35 results about "Quantitative methodology" patented technology

Disclosed is a method of extracting all metabolites existing in a biological sample to detect a comprehensive difference between metabolites of a control group and a test group, thereby verifying significance thereof. More particularly, the invention comprises a first step of analyzing a fraction extracted with a solid phase extraction method, a fraction obtained by extracting the remnant fraction with a liquid-liquid extraction method and fractions extracted with the liquid-liquid extraction method at two pH different from each other after the hydrolysis, with a gas chromatography-mass spectrometry; a second step of converting the chromatogram result into numerical values capable of being statistically processed; and a third step of analyzing the numerical values with a principal component analysis (PCA) and a discriminant analysis (DA) to detect a difference between the control group and the test group. According to the invention, the difference between the two groups can be comprehensively detected with the areas of the peaks on the chromatogram, without a standard material or verified quantitative method. Therefore, it is possible to detect the metabolic change in the organism due to the disease or gene mutation, without an accurate quantitative analysis of the metabolites.

The invention discloses a Logging big data real time driving based in-service oil casing pipe defect automatic determination method. The method includes: determining the minimum wall thickness threshold and the maximum depth of an in-service oil casing pipe, the depth increment and the circumference increment recorded by a logging meter, and wall thickness big data of the oil casing pipe; performing a value compensation treatment and a smoothing treatment on the wall thickness big data of the oil casing pipe; determining a defect zone of the oil casing pipe; quantitatively calculating out basic parameters of the defect zone of the oil casing pipe; and determining the qualitative type of a defect of the oil casing pipe through a quantitative analysis method. The method can perform data treatment and analysis in real time according to the logging big data, can effectively detect the defect zone of the oil casing pipe, can quantitatively calculating out the basic parameters of the defect zone of the oil casing pipe so as to achieve accurate positioning of the defect zone, and can accurately determine the qualitative type of the defect of the oil casing pipe through the quantitative analysis method. The method is good in real-time performance, is high in accuracy, is high in reliability, is full in information, and is high in degree of automation.