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Use of anthracycline antibiotics and pharmaceutically acceptable salts thereof in the treatment of retinal vein occlusion

A technology of retinal veins and antibiotics, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as reducing the quality of life of patients

Active Publication Date: 2016-12-07
张雅珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its blinding properties, it will seriously reduce the patient's quality of life

Method used

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  • Use of anthracycline antibiotics and pharmaceutically acceptable salts thereof in the treatment of retinal vein occlusion
  • Use of anthracycline antibiotics and pharmaceutically acceptable salts thereof in the treatment of retinal vein occlusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] ① Take 300mg of poly(lactic-co-glycolic acid) (PLGA) and add it into 1ml of dichloromethane to prepare a solution;

[0021] ② Add 50 mg of arubicin to the solution prepared in ①, and mix well by ultrasonic;

[0022] ③Use a syringe to slowly inject the solution in ② into the cottonseed oil containing 0.05% egg yolk oil, stir at 1000r / min for 20min, then reduce the speed to 200r / min and continue stirring for 4h;

[0023] ④Add 20ml petroleum ether to step ③, centrifuge at 8000r / min for 5min after 30min;

[0024] ⑤ Collect the microspheres, wash with petroleum ether and evaporate to dryness.

Embodiment 2

[0026] ① Take 200mg PLGA and add it to 1ml tetrahydrofuran solution to prepare a solution;

[0027] ② Add 50 mg of mitoxantrone to 0.2 ml of glycerin, mix well and add to the solution prepared in ①, stir with a homogenizer for 1 min to obtain colostrum;

[0028] ③Add it to 12ml of 2% polyvinyl alcohol (PVA) solution, stir at 1000r / min for 5min, then add 120ml of 0.5%PVA solution to obtain double emulsion;

[0029] ④ Reduce the rotational speed to 200r / min and continue stirring for 4h, then centrifuge at 8000r / min for 5min;

[0030] ⑤ The microspheres were collected, washed with distilled water and freeze-dried.

Embodiment 3

[0032] ① Take 100mg of PSA-PEG and add it to 1ml of dichloromethane solution to prepare a solution;

[0033] ② Add 50 mg of arubicin to the solution prepared in ①, and mix well by ultrasonic;

[0034] ③ Add the solution prepared in ② into 15ml 1% PVA solution;

[0035] ④ Reduce the rotational speed to 200r / min and continue stirring for 4h, then centrifuge at 8000r / min for 5min;

[0036] ⑤ Collect microspheres, wash with distilled water and collect.

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Abstract

The invention discloses an application of anthracene nucleus antibiotic and its pharmaceutical salt for treating retinal vein occlusion. The invention found that the anthracene nucleus antibiotic and its pharmaceutical salt have good effect on treatment of retinal vein occlusion, and especially the anthracene nucleus antibiotics can be prepared to prolonged action preparations such as a nano preparation, a microballoon preparation, liposome and hydrogel, the toxicity of anthracene nucleus antibiotic is reduced, and the anthracene nucleus antibiotic enables ophthalmic administration, administration dosage is simultaneously enlarged, the duration time of drug effect is long, the medicament curative effect is stronger than that of the common preparations of the anthracene nucleus antibiotic, when the ophthalmic administration is carried out, the anthracene nucleus antibiotic has good treatment effect for treating retinal vein occlusion, and the blank that no medicine is good for treating retinal vein occlusion can be filled.

Description

technical field [0001] The present invention relates to a medicine for treating retinal vein occlusion, in particular to the new application of a series of traditional antitumor antibiotics anthracyclines and pharmaceutically acceptable salts thereof in the preparation of medicines for treating retinal vein occlusion, in particular, the anthracyclines Antibiotics and their pharmaceutically acceptable salts are prepared into long-acting preparations such as nanometer preparations, microsphere preparations, liposomes and hydrogels. Background technique [0002] Retinal vein occlusion is a relatively common retinal disease. According to the location of retinal vein occlusion, it can be divided into central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). Retinal vein occlusion is characterized by dilated and tortuous veins. Hemorrhage, edema and exudate. Although the etiology classification, complication prognosis and treatment of this disease have been...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/136A61P27/02
Inventor 张雅珍李铁力白毅
Owner 张雅珍
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