An ophthalmic device is disclosed, the ophthalmic device comprising: (a) a step of providing a reactive composition, the reactive composition comprising (i) a
polymerization initiator capable of forming two or more free radical groups upon first activation, wherein at least one of the free radical groups is further activatable by subsequent activation, (ii) one or more ethylenically unsaturated compounds, and (iii) a crosslinking agent; (b) a step of subjecting the reactive composition to a first activation step such that the reactive composition polymerizes thereto form a crosslinked
substrate network containing covalently bonded activatable free radical initiators; and (c) inactivating at least a portion of the covalently bonded activatable free radical initiators in one or more selected regions of the crosslinked
substrate network. An ophthalmic device manufactured by a process comprising: (d) a step of ensuring that the crosslinked
substrate network contains retained covalently activatable free radical initiators outside one or more selected regions and optionally within one or more selected regions; (b) a step of contacting the crosslinked substrate network with a
grafting composition containing one or more ethylenically unsaturated compounds, wherein the contact is carried out under conditions such that the
grafting composition penetrates into the crosslinked substrate network; and (e) a step of activating the retained covalently activatable free radical initiators so that the
grafting composition polymerizes with the crosslinked substrate network, thereby forming a grafted
polymer network outside the selected regions and optionally partially within the selected regions.