37results about How to "Play a long-term role" patented technology

The invention is concerned with a kind of chiral compound and its sustained and controlled release double deck pieces compound with (S)-ibuprofen and levocetirizine. The weight ratio of the both is 50:1 to 500:1, and the said troche has two layers and one layer is the sustained and controlled release part made of (S)-ibuprofen, levocetirizine dihydrochloride and acceptable rapidly release assistant stuff. It can collapse quickly to be absorbed by body to take effect and work with antipyretic and analgesic effects, lighten sneezing, nasal stiffness and rhinocnesmus. The other layer is controlled release layer made on (S)-ibuprofen and acceptable controlled release assistant stuff. It can release with sustained and controlled in body to keep the concentration of blood and medicine in body of (S)-ibuprofen and work with antipyretic and analgesic effects to reduce the symptom of cold.

The invention relates to a cinnamic acid compound of which the structure is as shown in the formula (I), wherein R1, R2, R3, R4 and R5 are separately selected from a group consisting of hydrogen, hydroxyl and methoxy, and R6 is a linear chain alkyl group with 3-6 carbon atoms. The invention further relates to a medical composition which comprises a styrene acid compound, organic carboxylic acid, a pH-regulating agent and one or more optional auxiliary materials which are pharmaceutically acceptable, and the pH value of the medical composition is 6-8. The styrene acid compound accounts for 0.05-1.00wt% of the medical composition, and the organic carboxylic acid accounts for 0.01-0.50wt% of the medical composition. The invention further relates to the application of the cinnamic acid compound and the medical composition for preparing medicines for preventing and / or treating eye diseases caused by diabetes.

The invention discloses a preparation method of a long-acting veterinary compound oxytetracycline injection. The preparation method comprises the following steps: 1) taking a proper amount of water for injection, adding magnesium chloride and eisodium edentate (EDTA-2Na), stirring for dissolving, adding nicotinamide and sodium salicylate, and stirring for standby use, namely obtaining a liquid 1; 2) taking a proper amount of water for injection, and dissolving sodium formaldehyde sulfoxylate for use, namely obtaining a liquid 2; 3) adding a small amount of alpha-pyrrolidone and N,N-dimethyl formamide into the liquid 1 obtained in the step 1, stirring, slowing adding a small amount of oxytetracycline hydrochloride, and stirring for dissolving; 4) adding the liquid 2 obtained in the step 2 into liquid obtained in the step 3, and uniformly stirring; 5) regulating a pH value by using a pH regulator; 6) fixing the volume, filtering in a sterile environment, and filling and sealing. The long-acting veterinary compound oxytetracycline injection is stable in quality, good in medicinal effect and long in acting time.

The invention relates to a long-acting synergistic multifunctional stable green fertilizer, in particular to a green fertilizer which is prepared by using polyaspartic acid, compound selenium nucleic acid, compound sodium nitrophenolate, medium trace elements and an organic matter as raw materials, and is subjected to mixing, co-crystallizing and granulating, belonging to the field of agricultural fertilizer. The long-acting synergistic multifunctional stable green fertilizer is prepared by proportioning the polyaspartic acid, the compound selenium nucleic acid, the compound sodium nitrophenolate, the medium trace elements and the organic matter in percentage terms, mixing, stirring, granulating, drying, cooling, sieving, metering and packaging. The long-acting synergistic multifunctional stable green fertilizer has the advantages of long acting, synergy, quick acting, green, high yield and high quality. The medium trace elements in the fertilizer provided by the invention are used for adjusting the balance relation of elements in soils so that the pests and diseases are reduced effectively and the use amount of the pesticides and fungicides is reduced greatly. The organic matter in the fertilizer has the efficacy of activating the soil, improving the water and fertilizer retention of soils, promoting the growth of crops, enhancing the disease resistance of the crops and improving the quality of the crops and is green and environment-friendly.

The invention belongs to the field of medical equipment, and particularly relates to a polyelectrolyte-containing drug coating and a preparation method thereof. The drug coating provided by the invention is formed by alternately coating at least one material with positive charges and at least one bipolar polyelectrolyte; preferably, the drug coating also comprises a top layer above the drug coating. When the saccule reaches the lesion, two polyelectrolytes with the same charges are quickly released (a quick release effect) due to the repulsive interaction of the charges; one end of the polyelectrolyte with positive charges is connected with drug microparticles through a hydrogen bond, and the other end is adsorbed on a cell membrane with negative charges so as to realize a long-acting effect. Moreover, the top layer on the drug coating guarantees the compliance of the operation process and avoids the release of the drug before reaching the lesion.

The invention discloses a long-acting compound terramycin injection for animals. Each 1000 ml of long-acting compound terramycin injection contains 190-250g of occrycetin, 400-450g of alpha-pyrrolidone, 300-350ml of N,N-dimethyl formamide, 35-50g of nicotinamide, 35-50g of sodium salicylate, 100-130g of magnesium chloride, 100-130g of hydroxymethanesulfinic acid sodium hydrosulfite and 4-7g of disodium edetate dehydrate. A pH conditioning agent adjusts the pH value to 8.0-9.0; injecting water is used to perform calibration until the constant volume is 1000 ml; the pH conditioning agent is ethanol amine. According to the long-acting compound terramycin injection for animals, the chelating temperature is low and within 30-60 DEG C, products is high in chelating degree and steady in quality, and can still keep the standard amber within 2-year period of validity; an extended agent is added, so that drug function is good and the acting time is long; the drug function keeps for 72 hours after the drug in a normal dosage is administrated, so that the inconvenience of repeated drug administration is solved, and thus the long-acting function is played.

The invention discloses a levosulpiride injection and a preparation method thereof. The preparation method is characterized by comprising the following steps: selecting a biodegradable encysting material; smashing levosulpiride powder to nanopowder; and preparing a slow release nanocapsule injection under an ultrasonic condition. The purpose of quick effect, stable effect and long effect is realized, the half-life period is prolonged, the compliance is improved, the product stability is increased, and the promising result is obtained.