieve to form a composite molecular sieve catalyst, then adding rare earth metals, Group VIII, Group IIIB and Group IVB as modifying elements, and reducing the catalyst with hydrogen to improve the selectivity and thermal stability of the catalyst, while increasing the life of the catalyst and improving the economic efficiency of the device.

The present invention discloses a photocatalyst for the regeneration of coenzyme NADH and a preparation method thereof, wherein the photocatalyst is a donor-π-acceptor type conjugated organic polymer, with a triazine-based ligand as an acceptor unit and a heterocyclic ligand as a donor unit, wherein the molar ratio of the triazine-based ligand to the heterocyclic ligand is 1:(1-2), the triazine-based ligand raw material selects 2,4,6-trimethyl-1,3,5-triazine, and the heterocyclic ligand raw material selects a heterocyclic diformaldehyde containing a furan or thiophene structure. The photocatalyst is prepared by a solvothermal method through a Knoevenagel aldol condensation reaction, the reaction solvent selects a mixed solvent of n-butanol and o-dichlorobenzene or a mixed solvent of mesitylene and 1,4-dioxane, and the catalyst used in the reaction selects at least one of trifluoroacetic acid, potassium hydroxide, 1,8-diazabicycloundecane-7-ene, sodium hydroxide, and cesium carbonate. The developed photocatalyst has a donor-π-acceptor type conjugated structure, and has high catalytic activity, high selectivity, good stability, and easy separation and recovery for the regeneration of coenzyme NADH.

The invention discloses a method for preparing nitro-mesitylene through a micro-channel nitration reaction. The method comprises the following steps: respectively conveying mesitylene, fuming nitric acid and sulfuric acid to a micro-channel reaction module through a metering pump, and completing nitration reaction within a retention time of tens of seconds to several minutes. The introduction sequence of nitration reaction materials, the reaction retention time and the reaction temperature are cooperatively controlled, the nitration reaction is completed in the microchannel reactor in a continuous flow mode, operation is easy and convenient, safety is high, efficient continuous production can be achieved, meanwhile, emission of three wastes is reduced, and the industrial application advantages of being environmentally friendly and economical are achieved.

The invention relates to the technical field of compound synthesis, and discloses a preparation method of 1, 3, 5-trimethyl-2, 4, 6-tri (3, 5-di-tert-butyl-4-hydroxy benzyl) benzene. The preparation method comprises the following steps: under the action of a catalyst, carrying out Friedel-Crafts alkylation reaction on 3, 5-di-tert-butyl-4-hydroxy benzyl methyl ether and mesitylene, so as to generate 1, 3, 5-trimethyl-2, 4, 6-tri (3, 5-di-tert-butyl-4-hydroxy benzyl) benzene); the catalyst comprises a modified molecular sieve HZSM-5 and double active components loaded on the modified molecular sieve, the double metals are Ce and La, the double active components comprise a Lewis acid active component FeCl3 or SnCl4 and a metal oxide auxiliary agent, and the metal oxide auxiliary agent is selected from one or more of MgO or ZnO. The catalyst provided by the invention is used for catalytically synthesizing 1, 3, 5-trimethyl-2, 4, 6-tri (3, 5-di-tert-butyl-4-hydroxybenzyl) benzene, the product selectivity is high, the catalyst stability is strong, the catalyst can be efficiently and repeatedly utilized, and the catalytic reaction condition is mild.

The invention discloses preparation and application of a degradable nano delivery system with tumor microenvironment responsiveness, and belongs to the technical field of medicines.The nano delivery system is composed of copper ion doped nano enzyme with photothermal conversion capacity, an indissolvable photosensitizer and a ligand capable of turning charges in a weak acid environment, the copper ion doped nano-enzyme with photo-thermal conversion capacity is a high-molecular polymer formed by dopamine oxidation auto-polymerization and chelating auto-assembly with metal copper ions at the same time; the preparation method comprises the following steps: (1) reacting F127, mesitylene, a trihydroxymethyl aminomethane solution, dopamine hydrochloride and CuCl2. 2H2O to prepare copper ion doped mesoporous polydopamine; 2) reacting the copper ion-doped mesoporous polydopamine with a charge-reversible ligand in a weak acid environment in an alkaline environment to obtain a charge-reversible ligand modified nano-enzyme; and 3) co-incubating the nano-enzyme modified by the charge overturning ligand and an insoluble photosensitizer under ultrasonic waves to obtain the nano-delivery system.

The invention discloses a supported catalyst and a preparation method and application thereof, the supported catalyst comprises a carrier and an active component, the active component comprises V-Tia-Mob-Mc-Nd-Ox, a = 1-100, b = 0.001-0.5, c = 0-0.1, d = 0-0.1, x is a value determined by the total valence of elements except oxygen in the general formula, M is selected from at least one of non-metallic elements, and x is selected from at least one of non-metallic elements. N is selected from at least one of metal elements except vanadium, titanium and molybdenum. The supported catalyst can be used for durene gas phase oxidation reaction, and solves the problem of low product yield in the existing process of preparing pyromellitic dianhydride by durene oxidation.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of trimethylbenzoquinone, which comprises the following steps: mixing a reaction solution containing unsym-trimethylbenzene and an organic solvent with a catalyst, and adding an oxidizing agent to carry out oxidation reaction to obtain trimethylbenzoquinone, wherein the catalyst comprises a pyridine compound and methylrhenium trioxide. According to the method, the unsym-trimethylbenzene is adopted as a raw material, the methylrhenium trioxide and the pyridine compound are adopted as catalysts, the trimethylbenzoquinone is prepared through oxidation of the oxidizing agent, the product yield is high, and the consumption of the oxidizing agent is low.

The present application relates to the technical field of catalyst preparation, and is a catalyst for producing mesitylene from C9 mixed aromatic hydrocarbons and a preparation method thereof.The former is a non-noble metal supported molecular sieve catalyst, the catalyst carrier comprises a molecular sieve and a binder, the molecular sieve accounts for 70% to 90% of the weight percentage of the catalyst carrier, the loading of each element accounts for 1wt% to 10wt% of the weight percentage of the catalyst carrier, and the total loading of elements accounts for 5wt% to 15wt% of the weight percentage of the catalyst carrier.The catalyst for producing mesitylene from C9 mixed aromatic hydrocarbons has good catalytic performance, is applied to the process of producing mesitylene from C9 mixed aromatic hydrocarbons as a catalyst for alkylation reaction and isomerization reaction, finally eliminates the interference of methyl ethyl benzene, maximizes the production of mesitylene, the content of methyl ethyl benzene is less than 0.5%, and the yield of mesitylene is greater than 25%.

The application belongs to the technical field of electrochemiluminescence materials, and particularly relates to an electroluminescent organic polymer material and a preparation method and application thereof, and the preparation method comprises the following steps: 1) dissolving meso-tetra(4-carboxyphenyl) porphyrin and a zinc salt in a solvent to obtain a mixed system, stirring and reacting, centrifuging, and drying to obtain a zinc porphyrin ligand; 2) adding tetra-(4-aminophenyl) ethylene, dichlorosulfoxide and mesitylene into the synthesized zinc porphyrin ligand respectively, stirring uniformly to obtain a secondary mixed system; 3) adding polyvinylpyrrolidone into the secondary mixed system, and heating and refluxing at 70-80 DEG C for 20-25 h; and 4) centrifuging and washing after reaction, and drying to obtain the product. Compared with Zn-Tccp-Tpe polymer and PVP-Tccp-Tpe polymer, the PVP-Zn-Tccp-Tpe organic polymer has stronger electrochemiluminescence signals and more stable luminescent performance.

The application discloses a kind of covalent organic framework and its preparation method, application in protein renaturation, belong to composite functional material technical field.The covalent organic framework with the pore size of 1.2-6.5nm provided in the application is prepared by Schiff base reaction of aldehyde group monomer and phenanthridine amino monomer.The preparation method provided in the application: under the catalysis of acetic acid, aldehyde group monomer and amino phenanthridine monomer are dissolved in the mixed solution of mesitylene and 1, 4-dioxane and react, separate and collect, obtain the covalent organic framework.The covalent organic framework prepared in the application can limit the degree of freedom of denatured protein, reduce protein misfolding and aggregation, promote protein correct folding, and can stabilize the correct folding intermediate state through hydrophobic interaction and π-π conjugation interaction, and through the precise regulation of confined space and interface interaction, the complete renaturation of protein can be realized, at the same time, the renaturation of most denatured proteins can be realized, with wide universality.

The utility model relates to the technical field of desolventizing mechanisms, in particular to a desolventizing mechanism for producing mesitylene, which comprises a desolventizing kettle, a kettle cover is arranged at the top end of the desolventizing kettle, the kettle cover is mounted at the top end of the desolventizing kettle through a mounting component, a feeding valve is mounted at the top end of the kettle cover, a bottom probing pipe is vertically mounted at the bottom end of the feeding valve, and the bottom probing pipe is connected with the desolventizing kettle. According to the steam desolventizing kettle, by arranging the jacket, the air inlet pipe, the first annular pipe, the connecting pipe, the heat conducting plate, the second annular pipe, the air outlet pipe, the drain valve and the water outlet pipe, when the desolventizing kettle is heated, the steam generating device is started, and at the moment, steam enters the first annular pipe, the connecting pipe and the second annular pipe through the air inlet pipe; heat of steam is uniformly conducted to the inner side of the jacket through the heat conducting plate and the connecting pipe, most of the steam is discharged through the air outlet pipe and is uniformly blown to the inner side of the jacket, so that the jacket and the desolventizing kettle are slowly heated, the heat of the steam can be uniformly guided into the jacket and the desolventizing kettle through the design, and the desolventizing kettle is more uniformly heated.

The present invention discloses a method for preparing curved carbon nanobelts by removing HCl by Pd catalysis, wherein the structure of the curved carbon nanobelts is shown as follows: wherein R is hydrogen, C 1‑20 Alkyl, C 1‑20 Alkoxy, mesitylene, phenyl or its large π extension derivative, n is 1 or 3. The product prepared by the method of the present invention can be regarded as a sidewall fragment of a (m, m)-type carbon nanotube. The present invention uses a compound with a borate group and a compound with a halogen to undergo Suzuki-Miyaura cross-coupling reaction and reductive aromatization reaction to obtain a carbon nanocyclic compound, and then further undergoes a Suzuki-Miyaura cross-coupling reaction and Pd-catalyzed deHCl to obtain armchair-type carbon nanobelts of different sizes. The synthesis method of the present invention is unique, the structure is novel, it has good photophysical properties, and it has potential applications in bottom-up growth of single-walled carbon nanotubes.

This invention provides a method for preparing mesitylene, comprising the following steps: reacting C9 aromatics with methanol in the presence of a catalyst to obtain mesitylene; wherein the reaction temperature is 350–420°C, the reaction pressure is 0.5–5.0 MPa, the molar ratio of methanol to C9 aromatics is 1:1–7:1, and the catalyst is a modified HZSM-5 molecular sieve. In this method for preparing mesitylene, C9 aromatics directly participate in the reaction without separation, resulting in high production efficiency, a short process, and low cost.

This invention discloses a poly(amylated oxime-ethyleneimine) modified foam-like mesoporous silica, its preparation, and its application, belonging to the fields of environmental energy chemistry and new materials technology. Firstly, using Pluronic P123 / mesotriene as a pore-forming / expanding agent and tetraethyl silicate as a raw material, foam-like mesoporous silica is obtained through hydrolysis, aging, high-temperature pore expansion, and calcination. After activation, epoxy-modified foam-like mesoporous silica is obtained through a silanization reaction. Subsequently, polyethyleneimine-modified foam-like mesoporous silica is prepared by reacting amino groups with epoxy groups. Then, it is reacted with acrylonitrile to obtain poly(acrylonitrile-ethyleneimine) modified foam-like mesoporous silica. Finally, it is reacted with NH2OH·HCl to obtain poly(amylated oxime-ethyleneimine) modified foam-like mesoporous silica. The poly(amylated oxime-ethyleneimine) modified foam-like mesoporous silica of this invention exhibits extremely high adsorption capacity and extremely fast adsorption rate for uranyl ions, and demonstrates high affinity, selectivity, and good reusability, making it applicable to large-scale seawater uranium extraction projects.

The application discloses a preparation method of a catalyst for catalyzing directional polycondensation of acetone to produce mesitylene and isophorone, and belongs to the field of catalysis technology. The catalyst is prepared by using a co-precipitation method to prepare magnesium-aluminum-zinc composite oxides, and simultaneously introducing active components and metal modified additive components in the co-precipitation process, and then drying and calcining to obtain a finished catalyst. The application realizes efficient synergistic effect of the active metal components and the additive metal components on the composite basic oxides and adjustment of the distribution of acid and base sites of the catalyst, so that the effect of co-producing isophorone and mesitylene through directional polycondensation of acetone is achieved. The catalyst prepared by the method is suitable for catalyzing polycondensation of acetone to co-produce isophorone and mesitylene, and has the advantages of simple preparation process, high catalytic activity and good stability.

The invention relates to a preparation method of a polymaleic anhydride-proline / COF hollow mesoporous catalyst as well as a product and application thereof, and belongs to the technical field of preparation of functional materials. A self-stabilization precipitation polymerization method is adopted, no stabilizer or surfactant needs to be added, and the prepared microspheres are clean in surface, simple in post-treatment, free of stirring, simple in reaction system, short in reaction time and high in polymerization efficiency. The preparation method comprises the following steps: firstly, synthesizing COF serving as a template from 4, 4-bibenzaldehyde and s-triphenylamine, and performing dehydration polymerization on residual-NH2, divinyl benzene, maleic anhydride and proline to form a special hollow mesoporous catalyst which is relatively good in crystallinity, high in specific surface area, uniform in pore distribution and compact in structure arrangement, namely a polymaleic anhydride-proline / COF hollow mesoporous catalyst. Excellent stereoselectivity and yield are obtained by catalyzing direct nitro-Mannich asymmetric cascade reaction, and the preparation method is simple and high in yield.

The invention discloses a covalent organic framework material for directly capturing carbon dioxide in air and coupling solar photo-thermal rapid desorption and a preparation method of the covalent organic framework material, and belongs to the field of materials. According to the material, piperazine with secondary amine sites and dialdehyde derivatives are used as raw materials, dioxane and mesitylene, m-xylene and mesitylene or o-xylene and mesitylene are used as solvents, and solvothermal reaction is performed; and after the reaction is finished, sequentially carrying out suction filtration and washing by using DMF and THF, carrying out Soxhlet extraction for 24 hours, and then carrying out vacuum drying to obtain the covalent organic framework. The aldehyde and the secondary amine are condensed according to the proportion of 1: 2, and the secondary amine site of the raw material piperazine is converted into the tertiary amine site in the covalent organic framework through aminal reaction. Tertiary amine nitrogen atoms can specifically recognize carbon dioxide in air and perform chemical adsorption, and firm covalent bonds can ensure the stability of a covalent organic framework, so that efficient air carbon dioxide capture is realized. In addition, ionic bonds formed by the covalent organic framework and carbon dioxide are also beneficial to coupling solar photo-thermal low-energy-consumption desorption.

The present invention belongs to the technical field of gasoline additives, and relates to a gasoline octane number additive, a preparation method thereof and an application. By weight, the gasoline octane number additive comprises: 35-55 parts of mixed heavy aromatics, 18-35 parts of p-xylene, and 5-20 parts of 3,5-xylenol. Among them, the mixed heavy aromatics comprise: 20-35 parts of mesitylene, 20-30 parts of pseudocumene, 15-25 parts of durene, 10-20 parts of dicyclopentadiene, and 5-10 parts of naphthalene. The gasoline octane number additive further comprises 1-6 parts of a regulator. The preparation method of the gasoline octane number additive comprises: mixing each component by mass, stirring, and standing to obtain the gasoline octane number additive. The product of the present invention can effectively improve the gasoline octane number, and has the advantages of simple process, good anti-knock performance, unrestricted usage amount, and environmental protection.

The application discloses a system for producing isophorone and mesityl oxide by a gas phase condensation method, characterized in that a ketone vaporization tower is provided with a ketone inlet, the ketone vaporization tower is sequentially connected with a first ketone gas phase condensation reactor and a second ketone gas phase condensation reactor, the second ketone gas phase condensation reactor is connected with a ketone recovery tower through a ketone heat exchanger, the ketone recovery tower is connected with the ketone vaporization tower, the ketone recovery tower is connected with a decanter through a ketone recovery tower bottom cooler, a water phase outlet of the decanter is connected with a waste water tower, an oil phase outlet of the decanter is connected with a light component removal tower, the light component removal tower is connected with a mesityl oxide refining tower, the light component removal tower is connected with a mesitylene refining tower, a top of the mesitylene refining tower is provided with a mesitylene product outlet, the mesitylene tower is connected with an isophorone refining tower, and the isophorone refining tower is provided with an isophorone product outlet.

The application relates to preparation of a TpBD-TpTAPT composite material and application of the composite material in photocatalytic decomposition of water to produce hydrogen. The application aims to solve the problems of low light utilization rate and low hydrogen production efficiency of existing single COF materials, i.e. TpBD and TpTAPT photocatalytic water decomposition hydrogen production materials, and provides a novel preparation method of a TpBD-TpTAPT composite material. First, 4,4'-diaminobiphenyl and 1,3,5-triformylphloroglucinol, 2,4,6-tris(4-aminophenyl)-1,3,5-triazine and 1,3,5-triformylphloroglucinol are respectively dispersed into a mixed solution of 1.75ml of mesitylene and acetic acid (6:1) to prepare TpBD and TpTAPT COF precursors through solvent dispersion; and then the obtained two kinds of COF precursors are compounded through a solvothermal method under the condition of heating at 120 DEG C for 72h to obtain the TpBD-TpTAPT composite material. The preparation process is simple and effective, reagent consumption is low, and the yield is high; and the photocatalyst provided by the application can effectively improve the problem of low photocatalytic water decomposition hydrogen production efficiency. The application is applied to the field of photocatalytic decomposition of water to produce hydrogen, and experiments show that the composite material has excellent photocatalytic decomposition of water to produce hydrogen performance, and the water decomposition hydrogen production rate can reach 34.91mmol.h ‑1 ·g ‑1 under visible light irradiation.

The present invention relates to a particulate composition comprising ensafetine wherein the particulate composition further comprises: from more than 0.00% to 0.60% by weight of 1, 3-bis (2-(2-(mesitylene imino)-9, 10-dimethoxy-4-oxo-6, 7-dihydro-2H-pyrimido [6, 1-a] isoquinolin-3 (4H)-yl) ethyl) urea (BMIQU), relative to the total weight of ensafetine, and a particulate composition comprising: from more than 0.00% to 0.60% by weight of 1, 3-bis (2-(2-(mesitylene imino)-9, 10-dimethoxy-4-oxo-6, 7-dihydro-2H-pyrimido [6, 1-a] isoquinolin-3 (4H)-yl) ethyl) urea And 0.00% to 0.50% by weight of a biuret impurity of formula (A) with respect to the total weight of ensefin. Also described are liquid pharmaceutical compositions comprising the particulate compositions, as well as methods for producing the particulate compositions.

The invention belongs to the technical field of water adsorption, and particularly relates to a high-hygroscopicity MOFs (Metal-Organic Frameworks) material as well as a preparation method and application thereof. The preparation method of the high-hygroscopicity MOFs material comprises the following steps: dissolving a surfactant in water to form a micelle system, then adding a mediating salt, a Zr salt, a crystal growth regulator, mesitylene and an organic ligand, and carrying out micelle and precursor co-assembly and post-treatment under stirring and heating conditions to prepare the MOFs material, the surfactant is a triblock copolymer F127; the organic ligand is 2-aminoterephthalic acid. The MOFs material prepared by the method can form an ordered mesoporous structure, can reach the maximum adsorption value more quickly, and has excellent moisture absorption dynamic performance; in addition, the fabric also has higher moisture absorption capacity.

The invention discloses a preparation method of hydrobromic acid vortioxetine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking o-aminothiophenol and Boc2O as initial raw materials, carrying out amino protection to obtain an intermediate 1; reacting the intermediate 1 with 2, 4-dimethyl bromobenzene under an alkaline condition to form a thioether bond, and acidifying to obtain an intermediate 2; carrying out high-temperature cyclization on the intermediate 2 and bis (2-bromoethyl) amine hydrobromide in mesitylene, so as to obtain a crude product of the hydrobromic acid vortioxetine; and recrystallizing the crude product with 95% ethanol to obtain a high-purity final product. The route is simple, only three-step reaction is needed, a noble metal catalyst is not needed in the whole process, and the problem of metal residues is fundamentally avoided; the selected raw materials are easy to obtain, the reaction condition is mild, the operation is simple and convenient, the process is stable, the total yield is good, the product purity is as high as 99.9%, and the method is suitable for large-scale production.

The invention provides a Mo element modified nano hierarchical pore ZSM-12 molecular sieve and application thereof in preparation of mesitylene through arene transalkylation, and the Mo element modified ZSM-12 molecular sieve is prepared by the following steps: uniformly mixing a silicon source, an aluminum source, water and a template agent, adding a growth inhibitor, and carrying out a hydrothermal crystallization reaction; and separating and drying, and impregnating and modifying with metal Mo to obtain the catalyst. In the invention, the protection type catalyst is used for carrying out transalkylation reaction on C7-C10 aromatic hydrocarbon to prepare mesitylene, and the catalyst in the reaction has good catalytic activity and selectivity. And the Mo modified catalyst can effectively inhibit the generation of carbon deposition in the reaction process in the presence of hydrogen, so that the service life of the catalyst is prolonged, and the catalyst has a good industrial application prospect.

The application discloses a preparation method of diphenyl 2,4,6-trimethylphenyl sulfonium trifluoromethanesulfonate. Diphenyl sulfoxide, trifluoromethanesulfonic acid and mesitylene are used as starting materials, and diphenyl 2,4,6-trimethylphenyl sulfonium trifluoromethanesulfonate is generated through reaction under the catalysis of trifluoroacetic anhydride and solid acid, and then the crude product is obtained through liquid separation and concentration, and then the product is obtained through washing and second concentration. The mass ratio of the diphenyl sulfoxide, trifluoromethanesulfonic acid, mesitylene, trifluoroacetic anhydride and solid acid is 1:0.8-1.0:0.7-0.9:2.0-3.0:0.3-0.5. The reaction needs to be carried out in an organic solvent system. The product has high purity, the content of metal impurities can be controlled below 60 ppb, there is only one impurity under liquid phase condition, and the product can fully meet the use requirements as an electronic chemical raw material.