187 results about "Influenza prevention" patented technology

This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.

The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the activity of p59-HCK and to a method of screening for a candidate drug substance intended to prevent or treat influenza virus infection in a subject, said method comprising identifying a test substance capable of inhibiting p59-HCK activity.

The invention relates to pharmaceutical compositions that contain a calcium salt as an active ingredient and also comprise another anti-influenza agent, and to methods for treating or preventing influenza virus infection.

Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides, polynucleotides encoding NS1 variant polypeptides, a reverse genetics system for producing attenuated influenza virus NS1 variants, immunogenic compositions comprising live attenuated influenza virus NS1 variants, methods of stimulating an immune response against influenza virus, methods of interfering with influenza virus replication, and methods of treating and preventing influenza virus infection are described.

The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by influenza virus. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions.

The invention relates to a rice aroma beef sauce and a preparation method thereof. The rice aroma beef sauce is characterized in that the rice aroma beef sauce is prepared from the following raw materials by weight: 50-55 parts of beef, 2-2.4 parts of creeping liriope, 1-1.2 parts of equisetum hyemale l, 0.8-1 part of american ginseng, 1-1.2 parts of rehmannia glutinosa(gae-rtn.) libosch, 0.9-1 part of gerbera anandria (linn.)sch.-bip, 1.1-1.4 parts of monochoria vaginalis, 3-4 parts of propolis, 7-8 parts of hulless barley powder, 3-4 parts of capsella bursa-pastoris, 4-5 parts of flammulina velutipes, 4-4.5 parts of garlic sprouts, 22-25 parts of sunflower seed kernel, 30-35 parts of glutinous rice, 10-11 parts of crab meat, 0.1-0.2 part of a composite flavor protease, 350-370 parts of sweet flour paste, and 4-5 parts of a nutritional additive. According to the present invention, the aroma and the sweet taste of the glutinous rice and the delicious taste of the crab meat are fused into the rice aroma beef sauce, such that the rice aroma beef sauce has the unique flavor; the rice aroma beef sauce is rich in nutrition, wherein the hulless barley powder is rich in dietary fibers so as to remove toxins from the body, and the garlic sprouts contain capsaicine so as to provide effects of sterilization and influenza prevention; and the rice aroma beef sauce further contains a variety of Chinese herbal ingredients so as to provide effects of lung moisturizing, heart-fire clearing, eyesight improving, nebula removing, qi reinforcing and yin nourishing after regular taking.

The invention relates to a robot with environment monitoring and haze removal, formaldehyde removal and sterilization functions. The robot comprises a robot head (1), a connecting part (2), a torso (3), an air monitoring device (4) and a haze removal and formaldehyde removal sterilization device (5), wherein the robot head (1) is rotationally connected with the connecting part (2), and the robot head (1) and the connecting part (2) are fixedly connected to the torso (3); and the air monitoring device (4) is wirelessly connected with the robot head (1), and the haze removal and formaldehyde removal sterilization device (5) is wirelessly connected with the robot head (1). The robot with the environment monitoring and haze removal, formaldehyde removal and sterilization functions can monitorthe air quality, meanwhile, the robot can intelligently turn on the air purification function or the ozone sterilization and disinfection function according to the air quality condition, the occupiedspace is small, and the use is convenient, in addition, the robot can analyze the body temperature health condition of people in the flu season through face recognition and body temperature detection,the robot can provide early warning for people with significantly elevated body temperature, and the effect of influenza prevention is achieved.

The invention provides an azacyclo diketone compound, which is a compound represented by the following structure defined in the specification, or a pharmaceutically acceptable salt thereof. The invention provides a compound having an inhibitory activity on influenza (flu) virus proliferation, particularly on influenza-related cap-dependent endonuclease to inhibit influenza virus proliferation so as to treat or prevent influenza. The present invention relates to a substituted azacyclo diketone compound having inhibitory activity on cap-dependent endonuclease, and a pharmaceutical composition containing the substituted azacyclo diketone compound.

The present invention relates to mRNA sequences usable as mRNA-based vaccines against infections with influenza viruses. Additionally, the present invention relates to a composition comprising the mRNA sequences and the use of the mRNA sequences or the composition for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the prophylaxis or treatment of influenza virus infections. The present invention further describes a method of treatment or prophylaxis of infections with influenza virus using the mRNA sequences.

The invention relates to an anti-influenza and anti-avian influenza medicament, wherein the chemical name is (1S, 2S, 3R, 4R)-3-((1S)-1-acetamido-2-ethyl-butyl)-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid, the structure is as shown in the figure (the compound is called compound A for short), and different groups are connected on carboxyl or/and amino of the compound A in the research to get the derivatives of the compound A. The derivatives can be combined with pharmaceutically acceptable excipients to be used for treating and/or preventing influenza and avian influenza.

The invention discloses an application of berberine in medicine for treating or preventing influenza virus. The application proves that berberine enjoys the good function of resisting influenza virus on MDCK cells infected by A-type influenza virus such as H5N1 and H3N2 and on A549 cells.Meanwhile, the berberine can kill influenza virus to a certain extent, prevent attack from the influenza virusand inhibit cells infected by the influenza virus; the berberine enjoys similar effect to amantadine, a positive control medicine; in addition, the berberine can well inhibit inflammatory responses triggered by the influenza virus and is disclosed to enjoy the prospect of being developed into the medicine for resisting the influenza virus.

The invention relates to a preparation method and application of a total extractive of artemisia rupestris L. The method comprises the following steps of: crushing a dry artemisia rupestris L. medicinal material, extracting by using ethanol as an organic solvent, carrying out resin separation and purification to obtain the total extractive of the artemisia rupestris L., wherein the total extractive of the artemisia rupestris L. mainly contains sesquiterpenoids and flavonoid constitutes, a sesquiterpenoid and the flavonoid constitute compound is in the mass percentage of 25-90%, a sesquiterpenoid compound is in the mass percentage of 5-25%, a flavonoid constitute compound is in the mass percentage of 20-65%, and rupestonic acid of the sesquiterpenoid compound is in the mass percentage of 3-15%. Proved by a primary activity screening test, the total extractive of the artemisia rupestris L., obtained by using the method provided by the invention, has remarkable in vitro and vivo influenza virus resistance, bacteriostasis and sterilization effects and can also be used for effectively preventing influenza viruses. The method disclosed by the invention is simple in process, free of high-temperature and high-pressure equipment, low in production cost, stable in quality of effective components and easy to control.

The invention relates to a preparation for preventing influenza, which contains the following components in percentage: 10 percent of heterophylly falsestarwort root, 20 percent of bupleurum root, 6 percent of tuckahoe, 20 percent of licorice root and 44 percent of honeysuckle. The form of the preparation for preventing the influenza is capsules, sugar granules, sugar-free granules, tablets or oral liquid. (1) The bupleurum root contained in the preparation has anti-febrile, analgesia and anti-inflammatory effects and has little injury to the liver. (2) The tuckahoe contained in the preparation has sweet character and taste, has the effects of excreting dampness and tonifying spleen, quickens metabolism, and has low side effect.

The invention discloses a primer composition for detecting different influenza viruses and an application thereof. The primer composition disclosed by the invention comprises any one of primer pairs represented by the following (1)-(4): (1) a DNA molecule shown in SEQ ID No.1 and a DNA molecule shown in SEQ ID No.2; (2) a DNA molecule shown in SEQ ID No.3 and a DNA molecule shown in SEQ ID No.4; (3) a DNA molecule shown in SEQ ID No.5 and a DNA molecule shown in SEQ ID No.6; and (4) a DNA molecule shown in SEQ ID No.7 and a DNA molecule shown in SEQ ID No.8. The primer composition has positive meanings on timely diagnosing and timely treating pathogenetic canine, timely forecasting epidemic trends, preventing influenza large pandemic, and implementing large-scale canine influenza virus epidemiology monitoring.

Recombinant, chimeric porcine influenza viruses are disclosed that include hemagglutinin segments from more than one influenza virus subtype. Also described are methods of producing the recombinant influenza viruses, immunogenic compositions comprising the recombinant influenza viruses, methods of stimulating an immune response against influenza virus, and methods of treating and preventing influenza virus infection.

The invention relates to a composition for preventing and curing cold. The composition is technically characterized in that the effective constituents of various plants are extracted and are combined reasonably; according to different seasons, the extractives with different prescriptions are selected; and the composition is put into an atomizer of the utility model of the inventor, thereby effectively preventing and curing the health harm caused by various influenza viruses.