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Recombinant antigens of human cytomegalovirus (HCMV)

A technology of recombinant antigens and antigens, applied in the field of diagnostic means, can solve the problems of unclear viral antigens, inability to provide sensitivity and specificity, changes in serum immunoglobulins, etc.

Inactive Publication Date: 2009-12-16
SIGMA TAU IND FARMACEUTICHE RIUNITE SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, available commercial assays do not provide sufficient sensitivity and specificity to correctly diagnose the infection in all patients
Furthermore, most currently available immunoassays use poorly defined viral antigens derived from HCMV-infected fibroblast cultures and vary in their ability to detect serum immunoglobulins
Finally, due to the lack of a gold standard, another problem in the HCMV serodiagnosis problem is the true classification of the obtained results

Method used

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  • Recombinant antigens of human cytomegalovirus (HCMV)
  • Recombinant antigens of human cytomegalovirus (HCMV)
  • Recombinant antigens of human cytomegalovirus (HCMV)

Examples

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Embodiment Construction

[0024] The main object of the present invention is to provide recombinant antigenic fragments of HCMV gene products, and to provide recombinant chimeric antigens obtained by fusing different antigenic regions of HCMV proteins, and the recombinant products obtained thereby are used for the development of selective diagnosis and treatment The use of the means.

[0025] The major advantage of using the chimeric antigens of the invention over other types of antigens or antigen fragments known in the literature described above when using the chimeric antigens of the invention in diagnostic immunoassays using serum to detect infection As follows, and the advantages are obvious:

[0026]- In the case of the use of intact HCMV antigens (which are prepared by lysis, derived from whole cell extracts of infected cells), said recombinant chimeric antigens have the ability to avoid non-specific reactions due to the presence of other non-viral substances , and offers the advantage of good ...

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Abstract

The invention described herein relates to a method for identifying the antigenic regions of HCMV proteins involved in the human B-cell response to HCMV infection, for combining such antigenic regions in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.

Description

technical field [0001] The invention described herein relates to the technical field of preparing diagnostic means that are not directly applied to animals or humans. [0002] The present invention also provides a variety of compounds, their preparation methods, their use methods and compositions containing these compounds, wherein said compounds are suitable for industrial application in the field of medicine and diagnosis, especially for human giant cell Detection and diagnosis of viral infections, and use in the treatment and prevention of said infections. Background technique [0003] In all therapeutic areas, early diagnosis is preferred and a highly desirable goal, especially since early diagnosis would improve the lives of patients considerably, with attendant savings to both the health care system and patients. Especially in the context of the invention described herein, in cases of potential or already occurring cytomegalovirus infection in pregnant women, special ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/045C07K19/00A61K39/245G01N33/569C12N15/10
CPCC07K2319/23C12N15/1037C07K2319/43C12N2710/16122G01N33/569G01N2333/045A61K39/00C07K14/005A61P31/12C07K19/00A61K39/245C12N15/11
Inventor N·加尔加诺E·贝赫托A·斯帕东尼F·德帕奥利斯
Owner SIGMA TAU IND FARMACEUTICHE RIUNITE SPA
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