Compound racanisodamine eye drops

A technology of anisodamine and eye drops, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, peptide/protein components, etc., can solve problems such as eye discomfort, low distance vision, and limited efficacy, and achieve the elimination of eye discomfort , the control effect is obvious, the control effect is effective

Inactive Publication Date: 2021-02-12
ZHENJIANG HENGXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, with the acceleration of social modernization and the continuous improvement of people's living standards, the incidence of myopia has continued to increase. Myopia has become one of the eye diseases with the highest incidence in the world today; remarkable achievements have been made in the prevention and treatment of common diseases among students However, the myopia rate of students continues to rise. Research statistics show that because primary school students are still in the developmental stage, the eye structure is extremely unstable, and they are prone to pseudomyopia. If it is not controlled, it will develop rapidly. High myopia, the adjustment function of the high myopia is weak, and the atrophy of the adjustment muscles can be measured, and as various electronic devices such as computers, mobile phones, and electronic game consoles enter society and families, these electronic devices are bringing great benefits to people's work and study. At the same time of convenience, it also has some impact on people's eyesight, especially the eye fatigue caused by excessive use of eyes by young children due to long-term use of these electronic devices is an important factor for the current in...

Method used

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  • Compound racanisodamine eye drops
  • Compound racanisodamine eye drops
  • Compound racanisodamine eye drops

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The compound racemic anisodamine eye drops is made from the following raw materials: racemic anisodamine 0.018 wt%, tropicamide 0.005 wt%, sodium chondroitin sulfate 1.9 wt%, diclofenac sodium 0.15 wt%, recombinant Human epidermal growth factor 0.12wt%, sodium chloride 0.84wt%, thimerosal 0.008wt%, pH regulator to adjust pH to 5.5-6.5, water for injection balance;

Embodiment 2

[0022] The compound racemic anisodamine eye drops is made from the following raw materials: racemic anisodamine 0.012 wt%, tropicamide 0.007 wt%, sodium chondroitin sulfate 2.2 wt%, diclofenac sodium 0.33 wt%, recombinant Human epidermal growth factor 0.09wt%, sodium chloride 1.18wt%, thimerosal 0.008wt%, pH regulator to adjust pH to 5.5-6.5, water for injection balance;

Embodiment 3

[0024] The compound racemic anisodamine eye drops is made from the following raw materials: racemic anisodamine 0.014 wt%, tropicamide 0.005 wt%, sodium chondroitin sulfate 2.6 wt%, diclofenac sodium 0.28 wt%, recombinant 0.13wt% of human epidermal growth factor, 1.05wt% of sodium chloride, 0.011wt% of thimerosal, a pH regulator to adjust the pH to 5.5-6.5, and the balance of water for injection;

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Abstract

Provided is compound racanisodamine eye drops prepared from the following raw materials: 0.010-0.02 wt% of racanisodamine, 0.005-0.01 wt% of tropicamide, 1.5-2.8 wt% of sodium chondroitin sulfate, 0.05-0.4 wt% of diclofenac sodium, 0.05-0.15 wt% of a recombinant human epidermal growth factor, 0.72-1.25 wt% of sodium chloride, 0.005-0.012 wt% of thiomersalate, a pH regulator for adjusting pH to 5.5-6.5, and the balance being injection water. The compound racanisodamine eye drops disclosed by the invention are applied to adolescents, children and adults who often use eyes at a short distance, sothat the delaying and preventing effects on myopia of the adolescents and children are more obvious and effective after the compound racanisodamine eye drops are dripped for a long time, and for adults, visual fatigue can be significantly improved, and the elimination of eyeball discomfort and other symptoms can be accelerated; diclofenac sodium and racemic anisodamine are combined to achieve a good synergistic effect, diclofenac sodium is used as a ligand and matched with racemic anisodamine to generate a synergistic effect of biological activity, and meanwhile, diclofenac sodium and racemicanisodamine have the possibility of reducing toxicity, are low in price and easy to obtain and are worthy of popularization clinically.

Description

technical field [0001] The present invention relates to the technical field of ophthalmic drug production of pharmaceutical preparations, more specifically relate to a kind of compound racemic anisodamine eye drops. Background technique [0002] In recent years, with the acceleration of social modernization and the continuous improvement of people's living standards, the incidence of myopia has continued to increase. Myopia has become one of the eye diseases with the highest incidence in the world today; remarkable achievements have been made in the prevention and treatment of common diseases among students However, the myopia rate of students continues to rise. Research statistics show that because primary school students are still in the developmental stage, the eye structure is extremely unstable, and they are prone to pseudomyopia. If it is not controlled, it will develop rapidly. High myopia, the adjustment function of the high myopia is weak, and the atrophy of the adj...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K38/18A61K47/36A61P27/02A61P27/10A61K31/196A61K31/4409A61K31/46
CPCA61K31/46A61K31/4409A61K31/196A61K38/1808A61K9/08A61K9/0048A61K47/36A61P27/10A61P27/02A61K2300/00
Inventor 朱永星樊海声张鹏陈娟
Owner ZHENJIANG HENGXIN PHARMA
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