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168results about "Omegatrons" patented technology

Instrument for separating ions in time as functions of preselected ion mobility and ion mass

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and / or mass reaction instrumentation.
Owner:INDIANA UNIV RES & TECH CORP

Programmed electron flux

A quantity of electrons that will be used in the ionization event in an FTICR MS is preprogrammed. When the number of electrons produced reaches that number, the electron beam is turned off. This approach assures that the same number of electrons are used for every measurement and eliminates the variations due to fundamental characteristics of the electron sourcere and the variations in temperature due to changing ambient conditions.
Owner:SIEMENS AG

Microfabricated cylindrical ion trap

A microscale cylindrical ion trap, having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale cylindrical ion trap to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The microscale CIT has a reduced ion mean free path, allowing operation at higher pressures with less expensive and less bulky vacuum pumping system, and with lower battery power than conventional- and miniature-sized ion traps. The reduced electrode voltage enables integration of the microscale cylindrical ion trap with on-chip integrated circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of microscale cylindrical ion traps can be realized in truly field portable, handheld microanalysis systems.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC

Tandem mass spectrometry method

Multiply charged ions are trapped and accumulated in a spatially limited region before being injected into an ion trap mass spectrometer such as a Fourier transform ion cyclotron resonance mass spectrometer (FTICR MS). In the ion trap electron capture dissociation (ECD) and vibrational excitation dissociation are sequentially applied on ions of the same ion ensemble. The first dissociation process does not fragment all primary ions. Following the detection of the dissociation products, the primary ions that remain undissociated undergo the vibrational excitation and again, a part of them dissociate, and the fragments are detected. Thus, the same ion ensemble is used for two fragmentation processes. During these processes, further ions generated in the external ion source are accumulated in the spatially limited region for subsequent analyses.
Owner:BRUKER DALTONIK GMBH & CO KG

Circuit for applying suplementary voltages to RF multipole devices

A circuit is described for applying RF and AC voltages to the elements or electrodes of an ion trap or ion guide. The circuit includes an RF transformer having a primary winding and a secondary winding. The secondary winding includes at least two filars. A broadband transformer adapted to be connected to a source of AC voltage applies AC voltage across the low-voltage end of two of the filars. Another broadband transformer connected to the filars at the high-voltage end provides a combined RF and AC output for application to selected electrodes. Also described is a circuit employing a multi-filar RF transformer and broadband transformers for applying RF and AC voltages to spaced rods of a linear ion trap. Also described is a circuit employing a multi-filar RF transformer and broadband transformers for applying RF and AC voltages to the electrodes in each section of a linear ion trap of the type having a center section and end sections, and different DC voltages to the electrodes in the end sections.
Owner:THERMO FINNIGAN

Compact superconducting magnet configuration with active shielding having a shielding coil contributing to field formation

A superconducting magnet configuration (4; 14) for generating a homogeneous magnetic field B0 in an examination volume (4b), has an interior radial superconducting main field coil (1) which is disposed rotationally symmetrically about an axis (z-axis) and an oppositely driven coaxial radially exterior superconducting shielding coil (2) is characterized in that the magnet configuration (4; 14) consists of the main field coil (1), the shielding coil (2), and a ferromagnetic field formation device (3; 18), wherein the ferromagnetic field formation device (3; 18) is located at the radially inside of the main field coil (1), the main field coil (1) consisting of an unstructured solenoid coil or of several radially nested unstructured solenoid coils (15, 16) which are driven in the same direction, the axial extent Labs of the shielding coil (2) being smaller than the axial extent Lhaupt of the main field coil (1), wherein the axial magnetic field profile (5) generated by the main field coil (1) and the shielding coil (2) during operation has a minimum of the field strength along the axis (z-axis) in the center (4a) and a maximum of the field strength on each side of the center (4a), and wherein the axial magnetic field profile (6) generated by the ferromagnetic field formation device (3; 18) during operation has a maximum of the field strength along the axis (z-axis) in the center (4a) and a minimum of the field strength on each side of the center (4a). The magnet configuration in accordance with the invention has a very simple structure.
Owner:BRUKER BIOSPIN

Permanent magnet structure with axial access for spectroscopy applications

InactiveUS20060232369A1Eliminate and overcomeMaximize the flux density generated per weight of magnetic materialPermanent magnetsOmegatronsMagnetic sourceMagnetic flux
A mass spectrometer with a magnet structure including a plurality of magnetic flux sources disposed along a common axis. The plurality of magnetic flux sources includes at least one permanent magnet flux source having at least one through-hole body along the common axis. The plurality of magnetic sources generates a resultant magnetic field. A direction of a magnetic field component of the resultant magnetic field along the common axis is at least once reversed along the common axis within the magnet structure.
Owner:MAKROCHEM

Measuring methods for ion cyclotron resonance mass spectrometers

The invention relates to measuring methods and corresponding measuring cells for ion cyclotron resonance mass spectrometers (FTMS). The invention provides measuring methods with measuring cells, the ends of which each incorporate a large number of trapping electrodes, DC voltages of opposite polarities being applied across adjacent electrodes. For orbiting ions this builds up a repelling pseudopotential, which holds the ions in the measuring cell by reflection. This facilitates measurement of the image currents without the disturbing influence of RF voltages
Owner:BRUKER DALTONIK GMBH & CO KG

Instrument for separating ions in time as functions of preselected ion mobility and ion mass

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and / or mass reaction instrumentation.
Owner:INDIANA UNIV RES & TECH CORP

Method Of Improving A Mass Spectrum

The present invention provides a method of improving a mass spectrum collected from a mass spectrometer comprising a detector for collecting a mass spectrum from ions stored in or released from an ion trapping volume, wherein assignment of masses to peaks appearing in the mass spectrum is sensitive to an experimental parameter related to the mass spectrometer or the operation thereof, such as ion abundance, the method comprising: determining a positional value of a peak; determining the experimental parameter associated with the mass spectrum; comparing the determined positional value with positional values of peaks contained in a calibration dataset; and improving the determined positional value of the peak from adjacent peak positional values by interpolation thereby to provide a corrected mass assignment for the peak. The present invention also provides a method of calibrating such a mass spectrometer.
Owner:THERMO FINNIGAN

Method and Apparatus for Mass Analysis

A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyser; the batch of ions accumulated in the mass analyser is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyser is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyser; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyser.
Owner:THERMO FISHER SCI BREMEN

Permanent magnet structure with axial access for spectroscopy applications

InactiveUS20060232368A1Eliminate and overcomeMaximize the flux density generated per weight of magnetic materialPermanent magnetsOmegatronsSpectroscopyMagnetic flux
A magnet structure or instrument for spectroscopy including a plurality of magnetic flux sources disposed along a common axis. The plurality of permanent magnetic flux sources include a first magnet flux source having a first through-hole body, and include second and third magnet flux sources located respectively on opposite sides of the first magnet flux source, with at least one of the second and third magnet flux sources having a side through-hole body. Magnetic flux within the first magnet flux source is oriented to generate a first magnetic field directed along the common axis. Respective magnetic fluxes within the second and third magnet flux sources are oriented to generate second and third magnetic fields directed along the common axis, with at least one field component of either the second or third magnetic fields along the common axis inside the respective second or third magnet flux sources opposed to a direction of the first magnetic field on said common axis inside the first magnet flux source.
Owner:MAKROCHEM

Estimation of ion cyclotron resonance parameters in fourier transform mass spectrometry

The present invention comprises a method and system for accurate estimation of the ion cyclotron resonance (ICR) parameters in Fourier-transform mass spectrometry (FTMS / FT-ICR MS). The parameters are essential to estimating the mass to charge ratio of an ion from FT-ICR MS data, the intended purpose of the instrument. Achieving greater accuracy in the parameters assists in greater accuracy of the mass to charge ratio of an ion, and obtaining an accurate estimation of the mass to charge ratio of an ion further aides in detecting mass with sub-ppm accuracy. Estimating mass in this manner enhances identification and characterization of large molecules. The inventive method and system thereby enhances the data obtained by conventional FTMS by accurately estimating ICR parameters. Ultimately, accurate estimates of the masses of molecules and detection and characterization of molecules from FT-ICR MS data are obtained.
Owner:CEDARS SINAI MEDICAL CENT

Method of Processing Mass Spectrometry Data

A method of processing Fourier Transform Mass Spectrometry (FTMS) data comprises carrying out a Fourier Trans-form of a part of a time domain transient and identifying from that transformed data signal peaks representative of the presence of ions. Once the peaks have been identified, the full transient is then transformed, and the peaks identified in the partial transient transform are used to locate true peaks in the transformed full transient. The number of ‘false’ peaks resulting from random noise has been found to correlate to the resolution, so that using a partial transient to identify true peaks reduces the risk of false peaks being included; nevertheless this information can then be applied to the full data set when transformed. As an alternative, different parts of the full data set can be transformed and then correlated; because any noise will be random, false peaks should occur at different places in the two partial transforms.
Owner:THERMO FINNIGAN

Method of generating a mass spectrum having improved resolving power

A method is disclosed for generating a mass spectrum, e.g. for Fourier transform mass spectrometry, having improved resolving power. The method includes steps of acquiring a plurality of mass spectra from a mass spectrometer using image current detection determining the centroids of at least some of the peaks which have a sufficient signal-to-noise (S / N) ratio so that the variation of the centroid of each such peak from the plurality of mass spectra is significantly lower than the full-width at half-maximum, dM, of the peak in the m / z domain; and generating a histogram of the centroids determined from the plurality of acquired mass spectra thereby forming a composite mass spectrum. The resultant composite mass spectrum comprises peaks having full-width at half-maximum, dMC, significantly narrower than the peak width, dM, of the corresponding peaks in the plurality of acquired mass spectra.
Owner:THERMO FISHER SCI BREMEN

Method and apparatus for fourier transform ion cyclotron resonance mass spectrometry

A novel method and apparatus for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS). The FTICR-MS apparatus has a pre-ICR mass separation and filtering device capable of receiving ionized molecules with a plurality of mass to charge (M / Z) sub-ranges. The pre-ICR mass separation and filtering device divides the ionized molecules into a plurality of smaller packets, each of the smaller packets is within one of the M / Z sub-ranges. A magnet in the FTICR-MS apparatus provides a controlled magnetic field. A plurality of ion cyclotron resonance (ICR) cells are arranged in series in the controlled magnetic field and operate independently. An ion trapping device connects the pre-ICR mass separation and filtering device, and stores one of the plurality of smaller packets, prior to sending it to one of the plurality of ICR cells.
Owner:MED LIFE DISCOVERIES LP

Permanent magnet ion trap and a mass spectrometer using such a magnet

A vacuum ion trap includes a gastight processing enclosure and a permanent magnet defining a cavity and creating a directed magnetic field in the cavity, the enclosure being disposed inside the cavity and containing a confinement cell having at least two mutually parallel trapping electrodes perpendicular to the directed magnetic field, the trapping electrodes being connectable to a voltage generator. The trap includes at least one permanent magnet in the form of a hollow cylinder and structured with a Halbach cylinder type structure so as to generate the permanent magnetic field directed perpendicularly to the longitudinal axis of the cavity of the magnet. The trap is applicable in particular to Fourier transform mass spectrometry (FTICR).
Owner:30 LUNIV PARIS SUD +2

Spectral deconvolution in ion cyclotron resonance mass spectrometry

A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.
Owner:SCI & ENG SERVICES

Fourier transform mass spectrometer and method for generating a mass spectrum therefrom

A method of generating a mass spectrum from an FTMS is disclosed. A first quantity of ions from a source, having a first m / z range, is captured and detected in the FTMS measurement cell to produce a first output. A second quantity of ions, having a second m / z range which at least partially does not overlap with the first m / z range, is then captured and detected so as to produce a second output. The two outputs are then combined using a processor so as to “stitch” together the outputs, which may be FTMS transients or may first be Fourier Transformed into the frequency mass domain, into a composite output from which a composite mass spectrum covering the full range of m / z ratios included by the first and second ranges can be produced.
Owner:THERMO FINNIGAN

Locking device

A locking device is disclosed for preventing rotation of one component relative to another component to which it is connected. The locking device comprises a locking plate having a component engaging portion to engage one component, A surface of the locking plate is grooved to engage with a grooved surface carried by the other component. One or more fixing holes are provided for one or more fixing members to be passed through, to force the grooved surface of the locking plate into engagement with the grooved surface carried by the other component.
Owner:PARKER HANNIFLIN +1

Kingdon mass spectrometer with cylindrical electrodes

The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments. Appropriate voltages at the sheath electrode segments generate a potential distribution between the two concentric cylindrical surfaces which forms a parabolic potential well in the axial direction for orbiting ions. The ion clouds oscillating harmonically in the axial direction in this potential well induce image currents in suitable electrodes, from which the oscillation frequencies can be determined by Fourier analyses.
Owner:BRUKER DALTONIK GMBH & CO KG

Measuring cell for ion cyclotron resonance mass spectrometer

The invention relates to a measuring cell for an ion cyclotron resonance mass spectrometer (FTMS). The invention provides a measuring cell which, on the one hand, consists of two ion-repelling RF grids at the front ends as trapping electrodes and thus produces a pure cyclotron motion of the ions without the usually co-existing magnetron motion and, on the other hand, measures a multiplied cyclotron frequency by means of a plurality of detection electrodes, whereby either a higher mass accuracy or a shorter measuring time can be achieved.
Owner:BRUKER DALTONIK GMBH & CO KG

Ion detection

Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.
Owner:THERMO FISHER SCI BREMEN

Mass spectrometer

An improved FT-ICR Mass Spectrometer has an ion source 10 which generates ions that are transmitted through a series of multipoles 20 to an ion trap 30. Ions are ejected from the trap 30, through a series of lens and multipolar ion guide stages 40–90, and into a measurement cell 100 via an exit / gate lens 110. The measurement cell is mounted in a vacuum chamber 240 and this assembly is slideably moveable into a bore of a superconducting magnet 400 which provides the magnetic filed to cause cyclotron motion of the generated ions in the cell 100. By minimising the distance between the source 10 and cell 100, and by careful alignment of the ion optics, the ions can travel at high energies right up to the front of the measurement cell 100. The cell 100 extends in the longitudinal direction of the magnet bore and is coaxial with that. The ratio of the sectional area of the magnet bore to the sectional area of the cell volume is small (less than 3). The magnet is asymmetric and is relatively short on the ion injection side. The cell 100 is supported from in front of the cell and electrical contact is from the rear thereof.
Owner:THERMO FINNIGAN
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