3 results about "Triptonide" patented technology

Disclosed herein is a method for preparing triptolide, wherein triptolide is prepared by means of highly stereoselective reduction of triptonide. Specifically, in a solvent, triptonide, as shown in formula II, is mixed with a reductant for reaction to give triptolide, as shown in formula I, wherein the reductant is MRxBHy or MAlHR'm(R"O)n. The method of the present invention features commercially available reagents, a simple process, and ease of industrialization.

The invention discloses an application of triptolide ketone in preparation of a preparation which is independently used or used in combination with other preparations to prevent and treat influenza, slow down influenza or inhibit influenza virus proliferation. The triptonide and the composition containing the triptonide are good in safety, can well inhibit influenza virus proliferation, and have application prospects for treating influenza.

Disclosed in the present invention are a derivative of triptolide and triptonide, and a synthesis method therefor and the use thereof. The derivative of the present invention has the structure as shown in general formula I, and the definition of each substituent is as described in the description and claims. The derivative of triptolide and triptonide of the present invention exhibits a high anti-tumor activity, and good development and application prospects.