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Ibuprofen solutions for capsule-filling and capsule preparations

A technology for filling liquid and capsules, which can be used in capsule delivery, anti-inflammatory agents, non-central analgesics, etc., and can solve problems such as not being obtained

Inactive Publication Date: 2004-01-28
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] From the description of the above points, it can be seen that there is no satisfactory filling liquid composition for capsules that does not have crystallization of ibuprofen when it is mixed with water.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A mixture of 274g polyethylene glycol 400 and 50g purified water was heated to about 60°C. To this mixture, 75 g of ibuprofen and 1 g of l-menthol were added, followed by stirring to dissolve to obtain a colorless and transparent solution. This transparent solution was packed into capsules by a conventional method, and each capsule was filled with 400 mg to obtain 1000 hard capsules.

Embodiment 2-6 and comparative example 1-3

[0053] In the same manner as in Example 1, using the ingredients shown in Table 1 and Table 2, the capsules of Examples 2-6 and Comparative Examples 1-3 were produced.

Embodiment 7

[0055] A mixture of 221.4 g polyethylene glycol 400 and 40 g purified water was heated to approximately 60°C. To this mixture were added 75 g of ibuprofen, 0.6 g of d-chloroaniline maleate, 10 g of dl-methedrine hydrochloride, 4 g of dihydrocodeine phosphate, 42 g of guaifenesin, and 7 g of l-menthol, followed by stirring It was dissolved to obtain a colorless and transparent solution. This transparent solution was packed into capsules by a conventional method, and each capsule was filled with 400 mg to obtain 1000 hard capsules.

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PUM

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Abstract

Capsule preparations are produced by using solutions for capsule-filling which contain ibuprofen, polyethylene glycol, water and terpenes (menthol, limonene, borneol, dl-camphor, mentha oil, etc.) optionally together with one or more drugs selected from among antipyretic analgesics, antihistamines, antitussives, expectorants, sympathetic stimulant, analeptics, hypnotic sedatives and anti-inflammatory agents, solubilizers, thickeners, pH controlling agents, colorants, etc. Thus, it is attempted to relieve the bitterness of ibuprofen and establish an immediate action at the same time.

Description

technical field [0001] The present invention relates to a capsule filling liquid composition and a capsule preparation in which ibuprofen is dissolved, which do not crystallize ibuprofen even when water is mixed into the composition. Background technique [0002] Ibuprofen is a phenylpropionic acid-based antipyretic, anti-inflammatory, and analgesic. It is used as a medical drug for chronic joint rheumatism, arthralgia, and neuralgia. In addition, it is used as an antipyretic analgesic and a cold medicine as a general drug. As ibuprofen preparations, there are dragees, filmed tablets, granules, and hard capsules (filled with granules). However, it is difficult to prevent the bitter taste of ibuprofen when taking it and keep the quick-acting property. It can be considered that the capsule filled with the ibuprofen solution is such a preparation that prevents the bitter taste of the ibuprofen when taking it and maintains the quick-acting property. This capsule formulation c...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/05A61K31/192A61K31/232A61K45/06
CPCA61K45/06A61K9/4866A61K31/192A61K9/4858A61K31/05A61K31/232A61P11/10A61P11/14A61P19/02A61P25/02A61P25/20A61P25/26A61P29/00A61P29/02A61P43/00A61K2300/00A61K9/48
Inventor 加藤宗一郎津守克之筱田泰雄稻木敏男
Owner KOWA CO LTD
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