35 results about "Sodium Diclofenac" patented technology

The invention relates to the field of preparation of traditional Chinese medicinal liquor, and particularly discloses medicinal liquor for rapidly relieving arthralgia and myalgia and traumatic injury and a preparation method thereof. The medicinal liquor is prepared from various traditional Chinese medicine raw materials such as radix clematidis, radix aconiti and radix aconiti agrestis, active ingredients such as panax notoginseng saponins and curcumin, and white spirit of 50-60 degrees. The preparation method comprises the steps of traditional Chinese medicine crushing, ultrasonic-assisted extraction, dynamic counter-current extraction, high-speed shearing emulsification, nitrogen filling and the like, wherein the ultrasonic extraction and dynamic counter-current extraction technologies improve the extraction efficiency of effective components. The medicinal liquor is particularly suitable for treating distension (including hyperosteogeny type and soft tissue hyperplasia type), muscle stiffness caused by wind-cold damp evil, I-II grade traumatic injury and pain symptoms caused by lumbar intervertebral disc protrusion. In addition, the medicinal liquor can also be combined with diclofenac sodium for internal and external treatment, and has a remarkable curative effect.

The invention discloses a composite flocculant and a preparation method and application thereof, and relates to the technical field of flocculants.The preparation method of the composite flocculant comprises the following steps that S1, titanium dioxide nanoparticles are dispersed in a mixed solvent, then aminopropyltriethoxysilane is added for surface modification, and dispersion liquid is obtained; s2, sequentially adding polydopamine and chitosan into the dispersion liquid prepared in S1 under a heating condition, and continuously stirring to prepare a composite material through a Schiff base reaction; s3, centrifuging, washing and drying the composite material prepared in S2 to obtain a composite flocculant; the invention also provides the composite flocculant prepared by the method and application of the composite flocculant in treatment of sewage containing diclofenac sodium.

The invention relates to the technical field of biological medicines, in particular to pH-responsive hydrogel as well as a preparation method and application thereof. The hydrogel is prepared from the following raw materials: a modified chitosan aqueous solution, a modified polyethylene glycol aqueous solution, a polyvinyl alcohol aqueous solution and dopamine hydrochloride. The hydrogel is prepared by compounding a methacrylic anhydride modified chitosan aqueous solution, an aldehyde-terminated polyethylene glycol aqueous solution, a polyvinyl alcohol aqueous solution and dopamine hydrochloride, and the hydrogel with the pH response characteristic can be prepared and has reliable mechanical supporting strength; and the drug-resistant drugs (such as diclofenac sodium) can be effectively adsorbed, and a slow release effect is generated, so that the treatment of IVD is fundamentally realized.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

A medicated eyelid cleansing composition comprising a medicated scrub composition and an eyelid cleansing composition. The medicated scrub composition has one or more antibacterial and anti-inflammatory agents, including azithromycin and diclofenac sodium or dexamethasone phosphate. The medicated scrub composition can further include a combination of metronidazole and ivermectin. The composition is optimized for physiological compatibility and can be combined with a suitable substrate for use as a medicated eyelid cleanser.

The application provides a drug-loaded acupuncture needle and a preparation method and application thereof, and belongs to the technical field of combination of traditional Chinese medicine and western medicine. The preparation method of the drug-loaded acupuncture needle comprises the following steps: after the surface of the acupuncture needle is modified by silanization, the acupuncture needle is repeatedly soaked in sodium polystyrene sulfonate solution and polyallyl ammonium chloride solution in sequence, a high-molecular drug-loaded film is formed on the surface of the acupuncture needle, and the acupuncture needle is loaded with target drugs in a diclofenac sodium solution, so that the drug-loaded acupuncture needle is obtained. The acupuncture needle is combined with drugs, so that the same-acupoint drug administration can be realized. On one hand, the acupoint is mechanically stimulated, and the internal regulation of the body is exerted; on the other hand, the drug efficacy is exerted. The acupoint stimulation and drug treatment play the same effect and are complementary to each other. Animal experiment results show that the acupuncture needle and the diclofenac sodium in the drug-loaded acupuncture needle have a synergistic effect, and the acupuncture-needle-drug combination treatment mode has obvious effects on the treatment of rheumatoid arthritis.

According to the method for detecting the nitrosamine impurity in the diclofenac sodium preparation, disclosed by the invention, the N-nitroso-diclofenac impurity in the diclofenac sodium preparation can be quantitatively and efficiently detected, and auxiliary materials in the diclofenac sodium preparation can be effectively separated from the N-nitroso-diclofenac impurity through limited chromatographic conditions; the separation degree between the N-nitroso-diclofenac and adjacent impurities reaches 1.5 or above, and effective monitoring on the N-nitroso-diclofenac impurities is realized. The sensitivity is high, and N-nitroso-diclofenac impurities with the concentration equivalent to 0.96 ppm of a test sample can be detected.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a diclofenac sodium sustained release tablet and a preparation method thereof. The diclofenac sodium sustained-release tablet is prepared from diclofenac sodium, an ellagic acid-shellac-chitosan sustained-release material, a filling agent, a lubricating agent and an adhesive. According to the invention, a sustained-release material is prepared through solution preparation, film formation and post-treatment, and then the sustained-release tablet is prepared by adopting a wet granulation and tabletting method. Experiments show that the diclofenac sodium sustained-release tablet is good in stability, the content of diclofenac sodium basically remains unchanged after 6 months of an acceleration test, the sustained-release effect is ideal, the effective concentration maintaining time of a medicine in a body can be effectively prolonged, the medicine taking frequency is reduced, and the diclofenac sodium sustained-release tablet has good process feasibility and industrial production prospects.

The invention discloses a Jinhuang powder external application paste and application thereof in preparation of drugs for treating gonitis synovitis, the external application paste is prepared from ten traditional Chinese medicines including turmeric, rheum officinale, golden cypress, radix angelicae, rhizoma arisaematis, pericarpium citri reticulatae, rhizoma atractylodis, mangnolia officinalis, liquorice and radices trichosanthis, honey, edible vegetable oil, paraffin oil and water through a specific emulsification process, the pH value is 6.0-7.0, and the viscosity is 3000-5000 mPa.s; standard random control clinical tests prove that the total effective rate of the external application ointment for treating gonarthromeningitis reaches 99.04%, the Lyshilm score is improved by 30.2 score, the VAS score is reduced by 5.39 score and is greatly superior to that of a diclofenac sodium control group, the adverse reaction occurrence rate is only 3.85%, the levels of serum TNF-alpha, IL-1beta and IL-6 and the synovial thickness can be greatly reduced, and the external application ointment has a good clinical application prospect. The method is suitable for K-L grading I-II and postoperative rehabilitation patients.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

The invention relates to the field of medicine detection, in particular to a method for detecting related substances of diclofenac sodium and chlorpheniramine maleate in a lofenac tablet. According to the method, impurities of diclofenac sodium and chlorpheniramine maleate in the lofenac sodium and chlorpheniramine maleate tablet are detected through high performance liquid chromatography (HPLC), the method for detecting related substances in the lofenac sodium and chlorpheniramine maleate tablet can conduct integrated quality control on a compound preparation, the method is better in separation efficiency, higher in sensitivity and higher in durability, and the method is suitable for large-scale popularization and application. The method can ensure that all known impurities are completely separated and accurately quantified, and has enough detection capability on unknown impurities, thereby providing more reliable technical support for ensuring the safety, effectiveness and quality consistency of the medicine.

The invention belongs to the technical field of pharmaceutical preparation analysis and detection, and particularly relates to a determination method of a dissolution curve of diclofenac sodium sustained release tablets. According to the method, a sample dissolution method is optimized, and a reciprocating cylinder method is used for dissolving out the sample, so that the determination method is not influenced by the release speed of the diclofenac sodium sustained release tablet in an acid medium and the degradation degree of the released raw material medicine, the in-vivo release environment of the medicine is better simulated, the accuracy is high, the reliability and the repeatability are good, and the method is suitable for industrial production. The method can be used for judging whether a self-made preparation of a BE test is equivalent to a reference or not, and the method for determining the dissolution curve established by the invention can provide guidance for the process research of a preparation prescription required by the declaration of a generic drug.

This invention belongs to the field of biomedical materials technology, specifically relating to an in-situ drug-loaded hydrogel based on nanobottle encapsulation technology, its preparation method, and its application. The in-situ drug-loaded hydrogel is formed by cross-linking copper chloride and reduced thiourea groups grafted onto hyaluronic acid within drug-loaded polydopamine nanobottles under near-infrared light irradiation. Diclofenac sodium is dispersed on the periphery and within the pores of the in-situ drug-loaded hydrogel; Kartogenin is encapsulated within the drug-loaded polydopamine nanobottles. Compared with existing technologies, this invention utilizes nanobottle encapsulation technology to achieve in-situ gelation and time-controlled drug release, solving the problems of non-in-situ hydrogels failing to adhere to irregular tissues and in-situ hydrogels struggling to simultaneously possess controllable time-controlled drug release capabilities. This solution achieves perfect adhesion of the hydrogel to the joint cavity through controllable in-situ gelation to protect the joint; simultaneously, it enables rapid release of diclofenac sodium and sustained release of Kartogenin, thereby achieving staged treatment of osteoarthritis.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a full-continuous chemical synthesis method of diclofenac sodium. According to the method, aniline and chloroacetyl chloride are taken as starting raw materials, a fully continuous device consisting of a plurality of micro-mixers, micro-reactors, online solvent recovery equipment and the like which are sequentially communicated and are subjected to improved design is adopted, a high-purity (the purity is greater than 98.5%) diclofenac sodium product is synthesized through six-step chemical reaction and continuous operation, the recovery and reuse of the solvent are realized, and the method is suitable for industrial production. The problems of hydrochloride blockage and the like are solved, and three-waste discharge is obviously reduced. And through continuous synthesis, the production efficiency and the process control accuracy are greatly improved, and the stable product quality is ensured. In addition, the use amount of aluminum trichloride is reduced by more than 30%, the material loss caused by solvent switching is effectively reduced, and the production cost is reduced.

The invention discloses a triboelectric response DNA hydrogel dressing for promoting wound healing as well as a preparation method and application of the triboelectric response DNA hydrogel dressing. The hydrogel can simultaneously load a silver nano-cluster, VEGF and diclofenac sodium through a DNA three-way junction structure containing a cytosine ring, a DNA connecting chain containing a VEGF aptamer sequence and a cross-linked skeleton deposited by polypyrrole. The DNA hydrogel dressing prepared by the invention can realize on-demand administration by utilizing the triboelectric response characteristic, promotes healing of bacterial infected diabetic wounds, has the characteristics of good biocompatibility, excellent antibacterial property, high response speed, remarkable healing effect and the like, and is simple in preparation process, low in cost and easy for large-scale production. Therefore, the problems that an existing wound dressing is insufficient in antibacterial performance, poor in conductivity and low in healing efficiency are solved, the application of the wound dressing in chronic wound and diabetes wound treatment can be further expanded, and an important solution is provided for wound nursing and infection control.

The invention relates to the technical field of covalent organic framework materials and sample pretreatment, in particular to a cation covalent organic framework and a preparation method and application thereof.The preparation method of the cation covalent organic framework comprises the following steps that triaminoguanidine hydrochloride and 2, 6-dialdehyde-1, 5-dihydroxy naphthalene are dissolved in a reaction solvent, stirring is carried out, and the cation covalent organic framework is obtained; performing ultrasonic dispersion; vacuumizing the system after liquid nitrogen freezing, repeating for three times after unfreezing at room temperature, finally adding a catalyst, introducing nitrogen, and carrying out polymerization reaction, so as to obtain a dark brown precipitate. The prepared cation covalent organic framework has the advantages of being good in chemical stability, high in ion density, high in diclofenac sodium adsorption capacity and fast in adsorption kinetics, is far superior to a traditional adsorbent, is used as a dispersive solid-phase extraction adsorbent to be combined with HPLC-PDA to detect diclofenac sodium in food, and is simple in operation steps, short in extraction time and high in efficiency. The linear range is wide, the detection limit is low, and the accuracy and precision are high.

The invention discloses a diclofenac sodium sustained-release tablet and a preparation method thereof, the sustained-release tablet takes diclofenac sodium as an active ingredient, a waxy sustained-release framework material, a filler, an adhesive, a glidant, a lubricant and a coating material are supplemented, and 12-24 hours of stable release is realized by optimizing a hot melting granulation process; by expanding the selection range of auxiliary materials and simplifying the production steps, the product has good compressibility, hardness of 60-100N, friability of less than 0.6%, excellent dissolution performance, release of 25%-30% in one hour and release of more than or equal to 90% in 24 hours in a phosphate buffer solution with pH of 6.8, stability, acceleration of 6 months at 40 DEG C / 75% RH and long-term storage of 12 months at 25 DEG C / 60% RH, is consistent with in-vitro pharmaceutical characteristics of a control preparation, and is suitable for industrial production.

The present invention provides a patch for relieving lumbago, the patch comprising a backing and an adhesive layer laminated on the backing, wherein the adhesive layer comprises an adhesive base and 0.70 to 1.50 mg of diclofenac sodium per cm2 of application area, and the patch is used by applying the patch once a day to the chest region, the abdominal region, the dorsal region, the brachial region, or the femoral region of a human.

A method of compounding a topical cream includes combining ingredients including lidocaine hydrochloride, 4%, topical solution, diclofenac sodium, 1.5%, topical solution, lidocaine hydrochloride USP powder, and diclofenac sodium powder.

The invention discloses a diclofenac sodium transdermal microneedle patch for treating motor system diseases and a preparation method of the diclofenac sodium transdermal microneedle patch. The patch comprises a backing layer, a solid insoluble microneedle array and a drug coating positioned at the tip of a microneedle, the drug coating takes diclofenac sodium nanocrystals as an active ingredient and contains a stabilizer, a film-forming agent, a plasticizer and other auxiliaries, and the limitation that diclofenac sodium is difficult to dissolve in water and the transdermal permeability of an external preparation is insufficient is overcome by combining nanocrystallization treatment with a mixed solvent system of PEG400, propylene glycol and ethanol and a mild drying process. And the microneedle matrix has high mechanical strength and can be completely recovered after administration, so that the untoward effects of the whole body are reduced while pain and inflammation are relieved, and the stability and the safety of the preparation are improved.

The invention relates to a cell sugar and lipid metabolism regulation type drug-loaded linoleic acid lipid hybrid vesicle as well as a preparation method and application thereof, and the cell sugar and lipid metabolism regulation type drug-loaded linoleic acid lipid hybrid vesicle comprises a linoleic acid lipid hybrid vesicle, a sugar metabolism drug and a lipid metabolism drug, the glycometabolism drug and the lipid metabolism drug are loaded in the linoleic acid lipid hybrid vesicles; wherein the glycometabolism medicine is prepared from alkannin, tripterine, scutellarin or luteolin, and the lipid metabolism medicine is prepared from cinnamyl aldehyde, curcumin, myricetin, squalene or diclofenac sodium. The drug-loaded linoleic acid lipid hybrid vesicles prepared by the invention have uniform particle size and very stable structure and property, are naturally targeted to macrophages, can enhance the ability of host cells to remove intracellular bacteria, and have a remarkable effect on treatment of staphylococcus aureus and escherichia coli drug-resistant bacterial infection.

This invention relates to the field of medical devices, specifically to a patch application, its preparation method, and its application. The patch comprises an immediate-release layer, a cross-linking layer, and a sustained-release layer; the cross-linking layer is placed between the immediate-release and sustained-release layers, with the immediate-release layer in contact with the skin; the immediate-release layer comprises a first microsphere, which has a polyvinyl alcohol coating and an ibuprofen core; the cross-linking layer is a calcium ion cross-linked membrane obtained by cross-linking sodium alginate and calcium chloride; the sustained-release layer comprises a second microsphere, which has a polylactic acid-glycolic acid copolymer coating and a diclofenac sodium core. The patch application provided by this invention can rapidly reduce inflammation and pain through the anti-inflammatory and analgesic microspheres and maintain the surgical patch for a certain period of time, while also providing local physical cooling. Compared with traditional patches, it alleviates postoperative pain to a certain extent and accelerates wound healing.

The present invention relates to a quality detection method for diclofenac sodium and lidocaine hydrochloride injection, belonging to the field of drug detection. The present invention provides a quality detection method for diclofenac sodium and lidocaine hydrochloride injection. Through a large number of screenings and developments on the basis of the legal standards, the present invention conducts the specificity investigation of known impurities and the specificity investigation of unknown impurities, realizing the accurate and specific detection of related substances in diclofenac sodium and lidocaine hydrochloride injection, providing a reasonable and scientific detection method for the release of manufacturers of diclofenac sodium and lidocaine hydrochloride injection, providing a practical basis for the improvement of the quality standard of related substances in diclofenac sodium and lidocaine hydrochloride injection, and providing a guarantee for the safety of clinical medication. The detection efficiency, specificity, operability, low detection cost and quality control of the method are significantly better than the literature methods and legal standards reported at present.

The utility model relates to the technical field of medicine processing, and discloses a centrifugal treatment device for preparing diclofenac sodium liniment.The centrifugal treatment device comprises a centrifugal tank, a telescopic column is fixedly connected to the center of the interior of the centrifugal tank, a switch knob is rotationally connected to the right side of the centrifugal tank, and an adjusting plate is rotationally connected to the middle of the switch knob; the end, away from the switch knob, of the adjusting plate is rotationally connected with a special-shaped batten, the left end of the special-shaped batten is rotationally connected with a connecting plate, an electric telescopic rod is fixedly connected to the interior of the centrifugal tank, the connecting plate is rotationally connected with the electric telescopic rod, a filter cone is rotationally connected to the interior of the centrifugal tank, and an annular groove is formed in the upper portion of the inner wall of the centrifugal tank. According to the invention, when the filter cone in the centrifugal tank is subjected to rotary centrifugal treatment, each filter hole of the filter cone can be subjected to rotary cleaning, so that the filter cone is prevented from being blocked due to the influence of diclofenac sodium liniment raw materials, and the rotary cleaning mechanism can dynamically remove residues, prevent the filter holes from being blocked and ensure that the treatment process is continuous and efficient.

The invention relates to an enteric analgesic suppository for treating haemorrhoids and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine suppositories. The haemorrhoid relieving enteric-coated analgesic suppository is prepared from the following raw materials in parts by weight: 23 to 28 parts of vinegar-processed rhizoma corydalis, 23 to 28 parts of radix angelicae, 2 to 5 parts of borneol, 1 to 2 parts of belladonna extract, 3 to 6 parts of nefopam, 8 to 12 parts of diclofenac sodium, 0.5 to 1 part of meloxicam and 160 to 190 parts of matrix. The traditional Chinese medicines and the western medicines are reasonably configured by analyzing the mechanism of the medicine effect on nerves, the related nerves are influenced from different levels, the mechanism of generating local pain is inhibited or blocked from different angles and different levels, the synergistic analgesia is realized, the obvious analgesic and anti-inflammatory effects are realized, the obvious stimulation to local tissues is avoided, and the safety is good. The suppository analgesic can directly introduce the medicine into an action target position to play a local effect, so that the influence of the medicine on the whole body is reduced.

The invention discloses an external application preparation for treating meniscus sport injury and a preparation method, and relates to the technical field of external application preparations for meniscus. The medicine comprises diclofenac sodium gel paste, a Chinese patent medicine patch, an adjuvant A and an adjuvant B, the diclofenac sodium gel cream is prepared from the following raw materials: diclofenac sodium, propylene glycol, carbomer, triethanolamine, glycerol, absolute ethyl alcohol, menthol and water. The Chinese patent medicine patch comprises the following raw materials: frankincense, myrrh, angelica sinensis, ligusticum wallichii, borneol and menthol. The adjuvant A is prepared from the following raw materials: rhizoma cyperi, radix angelicae, ground beetle and radix puerariae; the adjuvant B is prepared from the following raw materials: flos carthami and rhizoma zingiberis. The traditional Chinese medicine plaster and the traditional Chinese medicine patch are prepared to achieve Chinese and western combined treatment, the traditional Chinese medicine ingredients are subpackaged according to the medicine effect, the traditional Chinese medicine ingredients can be used by different patients in different proportions, and the problems that an existing external application preparation is single in medicine effect, cannot be matched with different patients for ingredient matching application, cannot achieve Chinese and western combined application and the like are solved.

The invention belongs to the technical field of biomedical materials, and particularly relates to in-situ drug-loading hydrogel based on a nano-bottle packaging technology and a preparation method and application thereof.The in-situ drug-loading hydrogel is formed by crosslinking copper chloride encapsulated in a drug-loading polydopamine nano-bottle and reduced thiourea group grafted hyaluronic acid under irradiation of near-infrared light; the diclofenac sodium is dispersed in the periphery and pores of the in-situ drug-loading hydrogel; and Kartogenin is encapsulated in the drug-loaded polydopamine nano bottle. Compared with the prior art, in-situ gelation and medicine time sequence controllable release are realized by adopting a nano bottle packaging technology, and the problems that ex-situ hydrogel cannot be attached to irregular tissues and the in-situ hydrogel is difficult to have the medicine time sequence controllable release capability at the same time are solved. According to the scheme, the hydrogel is perfectly attached to an articular cavity through controllable in-situ gelation so as to protect the joint; meanwhile, the effects of quickly releasing diclofenac sodium and continuously releasing Kartogenin can be realized, so that the phased treatment of osteoarthritis is realized.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick release layer, a slow release layer and an enteric coating layer, the quick release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricating agent and 1-5 parts of an adhesive; the sustained release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of cross-linked chitosan, 1-3 parts of a lubricant and 1-5 parts of an adhesive; the enteric coating layer is prepared from the following components in parts by weight: 20 to 45 parts of enteric material and 5 to 15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet disclosed by the invention has excellent in-vitro accumulative release rate, relatively low hygroscopicity and relatively high stability and friability.

[Problem] To provide a pharmaceutical composition for external use, which comprises indomethacin, diclofenac sodium, biphenylacetic acid, a salicylic acid, or a heparin, and which alleviates irritation to a site to which the pharmaceutical composition is applied. [Solution] A pharmaceutical composition for external use, which is a composition that mitigates irritation to an application site, and which contains: one or more components (A) selected from the group consisting of the following components (A-1)-(A-5), and (B) one or more components (B) selected from the group consisting of the following components (A-1)-(A-5), the component (B) being one or more selected from the group consisting of the following components (A-1)-(A-5); component (A-1): indomethacin component (A-2): diclofenac sodium component (A-3): biphenylacetic acid component (A-4): salicylic acid component (A-5): heparin analogue component (B): one or more substances selected from the group consisting of loxoprofen, salts thereof, and hydrates thereof.

The invention relates to preparation of a novel mitochondrial-targeting diclofenac sodium derivative and application of the novel mitochondrial-targeting diclofenac sodium derivative in an anti-tumor aspect. The structural formula of the compound is shown in the specification. Rat foot swelling experiments show that the swelling inhibition effect of the compound 1a is better than that of a parent compound DCF, and the anti-inflammatory effect is not weakened under modification. Meanwhile, an in-vitro anti-tumor activity screening result shows that the compound 1a shows more remarkable inhibitory activity on human colon cancer (HT-29), human brain glioma (U87) and human gastric cancer (803) than DCF. In HT-29 cells, the cytotoxic activity of the compound 1a is the highest, and the IC50 of the compound 1a is 53.12 [mu] M, which is significantly superior to 246.20 [mu] M of DCF. In order to determine the intracellular localization of the compound 1a, after co-incubation of the compound 1a and HT-29 cells, Mito Tracker is used for dyeing, observation is carried out through a confocal microscope, and the result shows that the blue fluorescence of the compound 1a highly coincides with the red fluorescence of the Mito Tracker, which indicates that the 1a is mainly localized in mitochondria. Protein immunoblotting results show that the compound 1a dose-dependently up-regulates acetylation of SOD2 K68 and K122, and down-regulates SOD2 protein expression. Therefore, the mitochondria-targeted diclofenac sodium derivative is expected to be developed into a novel anti-tumor drug with anti-inflammatory activity. # imgabs0 #