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Preparation method of long-acting veterinary compound oxytetracycline injection

A technology of injection and oxytetracycline, applied to medical preparations containing active ingredients, pharmaceutical formulas, active ingredients of salicylic acid, etc., can solve problems such as high market prices, unstable performance, and low temperature resistance, and achieve Not easily affected by high temperature, long storage time, and low chelation temperature

Active Publication Date: 2018-02-16
CHONGQING ZONGYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Imported oxytetracycline injection has good quality and long efficacy, but the market price is very high
Domestic veterinary oxytetracycline injection is unstable in performance, prone to discoloration, precipitation, and failure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare long-acting veterinary compound oxytetracycline injection of the present invention according to the following steps:

[0021] 1) Take an appropriate amount of water for injection, add 10g of magnesium chloride and 0.4g of EDTA-2Na, stir to dissolve, then add 3.5g of nicotinamide and 3.5g of sodium salicylate, stir (heat to dissolve if necessary), and control the temperature at 40-60°C , ready to use, that is, No. 1 solution.

[0022] 2) Take an appropriate amount of water for injection and dissolve 10g of sodium formaldehyde sulfoxylate, (heat to dissolve if necessary) and control the temperature at 50-70°C, and wait for use, which is the No. 2 solution.

[0023] 3) Add 40g of ɑ-pyrrolidone and 30g of N,N-dimethylformamide into No. 1 solution and stir thoroughly, slowly add 19g of oxytetracycline hydrochloride, stir to dissolve, cool with cold water while stirring, and the reaction time should not be too long (interval Control within 30 minutes), in order to pr...

Embodiment 2

[0028] Prepare long-acting veterinary compound oxytetracycline injection of the present invention according to the following steps:

[0029] 1) Take an appropriate amount of water for injection, add 12g of magnesium chloride and 0.6g of EDTA-2Na, stir to dissolve, then add 4.0g of nicotinamide and 4.5g of sodium salicylate, stir (heat to dissolve if necessary), and control the temperature at 40-60°C , ready to use, that is, No. 1 solution.

[0030] 2) Take an appropriate amount of water for injection and dissolve 12g of sodium formaldehyde sulfoxylate, (heat to dissolve if necessary), control the temperature at 50-70°C, and wait for use, which is the No. 2 solution.

[0031] 3) Add 43g of ɑ-pyrrolidone and 33g of N,N-dimethylformamide to No. 1 solution and stir thoroughly, slowly add 22g of oxytetracycline hydrochloride, stir to dissolve, cool with cold water while stirring, and the reaction time should not be too long (interval Control within 30 minutes), in order to prevent...

Embodiment 3

[0036] Prepare long-acting veterinary compound oxytetracycline injection of the present invention according to the following steps:

[0037] 1) Take an appropriate amount of water for injection, add 13g of magnesium chloride and 0.7g of EDTA-2Na, stir to dissolve, then add 5.0g of nicotinamide and 5.0g of sodium salicylate, stir (heat to dissolve if necessary), and control the temperature at 40-60°C , ready to use, that is, No. 1 solution.

[0038] 2) Take an appropriate amount of water for injection and dissolve 13g of sodium formaldehyde sulfoxylate, (heat to dissolve if necessary) and control the temperature at 50-70°C, and wait for use, which is the No. 2 solution.

[0039] 3) Add 45g of ɑ-pyrrolidone and 35g of N,N-dimethylformamide into No. 1 solution and stir thoroughly, slowly add 25g of oxytetracycline hydrochloride, stir to dissolve, cool with cold water while stirring, and the reaction time should not be too long (interval Control within 30 minutes), in order to pr...

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PUM

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Abstract

The invention discloses a preparation method of a long-acting veterinary compound oxytetracycline injection. The preparation method comprises the following steps: 1) taking a proper amount of water for injection, adding magnesium chloride and eisodium edentate (EDTA-2Na), stirring for dissolving, adding nicotinamide and sodium salicylate, and stirring for standby use, namely obtaining a liquid 1; 2) taking a proper amount of water for injection, and dissolving sodium formaldehyde sulfoxylate for use, namely obtaining a liquid 2; 3) adding a small amount of alpha-pyrrolidone and N,N-dimethyl formamide into the liquid 1 obtained in the step 1, stirring, slowing adding a small amount of oxytetracycline hydrochloride, and stirring for dissolving; 4) adding the liquid 2 obtained in the step 2 into liquid obtained in the step 3, and uniformly stirring; 5) regulating a pH value by using a pH regulator; 6) fixing the volume, filtering in a sterile environment, and filling and sealing. The long-acting veterinary compound oxytetracycline injection is stable in quality, good in medicinal effect and long in acting time.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a preparation method of long-acting veterinary compound oxytetracycline injection. Background technique [0002] As the most widely used antibiotic in livestock and poultry and other animals, oxytetracycline is the basic drug for livestock and poultry health care. It is mainly used for the treatment of respiratory tract, urinary tract and gastrointestinal tract infection caused by various bacteria, mycoplasma and chlamydia in animals. It can also be used Three-needle health care for young animals. Imported oxytetracycline injection is of good quality and long-lasting effect, but the market price is very high. Domestic veterinary oxytetracycline injection is unstable in performance, prone to discoloration, precipitation, and failure. Contents of the invention [0003] The purpose of the present invention is to aim at the deficiencies of the prior art, and provide a kind of prep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61K9/08A61P31/04A61P29/00A61K31/455A61K31/60
CPCA61K9/08A61K31/455A61K31/60A61K31/65A61K2300/00
Inventor 梁金权
Owner CHONGQING ZONGYI PHARMA
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