Long-acting Veterinary Compound Oxytetracycline Injection

A technology of injection and oxytetracycline, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, inorganic non-active ingredients, etc., can solve problems such as easy blackening, unstable performance, and high temperature resistance, and achieve long-term action Long, long storage time, prolonging the effect of the drug

Active Publication Date: 2018-01-02
CHONGQING ZONGYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Imported oxytetracycline injection has good quality and long efficacy, but the market price is very high
Domestic veterinary oxytetracycline injection is unstable in performance, prone to discoloration, precipitation, and failure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prepare long-acting veterinary compound oxytetracycline injection of the present invention according to the following steps:

[0023] 1) Take an appropriate amount of water for injection, add 10g of magnesium chloride and 0.4g of EDTA-2Na, stir to dissolve, then add 3.5g of nicotinamide and 3.5g of sodium salicylate, stir (heat to dissolve if necessary), and control the temperature at 40-60°C , ready to use, that is, No. 1 solution.

[0024] 2) Take an appropriate amount of water for injection and dissolve 10g of sodium formaldehyde sulfoxylate, (heat to dissolve if necessary) and control the temperature at 50-70°C, and wait for use, which is the No. 2 solution.

[0025] 3) Add 40g of ɑ-pyrrolidone and 30g of N,N-dimethylformamide into No. 1 solution and stir thoroughly, slowly add 19g of oxytetracycline hydrochloride, stir to dissolve, cool with cold water while stirring, and the reaction time should not be too long (interval Control within 30 minutes), in order to pr...

Embodiment 2

[0030] Prepare long-acting veterinary compound oxytetracycline injection of the present invention according to the following steps:

[0031] 1) Take an appropriate amount of water for injection, add 12g of magnesium chloride and 0.6g of EDTA-2Na, stir to dissolve, then add 4.0g of nicotinamide and 4.5g of sodium salicylate, stir (heat to dissolve if necessary), and control the temperature at 40-60°C , ready to use, that is, No. 1 solution.

[0032] 2) Take an appropriate amount of water for injection and dissolve 12g of sodium formaldehyde sulfoxylate, (heat to dissolve if necessary), control the temperature at 50-70°C, and wait for use, which is the No. 2 solution.

[0033] 3) Add 43g of ɑ-pyrrolidone and 33g of N,N-dimethylformamide to No. 1 solution and stir thoroughly, slowly add 22g of oxytetracycline hydrochloride, stir to dissolve, cool with cold water while stirring, and the reaction time should not be too long (interval Control within 30 minutes), in order to prevent...

Embodiment 3

[0038] Prepare long-acting veterinary compound oxytetracycline injection of the present invention according to the following steps:

[0039] 1) Take an appropriate amount of water for injection, add 13g of magnesium chloride and 0.7g of EDTA-2Na, stir to dissolve, then add 5.0g of nicotinamide and 5.0g of sodium salicylate, stir (heat to dissolve if necessary), and control the temperature at 40-60°C , ready to use, that is, No. 1 solution.

[0040] 2) Take an appropriate amount of water for injection and dissolve 13g of sodium formaldehyde sulfoxylate, (heat to dissolve if necessary) and control the temperature at 50-70°C, and wait for use, which is the No. 2 solution.

[0041] 3) Add 45g of ɑ-pyrrolidone and 35g of N,N-dimethylformamide into No. 1 solution and stir thoroughly, slowly add 25g of oxytetracycline hydrochloride, stir to dissolve, cool with cold water while stirring, and the reaction time should not be too long (interval Control within 30 minutes), in order to pr...

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PUM

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Abstract

The invention discloses a long-acting compound terramycin injection for animals. Each 1000 ml of long-acting compound terramycin injection contains 190-250g of occrycetin, 400-450g of alpha-pyrrolidone, 300-350ml of N,N-dimethyl formamide, 35-50g of nicotinamide, 35-50g of sodium salicylate, 100-130g of magnesium chloride, 100-130g of hydroxymethanesulfinic acid sodium hydrosulfite and 4-7g of disodium edetate dehydrate. A pH conditioning agent adjusts the pH value to 8.0-9.0; injecting water is used to perform calibration until the constant volume is 1000 ml; the pH conditioning agent is ethanol amine. According to the long-acting compound terramycin injection for animals, the chelating temperature is low and within 30-60 DEG C, products is high in chelating degree and steady in quality, and can still keep the standard amber within 2-year period of validity; an extended agent is added, so that drug function is good and the acting time is long; the drug function keeps for 72 hours after the drug in a normal dosage is administrated, so that the inconvenience of repeated drug administration is solved, and thus the long-acting function is played.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a long-acting veterinary compound oxytetracycline injection. Background technique [0002] As the most widely used antibiotic in livestock and poultry and other animals, oxytetracycline is the basic drug for livestock and poultry health care. It is mainly used for the treatment of respiratory tract, urinary tract and gastrointestinal tract infection caused by various bacteria, mycoplasma and chlamydia in animals. It can also be used Three-needle health care for young animals. Imported oxytetracycline injection is of good quality and long-lasting effect, but the market price is very high. Domestic veterinary oxytetracycline injection is unstable in performance, prone to discoloration, precipitation, and failure. Contents of the invention [0003] The object of the present invention is to provide a compound oxytetracycline injection for animals that is not easily affected by hig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61K33/06A61K9/08A61P31/04A61P11/00A61P13/02A61P1/00
CPCA61K9/0019A61K9/08A61K31/455A61K31/60A61K31/65A61K47/02A61K47/08A61K47/18A61K47/22A61K2300/00
Inventor 梁金权
Owner CHONGQING ZONGYI PHARMA
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