39 results about "Racanisodamine" patented technology

The invention discloses a process (method) for preparing racanisodamine hydrochloride used for injection. The invention overcomes the defects that the traditional racanisodamine hydrochloride preparation process cannot effectively guarantee clarity and complete filtering of impurities such as fibers by utilizing high pressure ultrafiltration equipment and provides a preparation process with low cost, high yield and more stable quality of the finished product. The preparation process comprises the following steps: (1) placing water used for injection in a preparation tank, lowering water temperature to 39-41 DEG C; (2) dissolving sodium chloride with the water used for injection in the preparation tank for spare use, adding the racanisodamine hydrochloride into the preparation tank, opening a stirrer, adding 0.2mol / L of hydrochloric acid into the preparation tank, adding sodium chloride solution into the preparation tank, circulating and stirring until racanisodamine is completely dissolved; and (3) regulating pH value of liquid medicine obtained in step (2) to be 5.5-6.0 with 0.2mol / L of hydrochloric acid. The liquid medicine is filtered by a high pressure ultrafilter, then whether an intermediate product is qualified is inspected, a filling process is carried out, and the preparation process disclosed by the invention enhances market competitiveness of the racanisodamine hydrochloride product, is convenient to the marketing of the racanisodamine hydrochloride product and is worthy of popularization.

The invention belongs to the technical field of a medicine, and in particular relates to a navel-warming paste capable of warming the spleen and the stomach for dispelling cold and a preparation method thereof. The navel-warming paste capable of warming the spleen and the stomach for dispelling cold is characterized by being mainly prepared from the following crude medicines: 20-25 parts of cinnamon, 10-15 parts of white pepper, 20-25 parts of pericarpium granati, 20-25 parts of fructus chebulae, 20-25 parts of Chinese gallnut, 5-7 parts of clove, 0.5-0.75 parts of a raceanisodamine hydrochloride tablet and 235-250 parts of yellow lead. The navel-warming paste disclosed by the invention has the beneficial effects of combining various medicines to warm the spleen and the stomach for dispelling cold as well as to relieve diarrhea and paint; the navel-warming paste has remarkable effect on treating acute and chronic abdominal pain and diarrhea, dyspepsia, inappetence and night sweat caused by pathogenic cold, and the cure rate is 90%; the navel-warming paste can cure generally by 1-2 courses of treatment, so that the course of disease is effectively shortened and paint of the patient is rapidly removed.

The invention discloses a method for separating anisodamine and / or tropic acid mixed enantiomer. The method has the advantages that the anisodamine and tropic acid enantiomers can be respectively separated from a racemization anisodamine and tropic acid mixture; the structural formula is shown in formulas I to VI; the formulas I to VI are shown in the description. The method is a capillary electrophoresis method, and comprises the following steps that (1) an electrophoresis buffer solution contains a chiral resolution agent, and the chiral resolution agent is selected from a mixture of sulfobutyl-beta-cyclodextrin, and / or sulfobutyl-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin; (2) the separation voltage is -8kV to -18kV.

The invention relates to a nasal drop and a preparation method thereof. The nasal drop is prepared from the following raw material medicines in parts by weight: 1-2mL of a chlorpheniramine maleate injection which comprises 10-20mg of chlorpheniramine maleate, 1-3mL of a moroxydine hydrochloride injection which comprises 50-150mg of moroxydine hydrochloride, 0.1-0.5mL of a hydrochloric acid racanisodamine injection which comprises 1-5mg of hydrochloric acid racanisodamine, and 3-6mL of a radix bupleuri extract. The preparation method specifically comprises the following steps of: mixing the raw material medicines according to the ratio, and filling into a nasal drop container. The nasal drop is safe in medicinal formula, small in toxic and side effect, reasonable in matching of traditional Chinese medicines and western medicines, applicable to infants, free of hormone and free of drug dependency.

The invention relates to a medicinal preparation for treating rhinitis, wherein the formulation comprises astragalus root, xanthium. spp., white atractylodes rhizome, ledebouriella root, dahurian angelica root, asaryl, centipeda, wild chrysanthemum flower, grassleaved sweetflag rhizome, Ligusticum wallichii, flower bud of lily magnolia, Japanese yam, cuttle-bone, Chinese ephedra, cassia twig, keel, oyster shell, chlorpheniramine, racanisodamine hydrochloride, flower bud of lily magnolia, and asaryl.

The embodiment of the invention discloses ointment for treating bedsore, diabetic wound and scald. The ointment comprises the following components in percentage by weight: 1.5 to 6.5 percent of sulfanilamide crystal, 1.5 to 6.5 percent of sulfadiazine, 2.0 to 10.0 percent of zinc oxide, 0.4 to 4.0 percent of cod liver oil, 0.1 to 3.0 percent of racanisodamine, 0.02 to 1.4 percent of borneol, 5.0 to 30.0 percent of herba violae, and the balance of medical vaseline. By adopting the ointment, tissue permeability at the afflicted part of a patient can be enhanced, moisture evaporation of the ointment is reduced, the acting time of the medicament at the afflicted part is prolonged, bacteria at the afflicted part are inhibited, local microcirculation is obviously improved, discontinuity during capillary blood perfusion is avoided, and healing of the afflicted part is promoted.

A combined adjuvant for soaked vaccines for fish and its application and use method, characterized in that the combined adjuvant is a combination of three adjuvants of dithiothreitol, vitamin D3 and racemic anisodamine, wherein dithiothreose Alcohol, vitamin D3 and racemic anisodamine are used at concentrations of 1-50mg / L, 0.1-20mg / L and 1-60mg / L respectively, and the synergistic effect is achieved in soaking vaccines including seawater and freshwater fish. immune effect. When using, first select fish to be immunized with a body weight of more than 2g per fish and with intact body surface; move the fish to be immunized into the dithiothreitol pretreatment solution with a concentration range of 1-50mg / L and soak for 1-20min, and then Add VD3 with a concentration range of 0.1-20mg / L and the vaccine to soak for 2-20 minutes, then add racemic anisodamine with a concentration range of 1-60mg / L and soak for 5-20 minutes. The invention significantly improves the immune effect of the vaccine, has simple and safe use method, low cost, does not need additional facilities and procedures, has no influence on the survival rate and growth speed of fish, and is also harmless to the environment and operators.