Monepantel emulsion and preparation method thereof

Abstract

The invention relates to a monepantel emulsion. Every 100g of the emulsion is prepared from the following components by weight: 0.01 to 3.0 g of monepantel, 1.0 to 8.0 g of peach kernel oil, 0.1 to 6.0 g of ethyl caprylate, 2.0 to 4.0 g of oleyl alcohol, 2.0 to 10.0 g of polyoxyethylene (10) castor oil, 2.0 to 12.0 g of tetrabutyl phenolic aldehyde, 5.0 to 15.0 g of tween-85, .1 to 3.0 g of benzyl alcohol and the balance of deionized water. The monepantel drug particles provided by the invention are distributed in a multi-particle-size range, and can achieve quick-acting, slow-release and long-acting effects after being injected, so that the administration frequency is remarkably reduced. Meanwhile, the problem of poor water solubility of the monepantel is solved, mass-occurring nematode infection of livestock and poultry can be treated in a water drinking mode, the stability is good, medication is uniform, the time and labor are saved, and the monepantel emulsion is mainly used for preventing and treating nematode diseases of livestock and poultry. The invention further discloses a preparation method, the process and technology are easy to transform, and the market prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a monepal emulsion and a preparation method thereof. Background technique [0002] Nematodes are a kind of helminth parasites, which are relatively common in the aquaculture production process. They cause harm to the body by consuming nutrients, destroying tissues and organs, and secreting toxins, which seriously hinder the development of the aquaculture industry. There are many types of veterinary drugs used to control nematodes, such as albendazole, ivermectin, levamisole, etc., but after long-term use of these drugs, drug resistance of parasites has widely appeared, and the efficacy of these drugs has also declined. In order to maintain the desired effect, farms often habitually increase the dosage of drugs and extend the time of drug use to prevent and control the disease, resulting in higher and higher drug dosage, faster drug resistance, and...

AI Technical Summary

Problems solved by technology

However, currently there is only one dosage form of oral liquid for monepal, and it is troublesome to use for infusion, and it requires a lot of manpower when administering large groups, which is time-consuming and labor-intensive.

In addition, the water solubility of the drug is very poor, less than 0.1 mg per liter of water can be dissolved at 20°C, which makes the drug unusable in drinking water clinically.

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