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Preparation method of polylactic acid-based suture line

A surgical suture and polylactic acid-based technology, which is applied in the field of preparation of polylactic acid-based surgical sutures, can solve the problems of different degrees of absorption and degradation of absorbable sutures, single function of absorbable sutures, and inability to completely absorb and degrade, etc., to achieve Excellent overall performance, short healing time, and good mechanical properties

Inactive Publication Date: 2016-10-26
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to differences in the human body, the degree of absorption and degradation of absorbable sutures varies, and some cannot be completely absorbed and degraded, and the current absorbable sutures have a single function, and do not have the functions of antibacterial, wound healing and no scarring

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of polylactic acid-based surgical suture, comprising the following preparation steps:

[0022] (1) In parts by weight, 60 parts of polylactic acid, 20 parts of polybutylene carbonate, 15 parts of polycaprolactone, 4 parts of cyclodextrin, 1 part of phenylalanine, 0.58 parts of silver carbonate, and 2 parts of copper sulfide 1 part of magnesium chloride, 2 parts of povidone iodine, 4 parts of polyvinyl alcohol, 3 parts of dopamine hydrochloride, 4 parts of diethylene glycol adipate, 2 parts of thiolated chitosan, 3 parts of fucoidan, 5 parts of chlorhexidine gluconate, 1 part of urea, 2 parts of acycloguanidine, 3 parts of sodium alginate and vitamin K 3 1 part was put into the mixer, and blended at 70°C for 30 minutes to obtain the blend;

[0023] (2) Put the blended material in step (1) into a twin-screw extruder, extrude and granulate, and dry to obtain a master batch. The screw speed is 50 rpm, and the temperature of each zone of the screw is s...

Embodiment 2

[0027] A preparation method of polylactic acid-based surgical suture, comprising the following preparation steps:

[0028] (1) In parts by weight, 72 parts of polylactic acid, 24 parts of polybutylene carbonate, 20 parts of polycaprolactone, 5 parts of cyclodextrin, 3 parts of phenylalanine, 1.1 parts of silver carbonate, and 3 parts of copper sulfide 2 parts of magnesium chloride, 2-6 parts of povidone iodine, 5 parts of polyvinyl alcohol, 4 parts of dopamine hydrochloride, 4-7 parts of diethylene glycol adipate, 2-8 parts of thiolated chitosan, 4.5 parts of fucoidan, 7 parts of chlorhexidine gluconate, 1.5 parts of urea, 3 parts of acycloguanidine, 4 parts of sodium alginate and vitamin K 3 2 parts were put into a blender, and blended at 80°C for 45 minutes to obtain a blend;

[0029] (2) Put the blended material in step (1) into a twin-screw extruder, extrude and granulate, and dry to obtain a master batch. The screw speed is 125 rpm, and the temperature of each zone of t...

Embodiment 3

[0033] A preparation method of polylactic acid-based surgical suture, comprising the following preparation steps:

[0034] (1) By weight, 85 parts of polylactic acid, 28 parts of polybutylene carbonate, 25 parts of polycaprolactone, 7 parts of cyclodextrin, 5 parts of phenylalanine, 1.8 parts of silver carbonate, and 4 parts of copper sulfide 3 parts of magnesium chloride, 6 parts of povidone iodine, 6 parts of polyvinyl alcohol, 5 parts of dopamine hydrochloride, 7 parts of diethylene glycol adipate, 8 parts of thiolated chitosan, 6 parts of fucoidan, 9 parts of chlorhexidine gluconate, 2 parts of urea, 4 parts of acycloguanidine, 5 parts of sodium alginate and vitamin K 3 3 parts were put into a blender, and blended at 90°C for 60 minutes to obtain a blend;

[0035] (2) Put the blended material in step (1) into a twin-screw extruder, extrude and granulate, and dry to obtain a master batch. The screw speed is 200 rpm, and the temperature of each zone of the screw is set to ...

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Abstract

The invention provides a preparation method of a polylactic acid-based suture line. The preparation method comprises the following steps of feeding polylactic acid, poly butylene carbonate, polycaprolactone, cyclodextrin, phenylalanine, silver carbonate, copper sulphide, magnesium chloride, povidone iodine, polyvinyl alcohol, dopamine hydrochloride, diethylene glycol adipate, thiolated chitosan, fucoidin, chlorhexidine digluconate, urea, acyclovir, sodium alginate and Vitamin K3 into a blender mixer, and mixing materials; feeding the mixture into a twin-screw extruder, and performing squeezing granulation; heating for melting, defoaming, and sequentially performing stretching twice by use of a spinneret plate; and finally performing sterilization and package, thereby obtaining polylactic acid-based suture line. The suture line prepared by the invention is high in anti-bacterial ratio and good in mechanical property, ensures that the healing time is shortened to 7-10, and is capable of accelerating wound healing; after a patient is healed, the suture line is completely absorbed, and no scar is generated on the healed surface, the comprehensive property is excellent, and the polylactic acid-based suture line can meet the application requirements of clinical medicine.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of polylactic acid-based surgical sutures. Background technique [0002] Surgical sutures are sterile threads used for wound closure, tissue ligation, and tissue fixation. At present, medical sutures can be divided into non-absorbable sutures and absorbable sutures according to their biodegradability. Absorbable sutures can be degraded into soluble products in body tissue and disappear from the implantation point within 2-6 months, making it a medical material with great development potential, which has attracted much attention and research. An ideal absorbable suture should be stable in vivo, have little tissue reaction, be difficult to loosen after knotting, and the suture itself will not fray or split. Absorbable sutures are non-toxic, compatible with human tissue and blood, and can be degraded. For the suturing of internal organs,...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/10A61L17/06D01F8/14D01F1/10
CPCA61L17/12A61L17/06A61L17/10A61L17/105C08L67/04D01F1/10D01F8/14C08L69/00C08L23/06C08L29/04C08L5/08C08L5/00C08L5/04
Inventor 林春梅
Owner 林春梅
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