The invention relates to a system for realizing cross-browser Javascript debugging in an enterprise Web application system, comprising a graphical Javascript debugging platform and a cross-browser Javascript debugging framework, wherein, the graphical Javascript debugging platform comprises a debugger engine module, an Http server module, a proxy server module, a compiling engine module, a debugging server module and a debugger UI module, the cross-browser Javascript debugging framework comprises a cross-browser supporting module, a debugging code API module, a call stack managing module and a debugging command resolving module. The invention also relates to a method for realizing cross-browser Javascript debugging in an enterprise Web application system based on the system. By adopting the system and the method for realizing cross-browser Javascript debugging in the enterprise Web application system, the debugging efficiency is high, the operation is simple, fast and convenient, the system performance is stable and reliable, the development and maintenance cost is reduced, the portability and the extendibility of the system are enhanced, the applicable scope is wide, thereby laying the solid foundation for the further development of the enterprise Web application software technology.