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Compound amur cork-tree temperature-sensitive gel for treating sore and ulcer and traumatic infection and preparing method thereof

A temperature-sensitive gel and Phellodendron technology, applied in the field of medicine, can solve problems affecting gel strength and bioadhesion, the effect of matrix excipients, complex components, etc., to achieve multi-level utilization, recycling, and small skin irritation Effect

Inactive Publication Date: 2016-10-19
SHANDONG HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the problem that the existing compound Phellodendron Phellodendri extract has complex components, often interacts with matrix excipients, and affects the strength and bioadhesion of the gel, and prepares a compound Phellodendron Phellodendri thermosensitive gel with good clinical effect

Method used

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  • Compound amur cork-tree temperature-sensitive gel for treating sore and ulcer and traumatic infection and preparing method thereof
  • Compound amur cork-tree temperature-sensitive gel for treating sore and ulcer and traumatic infection and preparing method thereof
  • Compound amur cork-tree temperature-sensitive gel for treating sore and ulcer and traumatic infection and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 2.1 Instrument

[0053] pH meter, electric constant temperature water bath, refrigerator, oven, electronic balance, rheometer, etc.

[0054] 2.2 Materials and reagents

[0055] Forsythia: the dry fruit of Forsythia suspensa (Thunb.) Vahl, a plant of Oleaceae.

[0056] Phellodendron chinense: the dry bark of Phellodendron chinense Schneid.

[0057] Honeysuckle: It is the dry flower bud or the first flower of Lonicera japonica Thunb.

[0058] Dandelion: the dried whole herb of Taraxacum mongolicum Hand.-Mazz., Taraxacumborealisinense Kitam. or several plants of the same genus

[0059] Centipede: It is the dry body of Scolopendra subspinipes mutilans L. Koch, a centipede animal with few spines.

[0060] The above-mentioned medicinal materials are in compliance with the provisions of the Chinese Pharmacopoeia 2005 Edition.

[0061] Acetic acid, triethanolamine, and ethyl p-hydroxybenzoate were all analytically pure.

[0062] Gel pharmaceutical excipients are all pharm...

Embodiment 2

[0116] The preparation process is the same as in Example 1, except that in the extraction process of the compound Phellodendron Phellodendri, the prescription of the compound Phellodendron Phellodendron is 70 parts by weight of Forsythia, 35 parts by weight of Phellodendron Cortex, 35 parts by weight of Flos Lonicerae, 35 parts by weight of Dandelion, and 2.1 parts by weight of Centipede.

Embodiment 3

[0118] The preparation process is the same as in Example 1, except that in the extraction process of compound Phellodendron Phellodendri, the prescription of compound Phellodendron Phellodendron is 90 parts by weight of forsythia, 45 parts by weight of Phellodendron cortex, 45 parts by weight of honeysuckle, 45 parts by weight of dandelion, and 2.7 parts by weight of centipede.

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Abstract

Compound amur cork-tree temperature-sensitive gel for treating sore and ulcer and traumatic infection and a preparing method thereof are provided. The temperature-sensitive gel comprises 5-15% by weight of a compound amur cork-tree extract liquid, 18-20% by weight of poloxamer 407, 1.5-2.5% by weight of poloxamer 188, 5-10% by weight of propylene glycol, 5-10% by weight of glycerol, 0.5-1% by weight of ethyl p-hydroxybenzoate and 41.5-65% by weight of distilled water. A problem that gel structures are irreversibly destroyed because traditional Chinese medicine extracts at present are complex in components and react with base auxiliary materials, or because traditional Chinese medicine extract liquids are hypertonic systems and cause exosmosis of water in gel substrate network structures is overcome. A gel substrate adopted can be primarily determined according to physical and chemical properties and dosage forms of effective components.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a compound Phellodendron thermosensitive gel for treating sores and trauma infections and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, with a total area of ​​1.2 to 2 square meters. Since it is the outermost layer, it is the most vulnerable part and bears a variety of physical and chemical damage, infection, inflammation and other damaging stimuli. According to the World Health Organization, skin diseases will be the most morbidity, disability and contagious diseases in human history in the 21st century, mainly including herpes, dermatitis, eczema, acne and trauma, etc., often causing redness, swelling and papules , herpes, exudate, erosion, abscess, ulcer, etc. With the process of social aging and the extension of the average life expectancy of the population, the spectrum of diseases has changed. Chronic wound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/06A61P17/02A61P31/02
Inventor 秦承雪
Owner SHANDONG HANFANG PHARMA
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