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Antiseptic biological active titanium coating and its production

A biologically active, titanium coating technology, applied in coating, metal material coating process, fusion spraying, etc., can solve the problem of increasing infection

Inactive Publication Date: 2007-11-21
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioactive titanium-coated surface may provide an environment for bacterial growth and reproduction, increasing the possibility of infection

Method used

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  • Antiseptic biological active titanium coating and its production
  • Antiseptic biological active titanium coating and its production
  • Antiseptic biological active titanium coating and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The titanium coating was prepared by vacuum plasma spraying method, immersed in 5M NaOH solution, kept at 60°C for 24h, taken out, ultrasonically cleaned with deionized water for 3 times, each time for 5 minutes, and then dried at 40°C for 24h. Formulated with Ag + Ion 0.02mM supersaturated calcium phosphate solution: Weigh 12.0700g NaNO in turn 3 , 0.8856g Ca(NO 3 ) 2 4H 2 O, 0.3423g K 2 HPO 4 ·3H 2 O, 0.0034gAgNO 3 , into 1000ml deionized water, at 25°C with HNO 3 And 6.0600g tris hydroxy aminomethane adjusts the pH value of solution to 7.42. The alkali-treated titanium coating was immersed in a supersaturated calcium phosphate solution, kept at 25°C for 48h, and then dried at 120°C for 2h. The sample number is CA0.02.

[0020] After Ag + The antibacterial rates of the modified titanium coating CA0.02 against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were 98%, 94% and 63%, respectively. See Figure 4 for the photos of colonies after...

Embodiment 2

[0022] Using the same method as above to prepare the formulation containing Ag + 0.06mM supersaturated calcium phosphate solution. Then adopt the same steps as in Example 1 to prepare Ag-containing + Modified titanium coating CA0.06. The antibacterial rates of CA0.06 coating against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were 99%, 99% and 95%, respectively. See Figure 4 for the photos of colonies after 24 hours of bacterial culture on the surface of the specimen. The results showed that the CA0.06 coating had a good antibacterial effect on Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa and positive bacteria such as Staphylococcus aureus. The in vitro cytotoxicity grade of CA0.06 detected by MTT colorimetry was 0, indicating no obvious cytotoxicity.

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Abstract

The invention is concerned with antibiotic resistance biological activity coating and its produce method. It adopts NaOH solution and supersaturated calcium phosphate solution with Ag+ to dispose the titanium coating, makes the coating with biological activity and antibiotic resistance capability. The titanium coating with Ag+ ion is 0.01 to 0.1 mm. Dispose titanium powder on the metal basal body (for example, titanium alloy) which having been cleaned and disposed with sand blasting through vacuum plasm sprying technology with favourable technology parameters. Dip the prepared titanium coating into 3 to 10 mol NaOH solution and keep warm for 12 to 48 hours under 20 to 80 degree, take out and ultrasonic clean with deionized water for 2 to 6 times and each time is 3 to 10 minutes, dry for 12 to 48 hours with 20 to 80 degree. Dip the dried titanium coating into supersaturated calcium phosphate solution with Ag+ and keep warm for 12 to 48 hours with 20 to 37 degree and dry for 2 to 6 hours with 100 to 150 degree. The titanium coating has nice antibiotic resistance performance without obvious cytotoxicity.

Description

technical field [0001] The invention relates to an antibacterial plasma sprayed biologically active titanium coating and a preparation method thereof, belonging to the field of medical biological coatings. Background technique [0002] Preparation of plasma sprayed titanium coating on the surface of metal implants such as titanium and titanium alloys is a common method to improve its integration with bone tissue. The rough titanium coating surface can increase the contact area between the implant and the bone tissue, increase the mechanical fit between the bone and the porous surface, and thus significantly improve the shear strength of the interface between the implant and the bone. Hard tissue implants such as artificial joints sprayed with plasma sprayed titanium coating have been clinically applied. However, titanium coating is a biologically inert coating, which has no biological activity and does not promote and induce the growth of bone tissue, and its clinical appli...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L31/08C23C4/08C23C4/18C23C4/134
Inventor 陈益凯郑学斌谢有桃季珩丁传贤
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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