This invention relates to the field of medical devices, specifically to a patch application, its preparation method, and its application. The patch comprises an immediate-release layer, a cross-linking layer, and a sustained-release layer; the cross-linking layer is placed between the immediate-release and sustained-release
layers, with the immediate-release layer in contact with the
skin; the immediate-release layer comprises a first
microsphere, which has a
polyvinyl alcohol coating and an
ibuprofen core; the cross-linking layer is a
calcium ion cross-linked membrane obtained by cross-linking
sodium alginate and
calcium chloride; the sustained-release layer comprises a second
microsphere, which has a
polylactic acid-
glycolic acid copolymer coating and a
diclofenac sodium core. The patch application provided by this invention can rapidly reduce
inflammation and pain through the anti-inflammatory and
analgesic microspheres and maintain the
surgical patch for a certain period of time, while also providing local physical cooling. Compared with traditional patches, it alleviates
postoperative pain to a certain extent and accelerates
wound healing.