58 results about "Sodium Diclofenac" patented technology

The invention relates to the field of pharmaceutical preparations, in particular to a diclofenac sodium sustained release tablet and a preparation method thereof. The diclofenac sodium sustained release tablet is prepared from the following components: diclofenac sodium, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, mannitol, organic acid salt, a flow aid and a lubricant. The diclofenac sodium sustained-release tablet provided by the invention can be stably released, has an excellent sustained-release effect, and is simple in preparation process, low in cost and suitable for industrial mass production.

The invention belongs to the technical field of medicine, and provides an external pharmaceutical composition for waist training injury pain and a patch thereof, the external pharmaceutical composition is prepared from scutellaria baicalensis, angelica sinensis, poria cocos, salvia miltiorrhiza, radix angelicae pubescentis, golden cypress, ligusticum wallichii, frankincense, garden balsam stem, safflower, galangal, liquorice and diclofenac sodium. According to the external medicine composition, the medicines generate a mutual synergistic effect in a manner of combined application of traditional Chinese medicines and western medicines, so that the purpose of enhancing the medicine effect is achieved, and the analgesic effect is remarkable. The combined action of Chinese and western medicines alleviates the side effect of pure western medicines and improves the problem of unstable curative effect of pure traditional Chinese medicines. The external medicine composition is high in safety, free of stimulation, exact in curative effect, free of pain in treatment, high in clinical cure rate and easy to accept by patients after being used for a long time.

The invention relates to the field of preparation of traditional Chinese medicinal liquor, and particularly discloses medicinal liquor for rapidly relieving arthralgia and myalgia and traumatic injury and a preparation method thereof. The medicinal liquor is prepared from various traditional Chinese medicine raw materials such as radix clematidis, radix aconiti and radix aconiti agrestis, active ingredients such as panax notoginseng saponins and curcumin, and white spirit of 50-60 degrees. The preparation method comprises the steps of traditional Chinese medicine crushing, ultrasonic-assisted extraction, dynamic counter-current extraction, high-speed shearing emulsification, nitrogen filling and the like, wherein the ultrasonic extraction and dynamic counter-current extraction technologies improve the extraction efficiency of effective components. The medicinal liquor is particularly suitable for treating distension (including hyperosteogeny type and soft tissue hyperplasia type), muscle stiffness caused by wind-cold damp evil, I-II grade traumatic injury and pain symptoms caused by lumbar intervertebral disc protrusion. In addition, the medicinal liquor can also be combined with diclofenac sodium for internal and external treatment, and has a remarkable curative effect.

The invention relates to a quality detection method of diclofenac sodium lidocaine hydrochloride injection, and belongs to the field of medicine detection. The invention provides a quality detection method of a diclofenac sodium lidocaine hydrochloride injection. According to the method, a large amount of screening development is carried out on the basis of a legal standard, the specificity of known impurities is investigated, the specificity of unknown impurities is investigated, and the related substances in the diclofenac sodium lidocaine hydrochloride injection are accurately and exclusively detected; a reasonable and scientific detection method is provided for release of diclofenac sodium lidocaine hydrochloride injection manufacturers, a practical basis is provided for improvement of quality standards of related substances of the diclofenac sodium lidocaine hydrochloride injection, and a guarantee is provided for clinical medication safety. The method is low in detection efficiency, specificity, operability and detection cost, and the quality control is obviously superior to that of currently reported literature methods and legal standards.

The present invention belongs to the field of biomedicine and relates to a preparation method of a pH-responsive dual-release hydrogel for promoting diabetic wound healing. The method comprises the following steps: (1) preparing oxidized sodium alginate; (2) preparing astilbin liposomes; (3) preparing oxidized sodium alginate solution with distilled water, adding astilbin liposomes to obtain OSA@AL solution; dissolving carboxymethylated chitosan and diclofenac sodium in distilled water to prepare CMCS@DS solution; mixing the above two solutions in equal volumes, and preparing ALD hydrogel through Schiff base reaction. The hydrogel releases DS (diclofenac sodium) in the early stage of wound formation and slowly releases AL (astilbin liposomes) in the middle stage of wound formation. By loading DS and AL in different regions of the hydrogel and utilizing its pH-responsive characteristics, the spatiotemporal controlled release of the drug is achieved, so that the hydrogel can play a role in the four stages of wound healing (hemostasis, inflammatory response, proliferation and tissue remodeling), thereby accelerating diabetic wound healing.

The invention discloses a composite flocculant and a preparation method and application thereof, and relates to the technical field of flocculants.The preparation method of the composite flocculant comprises the following steps that S1, titanium dioxide nanoparticles are dispersed in a mixed solvent, then aminopropyltriethoxysilane is added for surface modification, and dispersion liquid is obtained; s2, sequentially adding polydopamine and chitosan into the dispersion liquid prepared in S1 under a heating condition, and continuously stirring to prepare a composite material through a Schiff base reaction; s3, centrifuging, washing and drying the composite material prepared in S2 to obtain a composite flocculant; the invention also provides the composite flocculant prepared by the method and application of the composite flocculant in treatment of sewage containing diclofenac sodium.

The invention relates to the technical field of biological medicines, in particular to pH-responsive hydrogel as well as a preparation method and application thereof. The hydrogel is prepared from the following raw materials: a modified chitosan aqueous solution, a modified polyethylene glycol aqueous solution, a polyvinyl alcohol aqueous solution and dopamine hydrochloride. The hydrogel is prepared by compounding a methacrylic anhydride modified chitosan aqueous solution, an aldehyde-terminated polyethylene glycol aqueous solution, a polyvinyl alcohol aqueous solution and dopamine hydrochloride, and the hydrogel with the pH response characteristic can be prepared and has reliable mechanical supporting strength; and the drug-resistant drugs (such as diclofenac sodium) can be effectively adsorbed, and a slow release effect is generated, so that the treatment of IVD is fundamentally realized.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

A medicated eyelid cleansing composition comprising a medicated scrub composition and an eyelid cleansing composition. The medicated scrub composition has one or more antibacterial and anti-inflammatory agents, including azithromycin and diclofenac sodium or dexamethasone phosphate. The medicated scrub composition can further include a combination of metronidazole and ivermectin. The composition is optimized for physiological compatibility and can be combined with a suitable substrate for use as a medicated eyelid cleanser.

The present invention relates to the technical field of non-steroidal drug sustained-release, and specifically discloses a diclofenac sodium sustained-release tablet, including: a core material and a coating layer wrapped on the surface of the core material; the core material raw materials include by mass: 80-120 parts of diclofenac sodium, 10-30 parts of colloidal silicon dioxide, 80-120 parts of sucrose, 8-36 parts of polyvidone K301, 31-63 parts of a blocker, and 1-3 parts of a lubricant; the coating layer is obtained by spraying a coating liquid on the surface of the core material and then drying; the raw materials of the coating liquid include by mass: 1-3 parts of nano silicon dioxide, 0.01-0.1 parts of a silane coupling agent, 4-10 parts of acrylic acid, 1-4 parts of butyl acrylate, 0.1-1 parts of an initiator, 1-2 parts of a plasticizer, 5-10 parts of an anti-adhesive agent, and 1-3 parts of calcium lactate. The present invention discloses a preparation method of the above-mentioned diclofenac sodium sustained-release tablet.

The application provides a drug-loaded acupuncture needle and a preparation method and application thereof, and belongs to the technical field of combination of traditional Chinese medicine and western medicine. The preparation method of the drug-loaded acupuncture needle comprises the following steps: after the surface of the acupuncture needle is modified by silanization, the acupuncture needle is repeatedly soaked in sodium polystyrene sulfonate solution and polyallyl ammonium chloride solution in sequence, a high-molecular drug-loaded film is formed on the surface of the acupuncture needle, and the acupuncture needle is loaded with target drugs in a diclofenac sodium solution, so that the drug-loaded acupuncture needle is obtained. The acupuncture needle is combined with drugs, so that the same-acupoint drug administration can be realized. On one hand, the acupoint is mechanically stimulated, and the internal regulation of the body is exerted; on the other hand, the drug efficacy is exerted. The acupoint stimulation and drug treatment play the same effect and are complementary to each other. Animal experiment results show that the acupuncture needle and the diclofenac sodium in the drug-loaded acupuncture needle have a synergistic effect, and the acupuncture-needle-drug combination treatment mode has obvious effects on the treatment of rheumatoid arthritis.

The present invention belongs to the field of eye drops. In view of the problem that the existing diclofenac sodium ophthalmic preparations have poor efficacy and strong irritation on corneal neovascularization, the present invention provides a method for preparing diclofenac sodium eye drops. First, under ice bath conditions, a diclofenac solution is added to a ferrous sulfate solution. Subsequently, proanthocyanidins are coordinated with ferrous sulfate and diclofenac sodium to obtain an iron-based proanthocyanidin-diclofenac sodium nanozyme. The present invention obtains an iron-based proanthocyanidin-diclofenac sodium nanozyme by coordinating proanthocyanidins, ferrous sulfate and diclofenac sodium. The nanozyme is used for eye drops, which improves the inhibitory effect of diclofenac eye drops on corneal neovascularization, and can improve corneal sensitivity and maintain normal intraocular pressure.

According to the method for detecting the nitrosamine impurity in the diclofenac sodium preparation, disclosed by the invention, the N-nitroso-diclofenac impurity in the diclofenac sodium preparation can be quantitatively and efficiently detected, and auxiliary materials in the diclofenac sodium preparation can be effectively separated from the N-nitroso-diclofenac impurity through limited chromatographic conditions; the separation degree between the N-nitroso-diclofenac and adjacent impurities reaches 1.5 or above, and effective monitoring on the N-nitroso-diclofenac impurities is realized. The sensitivity is high, and N-nitroso-diclofenac impurities with the concentration equivalent to 0.96 ppm of a test sample can be detected.

The invention discloses an external diclofenac sodium solution composition which comprises a component A and a component B. The component A comprises the following raw materials in parts by weight: 0.1-0.3 part of nonionic cellulose ether and 40-60 parts of purified water; the component B is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of diclofenac sodium, 40 to 50 parts of ethanol, 4.5 to 5.5 parts of diisopropyl adipate, 0.05 to 0.15 part of epigallocatechin gallate and 0.04 to 0.06 part of lactic acid; the sum of the parts by weight of the component A and the component B is 100. The diclofenac sodium external solution composition disclosed by the invention contains epigallocatechin gallate for inhibiting growth and reproduction of various pathogenic bacteria at wounds and promoting wound healing, and also has an anti-oxidation effect, so that the stability of a preparation is improved.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a diclofenac sodium sustained release tablet and a preparation method thereof. The diclofenac sodium sustained-release tablet is prepared from diclofenac sodium, an ellagic acid-shellac-chitosan sustained-release material, a filling agent, a lubricating agent and an adhesive. According to the invention, a sustained-release material is prepared through solution preparation, film formation and post-treatment, and then the sustained-release tablet is prepared by adopting a wet granulation and tabletting method. Experiments show that the diclofenac sodium sustained-release tablet is good in stability, the content of diclofenac sodium basically remains unchanged after 6 months of an acceleration test, the sustained-release effect is ideal, the effective concentration maintaining time of a medicine in a body can be effectively prolonged, the medicine taking frequency is reduced, and the diclofenac sodium sustained-release tablet has good process feasibility and industrial production prospects.

The invention belongs to the technical field of non-steroidal anti-inflammatory drug preparations, and particularly relates to a high-permeability diclofenac sodium liniment and a preparation method thereof. The high-permeability diclofenac sodium liniment disclosed by the invention is prepared from diclofenac sodium, alanine, nonadienol, ethanol, glycerol, a pH (Potential of Hydrogen) regulator and water. In order to solve the problems of insufficient skin permeability and low safety of diclofenac sodium liniment in the prior art, the formula and the preparation method are optimized. Research finds that nonadienol-beta-alanine-glycerol is used as a novel permeation enhancing carrier, and can effectively promote the absorption of diclofenac sodium. The carrier improves the permeability of the medicine by improving the distribution of the medicine in the skin layer, so that the local curative effect of the medicine is enhanced.

The invention relates to a slow-release medical plaster based on diclofenac, in particular a medical plaster based on diclofenac sodium salt, the formulation of which allows the release of the active ingredient continuously and at locally therapeutically active concentrations for 24 hours, as well as an adhesive polymeric matrix (PSA) for use in a medical plaster based on diclofenac sodium salt.

The invention relates to Chinese and western patent medicines, in particular to a Chinese and western medicine composition for treating stubborn arthralgia. The traditional Chinese medicine composition is prepared from the following five traditional Chinese and western medicines: aconitum pendulum, semen strychni, VB1, diclofenac sodium and dexamethasone, still takes the traditional Chinese medicines as a mother agent and the western medicines as an auxiliary agent, has the characteristics of activating meridians to stop pain, removing stasis to subdue swelling and treating rheumatism and obstinate arthralgia, numbness and paralysis and traumatic injury, and has the characteristics of special medicine, strong effect, quick effect and no toxic or side effect.

The invention discloses a Jinhuang powder external application paste and application thereof in preparation of drugs for treating gonitis synovitis, the external application paste is prepared from ten traditional Chinese medicines including turmeric, rheum officinale, golden cypress, radix angelicae, rhizoma arisaematis, pericarpium citri reticulatae, rhizoma atractylodis, mangnolia officinalis, liquorice and radices trichosanthis, honey, edible vegetable oil, paraffin oil and water through a specific emulsification process, the pH value is 6.0-7.0, and the viscosity is 3000-5000 mPa.s; standard random control clinical tests prove that the total effective rate of the external application ointment for treating gonarthromeningitis reaches 99.04%, the Lyshilm score is improved by 30.2 score, the VAS score is reduced by 5.39 score and is greatly superior to that of a diclofenac sodium control group, the adverse reaction occurrence rate is only 3.85%, the levels of serum TNF-alpha, IL-1beta and IL-6 and the synovial thickness can be greatly reduced, and the external application ointment has a good clinical application prospect. The method is suitable for K-L grading I-II and postoperative rehabilitation patients.

The invention belongs to the technical field of medical gel emplastrum, and particularly relates to a compound arnica flower-diclofenac sodium gel emplastrum, a preparation method thereof and application of the compound arnica flower-diclofenac sodium gel emplastrum in treatment of rheumatoid arthritis. The plaster comprises a backing layer, a plaster body layer and a protective layer, the plaster body layer is composed of drugs, a transdermal enhancer and a matrix, the matrix comprises a framework material, a cross-linking agent, a filler, a tackifier, a humectant, a cross-linking regulator and water, and the drugs comprise arnica tincture and diclofenac sodium. The invention discloses a preparation method of the compound arnica flower-diclofenac sodium gel emplastrum and provides application of the compound arnica flower-diclofenac sodium gel emplastrum in treating rheumatoid arthritis, and the prepared compound arnica flower-diclofenac sodium gel emplastrum has strong analgesic and anti-inflammatory effects and can be used for treating rheumatoid arthritis.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

The invention discloses a ZnS / ZnO nano photocatalyst, concrete containing the ZnS / ZnO nano photocatalyst and application of the ZnS / ZnO nano photocatalyst. The ZnS / ZnO nano photocatalyst is constructed by performing high-temperature calcination on ZnS in air; the method is applied to concrete. The nano photocatalyst designed by the invention not only has excellent photocatalytic performance, but also is simpler and more efficient in preparation method, and pervious concrete with excellent photocatalytic performance can be prepared within a shorter time; meanwhile, the adopted ZnS / ZnO nano photocatalytic material is low in price and environment-friendly, has better capability of degrading an anti-inflammatory drug pollutant diclofenac sodium, has excellent sunlight activity and pollutant removal capability after being used for the pervious concrete, is particularly suitable for the field of sponge cities, effectively reduces refractory organic pollutants in rainwater runoff, and has a good application prospect. The method is of great significance to improvement of urban water environment.

The invention relates to the field of medicine detection, in particular to a method for detecting related substances of diclofenac sodium and chlorpheniramine maleate in a lofenac tablet. According to the method, impurities of diclofenac sodium and chlorpheniramine maleate in the lofenac sodium and chlorpheniramine maleate tablet are detected through high performance liquid chromatography (HPLC), the method for detecting related substances in the lofenac sodium and chlorpheniramine maleate tablet can conduct integrated quality control on a compound preparation, the method is better in separation efficiency, higher in sensitivity and higher in durability, and the method is suitable for large-scale popularization and application. The method can ensure that all known impurities are completely separated and accurately quantified, and has enough detection capability on unknown impurities, thereby providing more reliable technical support for ensuring the safety, effectiveness and quality consistency of the medicine.

The invention belongs to the technical field of pharmaceutical preparation analysis and detection, and particularly relates to a determination method of a dissolution curve of diclofenac sodium sustained release tablets. According to the method, a sample dissolution method is optimized, and a reciprocating cylinder method is used for dissolving out the sample, so that the determination method is not influenced by the release speed of the diclofenac sodium sustained release tablet in an acid medium and the degradation degree of the released raw material medicine, the in-vivo release environment of the medicine is better simulated, the accuracy is high, the reliability and the repeatability are good, and the method is suitable for industrial production. The method can be used for judging whether a self-made preparation of a BE test is equivalent to a reference or not, and the method for determining the dissolution curve established by the invention can provide guidance for the process research of a preparation prescription required by the declaration of a generic drug.

This invention belongs to the field of biomedical materials technology, specifically relating to an in-situ drug-loaded hydrogel based on nanobottle encapsulation technology, its preparation method, and its application. The in-situ drug-loaded hydrogel is formed by cross-linking copper chloride and reduced thiourea groups grafted onto hyaluronic acid within drug-loaded polydopamine nanobottles under near-infrared light irradiation. Diclofenac sodium is dispersed on the periphery and within the pores of the in-situ drug-loaded hydrogel; Kartogenin is encapsulated within the drug-loaded polydopamine nanobottles. Compared with existing technologies, this invention utilizes nanobottle encapsulation technology to achieve in-situ gelation and time-controlled drug release, solving the problems of non-in-situ hydrogels failing to adhere to irregular tissues and in-situ hydrogels struggling to simultaneously possess controllable time-controlled drug release capabilities. This solution achieves perfect adhesion of the hydrogel to the joint cavity through controllable in-situ gelation to protect the joint; simultaneously, it enables rapid release of diclofenac sodium and sustained release of Kartogenin, thereby achieving staged treatment of osteoarthritis.

The present invention provides a preparation method of a diclofenac sodium intermediate, belonging to the field of diclofenac sodium. The preparation method of the diclofenac sodium intermediate, using indigo carmine as a starting material, through a primary reaction step and a secondary reaction step, obtains diclofenac sodium intermediate 1-(2,6-dichlorophenyl)-1,3-indolin-2-one. The preparation method of the diclofenac sodium intermediate of the present invention, without the need to use traditional process routes and anhydrous aluminum chloride as reaction reagents, can prepare diclofenac sodium intermediate 1-(2,6-dichlorophenyl)-1,3-indolin-2-one by conventional commercially available raw materials, high reaction efficiency, high intermediate product yield and purity, mild reaction conditions, low impact on production equipment and working environment, conducive to industrial scale production.

The invention relates to a powder mixing device and method for a diclofenac sodium enteric-coated tablet preparation process. The powder mixing device for the diclofenac sodium enteric-coated tablet preparation process comprises an outer cylinder, a powder mixing device and a powder mixing device, the top of the outer cylinder is provided with a feed hopper, and the bottom of the outer cylinder is provided with a plurality of discharge ports; the inner cylinder is arranged on the inner side of the outer cylinder, a rotating shaft is arranged in the middle of the inner cylinder, and the rotating shaft is connected with a cylinder body of the inner cylinder; the driving device is connected with the rotating shaft; the upper end of the circulating pipe is connected with the feeding hopper of the outer cylinder, and the lower end of the circulating pipe is connected with the discharging opening of the outer cylinder; and at least one vacuum pump, wherein each vacuum pump is connected with one circulating pipe. Compared with the prior art, the fluidity of powder can be improved, and the powder can be mixed more uniformly.

The invention discloses a method for determining related substances in diclofenac sodium gel, which comprises the following steps: (1) preparing: preparing a test solution, a contrast solution, a system applicability solution and a sensitivity solution by taking methanol as a solvent; (2) determination: determining the content of diclofenac sodium and related substances in the diclofenac sodium gel by adopting a high performance liquid chromatography, and respectively feeding a test solution, a contrast solution, a system applicability solution and a sensitivity solution; chromatographic conditions are as follows: a chromatographic column takes octadecylsilane chemically bonded silica as a filler, the column temperature is 25-45 DEG C, the detection wavelength is 254 nm, the feeding amount is 10 [mu] L, the flow velocity is 0.8-1.2 mL / min, a glacial acetic acid solution is taken as a mobile phase A, and methanol is taken as a mobile phase B for gradient elution. The method solves the technical problems of precipitation after preparation of the test solution, poor impurity peak separation degree, detection interference by the chromatographic peak of the bacteriostatic agent, impurity peak cracking and the like.

The invention relates to the technical field of medicinal preparations, and provides a diclofenac sodium medicinal preparation as well as a preparation method and application thereof. The diclofenac sodium pharmaceutical preparation is prepared from the following components in parts by weight: 1 to 10 parts of diclofenac sodium, 5 to 10 parts of cationic lipid, 1 to 5 parts of PEGylated lipid and 0.1 to 5 parts of a surfactant. The active component diclofenac sodium in the pharmaceutical preparation is delivered through liposome, so that the preparation is endowed with a better transdermal absorption effect; meanwhile, an excellent controlled release effect is achieved, so that the blood concentration is more stable, and the liposome microcapsule is encapsulated, so that the stimulation to the stomach and intestine is effectively reduced, and the compliance of a patient can be effectively improved; the pharmaceutical preparation not only can be prepared into an external transdermal patch, but also can be prepared into an oral controlled-release preparation, and is wide in application.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a full-continuous chemical synthesis method of diclofenac sodium. According to the method, aniline and chloroacetyl chloride are taken as starting raw materials, a fully continuous device consisting of a plurality of micro-mixers, micro-reactors, online solvent recovery equipment and the like which are sequentially communicated and are subjected to improved design is adopted, a high-purity (the purity is greater than 98.5%) diclofenac sodium product is synthesized through six-step chemical reaction and continuous operation, the recovery and reuse of the solvent are realized, and the method is suitable for industrial production. The problems of hydrochloride blockage and the like are solved, and three-waste discharge is obviously reduced. And through continuous synthesis, the production efficiency and the process control accuracy are greatly improved, and the stable product quality is ensured. In addition, the use amount of aluminum trichloride is reduced by more than 30%, the material loss caused by solvent switching is effectively reduced, and the production cost is reduced.