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4950results about "Selective adsorption" patented technology
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Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers
InactiveUS6175409B1Avoid backlogImprove throughputSequential/parallel process reactionsSamplingFlow injection analysisPolymer
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
High-temperature characterization of polymers
InactiveUS6260407B1Avoid backlogImprove throughputSequential/parallel process reactionsComponent separationElutionChromatography column
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. In preferred high-temperature embodiments, the polymer sample is maintained at a temperature of not less than about 75° C. during sample preparation, loading into a liquid chromatography or flow-injection analysis system, injection into a mobile phase of a liquid chromatography or flow-injection analysis system, and / or elution from chromatographic column. The described methods, systems, and device have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Rapid characterization of polymers
InactiveUS6406632B1More separatedHigh sample throughputSequential/parallel process reactionsSamplingFluid phasePhysical chemistry
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Indirect calibration of polymer characterization systems
InactiveUS6294388B1Avoid backlogImprove throughputIon-exchange process apparatusSamplingPolymer characterizationFlow injection analysis
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Parallel high-performance liquid chromatography with post-separation treatment
InactiveUS6436292B1High sample throughputEasy to findIon-exchange process apparatusSamplingChromatographic separationCombinatorial synthesis
High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves post-separation treatment of the plurality of samples to enhance one or more properties of the sample or of a component thereof, followed by detection of the one or more enhanced properties. Selective, tunable detection schemes are achievable, and are particularly advantageous as applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.
Owner:FREESLATE
Acid Zirconium Phosphate and Alkaline Hydrous Zirconium Oxide Materials For Sorbent Dialysis
ActiveUS20100078387A1Avoid disadvantagesRestore balanceCation exchanger materialsOrganic anion exchangersIon exchangeDialysis fluid
Owner:FRESENIUS MEDICAL CARE HLDG INC
Microfludic system (EDI)
InactiveUS6717136B2Minimal loss of precious materialCheap and disposableIon-exchange process apparatusMaterial nanotechnologyAnalyteEngineering
A microfluidic device comprising an MS-analyte presentation unit for a EDI-MS apparatus, said unit comprising an essentially planar support plate which on one side has one, two or more ports (MS-ports) comprising an area (EDI area) for presenting the MS-analyte to a mass spectrometer. The EDI area comprises a layer I of conducting material. The characteristic feature of the device is that layer (I) has a conductive connection and / or that there is a calibrator area in the proximity of the MS-port.
Owner:GYROS
Nanostructured separation and analysis devices for biological membranes
InactiveUS6913697B2Ion-exchanger regenerationVolume/mass flow measurementBiological membraneNanostructure
The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
Owner:STC UNM
Separation apparatus and separation method
InactiveUS20060000772A1Improve efficiencyHigh activityIon-exchange process apparatusSemi-permeable membranesBuffer solutionAnalytical chemistry
A channel (103) is formed in a substrate (101), and a portion of the channel (103) is provided with a separating portion (107). A number of pillars are formed in the separating portion (107), and an adsorptive substance layer having an adsorptive substance, which exhibits a specific interaction for a specific substance, immobilized on the surface thereof, is formed. Once a sample is introduced into the channel (103), the specific substance is adsorbed on the adsorptive substance layer to be separated from other components. After washing the inside of the channel (103) with a buffer solution, the specific substance is desorbed from the adsorptive substance layer by flowing a eluting solution through the channel (103) and the specific substance is recovered.
Owner:NEC CORP
Automated sampling methods for rapid characterization of polymers
InactiveUS6265226B1Avoid backlogImprove throughputSequential/parallel process reactionsComponent separationFlow injection analysisPolymer
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Microfluidic chromatography
InactiveUS7217367B2Ion-exchange process apparatusComponent separationChromatography columnDelivery system
The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.
Owner:FLUIDIGM CORP
Nanosize electropositive fibrous adsorbent
InactiveUS6838005B2Improve the immunityEfficient precipitationIon-exchanger regenerationLoose filtering material filtersFiberParticulates
Aluminum hydroxide fibers approximately 2 nanometers in diameter and with surface areas ranging from 200 to 650 m2 / g have been fount to be highly electropositive. When dispersed in water they are able to attach to and retain electronegative particles. When combined into a composite filter with other fibers or particles they can filter bacteria and nano size particulates such as viruses and colloidal particles at high flux through the filter. Such filters can be used for purification and sterilization of water, biological, medical and pharmaceutical fluids, and as a collector / concentrator for detection and assay of mirobes and viruses. The alumina fibers are also capable of filtering sub-micron inorganic and metallic particles to produce ultra pure water. The fibers are suitable as a substrate for growth of cells. Macromolicules such as proteins may be separated from each other based on their electronegative charges.
Owner:ARGONIDE CORP
Methods for time-alignment of liquid chromatography-mass spectrometry data
Nonlinear retention time variations in chromatography-mass spectrometry data sets are adjusted by time-alignment methods, enabling automated comparison of spectra for differential phenotyping and other applications.
Owner:CAPRION PROTEOMICS INC
Method for separating single-wall carbon nanotubes and compositions thereof
The invention relates to a process for sorting and separating a mixture of (n, m) type single-wall carbon nanotubes according to (n, m) type. A mixture of (n, m) type single-wall carbon nanotubes is suspended such that the single-wall carbon nanotubes are individually dispersed. The nanotube suspension can be done in a surfactant-water solution and the surfactant surrounding the nanotubes keeps the nanotube isolated and from aggregating with other nanotubes. The nanotube suspension is acidified to protonate a fraction of the nanotubes. An electric field is applied and the protonated nanotubes migrate in the electric fields at different rates dependent on their (n, m) type. Fractions of nanotubes are collected at different fractionation times. The process of protonation, applying an electric field, and fractionation is repeated at increasingly higher pH to separated the (n, m) nanotube mixture into individual (n, m) nanotube fractions. The separation enables new electronic devices requiring selected (n, m) nanotube types.
Owner:RICE UNIV
Multicapillary device for sample preparation
InactiveUS20070017870A1Large specific surface areaLoad largeIon-exchange process apparatusComponent separationStationary phaseMICRO PIPETTE
A multicapillary sample preparation device, especially useful for handling biological samples, comprising a plurality of uniform capillary tubes coated with a stationary phase, and arranged in a monolithic element. The multicapillary device is suitable for attachment to a pipette, micropipette, syringe, or other analytical or sample preparation instrument.
Owner:BIOEDGE
Fiber optic apparatus and use thereof in combinatorial material science
InactiveUS6519032B1Facilitate the discovery of commercially important polymericEffectively and efficiently characterizingSequential/parallel process reactionsComponent separationFiberHigh-Throughput Screening Methods
Methods, systems and devices are described for rapid characterization and screening of liquid samples to determine properties (e.g., particle size, particle size distribution, molar mass and / or molar mass distribution) thereof with static light scattering and / or dynamic light scattering. The liquid samples can be solutions, emulsions, suspensions or dispersions. One method, includes providing a vessel containing a liquid sample having an exposed surface that defines a gas-liquid sample interface, and analyzing the sample by light scattering methods that include transmitting light through the gas-liquid sample interface into the sample, and detecting light scattered from the sample or from a component thereof. Additional methods are directed to characterizing a plurality of liquid samples or components thereof. The methods, systems, and devices have applications in high-throughput screening, and particularly, in combinatorial materials research and in industrial process control.
Owner:WYATT TECH
Microfluidic chromatography
InactiveUS20050000900A1Ion-exchange process apparatusComponent separationChromatography columnDelivery system
The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.
Owner:FLUIDIGM CORP
Purification of proteins
ActiveUS20080255027A1Ion-exchange process apparatusPeptide/protein ingredientsElutionProcess conditions
The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and / or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.
Owner:MILLIPORE CORP
Pump, pump for liquid chromatography, and liquid chromatography apparatus
The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate and in discharging bubbles at startup. In a pump for liquid chromatography including a cylinder and a plunger that reciprocates in the cylinder to suck and discharge fluid, the pump further includes a large-flow-rate pump that feeds liquid by the plunger, a small-flow-rate pump that feeds the liquid by the plunger, motion conversion means that converts the rotational motion of a motor to a reciprocating motion, an actuator that directly drives the plunger, and a drive part that drives the actuator, and selectively switches means for driving the plunger.
Owner:HITACHI HIGH-TECH CORP
Adsorption/separation method and a medium for adsorption/separation
InactiveUS6428707B1Increase productionImprove productivityChromatographic cation exchangersCation exchanger materialsChemistrySeparation method
A method for adsorption of a substance from a liquid sample on a fluidized bead or stirred suspension, in which the beads used comprise a base matrix and exhibit a structure having affinity to the substance, characterized in that the structure is covalently bound to the base matrix via an extender. Populations of beads in which the beads contain a filler incorporated in a base matrix and an extender are also described.
Owner:GE HEALTHCARE BIOPROCESS R&D
Process for preparing major histocompatibility antigen class II protein and materials in which the same is bound
InactiveUS6630315B1Produce significantIon-exchanger regenerationMicroorganism based processesFiberMajor histocompatibility
This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as "MHC class II" for short) which occurs on the surfaces of antigen-presenting cells and the like, and MHC class II-bound materials in which MHC class II, alpha and / or beta subunit of MHC class II, or a part thereof is bound to a carrier such as beads, fibers and hollow fibers via covalent bond, as well as a module for removing superantigen using the same. This invention also provides a method for detecting or quantifying superantigens using MHC class II or a part thereof having an affinity to the superantigens, as well as an assay kit therefor.
Owner:TORAY IND INC
Purification of carbon dioxide
Impure carbon dioxide (“CO2”) comprising a first contaminant selected from the group consisting of oxygen (“O2”) and carbon monoxide (“CO”) is purified by separating expanded impure carbon dioxide liquid in a mass transfer separation column system. The impure carbon dioxide may be derived from, for example, flue gas from an oxyfuel combustion process or waste gas from a hydrogen (“H2”) PSA system.
Owner:AIR PROD & CHEM INC
Separation column devices and fabrication methods
Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits. One or more splitters may be provided to distribute slurry and / or mobile phase among multiple separation columns. In one embodiment, separation devices are substantially planar and fabricated with multiple device layers. Systems and methods employing slurry for packing separation devices are also provided.
Owner:AGILENT TECH INC
Porous hybrid particles with organic groups removed from the surface
InactiveUS7175913B2Reduced peak tailingEasy to separateComponent separationIon-exchanger regenerationChromatographic separationHybrid material
A material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, porous inorganic / organic hybrid materials are provided with a decreased concentration of surface organic groups. These particles may be surface modified and have enhanced stability at low pH.
Owner:WATERS TECH CORP
Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation
InactiveUS7250214B2Extended service lifeReduce back pressureComponent separationIon-exchanger regenerationChromatographic separationNew materials
Owner:WATERS TECH CORP
Single-particle analysis of particle populations
ActiveUS20130323732A1Ion-exchange process apparatusIon-exchanger regenerationPhysical chemistryTwo parameter
In certain embodiments, the invention provides methods and devices for assaying single particles in a population of particles, wherein at least two parameters are measured for each particle. One or more parameters can be measured while the particles are in the separate reaction volumes. Alternatively or in addition, one or more parameters can be measured in a later analytic step, e.g., where reactions are carried out in the separate reaction volumes and the reaction products are recovered and analyzed. In particular embodiments, one or more parameter measurements are carried out “in parallel,” i.e., essentially simultaneously in the separate reaction volumes.
Owner:FLUIDIGM CORP
Miniature actual moving bed assembly
An apparatus is presented for separating chemicals using adsorption separation methods. The apparatus uses a plurality of adsorption units holding adsorbent, where the adsorption units positioned in a cylindrical spool, are serially connected and the spool is rotated to shift the relative position of the feeds and drawoffs to the apparatus.
Owner:UOP LLC
Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
InactiveUS20130112605A1Prevent fine generationInhibit aggregationIon-exchanger regenerationPretreated surfacesChromatographic separationHybrid material
Novel chromatographic materials for chromatographic separations, columns, kits, and methods for preparation and separations with a superficially porous material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core. The material of the invention is comprised of superficially porous particles and a narrow particle size distrution. The material of the invention is comprised of a superficially porous monolith, the substantially nonporous core material is silica; silica coated with an inorganic / organic hybrid surrounding material; a magnetic core material; a magnetic core material coated with silica; a high thermal conductivity core material; a high thermal conductivity core material coated with silica; a composite material; an inorganic / organic hybrid surrounding material; a composite material coated with silica; a magnetic core material coated with an inorganic / organic hybrid surrounding material; or a high thermal conductivity core material coated with an inorganic / organic hybrid surrounding material.
Owner:WATERS TECH CORP
Process for chromatographic separation of peptides and nucleic acid, and new high affinity ion exchange matrix
InactiveUS6090288ACation exchanger materialsComponent separationChromatographic separationTransferrin
PCT No. PCT / SE97 / 00237 Sec. 371 Date Dec. 29, 1998 Sec. 102(e) Date Dec. 29, 1998 PCT Filed Feb. 14, 1997 PCT Pub. No. WO97 / 29825 PCT Pub. Date Aug. 21, 1997Process for separating off a peptide or a nucleic acid by an anion exchanger (I) characterized in that a) the anion exchanger (I) exhibits ligands, which (i) contain a primary, secondary or tertiary amino group and (ii) are covalently bound to an organic polymer (matrix), b) there on a carbon atom at a distance of 2 or 3 atoms away from an amino nitrogen in the ligands is a hydroxyl group or a primary, secondary or tertiary amino group, and c) the maximum elution ionic strength in the pH range 2-14 for at least one of the proteins transferrin, ovalbumin 1, ovalbumin 2, beta -lactoglobulin 1 and beta -lactoglobulin 2 on the anion exchanger is higher than the elution ionic strength required for a quaternary comparative ion exchanger.
Owner:GE HEALTHCARE BIOPROCESS R&D
Parallel fluid processing systems and methods
ActiveUS7178386B1Ion-exchange process apparatusWave based measurement systemsFactor baseRetention time
A parallel fluid processing system including multiple fluid process regions containing solid material in fluid communication with a common first fluid source may be used to conduct analyses and / or synthesis in parallel. A parallel fluid processing data correction method includes supplying and processing a calibrant in each fluid process region, measuring a first physical parameter and deriving at least one correction factor based on the parameter, supplying and processing at least one second fluid in each fluid process region, and then applying the correction factor to yield corrected process data. Retention time correction, peak area correction, and other useful data corrections may be performed. Parallel fluid processing may be performed with microfluidic devices and systems. A system for correcting retention times in parallel liquid chromatography is further provided.
Owner:AGILENT TECH INC
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