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Notoginseng extract and application thereof

A technology of extract and Panax notoginseng, applied in the field of active extracts, can solve the problems such as anti-human cytomegalovirus and other problems that have not been found in Panax notoginseng extracts

Inactive Publication Date: 2011-08-31
桂林英美特生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies have shown that the triterpenoid saponins in Tianqi have anti-tumor and anti-oxidative effects, but so far it has not been found that Tianqi extract has anti-human cytomegalovirus effects

Method used

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  • Notoginseng extract and application thereof
  • Notoginseng extract and application thereof
  • Notoginseng extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] 1) Take Tianqi and crush it through a 100-mesh sieve, put it in an extraction tank, add 6 to 8 times the amount of 95% ethanol to reflux and extract twice, the extraction temperature is 65°C, filter, combine the filtrates, and concentrate to extract;

[0081] 2) Dissolving the extract with an appropriate amount of methanol, passing through D101 macroporous adsorption resin, the amount of which is 1.2 to 1.5 times that of the raw material, and then eluting with 30 to 50% ethanol, collecting the eluent to obtain eluent A; Elute with 55-70% ethanol, collect the eluent, and obtain eluent B;

[0082] 3) Concentrating eluent A to dryness to obtain total saponins, and concentrating eluent B to dryness to obtain total flavonoids.

Embodiment 2

[0084] Take the total flavonoids and total saponins obtained in Example 1, add conventional auxiliary materials in a mass ratio of 3.5:1, make granules according to conventional processes, and pack them into 10 g / bag.

Embodiment 3

[0086] Take the total flavonoids and total saponins obtained in Example 1, add conventional excipients in a mass ratio of 4:1, and make capsules according to conventional processes, and the specification of the capsules is PN capsules.

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Abstract

The invention discloses notoginseng extract and application thereof. In the notoginseng extract, the mass ratio of total flavone matters to total saponin matters is 2-5:1. Tests show that the notoginseng extract has little cytotoxicity, can effectively inhibit pathological changes caused by human cytomegalovirus and has a similar effect as ganciclovir; moreover, the notoginseng extract has a quite effect of preventing and treating cytomegalovirus infection during pregnancy, and can be used as an active component for novel anti-cytomegalovirus medicaments.

Description

technical field [0001] The invention relates to active extracts in plants, in particular to a Panax notoginseng extract and its application. Background technique [0002] Human cytomegalovirus (Human Cytomeglovirus, HCMV) has a high recessive infection rate in the population, and the positive rate of human serum HCMV-IgG reported in the literature is between 40% and 90%. Normal people generally do not produce clinical symptoms after being infected with HCMV, but when they are in a pathological or physiological state with suppressed immunity, such as AIDS patients, organ transplant patients and women during pregnancy, the virus may be activated, causing fever, retinitis, Pleurisy, arteriosclerosis, colonic diverticulitis, etc., and HCMV infection in women in early pregnancy is closely related to stillbirth and neonatal congenital teratogenicity. Currently FDA-approved drugs for the treatment of HCMV infection include ganciclovir, valganciclovir, cidofovir, foscarnet, fomivir...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P31/22
Inventor 黄英星沈星灿蔡豪斌张旋
Owner 桂林英美特生物技术有限公司
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