Multi-peak quantification method based on photoionization ion mobility spectrometry

A technology of ion mobility spectrometry and ionization, applied in the field of multi-peak quantification based on photoionization ion mobility spectrometry, can solve problems such as inapplicability, limitation of ion mobility spectrometry application scenarios, complex ionization reactions, etc., to expand the scope of application and shorten the data The effect of long analysis time and broad application prospects
CN112649494AInactive Publication Date: 2021-04-13DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2021-04-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a multi-peak quantification method based on photoionization ion mobility spectrometry. The method comprises the following steps: analyzing the maximum signal intensity of reagent molecules and the integral area of a certain product ion peak in the whole analysis process of a substance which generates two product ion peaks and has a fixed ion number ratio in an ion-molecular reaction in the ion mobility spectrometry of a negative ion mode; and establishing a linear quantitative relationship between the ratio of the integral area to the maximum signal intensity and the concentration of the substance to be detected in the sample. Propofol in blood is taken as an example, a standard quantitative curve of the photoionization ion mobility spectrometry is established in a concentration range of 0.1-20 ngmuL<-1 >, wherein Y= 0.05 X-0.0004 and a correlation coefficient R<2>= 0.997. The method enlarges the application range of the ion mobility spectrometry as a quantitative instrument, shortens data analysis time, simplifies quantitative operation, is quicker and more accurate, and has a wider application prospect.
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Description

technical field

[0001] The invention relates to the technical field of ion mobility spectrometry application and analysis and detection, in particular to a multi-peak quantitative method based on photoionization ion mobility spectrometry. Background technique

[0002] Ion mobility spectrometry is a separation and detection technology based on the different moving speeds of gas phase ions in an external electric field under atmospheric pressure. It has the advantages of fast detection speed, high sensitivity, and low price. It is a real-time dynamic detection technology with great application prospects. . At present, ion mobility spectrometry technology is widely used in public security, environmental monitoring, clinical diagnosis and other fields. However, due to the influence of various external conditions and the conditions of the instrument itself, the quantitative accuracy of ion mobility spectrometry is limited. The ionization source provides energy to ionize the reag...

Claims

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