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Method of controlling release of antimicrobial agents in chewing gum and gum produced thereby

A technology of antibacterial agent and chewing gum, applied in the field of chewing gum, can solve the problem of undisclosed controlled release and the like

Inactive Publication Date: 2001-03-07
WM WRIGLEY JR CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although all these antimicrobial agents are disclosed in the form of chewing gum, there is no disclosure of controlled release of their increased effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1   Embodiment 2

[0067] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6

[0068] Sugar 62.2 61.9 60.8 60.8 60.8 58.3

[0069] Gum base 19.2 19.2 19.2 19.2 19.2 19.2

[0070] Glycerin 1.4 1.4 0.0 0.0 0.0 1.4

[0071] Corn syrup 15.9 15.9 12.9 12.9 12.9 -

[0072] Lecithin 0.2 0.2 0.2 0.2 0.2 0.2

[0073] Mint flavor 0.9 0.9 0.9 0.9 0.9 0.9

[0074] Liquid / gluconic acid 0.2 0.5 6.0 6.0 6.0 20.0

[0075] Chlorhexidine mixture

[0076] Examples 1 and 2 - Direct addition of chlorhexidine gluconate to gum.

Embodiment 3

[0077] Example 3 - A 1.0 g portion of chlorhexidine gluconate was dissolved in 99.0 g of hot water to make a 20.0% solution and added to the gum.

Embodiment 4

[0078] Example 4 - A 0.5 g portion of chlorhexidine gluconate was dissolved in 99.5 g of hot propylene glycol to make a 5.0% solution and added to the gum.

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PUM

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Abstract

A method for producing a chewing gum with a controlled release of an antimicrobial agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the antimicrobial agent by coating and drying. The antimicrobial agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated antimicrobial agent is preferably then co-dried and particle sized to produce a release-modified antimicrobial agent for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. The preferred antimicrobial agent is chlorhexidine digluconate

Description

Background of the invention [0001] The present invention relates to the production method of chewing gum. More specifically, the present invention relates to the production of chewing gum containing antimicrobial agents. Antimicrobial agents added to chewing gum are treated to control their rate of release in the chewing gum. [0002] In recent years, much work has been devoted to the controlled release of various ingredients in chewing gum. In particular, many attempts have been made to delay the release of sweeteners and flavors in various chewing gum formulations in order to prolong the satisfactory chewing time of the gum. Delaying the release of sweeteners and flavors also avoids an undesirably intense burst of sweetener or flavor release during the initial chew. On the other hand, some ingredients are treated so as to increase their release rate in the chewing gum. [0003] In addition to sweeteners, other ingredients also require controlled release from chewing gum....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/68
Inventor 罗曼·M·巴拉波拉克史蒂文·E·基贝尔戴维·L·威克维茨迈克尔·J·格林伯格罗伯特·J·雅卡
Owner WM WRIGLEY JR CO
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