Oral combination shielding indisposed taste

Abstract

The present invention provides an oral solid-state combination for shielding indisposed taste (the pharmaceutical bitter). The present invention provides an oral combination shielding indisposed taste containing medicaments, acidic material and alkali earth metal salt and/or earth metal salt presenting indisposed taste, and a method shielding for shielding indisposed taste of acidic material and alkali earth metal salt and/or earth metal salt contained in the medicaments presenting indisposed taste.

Description

technical field [0001] The present invention relates to an oral composition and a method for masking unpleasant tastes such as astringent, astringent, irritating, bitter, and spicy tastes of drugs. Background technique [0002] Drugs often have unpleasant tastes such as astringent, irritating, bitter, astringent, and spicy, and cannot be taken directly. Therefore, it is necessary to cover up the unpleasant taste in the oral cavity. The method of masking the unpleasant taste of the drug is roughly divided into a method of controlling the dissolution of the drug in the oral cavity and a method of masking the taste of the drug itself with a taste-masking agent. [0003] As a method of controlling the dissolution of the drug in the oral cavity, a method of coating with a gastric-soluble polymer, an enteric-soluble polymer, a water-insoluble polymer, waxes, etc. (Patent Documents 1 to 6) to form a matrix for taste-masking The method (Patent Documents 7 and 8), the method of incl...

AI Technical Summary

Problems solved by technology

However, in order to control the dissolution, the dissolution property may slightly change, and the efficacy of the drug may be delayed

In addition, when it is used for highly water-soluble drugs, it is often necessary to use a large amount of film agent or matrix agent, or the masking of unpleasant taste is not sufficient.

Conversely, when used for drugs with low water solubility, the bioavailability of the drug may decrease and the efficacy may not be fully exerted

There are also disadvantages such as rough feeling when taking it, or if the particle size is adjusted to a smaller particle size, unpleasantness will appear shortly after taking it due to the particles remaining in the oral cavity, such as between the teeth. taste and excitement

These methods have little effect on dissolution, but on the other hand, the taste-masking effect is weak, and it is only effective for specific drugs, or the taste-masking effect is poor for astringent or irritating drugs, so it is not an easy-to-use method. Available drugs are often limited by taste-masking agents

In order to improve the above disadvantages, methods of combining flavoring agents and sweeteners (Patent Documents 22 and 23), methods of adding acids and sweeteners in combination (Patent Document 24) and other methods of combining various taste-masking agents have also been tried. , but the status quo is that the taste-masking effect cannot be fully achieved for many drugs such as astringent or irritating drugs and highly water-soluble drugs.