A novel sustained-release injection of traditional Chinese medicine, its preparation method and its application in the treatment of poultry synovial bursa mycoplasma disease

Abstract

A novel sustained-release injection of traditional Chinese medicine, its preparation method and its application in the treatment of poultry synovial bursa mycoplasma disease. The weight composition of the injection per 100g is: 0.01-2.0g of dendamicin, 0.01-5.0g of forsythol, 0.01-5.0g of forsythia Wen-80 10.0~40.0g, Poloxamer 407 0.5~10.0g, Glyceryl Behenate 0.1~8.0g, Ethyl Oleate 1.0~16.0g, 1,2-Propanediol 5.0~10.0g, the balance is Deionized water. At the same time, the invention further discloses its preparation method, which has strong process operability and is beneficial to production transformation. The sustained-release injection of the present invention is a bicontinuous phase emulsion, the main component of which is a traditional Chinese medicine extract, which will not cause food safety problems caused by drug residues. The number of injections reduces the stress of poultry, and the market prospect is broad.

Description

Technical field [0001] The present invention belongs to the technical field of veterinary pharmaceuticals, and therefore specifically relates to a new type of sustained release injection in Chinese medicine and preparation method and the application of the treatment of poultry slide in the treatment of poultry. Background technique [0002] Slip-liquid bladder protocide is a common poultry infectious disease caused by slide-liquid bladder, infected, infected birds, the joint site is inflamed, swollen, has a large amount of effusion, although it will not directly lead to animal death, it will affect its Walk, stand and other behaviors. The poultry activity of this disease has dropped, the spirit is slight, and the hair is dry, and it is easy to be dead and death. Due to the inconvenience of walking, the disease has indirectly affects acts such as feeding and drinking water, and the body will gradually decrease due to long-term nutrients, and growth and development are hindered. Th...

AI Technical Summary

Problems solved by technology

Due to the inconvenience of walking, the disease indirectly affects the behavior of eating and drinking water. The body will gradually weaken due to long-term nutritional deficiency, growth and development will be hindered, production performance will decline, and eventually it will die of exhaustion, which will bring huge economic losses to the farm.

[0003] At present, the drugs for the treatment of mycoplasma synovial bursae are mainly chemical antibiotics, such as enrofloxacin, tilmicosin, doxycycline, riscomycin, tiamulin fumarate, etc. The killing ability is strong, but the following three problems will appear in clinical use: First, these drugs belong to antibiotics, which are suitable for the treatment of young poultry and young poultry. Once the poultry enters the laying period, the use of antibiotics will remain in the eggs. Affect food safety, so chemical antibiotics are not suitable for poultry during the laying period; second, these antibiotics are absorbed and utilized throughout the body after use, but the lesions are in the joints, and the concentration of the actual drug effect in the joints is low, resulting in drug bioavailability The third is that the treatment of mycoplasma disease itself needs a long process, generally at least one week of clinical medication can gradually recover, in order to maintain blood drug concentration, continuous medication is required within a week, and chemical drugs have toxic side effects , continuous drug administration is very harmful to the body, and if it is administered by injection, the behavior of catching animals and injecting drugs every day will cause great stress to animals, seriously affect production performance, and it is time-consuming and laborious for farm workers

Images