This invention provides a polyfluorosiloxane alkylpolyurethane, its preparation method and application, and marine protective coatings, relating to the field of marine engineering protection technology. The polyfluorosiloxane alkylpolyurethane provided by this invention has a molecular chain comprising a soft segment component and a hard segment component. The soft segment component is a polylactic acid-polycarbonatecopolymer with dihydroxyl-terminated ends; the hard segment component has polyfluorosiloxane side chains. Using the polyfluorosiloxane alkylpolyurethane provided by this invention, a biomimetic super-lubricating surface marine engineering protective coating with self-healing function and highly stable surface lubricant can be prepared. The chemically bonded polyfluorosiloxane side chain structure endows the coating with longer-lasting corrosion protection performance; the addition of mercapto-modified nano-silica further enhances the mechanical properties and UV aging resistance of the coating; simultaneously, the preparation method of this polyurethane is simple, and the reaction conditions are mild and efficient.