25results about "Omegatrons" patented technology

An illustrative method comprises determining, based on a mass analysis performed by an electron multiplier-based mass analyzer on a first ion population produced from a sample, a mass spectrum comprising one or more peaks representing intensity as a function of mass-to-charge ratio (m / z) of the first ion population across a range of m / z values; determining, based on the mass spectrum, a total ion count of the first ion population and a peak ion count associated with a peak located at a particular m / z value; determining, based on the total ion count of the first ion population and the peak ion count, a total ion count of a second ion population produced from the sample and injected into an image current-based mass analyzer for mass analysis; and setting, based on the total ion count of the second ion population, a calibration parameter for the image current-based mass analyzer.

The present invention relates to a modular method and device for an all-permanent-magnet electron cyclotron resonance ion source, which includes: an ion source magnet composed of a first axial magnet, a second axial magnet, and a radial magnet, with the overall inner radius of the ion source being R0; the first axial magnet and the second axial magnet have opposite magnetization directions, and the first axial magnet and the second axial magnet are composed of magnetic rings with different radii, different axial thicknesses, and capable of providing an axial magnetic field; the first axial magnet and the second axial magnet are divided into multiple groups according to the axial thickness; the first axial magnet and the second axial magnet are divided into multiple groups according to the radial thickness; the radial magnet adopts a HALBACH structure with three numbers of circumferential magnetic blocks and is divided into multiple groups according to the axial thickness; the radial magnet, the first axial magnet, and the second axial magnet are all divided into n times 12 magnetic blocks along the angular direction; according to the performance requirements of the ion source, the first axial magnet, the second axial magnet, and the radial magnet with three numbers of circumferential magnetic blocks are arranged and combined according to n times the axial thickness d and the radial thickness r to form a complete ion source magnet.

An illustrative method comprises determining, based on a mass analysis performed by an electron multiplier-based mass analyzer on a first ion population produced from a sample, a mass spectrum comprising one or more peaks representing intensity as a function of mass-to-charge ratio (m / z) of the first ion population across a range of m / z values; determining, based on the mass spectrum, a total ion count of the first ion population and a peak ion count associated with a peak located at a particular m / z value; determining, based on the total ion count of the first ion population and the peak ion count, a total ion count of a second ion population produced from the sample and injected into an image current-based mass analyzer for mass analysis; and setting, based on the total ion count of the second ion population, a calibration parameter for the image current-based mass analyzer.

A method of carrying out mass spectrometry, comprising: using an electrostatic or electrodynamic ion trap to contain a plurality of ions, each ion having a mass to charge ratio, the ions having a first plurality of mass to charge ratios, each ion following a path within the electrostatic or electrodynamic ion trap having a radius; and for each of a second plurality of the mass to charge ratios: modulating the radii of the ions in a mass to charge ratio-dependent fashion dependent upon the mass to charge ratio; fragmenting the ions thus modulated in a radius-dependent fashion; and determining a mass spectrum of the ions.

A process for charge detection mass spectrometry includes: acquiring a time-varying signal representative of a current induced on a detector by oscillatory motion of ions within a trapping region; processing the time-varying signal to derive a frequency of the oscillating motion; generating resonant ion selective time overview (STORI) data representing a relationship of STORIreal value to time and a relationship of STORIimag value to time based on the amplitude of the time-varying signal and the derived frequency of the oscillatory motion; regenerating STORI data based on a change in the frequency of the oscillatory motion over time; and determining a state of charge of the ion based on the regenerated STORI data.

A method of determining an initial abundance of one or more of a plurality of ions in an ion sample is provided. The ion sample is analyzed by a Fourier transform mass spectrometer, and the plurality of ions decay over time during the analysis. The method includes obtaining a mass spectrum of an ion sample. The mass spectrum includes a plurality of peaks indicative of an abundance of each of the plurality of ions in the ion sample over an analysis duration. The method further includes calculating an initial amplitude of the transient signal for a first ion of the plurality of ions using a fitting of an inverse Fourier transform (FT) to the first peak of the plurality of peaks.

The application provides an ion cyclotron resonance device for mass spectrometry, a control method and a mass spectrometer. The device comprises a cylindrical space region for ion introduction, excitation and detection. In the ion excitation process, the ions are excited radially outward from the center of the cylindrical space region. A pair of magnets are arranged axially parallel to the cylindrical space region for generating a magnetic field in the space region. The magnets have opposite polarities. The opposite surfaces of the magnets are perpendicular to the axial direction. The magnetic field intensity of the central region of the space region is greater than that of the outer peripheral region along the radial direction. An electrode array is arranged between the pair of magnets. An alternating voltage is applied to the electrodes of the electrode array for exciting the ions. The ion cyclotron resonance device can solve multiple problems such as device miniaturization, resolution, equipment and manufacturing cost.

The invention relates to calibration of a mirror current-based mass analyzer included in a mass spectrometer. An exemplary method includes determining a mass spectrum including one or more peaks representing an intensity as a function of m / z of a first ion population across a range of mass-to-charge ratio (m / z) values based on a mass analysis performed by an electron multiplier-based mass analyzer on the first ion population generated from a sample; determining a total ion count of the first ion population and a peak ion count associated with a peak located at a particular m / z value based on the mass spectrum; determining a total ion count of a second ion population generated from the sample and injected into a mirror current-based mass analyzer for mass analysis based on the total ion count of the first ion population and the peak ion count; and setting a calibration parameter for the mirror current-based mass analyzer based on the total ion count of the second ion population.

The invention comprises a method for separating ions, comprising the steps of: providing an ion cyclotron resonance separator with a longitudinal axis; applying a magnetic field gradient along a length of the longitudinal axis; passing a single fixed radio frequency radially across the longitudinal axis; and spatially separating the ions at mass-to-charge ratio resonance locations along a length of the longitudinal axis, where the magnetic field gradient is within a range of 0 to 0.65 Tesla, where the single fixed radio frequency is maintained in a range of 40 kHz to 20 MHZ, and where the step of spatially separating further comprises the step of spiraling radially outward at a first resonance location a first set of ions, of the ions, the first set of ions comprising a first range of mass-to-charge ratios, the first resonance location comprising a first mass-to-charge ratio resonant with the applied radio frequency.

Apparatus and methods for performing charge detection mass spectrometry for measurement of the mass of a single ion of interest are disclosed. The ion of interest is caused to undergo harmonic oscillatory movement in the trapping field of an electrostatic trap, such that an image current detector generates a time-varying signal representative of the ion's oscillatory movement. This time-varying signal (transient) is processed (e.g., via a Fourier transform) to derive the ion's frequency and consequently determine the ion's mass-to-charge ratio (m / z). Ion charge is determined by construction of a Selective Temporal Overview of Resonant Ion (STORI) plot, which tracks the temporal evolution of signals attributable to the ion of interest, and where the slope of the STORI plot is related to the charge. The STORI plot may also be employed to identify ion decay events during transient acquisition and / or the presence of multiple ions of the same mass or non-resolvable ions.

In one aspect, a method of calibrating a Fourier Transform (FT) multipole mass spectrometer is disclosed, which comprises measuring a plurality of secular frequencies of a calibrant ion in a multipole FT mass analyzer for a plurality of RF voltages (VRF) applied to at least one rod of the multipole mass analyzer, calculating Mathieu β and q parameters for each of 5 the measured secular frequencies, and determining RF voltage amplitude (VRF) for each calculated q parameter. For each calculated q parameter, an offset RF voltage amplitude (ΔVRF) corresponding to a deviation of the applied VRF and the calculated VRF is determined so as to generate a ΔVRF v.s. q calibration curve.

A method is provided for determining the initial abundance of one or more ions from a plurality of ions in an ion sample. The ion sample is analyzed by a Fourier transform mass spectrometer, with the plurality of ions decaying over time during the analysis. The method includes acquiring a mass spectrum of the ion sample. The mass spectrum includes several peak values ​​that indicate the abundance of each ion from the plurality of ions over an analysis time period in the ion sample. The method further includes calculating the initial amplitude of a transient signal of a first ion from the plurality of ions using an inverse Fourier transform (FT) fitting of a first peak value from the plurality of peak values.

A method for determining an initial abundance of one or more of a plurality of ions in an ion sample is provided. The ion sample is analysed by a Fourier Transform Mass Spectrometer with the plurality of ions decaying over time during the analysis. The method comprises obtaining a mass spectrum of the ion sample. The mass spectrum includes a plurality of peaks indicating the abundance of each of the plurality of ions in the ion sample over an analysis time duration. The method further comprises calculating the initial amplitude of a transient signal of a first ion of the plurality of ions using a fit of an inverse Fourier Transform, FT, of a first peak of the plurality of peaks.

In one aspect, a method for performing mass spectrometry is disclosed, which comprises using a Fourier transform mass analyzer, which extends from an inlet port to an outlet port, to acquire a first mass spectrum of a first plurality of ions generated by ionizing a sample, where the first plurality of ions are radially confined within the mass analyzer under a first radial confinement condition. The method further includes using the Fourier transform mass analyzer to acquire a second mass spectrum of a second plurality of ions generated by ionizing the sample, where the second plurality of ions are radially confined within said mass analyzer using a second radial confinement condition, and comparing said first and second mass spectra to identify spurious mass signals.

In one aspect, a mass spectrometer is disclosed, which comprises a Fourier Transform (FT) mass analyzer having an input port for receiving ions and an exit port through which the ions exit the FT mass analyzer, a detector disposed downstream of said FT analyzer for detecting ions exiting the FT analyzer, and a multi-segment ion guide having a plurality of segments, said multi-segment ion guide being disposed upstream of said FT mass analyzer and having an input port for receiving ions and an output port through which ions exit the FT mass analyzer. The segments of the ion guide are configured to be independently activated via application of a DC offset voltage thereto so as to adjust a length through which ions passing through the ion guide experience collisional cooling.

Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

The objective of the present invention is to manufacture an acceleration device and a mass analysis device inexpensively and with a compact size, enabling them to be used by any person. The mass analysis device (300) is configured from a plurality of substrates, including a first main substrate (301), a first upper substrate (302) adhered to the upper surface of the first main substrate (301), and a first lower substrate (303) adhered to the lower surface of the first main substrate (301). A mass analysis chamber (308) is a passage formed in the first main substrate (301) and running from the upper surface of the first main substrate (301) to the lower surface of the first main substrate (301), and enclosed in the direction perpendicular to the substrate surfaces (the Z direction) by the upper substrate (302) and the lower substrate (303), enclosed on both sides in the direction (the direction X) which is orthogonal to the Z direction and is the direction of advance of charged particles (318) by first main substrate side plates (301-4, 301-5), and enclosed on both side surfaces in the direction (the Y direction) orthogonal to the Z direction and the X direction by the first main substrate (301). A center hole (310-4) is opened in the first main substrate side plate (301-4) to which the charged particles (318) are incident, and the charged particles (318) enter the mass analysis chamber (308) from the center hole (310-4) formed in the first main substrate side plate (301-4).

There is provided a method of analysing isotopes of an element present in a compound of interest from a mass spectrum obtained by a Fourier transform mass spectrometer. The method comprises generating

A method is disclosed for determining an initial abundance of a plurality of ions analysed by a Fourier Transform Mass Spectrometer (FTMS), which decays over time during the analysis. The method compr

The spectrograph assembly comprises a spectrograph and is arranged in the ambient temperature environment; the SQUID microwave receiver is arranged in the low-temperature shell; the impedance matching unit is arranged between the spectrograph and the SQUID receiver; and the signal up-conversion unit is arranged between the spectrograph and the SQUID receiver. The spectrometer may be a mass spectrometer, preferably an orbitrap (RTM) mass spectrometer, or a spectrometer using radio frequency detection of current. Also disclosed is an imaging assembly, comprising: an imaging device disposed in an ambient temperature environment; the SQUID microwave receiver is arranged in the low-temperature shell; the impedance matching unit is arranged between the imaging equipment and the SQUID receiver; and the signal up-conversion unit is arranged between the imaging equipment and the SQUID receiver.

A spectrometer assembly comprises a spectrometer disposed in an ambient temperature environment; a SQUID microwave receiver disposed in a cryogenic enclosure; an impedance matching unit disposed between the spectrometer and the SQUID receiver; a signal up-conversion unit, disposed between the spectrometer and the SQUID receiver. The spectrometer may be a mass spectrometer, preferably an Orbitrap(RTM) mass spectrometer, or a spectrometer using radiofrequency detection of current. There is also disclosed an imaging assembly comprising: an imaging device disposed in an ambient temperature environment; a SQUID microwave receiver disposed in a cryogenic enclosure; an impedance matching unit disposed between the imaging device and the SQUID receiver; a signal up-conversion unit, disposed between the imaging device and the SQUID receiver.