Wagnieres George

Abstract

The apparatus for imaging diagnosis of tissue (1) has selectivity to use at least two methods of diagnosis. One working mode uses diagnostic white light endoscopy (DWLE) and another mode uses diagnostic auto fluorescence endoscopy (DAFE). Optionally, a further DAFE diagnosis mode can be used. A lamp (2) delivers light to the tissue through an optic fiber (3). A lens (4) is used either by the human eye, or in combination with a camera (5) linked to an image processing unit (6) and a monitor (7). Most of the light used for both DAFE modes is generated from a narrow spectral band not more than30 nm, with a wavelength of 405 nm.

Description

technical field [0001] The present invention relates to a device for imaging diagnosis of tissue for the optional use of two or three diagnosis methods, namely a working mode DWLE for white light endoscopy for diagnosis, and a working mode for autofluorescence endoscopy for diagnosis The first mode of operation DAFE or DAFEI and, if necessary, the second mode of operation DAFEII for autofluorescent endoscopy for diagnosis, the imaging diagnostic equipment of the tissue has a light source, the light emitted by the light source is detected by the endoscope Guided to the tissue, it also has an image transmission unit and an image receiving unit, and an image processing unit is connected with the image receiving unit, and the image signal is provided for a monitor through the image processing unit, and the image transmission unit can also be connected with people Eyes are directly connected, in this case, the image receiving unit, image processing unit and monitor can be omitted. ...

AI Technical Summary

Problems solved by technology

[0005] However, the discriminative properties of these lesions represented by the above systems are problematic: in known autofluorescence images, inflamed and deformed tissue cannot be practically distinguished from dysplasia and carcinoma in situ, i.e. initial and early malignant lesions However, the two tissue forms of inflamed tissue and deformed tissue have not or have not yet developed into initial or early malignant transformation, which are collectively referred to as "non-malignant tissue changes" in the following description, so this distinction should be made in the diagnosis of patients In order to be able to draw reliable and final conclusions and to rule out (incipient) malignancy, it is necessary to carry out all the obvious places that appear in the autofluorescence map, both for initial and early malignant lesions and for inflamed and deformed tissues. Histologically examined and provided to the pathologist

However, there must be enough room for illumination fibers in the illumination channel or fluorescence excitation channel, otherwise there will not be enough fluorescence excitation light to produce brighter autofluorescence images on tissue

On the contrary, if the working channel is selected too small, it will damage the quality of the sample image

[0025] In addition, the system, like the one already described above, employs broadband fluorescence excitation, which only provides insufficient distinguishing properties for initial and early malignant lesions versus non-malignant tissue changes, and can also be obtained from the attached Figure's Figure 5 to Figure 10 The curves of the spectral fluorescence intensities in , show that, over a wide range of excitation bands, there is practically no discernibility between deformed and inflamed tissue on the one hand and dysplastic and carcinoma in situ on the other

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