36 results about "Chlorhexidine digluconate" patented technology

The present invention relates to a composition in the form of an oil-in-water emulsion in which the mean size of the oil globules ranges from 50 nm to 1000 nm containing at least one chlorhexidine salt. The chlorhexidine salt may be in particular chlorhexidine digluconate. The emulsion has good bacteriological protection, and exhibits the advantage of having a pH which remains stable over time, even at a temperature above ambient temperature. The compositions of the invention can be used in numerous cosmetic and dermatological applications. They can also be used for impregnating a support and constituting a wipe for the skin.

The invention relates to water-soluble, chlorhexidine-containing compositions having a long shelf life. The compositions are in the form of powder, granules or tablets and consist substantially of (i) a salt of chlorhexidine with 2 moles of a sugar acid and a microbicidally active quaternary ammonium bromide, or of (ii) chlorhexidine, a sugar acid or sugar lactone, with at least 2 moles of sugar acid or sugar lactone being present per mole of chlorhexidine, and a microbicidally active quaternary ammonium bromide. Peferred compositions consist substantially of chlorhexidine digluconate and N-cetyl-N,N,N-trimethylammonium bromide (cetrimide) in a weight ratio of 1:1 to 1:10. The solid compositions are stable, with little or no p-chloroaniline splitting off during storage.

The invention discloses antibacterial skincare hand disinfectant. The antibacterial skincare hand disinfectant is prepared from the following components in parts by weight: 50-80 parts of composite traditional Chinese medicinal material extract, 55-65 parts of ethanol, 0.8-1.2 parts of chlorhexidine digluconate solution, 1-2 parts of glycerin and 30-40 parts of purified water. In the hand disinfectant, chlorhexidine digluconate and ethanol are used as main germicidal components, Chinese stellera root, achnatherum inebrians, pulsatilla, circium japonicum and cynanchum komarovii extracts are used as auxiliary germicidal components to cooperate to quickly kill common pathogenic bacteria on skin surfaces, the antibacterial skin care hand disinfectant sterilizes and inhibits bacteria in a broad spectrum, and is durable in action, reliable in effect and free of potential health risk; moreover, the reasonably matched traditional Chinese medicine extracts or flower and fruit skincare components are added to reinforce the bactericidal effect and ensure good moisturizing, skin care, whitening and antioxidation effects, so as to overcome side effects caused by dry chapped skin after long term use.

The invention provides a preparation method of a polylactic acid-based suture line. The preparation method comprises the following steps of feeding polylactic acid, poly butylene carbonate, polycaprolactone, cyclodextrin, phenylalanine, silver carbonate, copper sulphide, magnesium chloride, povidone iodine, polyvinyl alcohol, dopamine hydrochloride, diethylene glycol adipate, thiolated chitosan, fucoidin, chlorhexidine digluconate, urea, acyclovir, sodium alginate and Vitamin K3 into a blender mixer, and mixing materials; feeding the mixture into a twin-screw extruder, and performing squeezing granulation; heating for melting, defoaming, and sequentially performing stretching twice by use of a spinneret plate; and finally performing sterilization and package, thereby obtaining polylactic acid-based suture line. The suture line prepared by the invention is high in anti-bacterial ratio and good in mechanical property, ensures that the healing time is shortened to 7-10, and is capable of accelerating wound healing; after a patient is healed, the suture line is completely absorbed, and no scar is generated on the healed surface, the comprehensive property is excellent, and the polylactic acid-based suture line can meet the application requirements of clinical medicine.

Composition for treatment of the oral cavity and corresponding uses. The composition comprises the combination of a chlorhexidine derivative, for example chlorhexidine digluconate, with triclosan and a zinc salt, for example zinc lactate or citrate. Preferably the chlorhexidine digluconate is present in a concentration of between 0.01 and 0.2%, the triclosan in a concentration of between 0.05 and 1%, and the Zn ion in a concentration of between 0.01 and 4%, expressed in weight with respect to the total weight of the composition. The composition can preferably be used for preparing a toothpaste, a gel or a mouthwash, for anti-plaque and/or gingivitis treatment.

A method for producing a chewing gum with a controlled release of an antimicrobial agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the antimicrobial agent by coating and drying. The antimicrobial agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated antimicrobial agent is preferably then co-dried and particle sized to produce a release-modified antimicrobial agent for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. The preferred antimicrobial agent is chlorhexidine digluconate

The invention discloses fresh fruit mint mouthwash, and belongs to the technical field of personal care products. The fresh fruit mint mouthwash comprises the following components in parts by weight: 95 to 98 parts of water, 1 to 2.5 parts of glycerin, 0.5 to 1.2 parts of PEG-40 hydrogenated castor oil, 3 to 5 parts of essence, 0.01 to 0.05 part of saccharin sodium, 0.01 to 0.02 part of menthol, 0.01 to 0.3 part of chlorhexidine digluconate, 0.1 to 0.3 part of cetyl pyridinium chloride, 0.05 to 0.3 part of methyl benzoate, 0.05 to 0.3 part of ethyl hydroxybenzoate, 0.05 to 0.3 part of nipasol, 0.01 to 0.3 part of butoben, 0 to 0.005 part of eugenol and 0 to 0.005 part of limonene. According to the mouthwash, bad breath can be effectively removed, fresh breath can be kept persistent, and antibacterial effects and anti-caries effects can be achieved.

A system of application for an intra-oral medication characterized by An applicating cannula having a suitable angle in order to reach any place with lesion in the mouth, and a container having a gel with adequate bioadhesive drainage to be inserted in periodontal pockets and mucosa folds that is screwed to the cannula. The composition of the gel consisit of chlorhexidine digluconate alone and together with other active principles such as a bisphosphonate, an analgesic or anesthetic substance, antibiotic, antimycotic, an antiviral, steroidal or non-steroidal anti-inflammatory, a coagulant substance or one aimed to modulate local hemosthasis, a cicatrizing substance, among the most outstanding.

A topical formulation comprising a first active agent that is pharmaceutically acceptable salt of a cationic bisbiguanide such as chlorhexidine digluconate (CHG), a secnd active agent which is a cationic quaternary ammonium compound such as cetylpyridinium chloride (CPC), methylisothiazolone, or chloroxylenol, and a propellant; and an aerosol dispenser containing the topical formulation. The topical formulation can be sprayed onto exposed skin to prevent or reduce the risk of skin infection.

The invention provides a no-washing type hand disinfectant with the moisturizing and bacterium preventing effects. The no-washing hand disinfectant is prepared form 20-30 parts of composite Chinese medicine material extracts, 1-15 parts of natural moisturizing factors, 55-65 parts of ethyl alcohol, 0.2-4.0 parts of chlorhexidine digluconate, 1-5 parts of glycerinum, 1-5 parts of tween-8-, 0.2-2.5 parts of penetrating agents, 0.01-0.05 part of ethylenediamine tetraacetic acid disodium salt (EDTA-Na2), 0.02-0.1 part of essences and 0.01-0.05 part of food coloring, the pH value of the mixture is regulated to 6.00-8.00 by a pH regulating agent, and then the mixture is supplemented to 100 parts with purified water. According to the no-washing type hand disinfectant with the moisturizing and bacterium preventing effects and the preparation method thereof, the formula is reasonable, the property is stable, the good sterilizing effect is achieved, pathogenic entero becteria, pyogenic cocci, pathogenic yeasts and common nosocomia infection bacteria can be effectively killed, efficient moisturizing is achieved, and the side effects such as chapped hand skin due to the disinfectant is used for a long term in large quantities can be effectively overcome.

The invention discloses a silk non-woven fabric used for baby wipes and a preparation method thereof. The silk non-woven fabric comprises a silk non-woven fabric body and wet wipe liquid, wherein theinside of the silk non-woven fabric body is adsorbed with the wet wipe liquid. The silk non-woven fabric has the advantages of scientific and reasonable structure, and safe and convenient use, can effectively reduce the irritation to the baby's skin, lengthen the bacteriostatic time after wiping, and can effectively solve the problem that the existing wet wipes have short bacteriostatic time and large irritation performance. the addition of glycerin, a honeysuckle extract, a scented flower extract and an aloe extract can reduce the stimulation of baby skin by cetylpyridinium chloride, chlorhexidine digluconate and ethylhexyl glycerol in a bacteriostatic agent. The pretreatment of silk by trypsin can effectively reduce the glue adhesion on the surface of the natural silk, so that the irritation of the baby's skin after silk preparation is reduced. By washing the silk after cooling, the silk can be effectively cleaned and purified to reduce the pretreatment raw materials attached to thesilk.

The invention relates to a process for reducing the residual amount of p-chloroaniline in chlorhexidine. Also, the invention relates to a process for preparing chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free of potential genotoxicity. In addition, the invention refers to the said chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free of potential genotoxicity. Further, the invention relates to an analytical HPLC method for the determination of potentially genotoxic impurities in samples of chlorhexidine, or of a pharmaceutically acceptable salt thereof. The invention also relates to stabilized chlorhexidine digluconate salt free of potential genotoxicity in aqueous solution, and to a method for stabilizing chlorhexidine digluconate salt free of potential genotoxicity in aqueous solution.

The invention provides a medical dressing for PICC (Peripherally Inserted Central Catheter). The medical dressing comprises at least one transparent film backing cloth; a sponge substrate layer which is composed of circular freeze-dried sponge is fixed on the film backing cloth; an elongated guide tube fixing opening for leading out and fixing a guide tube is formed between the circle center of the sponge substrate layer and the circumference in the radial direction; the opening end of the guide tube fixing opening is formed in the circumference; the length of the guide tube fixing opening is 20 to 45% of the radius of the sponge substrate layer; bactericide which is prepared from chlorhexidine digluconate or flamazine and at the mass concentration of 0.1 to 10% fills the sponge substrate layer. The dressing has the functions of absorbing liquid, inhibiting bacteria and stopping bleeding, is low in allergy rate and high in antibacterial permanence.

The invention relates to a preparation method of an induced abortion pudendum cleaning antibacterial spray and a combined preparation. The invention aims at providing the preparation method of the induced abortion pudendum cleaning antibacterial spray with simple and convenient preparation, good stability, convenient use and good use effect and the combined preparation. According to the technicalscheme, the preparation method of the induced abortion pudendum cleaning antibacterial spray is characterized in that the induced abortion pudendum cleaning antibacterial spray comprises benzalkoniumchloride or benzalkonium bromide, chlorhexidine or chlorhexidine acetate or chlorhexidine dihydrochloride or chlorhexidine citrate or 20% of chlorhexidine digluconate solution, polysorbate 20, motherwort extract, shrubby sophora extract and collagen. The combined preparation provided by the invention is suitable for sterilization and antisepsis of vulva, vagina and residual tissues and repairing and antisepsis of uterus.

The invention discloses a gargle having a bacteriostatic function and a preparation method thereof. The gargle includes 88.45% of water, 5% of glycerin, 0.15% of peppermint oil, 2% of butanediol, 1.5%of chlorhexidine digluconate, 0.3% of steviosin, 0.5% of PEG-60 hydrogenated castor oil, 1% of honeysuckle flower extract, 1% of tea extract and 0.1% of edible essence. The gargle of the invention can keep fresh breath and clean tartar, has good bactericidal and bacteriostatic effects, can quickly alleviate oral problems, maintain oral bacteria balance, effectively prevent and alleviate the symptoms such as bleeding gums, swollen gums, mouth ulcers, bad breath, tooth decay, ozostomia and plaque caused by gingivitis, pericoronitis, oral mucositis and the like, is easy to use, good in taste andsignificant in effect, can also be used for oral care and cleaning, can effectively eliminate oral odor and keep long-lasting fresh breath through long-term use, has good bactericidal and bacteriostatic effects, and can quickly alleviate the oral problems; in addition, the gargle has the advantages of stable system, simple preparation method, and broad application prospect.

An oral cleaning care solution with CRHD activity and a preparation method thereof belong to oral sterilization and disinfection products. In order to provide a mouthwash which has toxic and side effects, can nourish Yin and eliminate dampness, is soluble in water, strong in permeation and free from peculiar smell and is safe, simple and convenient, the technical scheme provided by the invention is that the oral cleaning care solution comprises the following ingredients: 2-6 parts of chlorhexidine digluconate, 3-25 parts of a Noni ethyl alcohol gel, 1-5 parts of thymol crystals, 3-15 parts ofa papain gel, 1-5 parts of an aloe gel, 0.5-5 parts of calcium hydroxide, 1-6 parts of boric acid, 10-20 parts of sodium chloride and the balance of CRHD deionized water. The oral cleaning care solution has antibacterial and anti-inflammation functions in an oral cavity and can remove dental pulp, the capability of disinfecting and killing pathogenic microorganism mucosa vitamin pathogenic bacteria in the oral cavity of a human body is improved, the functions of oral mucosa immunologic tissues are optimized, dental ulcer and gingival inflammation can be cured, and peculiar smell can be removed. The oral cleaning care solution is safe and is an environment-friendly healthy product having a huge market potential and welcomed by consumers.

The invention provides a wound disinfectant and a preparation method thereof. The wound disinfectant is characterized in that the raw materials of the wound disinfectant include 1%-20% of icodextrin in the total weight of the raw materials, and also include chlorhexidine digluconate, hyaluronic acid and water. The preparation method includes the following steps: dissolving icodextrin, chlorhexidine gluconate/hyaluronic acid in a certain amount of water according to the weight ratio of the raw materials of the wound disinfectant, performing even stirring, adding the remaining water until a constant volume, performing automatic canning, subpackage and sealing on the liquid, and performing detection so as to obtain the qualified finished product. The wound disinfectant is capable of cleaningand disinfecting surgical or accidental wounds, and has the effect of promoting healing of the wounds and preventing scars, the raw materials are selected and matched reasonably, the raw materials areeasily available, the cost is low, the preparation method is simple, and the wound disinfectant is suitable for large-scale industrial production.

The invention discloses dispersible baby wet wipes which are gentle, non-irritating, safe and environmentally friendly and can be continuously produced on a production line. Due to biodegradability of a dispersible non-woven fabric material, the strength of the wet wipes is poor, the wet wipes cannot be produced continuously, the wet strength of dispersible cloth is poor, the dispersible cloth is easily torn off if the water content is slightly high, the wet wipes hardly contain water if the water content is too low, requirements of the wet wipes are not met, and due to high viscosity of the dispersible cloth, edges of the cloth cannot be easily separated from the lower layer when the cloth is drawn. In order to solve the problems, the dispersible baby wet wipes are sheet dispersible non-woven fabrics which are soaked with a baby wet wipes formula solution, and the weight of the dispersible non-woven fabric in per square meter is 55-58 grams. The dispersible baby wet wipes consist of the following substances in percentages by mass: 0.02-0.08% of cetylpyridinium chloride, 0.3-0.75% of chlorhexidine digluconate, 0.04-0.1% of ethyl caproyl glycerinum and the balance of purified water.

The invention discloses a pet skin external lotion, which is prepared from the following raw materials in parts by weight: 16 to 20 parts of cleaning detergent and 0.5 to 3 parts of active ingredients, the cleaning and decontaminating agent is prepared from decyl glucoside, lauryl glucoside, sodium laureth sulfate, cocamide, sodium lauroyl glutamate, methyl glucose dioleate, glycol distearate and disodium ethylene diamine tetraacetate; the composition comprises the following active ingredients: chlorhexidine acetate, chlorhexidine digluconate, ketoconazole, fluconazole, itraconazole, clotrimazole, benzoyl peroxide, phytosphingosine, vitamin B6, nicotinamide, tocopherol, bisabolol and hydroxyphenyl propionamide benzoic acid. The invention belongs to the technical field of lotions for pets, and particularly provides an external lotion for pet skin, which combines the functions of decontaminating, moistening, sterilizing and resisting fungi, and achieves the effect of preventing or treating skin diseases while cleaning, decontaminating and moistening fur.