37results about How to "Play a long-term role" patented technology

The invention relates to a matrine diatomic alcohol plastid temperature-sensitive gel and a preparation method thereof, and aims to overcome the defects of vaginal dosage forms in the prior art. By adopting the matrine diatomic alcohol plastid temperature-sensitive gel, the medicine can be conveniently used, a patient does not have foreign body sensation, a medicine storage is formed in a vagina at the same time, the acting time of the medicine is long, and the bioavailability of matrine can be fully improved. The matrine diatomic alcohol plastid temperature-sensitive gel is prepared from the following raw materials in percentage by weight: 0.25-1.5% of matrine, 0.25-1.5% of lecithin, 0.5-1% of chitosan, 13-30% of low-molecular-weight alcohol, 38-55% of a phosphate buffer solution, 15-35% of poloxamer and 5-10% of glycerol. The diatomic alcohol plastid using ethanol and propanediol as softening agents has high encapsulation efficiency and stability, is stable in structure, can increase the in vivo and in vitro pereutaoeous permeation to ensure that the medicine can be slowly released, thereby improving the therapeutical effect; in addition, the gel does not have obvious toxicity.

The invention is concerned with a kind of chiral compound and its sustained and controlled release double deck pieces compound with (S)-ibuprofen and levocetirizine. The weight ratio of the both is 50:1 to 500:1, and the said troche has two layers and one layer is the sustained and controlled release part made of (S)-ibuprofen, levocetirizine dihydrochloride and acceptable rapidly release assistant stuff. It can collapse quickly to be absorbed by body to take effect and work with antipyretic and analgesic effects, lighten sneezing, nasal stiffness and rhinocnesmus. The other layer is controlled release layer made on (S)-ibuprofen and acceptable controlled release assistant stuff. It can release with sustained and controlled in body to keep the concentration of blood and medicine in body of (S)-ibuprofen and work with antipyretic and analgesic effects to reduce the symptom of cold.

The invention discloses a long-acting compound terramycin injection for animals. Each 1000 ml of long-acting compound terramycin injection contains 190-250g of occrycetin, 400-450g of alpha-pyrrolidone, 300-350ml of N,N-dimethyl formamide, 35-50g of nicotinamide, 35-50g of sodium salicylate, 100-130g of magnesium chloride, 100-130g of hydroxymethanesulfinic acid sodium hydrosulfite and 4-7g of disodium edetate dehydrate. A pH conditioning agent adjusts the pH value to 8.0-9.0; injecting water is used to perform calibration until the constant volume is 1000 ml; the pH conditioning agent is ethanol amine. According to the long-acting compound terramycin injection for animals, the chelating temperature is low and within 30-60 DEG C, products is high in chelating degree and steady in quality, and can still keep the standard amber within 2-year period of validity; an extended agent is added, so that drug function is good and the acting time is long; the drug function keeps for 72 hours after the drug in a normal dosage is administrated, so that the inconvenience of repeated drug administration is solved, and thus the long-acting function is played.

The invention provides a preparation method and application of an ecological modified bentonite phosphorus fixing agent. The preparation method of the ecological modified bentonite phosphorus fixing agent comprises the following steps: performing ultrasonic treatment on a lanthanum chloride solution in an alkaline environment, mixing and stirring the lanthanum chloride solution and bentonite in proportion, performing ultrasonic treatment, pouring an obtained mixture into a spherical mold, firing, inflating the mixture in the spherical mold to enable a fired finished product to be of a porous structure, and drying to obtain the ecological modified bentonite phosphorus fixing agent. The ecological modified bentonite phosphorus fixing agent is obtained. The fired ecological modified bentonite phosphorus fixing agent has a certain weight, can better sink at the bottom of a water body and continuously absorb phosphorus elements in bottom mud, and the ecological modified bentonite phosphorus fixing agent has a porous structure and is larger in contact area with water, so that the phosphorus fixing effect of the ecological modified bentonite phosphorus fixing agent is better, and the service life of the ecological modified bentonite phosphorus fixing agent is prolonged. Meanwhile, the porous structure can enable microorganisms to have an attached carrier, the water quality purification effect is improved, phosphorus materials in water and sludge can be continuously absorbed for a long time, and the long-acting effect on water quality purification of the whole body is achieved.

The invention relates to a cinnamic acid compound of which the structure is as shown in the formula (I), wherein R1, R2, R3, R4 and R5 are separately selected from a group consisting of hydrogen, hydroxyl and methoxy, and R6 is a linear chain alkyl group with 3-6 carbon atoms. The invention further relates to a medical composition which comprises a styrene acid compound, organic carboxylic acid, a pH-regulating agent and one or more optional auxiliary materials which are pharmaceutically acceptable, and the pH value of the medical composition is 6-8. The styrene acid compound accounts for 0.05-1.00wt% of the medical composition, and the organic carboxylic acid accounts for 0.01-0.50wt% of the medical composition. The invention further relates to the application of the cinnamic acid compound and the medical composition for preparing medicines for preventing and / or treating eye diseases caused by diabetes.

The invention relates to a matrine diatomic alcohol plastid temperature-sensitive gel and a preparation method thereof, and aims to overcome the defects of vaginal dosage forms in the prior art. By adopting the matrine diatomic alcohol plastid temperature-sensitive gel, the medicine can be conveniently used, a patient does not have foreign body sensation, a medicine storage is formed in a vagina at the same time, the acting time of the medicine is long, and the bioavailability of matrine can be fully improved. The matrine diatomic alcohol plastid temperature-sensitive gel is prepared from the following raw materials in percentage by weight: 0.25-1.5% of matrine, 0.25-1.5% of lecithin, 0.5-1% of chitosan, 13-30% of low-molecular-weight alcohol, 38-55% of a phosphate buffer solution, 15-35% of poloxamer and 5-10% of glycerol. The diatomic alcohol plastid using ethanol and propanediol as softening agents has high encapsulation efficiency and stability, is stable in structure, can increase the in vivo and in vitro pereutaoeous permeation to ensure that the medicine can be slowly released, thereby improving the therapeutical effect; in addition, the gel does not have obvious toxicity.

The invention discloses a preparation method of a long-acting veterinary compound oxytetracycline injection. The preparation method comprises the following steps: 1) taking a proper amount of water for injection, adding magnesium chloride and eisodium edentate (EDTA-2Na), stirring for dissolving, adding nicotinamide and sodium salicylate, and stirring for standby use, namely obtaining a liquid 1; 2) taking a proper amount of water for injection, and dissolving sodium formaldehyde sulfoxylate for use, namely obtaining a liquid 2; 3) adding a small amount of alpha-pyrrolidone and N,N-dimethyl formamide into the liquid 1 obtained in the step 1, stirring, slowing adding a small amount of oxytetracycline hydrochloride, and stirring for dissolving; 4) adding the liquid 2 obtained in the step 2 into liquid obtained in the step 3, and uniformly stirring; 5) regulating a pH value by using a pH regulator; 6) fixing the volume, filtering in a sterile environment, and filling and sealing. The long-acting veterinary compound oxytetracycline injection is stable in quality, good in medicinal effect and long in acting time.

The invention relates to a long-acting synergistic multifunctional stable green fertilizer, in particular to a green fertilizer which is prepared by using polyaspartic acid, compound selenium nucleic acid, compound sodium nitrophenolate, medium trace elements and an organic matter as raw materials, and is subjected to mixing, co-crystallizing and granulating, belonging to the field of agricultural fertilizer. The long-acting synergistic multifunctional stable green fertilizer is prepared by proportioning the polyaspartic acid, the compound selenium nucleic acid, the compound sodium nitrophenolate, the medium trace elements and the organic matter in percentage terms, mixing, stirring, granulating, drying, cooling, sieving, metering and packaging. The long-acting synergistic multifunctional stable green fertilizer has the advantages of long acting, synergy, quick acting, green, high yield and high quality. The medium trace elements in the fertilizer provided by the invention are used for adjusting the balance relation of elements in soils so that the pests and diseases are reduced effectively and the use amount of the pesticides and fungicides is reduced greatly. The organic matter in the fertilizer has the efficacy of activating the soil, improving the water and fertilizer retention of soils, promoting the growth of crops, enhancing the disease resistance of the crops and improving the quality of the crops and is green and environment-friendly.

The invention relates to a novel damping mechanism of an engineering water tank. The novel damping mechanism comprises an upper connecting assembly and a lower connecting assembly. The upper connecting assembly can fixedly connect a water chamber at the upper end of a radiator with a frame via a frame connecting plate of the water tank; the lower connecting assembly is arranged among a bottom frame and support columns at the lower end of the radiator and is in clearance fit with the bottom frame. The novel damping mechanism has the advantages that the novel damping mechanism is simple in structure and low in manufacturing cost; the water tank is separated from the steel frame by the upper connecting assembly via rubber pads, so that the influence of vibration of the frame on the water tank is reduced under the damping effects of the rubber pads when radiating packs are vibrated; the lower connecting assembly is additionally provided with a metal auxiliary sleeve arranged between a support sleeve and the frame, so that abrasion due to friction is prevented, the service life of the support sleeve is prolonged, and the rubber support sleeve can act for a long time, and the service life of the radiator is prolonged.

The invention belongs to the field of medical equipment, and particularly relates to a polyelectrolyte-containing drug coating and a preparation method thereof. The drug coating provided by the invention is formed by alternately coating at least one material with positive charges and at least one bipolar polyelectrolyte; preferably, the drug coating also comprises a top layer above the drug coating. When the saccule reaches the lesion, two polyelectrolytes with the same charges are quickly released (a quick release effect) due to the repulsive interaction of the charges; one end of the polyelectrolyte with positive charges is connected with drug microparticles through a hydrogen bond, and the other end is adsorbed on a cell membrane with negative charges so as to realize a long-acting effect. Moreover, the top layer on the drug coating guarantees the compliance of the operation process and avoids the release of the drug before reaching the lesion.

The invention relates to a wastewater, sewage and rainwater purifying and treatment system, in particular to a serial type rainwater ecological filtering and clean collecting device, which is applied to the field of organic wastewater and rainwater treatment of urban domestic sewage, food industry and agriculture. The serial type rainwater ecological filtering and clean collecting device comprises a purifying pool, wherein the purifying pool is provided with an upper opening; a first separating plate and a second separating plate are transversely arranged in the purifying pool from top to bottom, and are used for separating the purifying pool into an ecological filtering pool, a physical filtering pool and a rainwater collecting pool from top to bottom; a plurality of first water holes are formed in the first separating plate and are used for communicating the ecological filtering pool and the physical filtering pool; a plurality of second water holes are formed in the second separating plate and are used for communicating the physical filtering pool and the rainwater collecting pool; a soil layer and a first water filtering layer are filled into the ecological filtering pool, the first water filtering layer is positioned between the soil layer and the first separating plate, and a plurality of earthworms are put in the soil layer; a physical filtering layer is arranged in the physical filtering pool.

The invention discloses a long-acting compound terramycin injection for animals. Each 1000 ml of long-acting compound terramycin injection contains 190-250g of occrycetin, 400-450g of alpha-pyrrolidone, 300-350ml of N,N-dimethyl formamide, 35-50g of nicotinamide, 35-50g of sodium salicylate, 100-130g of magnesium chloride, 100-130g of hydroxymethanesulfinic acid sodium hydrosulfite and 4-7g of disodium edetate dehydrate. A pH conditioning agent adjusts the pH value to 8.0-9.0; injecting water is used to perform calibration until the constant volume is 1000 ml; the pH conditioning agent is ethanol amine. According to the long-acting compound terramycin injection for animals, the chelating temperature is low and within 30-60 DEG C, products is high in chelating degree and steady in quality, and can still keep the standard amber within 2-year period of validity; an extended agent is added, so that drug function is good and the acting time is long; the drug function keeps for 72 hours after the drug in a normal dosage is administrated, so that the inconvenience of repeated drug administration is solved, and thus the long-acting function is played.

The invention relates to calcium-nitrogen fertilizer and a preparation method thereof. The calcium-nitrogen fertilizer is characterized by being prepared from, by weight, 6-95 parts of urea, 5-94 parts of calcium source, inevitable impurities and water, wherein the calcium source is selected from at least one of calcium nitrate and ammonium calcium nitrate. Acyl nitrogen, nitric nitrogen and ammonium nitrogen coexist in the calcium-enriched fertilizer, and dissolution performance of calcium is good.

The invention discloses a levosulpiride injection and a preparation method thereof. The preparation method is characterized by comprising the following steps: selecting a biodegradable encysting material; smashing levosulpiride powder to nanopowder; and preparing a slow release nanocapsule injection under an ultrasonic condition. The purpose of quick effect, stable effect and long effect is realized, the half-life period is prolonged, the compliance is improved, the product stability is increased, and the promising result is obtained.

The invention discloses a tenacity coating used for corrosion prevention of a reinforcing steel bar and a coating method thereof. The tenacity coating used for corrosion prevention of the reinforcing steel bar is prepared from the following raw material components: 45-70 parts of feldspar powder, 25-50 parts of borax, 5-15 parts of fluorite, 4-8 parts of clay, 1.0-10 parts of adherence promoters, 1-2 parts of a pore-forming agent and 1.0-1.5 parts of a thickening agent. The invention also discloses a coating method of the tenacity coating used for corrosion prevention of the reinforcing steel bar. The coating method of the tenacity coating used for corrosion prevention of the reinforcing steel bar comprises the following steps: 1) carrying out dry mixing; 2) carrying out wet mixing; 3) carrying out pretreatment; 4) coating; 5) baking; 6) sintering; and 7) cooling at normal temperature. The tenacity coating used for corrosion prevention of the reinforcing steel bar has outstanding corrosion resistance, extremely high tenacity and relatively high self-durability.

The invnetion discloses a complex florfenicol composition which is composed of active ingredients, namely florfenicol and trimethoprim. The weight ratio of florfenicol to trimethoprim is 15-25:1-7. The composition provided by the invention is made into a freeze-dried powder injection and an injection. The prepared injection is prepared from the following raw materials, by weight, 18-22% of florfenicol, 3-5% of trimethoprim, 30-70% of dimethylacetamide and 10-14% of alpha-pyrrolidone. The composition provided by the invention can be used to inhibit synthesis of bacterial DNA, interfere with synthesis of bacterioprotein, enhance clinical application effects of florfenicol, prolong efffective in vivo antiviral acting time of florfenicol, generate synergistic effects and minimize treatment cost, and has a better antibacterial effect.