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35 results about "Triptonide" patented technology
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Triptonide is a diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.
Biogenic emulsifiable insecticide and method for preparing same
The invention discloses a biogenic emulsifiable insecticide and a method for preparing the biogenic emulsifiable insecticide. The biogenic emulsifiable insecticide comprises the following components in percentage by weight: 5-15% of pyrethroid, 2-4% of triptonide, 8-15% of an emulsifier and the balance of an organic solvent. The triptonide and the pyrethroid are used together to take the synergistic effect to effectively improve the capacity of killing the insects such as the mosquitoes and the flies of the biogenic emulsifiable insecticide. Because the biogenic triptonide is added into the biogenic emulsifiable insecticide, one part of pyrethroid can be replaced effectively, and the biogenic emulsifiable insecticide is more environmental friendly. The biogenic emulsifiable insecticide can be diluted and sprayed to kill the insects such as the adult mosquitoes and the adult flies to reduce the insect density rapidly.
Owner:博罗县富得针织有限公司
Application of triptonide to anti-angiogenesis drugs
ActiveCN103230401AAccelerated agingPromote differentiationOrganic active ingredientsAntineoplastic agentsApoptosisTumor vessel
The invention relates to the medicine field and discloses application of triptonide to anti-angiogenesis drugs. In-vitro and in-vivo tests for suppressing tumor neovascularization are carried out by adopting triptonide and the results show that the Chinese herbal medicine monomer triptonide can induce silencing of key genes for tumor neovascularization, promote tumor cell aging, differentiation and apoptosis, eliminate or reduce the neovascularization capacities of tumor cells, normalize and eliminate tumor vessels and improve the anticancer curative effects. Effective dose of triptonide and pharmaceutically acceptable auxiliary components can be used for preparing tablets, granules, capsules, suspension agents, syrup, emulsion or other common drug preparations. The drug preparations can be used for anti-angiogenesis. Besides, the extracts containing triptonide can be used for preparing the anti-angiogenesis drug preparations.
Owner:SUZHOU UNIV
Inhibitor capable of inhibiting excessive proliferation of keratinocytes, inhibitor composition, and applications of inhibitor
InactiveCN106880638AInhibition of secretion levelInhibition cycleOrganic active ingredientsDermatological disorderInflammatory factorsCXCL10
The invention belongs to the fields of biotechnology and medicine, and relates to an inhibitor capable of inhibiting the excessive proliferation of keratinocytes, an inhibitor composition, and applications of the inhibitor. The inhibitor taking triptolide, triptonide or tripterine as the representative can inhibit the excessive proliferation of the keratinocytes, specifically, the expression levels of STAT1 and p-STAT1 can be inhibited, then the expression level of miR-17-92mRNA is down-regulated, then, miR-17-92 target gene CDKN2B is regulated, the secretion levels of inflammatory factors CXCL1, CXCL10, CXCL16 and IL-6 in cells are inhibited, and finally, the cell cycle progression and immune function abnormity are inhibited; triptolide, tripterine and triptonide can effectively inhibit the proliferation of the keratinocytes, and the effective doses respectively achieve 60nM, 100nM and 80nM.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Tea tree essential oil mosquito-repellent incense
ActiveCN103931677AFresh and fragrantStrong repellent effectBiocidePest repellentsTriptonidePiperonyl butoxide
The invention discloses tea tree essential oil mosquito-repellent incense. The tea tree essential oil mosquito-repellent incense is composed of following raw materials in parts by weight: 0.2-0.6 part of tea tree essential oil, 0.01-0.03 part of triptonide, 0.2-0.8 part of dimefluthrin, 0.05-0.15 part of (1R)-chrysanthemolactone, 0.02-0.06 part of piperonyl butoxide and 100 parts of normal tetradecane in a mixing manner. The tea tree essential oil mosquito-repellent incense disclosed by the invention has a fresh and aromatic taste and has a relatively strong repelling effect on mosquitoes.
Owner:佛山市南海添惠日化有限公司
Tripterygium wilfordii lactone prodrugs having high aqueous solubility
Compounds useful in immunosuppressive and anti-inflammatory treatment are described. The compounds are hydrolyzable triptolide analogs with improved water solubility and generally lower toxicity than the parent compound.
Owner:法玛吉尼西斯公司
Chinese traditional medicine Tripterygium wilfordii and improving technique for attenuation and synergy of its extract
The invention discloses a modifying process of attenuation and synergy for Tripterygium wilfordii and its extract, wherein the procedure (1) comprises immersing Tripterygium wilfordii with acid solution, conversing Triptolidenol Triptonide into Tripchlo-rolide (II). While the procedure (2) comprises preparing concrete from Tripterygium wilfordii, then purifying Tripterygium wilfordii or its concrete, acid treating or immersing with acid solution.
Owner:杨更亮
Method for simultaneously detecting triptolide and triptonide in thunder god vine medicinal materials or preparations
The invention provides a method for simultaneously detecting triptolide and triptonide in thunder god vine medicinal materials or preparations, which realizes detection by using a micro-emulsion eletrokinetic chromatography method. The method establishes the brand new micro-emulsion eletrokinetic chromatography method, and is used for detecting important toxicity and the content of effective constituents in thunder god vine in a separated manner. Experimental results show the method provided by the invention has the advantages of good linear relation and high precision; and the triptolide and the triptonide in a sample can reach the effect of the base line separation within 10 minutes, and the method is high in separation degree, can be used for detecting an actual sample, and provides powerful supplement for quality control of the thunder god vine medicinal materials or preparations.
Owner:远大医药黄石飞云制药有限公司
Method for preparing triptonide
ActiveCN108033993AEfficient separationSuitable for industrial productionSteroidsHplc methodSilica column
The invention discloses a method for preparing triptonide. Structures of the triptonide, triptolide, tripdiolide and 2-epitripdiolide existed in common caulis tripterygii wilfordii are close, whereinthe tripdiolide and the 2-epitripdiolide are a pair of chiral isomers with big separating difficulty. The four compounds are separated by depending on repeated silica column chromatography in the prior art, while repeated silica column chromatography consumes solvent, is poor in reproducibility, only suitable for less separation in experiments, and hard to popularize in industrial production. In current industrial production, only used column chromatography is a macroporous resin. The method provided by the invention can be used for separating and preparing the triptonide, the triptolide, thetripdiolide and the 2-epitripdiolide without depending on repeated silica column chromatography. The HPLC (Hight Performance Liquid Chromatography) method provided by the invention can be used for effectively separating the chiral isomers i.e. the tripdiolide and the 2-epitripdiolide based on a conventional C18 chromatographic column, and is low in cost and high in repeatability.
Owner:HAIMEN BIWEI INTPROP SERVICE CO LTD
Dye-fixing agent for bright cloth, a preparation method of dye-fixing agent and method for preparing bright cloth
InactiveCN104846675AImprove color fastness to rubbingImprove light fastnessDyeing processFiberCross-link
The invention belongs to the field of textile and dyeing and relates to a dye-fixing agent for a bright cloth, a preparation method of the dye-fixing agent and a method for preparing the bright cloth. Specifically, the dye-fixing agent for the bright cloth contains the following components in parts by weight: 3-5 parts of triptolide, 2-4 parts of triptonide, 4-6 parts of dulcitol, 10-20 parts of Machilus butyrolactone, 10-20 parts of valepotriate, 6-14 parts of soybean polypeptide, 6-14 parts of 1, 4-diguanidylbutane and 80-120 parts of water. The invention further relates to a use of the dye-fixing agent for the bright cloth in preparing the bright cloth. The dye-fixing agent for the bright cloth provided by the invention can form a layer of reticular film in a cross-linking manner on the surfaces of bright cloth fibers, the surface color fastness to rubbing and color fastness to sunlight of the bright cloth can be effectively improved, and the dye-fixing agent for the bright cloth has the characteristics of natural and environmental-friendly raw materials, no influence on the surface gloss of the bright cloth and good dye-fixing effect.
Owner:UNKNOWN
Method for preparing tripdiolide and 2-epitripdiolide
ActiveCN108191948AEfficient separationSuitable for industrial productionSteroidsHplc methodTriptonide
The invention discloses a method for preparing tripdiolide and 2-epitripdiolide. Structures of triptonide, triptolide, tripdiolide and 2-epitripdiolide in common threewingnut root are quite similar, wherein tripdiolide and 2-epitripdiolide are a pair of chiral isomers and difficult to separate. When the four compounds are separated in the prior art, the separation depends on repeated silica-gel column chromatography, however, the repeated silica-gel column chromatography is high in solvent consumption, low in repeatability, just suitable for a small amount of separation in a laboratory and difficult to popularize in industrial production. The column chromatography which is only in use in the current industrial production is macroporous resin. According to the method, triptonide, triptolide, tripdiolide and 2-epitripdiolide can be separated and prepared without dependence on the repeated silica-gel column chromatography. With adoption of the HPLC method, tripdiolide and 2-epitripdiolidein the chiral isomers can be effectively separated on the basis of a conventional C18 chromatographic column, the cost is low, and the repeatability is high.
Owner:HAIMEN BIWEI INTPROP SERVICE CO LTD
Inhibitor capable of inhibiting killing effect of CD8<+>T cells on melanocytes, inhibitor composition and application
The invention belongs to the field of biotechnology and medicine and relates to an inhibitor capable of inhibiting a killing effect of CD8<+>T cells on melanocytes, inhibitor composition and an application to vitiligo preventing and treating drugs. When dose of triptolide, celastrol or wilforlide A are in 5-10 nM, the inhibitor capable of inhibiting the killing effect of the CD8<+>T cells on the melanocytes can inhibit the expression level of STAT1 (signal transducer and activator of transcription 1) in keratinocytes, then the expression level of IRF1 is down-regulated, secretion of CXCL10 and CXCL16 in the keratinocytes is inhibited, and chemotaxis of CXCL10 and CXCL16 on the CD8<+>T cells is further reduced, so that the killing effect of the CD8<+>T cells on the melanocytes is inhibited; the inhibitor capable of inhibiting the killing effect of the CD8<+>T cells on the melanocytes is a tripterygium wilfordii terpenoid and particularly is triptolide, celastrol or triptonide.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Method for preparing triptolide
ActiveCN108129545AEfficient separationSuitable for industrial productionSteroidsHplc methodTriptonide
The invention discloses a method for preparing triptolide. Triptonide, triptolide, tripdiolide and 2-epitripdiolide in common threewingnut roots are of very approximate structures, tripdiolide and 2-epitripdiolide are a pair of chiral isomers with large separation difficulties. In the prior art, the four compounds are separated all through repeated silica-gel column chromatography, however, repeated silica-gel column chromatography consumes a great amount of solvents and is poor in reproducibility, only applicable to slight separation in laboratories, and hard to popularize in industrial production. In conventional industrial production, only a macroporous resin is available as column chromatography in service. By adopting the method disclosed by the invention, triptonide, triptolide, tripdiolide and 2-epitripdiolide can be separated and prepared without repeated silica-gel column chromatography. On the basis of a common C18 chromatographic column, the HPLC (High Performance Liquid Chromatography) method disclosed by the invention is capable of effectively separating chiral isomers, namely tripdiolide and 2-epitripdiolide, and is low in cost and good in repeatability.
Owner:江西中德诚信科技有限公司 +1
Method for extracting and purifying 15-hydroxy triptonide
The invention discloses a method for extracting and purifying 15-hydroxy triptonide. The 15-hydroxy triptonide of which the purity achieves 99 percent or higher can be extracted and obtained through the steps of taking root hearts, root barks, stems and leaves of triptolide as raw materials, crushing, soaking, percolating, extracting, silica gel column chromatography separation and purification, re-crystallizing and the like, and the yield of the 15-hydroxy triptonide is about 9*10<-5> and is improved by about 80 times in compassion with an existing literature report extraction process, so that a material basis is provided for the study on chemical structure, pharmacologic action and the like of the 15-hydroxy triptonide.
Owner:FUJIAN ACAD OF MEDICAL SCI
Biogenic source insect-proof fabric and preparation method of biogenic source insect-proof fabric
The invention discloses a biogenic source insect-proof fabric and a preparation method of the biogenic source insect-proof fabric. The preparation method of the biogenic source insect-proof fabric is characterized by comprising the following steps: (1) diluting biogenic source insect-proof missible oil for 50 to 100 times with water to form impregnation liquid; (2) impregnating the fabric into the impregnation liquid; drying by spinning and washing with the water; drying by spinning again and sizing to prepare the biogenic source insect-proof fabric provided by the invention. The biogenic source insect-proof missible oil provided by the invention is prepared from the following components in percentage by weight: 5 percent to 15 percent of pyrethroid, 2 percent to 4 percent of triptonide, 8 percent to 15 percent of an emulsifier and the balance of an organic solvent. The biogenic source insect-proof fabric prepared by the invention has a high invasion repelling capability on insects including mosquitoes and the like and has a lasting mosquito-repelling effect.
Owner:QINGDAO SENMEIKE CHEM TECH CO LTD
Extraction and purification method of 2 alpha-hydroxytriptonide
The invention discloses an extraction and purification method of 2 alpha-hydroxytriptonide. By using root cores, root barks, stems and leaves of Tripterygium willfordii Hook. f as raw materials, through steps such as crushing, soaking, percolation, extraction, silica-gel column chromatography separation and purification and recrystallization, 2alpha-hydroxytriptonide with purity which is above 99 percent can be prepared, the yield is one ten thousandth and is improved by about 100 times compared with the yield by adopting extraction processes reported by the existing literatures, and a material basis can be provided for researches on chemical structures, pharmacological actions and the like of triptonide.
Owner:FUJIAN ACAD OF MEDICAL SCI
Application of triptonide
PendingCN110604737ALower blood sugar levelsOrganic active ingredientsMetabolism disorderAcute hyperglycaemiaTriptonide
The invention relates to the technical field of medicines, and discloses an application of triptonide. The invention finds that the Chinese herbal medicine monomer triptonide can significantly reducethe blood glucose level of a high-fat diet obesity mouse after prevention or treatment administration, and can also reduce the blood glucose content of the C57-ApoE knocked-out high-fat diet obesity model mouse. The result shows that the triptonide has prevention and treatment effects on hyperglycemia. The hyperglycemia is the main cause of the hyperglycemia type diabetes, so that the triptonide can also be applied to the preparation of related medicines of the hyperglycemia type diabetes.
Owner:SUZHOU UNIV
Application of triptonide in preparation of medicine for treating acute monocyte leukemia
PendingCN111407766ALimit concentrationAchieve inhibitionOrganic active ingredientsAntineoplastic agentsInducer CellsAcute leukemia
The invention provides application of triptonide in preparation of a medicine for treating acute monocyte leukemia, and belongs to the technical field of leukemia medicines. According to the application of the triptonide in preparation of the medicine for treating the acute monocyte leukemia, acute monocyte leukemia cells U937 are taken as research objects, U937 cells are treated by a triptonide solution, the cell activity of the U937 cells is detected by an MTT method, and the result shows that the triptonide has an effect of inhibiting proliferation of the U937 leukemia cells. The influenceof the triptonide on apoptosis of the U937 cells is detected by an Annexin V / PI double staining method, and the result shows that the triptonide can induce apoptosis of the U937 cells, and the apoptosis is more obvious along with increase of concentration. Therefore, the triptonide can inhibit proliferation of the acute leukemia cells and induce apoptosis, so that treatment of the acute monocyte leukemia is realized.
Owner:INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
A method for preparing triptolide and 2-epitriptolide
ActiveCN108191948BEfficient separationSuitable for industrial productionSteroidsHplc methodChemical compound
Owner:HAIMEN BIWEI INTPROP SERVICE CO LTD
A kind of method for preparing triptolide
ActiveCN108033993BEfficient separationSuitable for industrial productionSteroidsHplc methodSilica column
The invention discloses a method for preparing triptonide. Structures of the triptonide, triptolide, tripdiolide and 2-epitripdiolide existed in common caulis tripterygii wilfordii are close, whereinthe tripdiolide and the 2-epitripdiolide are a pair of chiral isomers with big separating difficulty. The four compounds are separated by depending on repeated silica column chromatography in the prior art, while repeated silica column chromatography consumes solvent, is poor in reproducibility, only suitable for less separation in experiments, and hard to popularize in industrial production. In current industrial production, only used column chromatography is a macroporous resin. The method provided by the invention can be used for separating and preparing the triptonide, the triptolide, thetripdiolide and the 2-epitripdiolide without depending on repeated silica column chromatography. The HPLC (Hight Performance Liquid Chromatography) method provided by the invention can be used for effectively separating the chiral isomers i.e. the tripdiolide and the 2-epitripdiolide based on a conventional C18 chromatographic column, and is low in cost and high in repeatability.
Owner:HAIMEN BIWEI INTPROP SERVICE CO LTD
High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide
ActiveCN108318599AEfficient separationSuitable for industrial productionComponent separationHplc methodTriptonide
The invention discloses a high-performance liquid chromatographic method for separating tripdiolide from 2-epitripdiolide. Triptonide, triptolide, tripdiolide and 2-epitripdiolide in tripterygium wilfordii are very close in structure, wherein the tripdiolide and the 2-epitripdiolide are a pair of chiral isomers, and are large in separation difficulty. The prior arts are all dependent on repeated silica-gel column chromatography when the four compounds are separated, but the repeated silica-gel column chromatography consumes a solvent, is poor in reproducibility and is difficult to be promotedin industrial production. In the prior industrial production, the only column chromatography which is being used is macroporous resin. The method provided by the invention can realize separated preparation of the triptonide, the triptolide, the tripdiolide and the 2-epitripdiolide in tripterygium wilfordii without dependence on the repeated silica-gel column chromatography. The HPLC method disclosed by the invention has the beneficial effects that on the basis of the conventional C18 chromatographic column, the chiral isomers (the tripdiolide and the 2-epitripdiolide) can be effectively separated, so that the cost is low and the repeatability is high.
![High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide](https://images-eureka.patsnap.com/patent_img/3d917872-5899-4c2a-9e2c-671f97153e87/HDA0001570889990000011.png "High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide")
![High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide](https://images-eureka.patsnap.com/patent_img/3d917872-5899-4c2a-9e2c-671f97153e87/HDA0001570889990000012.png "High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide")
![High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide](https://images-eureka.patsnap.com/patent_img/3d917872-5899-4c2a-9e2c-671f97153e87/HDA0001570889990000021.png "High-performance liquid chromatographic method for separating [Separate sth. from sth.]tripdiolide from 2-epitripdiolide")
Owner:绍兴市逸晨医疗科技有限公司
Biogenic emulsifiable insecticide and method for preparing same
The invention discloses a biogenic emulsifiable insecticide and a method for preparing the biogenic emulsifiable insecticide. The biogenic emulsifiable insecticide comprises the following components in percentage by weight: 5-15% of pyrethroid, 2-4% of triptonide, 8-15% of an emulsifier and the balance of an organic solvent. The triptonide and the pyrethroid are used together to take the synergistic effect to effectively improve the capacity of killing the insects such as the mosquitoes and the flies of the biogenic emulsifiable insecticide. Because the biogenic triptonide is added into the biogenic emulsifiable insecticide, one part of pyrethroid can be replaced effectively, and the biogenic emulsifiable insecticide is more environmental friendly. The biogenic emulsifiable insecticide can be diluted and sprayed to kill the insects such as the adult mosquitoes and the adult flies to reduce the insect density rapidly.
Owner:博罗县富得针织有限公司
Extraction method for tripterygium glycosides
The invention discloses an extraction method for tripterygium glycosides. The method comprises the following steps of: (1) sample pretreatment: cleaning and smashing tripterygium wilfordii Hook. f. roots to obtain a powder sample; (2) crude product extraction: adding the powder sample into 50-60% ethyl alcohol at a solid-liquid ratio of 1:15-25, carrying out ultrasound extraction for 70-100 min under a condition of 200-300 W and 60-75 DEG C, and concentrating an extraction solution to 15-25% of the volume; and (3) crude product purification: adding a concentrate obtained in S (2) into chloroform at a solid-liquid ratio of 1:1-2, carrying out microwave extraction for 90-120 min under a condition of 280-380 W and 60-62 DEG C, and concentrating the extraction solution until specific gravity is 1.2-1.6. According to the method, the use amount of harmful organic solvents can be greatly lowered, an extraction rate of the tripterygium glycosides is obviously improved, the purity of effectiveingredients, including triptolide, triptonide, tripterine and wilforlide A, can be obviously improved, in addition, the extraction method is convenient in an extraction operation and can be easily controlled, and industrial production efficiency is improved.
Owner:HUNAN QIANJIN XIELI PHARMA CO LTD
Chinese traditional medicine Tripterygium wilfordii and improving technique for attenuation and synergy of its extract
InactiveCN1325070CLow toxicityToxicity cannot be reducedAntipyreticDigestive systemMedicineTriptonide
Owner:杨更亮
Method for asymmetrically synthesizing Triptonide and Triptolide
ActiveCN113292630AImprove production efficiencyEasy to operateSteroidsAsymmetric synthesesTriptonideCombinatorial chemistry
The invention discloses a method for asymmetrically synthesizing triptonide and triptolide, the method comprises the following steps: starting from (-)-Taniguchi lactone, developing a framework structure of the triptolide through alkylation reaction, transition metal catalytic hydrogen atom transfer reaction and aldol type ring closing reaction, further completing total synthesis of the triptonide through oxidation reaction, and converting the triptonide into the triptolide through a known reduction reaction. The reaction operation in the synthesis is simple, the method can be widely popularized and used, and a foundation is laid for further structure-function relationship research and structure optimization of the triptolide and the triptolide.
Owner:PEKING UNIV
Application of triptonide in preparation of contraception and birth control drugs of macaca fascicularis
InactiveCN108938649ANo obvious side effectsNo significant changes in hormonesOrganic active ingredientsSexual disorderDrugTriptonide
The invention relates to application of triptonide and in particular relates to application of triptonide in preparation of contraception and birth control drugs of macaca fascicularis. The triptonidehas an excellent contraception effect, has a low effective dose, does not have any obvious side effect, is safe and effective, and has excellent application prospects.
Owner:广东省计划生育科学技术研究所
Method for simultaneously detecting triptolide and triptonide in thunder god vine medicinal materials or preparations
The invention provides a method for simultaneously detecting triptolide and triptonide in thunder god vine medicinal materials or preparations, which realizes detection by using a micro-emulsion eletrokinetic chromatography method. The method establishes the brand new micro-emulsion eletrokinetic chromatography method, and is used for detecting important toxicity and the content of effective constituents in thunder god vine in a separated manner. Experimental results show the method provided by the invention has the advantages of good linear relation and high precision; and the triptolide and the triptonide in a sample can reach the effect of the base line separation within 10 minutes, and the method is high in separation degree, can be used for detecting an actual sample, and provides powerful supplement for quality control of the thunder god vine medicinal materials or preparations.
Owner:远大医药黄石飞云制药有限公司
New application of polynucleotide-5'kinase-3'phosphatase
ActiveCN107529558BAccurate diagnosisRapid diagnosisOrganic active ingredientsMicrobiological testing/measurementPancreas CancersNucleotide
Owner:SUZHOU UNIV
Liquid chromatography-tandem mass spectrometry method for triptolide A, triptolide ketone, triptolide and triptolide
The invention relates to a liquid chromatography-tandem mass spectrometry test method of wilforlide, triptonide, triptolide and tripterine. The test method includes the following steps: taking liquid samples or tissue samples, cutting into pieces and placing into a tube with a stopper; adding a certain amount of a sodium hydroxide solution into the samples to adjust the pH to be 9-10, adding ethyl acetate, oscillating for 10 minutes, and performing high speed centrifugation for 10 minutes; after separation of an organic phase, adding an organic solvent for secondary extraction, mixing the two obtained organic phases, and placing on a concentrator with the temperature of 50 DEG C for evaporation until the organic phases are dried; using an initial mobile phase to dilute the residue, enabling the obtained solution to pass through a 0.22-[um]m microporous organic membrane, and taking the filtrate for analysis by a liquid chromatography-tandem mass spectrometer. The test method provided by the invention is simple, efficient, quick, sensitive, high in accuracy and extensive in practicability, can be applied to qualitative and quantitative testing for wilforlide, triptonide, triptolide and tripterine in biological samples, and is suitable for tests on in-vitro samples and suspicious physical evidences.
Owner:INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
A kind of method for preparing triptolide
ActiveCN108129545BEfficient separationSuitable for industrial productionSteroidsHplc methodTriptonide
The invention discloses a method for preparing triptolide. Triptonide, triptolide, tripdiolide and 2-epitripdiolide in common threewingnut roots are of very approximate structures, tripdiolide and 2-epitripdiolide are a pair of chiral isomers with large separation difficulties. In the prior art, the four compounds are separated all through repeated silica-gel column chromatography, however, repeated silica-gel column chromatography consumes a great amount of solvents and is poor in reproducibility, only applicable to slight separation in laboratories, and hard to popularize in industrial production. In conventional industrial production, only a macroporous resin is available as column chromatography in service. By adopting the method disclosed by the invention, triptonide, triptolide, tripdiolide and 2-epitripdiolide can be separated and prepared without repeated silica-gel column chromatography. On the basis of a common C18 chromatographic column, the HPLC (High Performance Liquid Chromatography) method disclosed by the invention is capable of effectively separating chiral isomers, namely tripdiolide and 2-epitripdiolide, and is low in cost and good in repeatability.
Owner:江西中德诚信科技有限公司 +1
Triptonide or a composition comprising triptonide for use in treating disorders
The present application provides Triptonide or a functional equivalent or pharmaceutically acceptable salt thereof, or a composition comprising the same for use in treating or preventing hyperproliferative disorders. Also provided is a method for treating or preventing hyperproliferative disorders, preferably cancer in a subject using the above substances.
Owner:GS THERAPEUTICS LTD
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