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Application of compound anisodamine injection in aspect of treating scalds

An anisodamine and injection technology, which is applied in the application field of compound anisodamine injection for treating scalds, can solve the problems of rapid treatment of people with severe burns and scalds, insufficient targeting of common drugs, prolonging post-injury survival time, and the like , to achieve the effect of improving microcirculation, prolonging survival time and reducing release

Pending Publication Date: 2022-05-27
范德里希(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, at first will save life to severe burn and scald person, and the medicine of treating burn and scald, infection injury on the market has its own characteristics respectively, also has shortcoming separately, for example: general medicine pertinence is insufficient, can not treat severe burn and scald person rapidly. treatment, reduce the patient's mortality rate, and prolong the post-injury survival time, so the present invention is committed to studying whether compound anisodamine intraperitoneal injection can reduce the effect of large area severe scald mortality

Method used

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  • Application of compound anisodamine injection in aspect of treating scalds
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  • Application of compound anisodamine injection in aspect of treating scalds

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Experimental program
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Effect test

preparation example Construction

[0020] 1. Preparation of the tested drug: It is composed of neostigmine injection and anisodamine injection in a ratio of 1:500, and compound anisodamine also includes a mixture with neostigmine injection and anisodamine injection, etc. volume of water for injection.

[0021] 2. Establishment of rat model: SD rats, source: BK company, grade: clean, body weight: 200-220g, gender: male, were divided into cages and reared adaptively for 7 days after purchase, and ordinary standard rats were used Feeding, free drinking water, temperature control at 18-20 °C, automatic switching between light and dark for 12 hours, fasting for 12 hours the day before the experiment, and no water.

[0022] 3. Establishment of self-made molds: self-made with wooden boards, the rats were calculated according to the average body weight of 230g, and the body surface area was calculated, and then oval holes, which accounted for about 30% of the rat body surface area, were opened on the wooden boards.

Embodiment 1

[0024] The test drug compound anisodamine injection was calculated based on the content of anisodamine in it: high-dose group (20 mg / kg).

Embodiment 2

[0026] The test drug compound anisodamine injection was calculated based on the content of anisodamine in it: the middle dose group (10 mg / kg).

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Abstract

The invention relates to the technical field of scald treatment, compound anisodamine is composed of a neostigmine injection and an anisodamine injection according to the proportion of 1: 500, and the proportion has good effects on hemorrhagic shock, allergic shock and increase of tolerance of mice to lethal dose endotoxin in the previous research of the unit. The pharmacological basis of the compound preparation is as follows: neostigmine is a reversible cholinesterase (AChE) inhibitor, temporarily inhibits cholinesterase activity, and increases the amount of acetylcholine (ACh) in vivo to excite an M receptor and an N receptor; a large dose of anisodamine has the effects of improving microcirculation and blocking M receptors, blocking of the M receptors enables N receptors to be more fully excited, in the excited N receptors and subtypes of the N receptors, after alpha 7 is excited, release of inflammatory factors can be reduced, and therefore it is proved that the compound anisodamine injection can remarkably reduce the mortality rate of serious scalds, and the compound anisodamine injection can be used for treating the severe scalds. The survival time after injury is prolonged.

Description

technical field [0001] The invention relates to the technical field of scald treatment, in particular to the application of compound anisodamine injection in treating scald. Background technique [0002] Burns and scalds are relatively common conditions in life, and they can happen to people at any time. Mild cases will bring pain to patients, severe cases will endanger the patient's life, and can also cause life-long injuries. Therefore, it is very important to understand the relevant knowledge of burns and scalds. [0003] Therefore, the first thing to do is to save the life of people with severe burns and scalds. Currently, the drugs on the market for treating burns and scalds and infected injuries have their own characteristics and shortcomings. Therefore, the present invention is devoted to studying whether intraperitoneal injection of compound anisodamine can reduce the mortality rate of severe scalds in large areas. SUMMARY OF THE INVENTION [0004] The object of ...

Claims

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Application Information

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IPC IPC(8): A61K31/46A61K9/08A61P17/02A61K31/27
CPCA61K31/27A61K31/46A61K9/08A61K9/0019A61P17/02A61K2300/00Y02A50/30
Inventor 苏定冯刘建国胡建杰陈璟宣苏一凌
Owner 范德里希(上海)生物科技有限公司
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