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A technology of compound florfenicol and florfenicol, which is applied in drug delivery, pharmaceutical formulation, antibacterial drugs, etc., can solve the problems of different antibacterial mechanisms and no application reports of compound injections, and achieve good antibacterial effect, Effect of overcoming trouble and uneconomical and reducing treatment cost
Inactive Publication Date: 2018-12-11
HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
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The antibacterial mechanisms of the two are different, they can act on different parts and different growth stages of pathogenic bacteria, and coordinate with each other, and the clinical data of the compatibility of the two show that trimethoprim has obvious synergistic effect on florfenicol, but At present, there is no report on the application of the compound injection of the two
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Embodiment 1
[0020] The preparation of embodiment 1 compound recipe Florfenicol and trimethoprim injection
[0021] Measure 60g of dimethylacetamide and heat to 60°C, add 3g of trimethoprim to dissolve, then add 18g of florfenicol and stir until completely dissolved, finally add 30g of α-pyrrolidone, stir evenly, to reach the specified amount. Coarse filtration, fine filtration, potting, steam sterilization at 100°C for 30 minutes, light inspection.
Embodiment 2
[0022] The preparation of embodiment 2 compound recipe florfenicol and trimethoprim injection
[0023] Measure 60g of dimethylacetamide and heat to 60°C, add 5g of trimethoprim to dissolve, then add 25g of florfenicol and stir until completely dissolved, finally add 40g of α-pyrrolidone, stir evenly, to reach the specified amount. Coarse filtration, fine filtration, potting, steam sterilization at 100°C for 30 minutes, light inspection.
Embodiment 3
[0024] The preparation of embodiment 3 compound recipe florfenicol and trimethoprim injection
[0025] Measure 60g of dimethylacetamide and heat to 60°C, add 1g of trimethoprim to dissolve, then add 5g of florfenicol and stir until completely dissolved, finally add 40g of α-pyrrolidone, stir evenly, to reach the specified amount. Coarse filtration, fine filtration, potting, steam sterilization at 100°C for 30 minutes, light inspection.
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Abstract
The invnetion discloses a complex florfenicol composition which is composed of active ingredients, namely florfenicol and trimethoprim. The weight ratio of florfenicol to trimethoprim is 15-25:1-7. The composition provided by the invention is made into a freeze-dried powder injection and an injection. The prepared injection is prepared from the following raw materials, by weight, 18-22% of florfenicol, 3-5% of trimethoprim, 30-70% of dimethylacetamide and 10-14% of alpha-pyrrolidone. The composition provided by the invention can be used to inhibit synthesis of bacterial DNA, interfere with synthesis of bacterioprotein, enhance clinical application effects of florfenicol, prolong efffective in vivo antiviral acting time of florfenicol, generate synergistic effects and minimize treatment cost, and has a better antibacterial effect.
Description
technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a compound florfenicol composition. Background technique [0002] Florfenicol, also known as fluprofen, is a monofluorinated derivative of thiamphenicol, so it is also commonly known as fluthiamphenicol, and its chemical name is D(+)-threo-l-p-thiamphenicol Phenyl-2-dichloroacetamido-3-fluoropropanol, molecular formula C 12 h 14 NO 4 C 12 SF, molecular weight is 358.22. Florfenicol is a broad-spectrum antibacterial drug for veterinary use. It is a new type of chloramphenicol antibacterial drug. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safety and high efficiency. The effect of disease treatment is remarkable. As a substitute for chloramphenicol, florfenicol avoids the occurrence of adverse reactions in aplastic anemia, and is significantly superior to chloramphenicol and thiamphenicol ...
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