44 results about "Sodium Diclofenac" patented technology

The invention relates to the field of preparation of traditional Chinese medicinal liquor, and particularly discloses medicinal liquor for rapidly relieving arthralgia and myalgia and traumatic injury and a preparation method thereof. The medicinal liquor is prepared from various traditional Chinese medicine raw materials such as radix clematidis, radix aconiti and radix aconiti agrestis, active ingredients such as panax notoginseng saponins and curcumin, and white spirit of 50-60 degrees. The preparation method comprises the steps of traditional Chinese medicine crushing, ultrasonic-assisted extraction, dynamic counter-current extraction, high-speed shearing emulsification, nitrogen filling and the like, wherein the ultrasonic extraction and dynamic counter-current extraction technologies improve the extraction efficiency of effective components. The medicinal liquor is particularly suitable for treating distension (including hyperosteogeny type and soft tissue hyperplasia type), muscle stiffness caused by wind-cold damp evil, I-II grade traumatic injury and pain symptoms caused by lumbar intervertebral disc protrusion. In addition, the medicinal liquor can also be combined with diclofenac sodium for internal and external treatment, and has a remarkable curative effect.

The invention discloses a composite flocculant and a preparation method and application thereof, and relates to the technical field of flocculants.The preparation method of the composite flocculant comprises the following steps that S1, titanium dioxide nanoparticles are dispersed in a mixed solvent, then aminopropyltriethoxysilane is added for surface modification, and dispersion liquid is obtained; s2, sequentially adding polydopamine and chitosan into the dispersion liquid prepared in S1 under a heating condition, and continuously stirring to prepare a composite material through a Schiff base reaction; s3, centrifuging, washing and drying the composite material prepared in S2 to obtain a composite flocculant; the invention also provides the composite flocculant prepared by the method and application of the composite flocculant in treatment of sewage containing diclofenac sodium.

The invention relates to the technical field of biological medicines, in particular to pH-responsive hydrogel as well as a preparation method and application thereof. The hydrogel is prepared from the following raw materials: a modified chitosan aqueous solution, a modified polyethylene glycol aqueous solution, a polyvinyl alcohol aqueous solution and dopamine hydrochloride. The hydrogel is prepared by compounding a methacrylic anhydride modified chitosan aqueous solution, an aldehyde-terminated polyethylene glycol aqueous solution, a polyvinyl alcohol aqueous solution and dopamine hydrochloride, and the hydrogel with the pH response characteristic can be prepared and has reliable mechanical supporting strength; and the drug-resistant drugs (such as diclofenac sodium) can be effectively adsorbed, and a slow release effect is generated, so that the treatment of IVD is fundamentally realized.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

A medicated eyelid cleansing composition comprising a medicated scrub composition and an eyelid cleansing composition. The medicated scrub composition has one or more antibacterial and anti-inflammatory agents, including azithromycin and diclofenac sodium or dexamethasone phosphate. The medicated scrub composition can further include a combination of metronidazole and ivermectin. The composition is optimized for physiological compatibility and can be combined with a suitable substrate for use as a medicated eyelid cleanser.

The application provides a drug-loaded acupuncture needle and a preparation method and application thereof, and belongs to the technical field of combination of traditional Chinese medicine and western medicine. The preparation method of the drug-loaded acupuncture needle comprises the following steps: after the surface of the acupuncture needle is modified by silanization, the acupuncture needle is repeatedly soaked in sodium polystyrene sulfonate solution and polyallyl ammonium chloride solution in sequence, a high-molecular drug-loaded film is formed on the surface of the acupuncture needle, and the acupuncture needle is loaded with target drugs in a diclofenac sodium solution, so that the drug-loaded acupuncture needle is obtained. The acupuncture needle is combined with drugs, so that the same-acupoint drug administration can be realized. On one hand, the acupoint is mechanically stimulated, and the internal regulation of the body is exerted; on the other hand, the drug efficacy is exerted. The acupoint stimulation and drug treatment play the same effect and are complementary to each other. Animal experiment results show that the acupuncture needle and the diclofenac sodium in the drug-loaded acupuncture needle have a synergistic effect, and the acupuncture-needle-drug combination treatment mode has obvious effects on the treatment of rheumatoid arthritis.

According to the method for detecting the nitrosamine impurity in the diclofenac sodium preparation, disclosed by the invention, the N-nitroso-diclofenac impurity in the diclofenac sodium preparation can be quantitatively and efficiently detected, and auxiliary materials in the diclofenac sodium preparation can be effectively separated from the N-nitroso-diclofenac impurity through limited chromatographic conditions; the separation degree between the N-nitroso-diclofenac and adjacent impurities reaches 1.5 or above, and effective monitoring on the N-nitroso-diclofenac impurities is realized. The sensitivity is high, and N-nitroso-diclofenac impurities with the concentration equivalent to 0.96 ppm of a test sample can be detected.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a diclofenac sodium sustained release tablet and a preparation method thereof. The diclofenac sodium sustained-release tablet is prepared from diclofenac sodium, an ellagic acid-shellac-chitosan sustained-release material, a filling agent, a lubricating agent and an adhesive. According to the invention, a sustained-release material is prepared through solution preparation, film formation and post-treatment, and then the sustained-release tablet is prepared by adopting a wet granulation and tabletting method. Experiments show that the diclofenac sodium sustained-release tablet is good in stability, the content of diclofenac sodium basically remains unchanged after 6 months of an acceleration test, the sustained-release effect is ideal, the effective concentration maintaining time of a medicine in a body can be effectively prolonged, the medicine taking frequency is reduced, and the diclofenac sodium sustained-release tablet has good process feasibility and industrial production prospects.

The invention relates to a slow-release medical plaster based on diclofenac, in particular a medical plaster based on diclofenac sodium salt, the formulation of which allows the release of the active ingredient continuously and at locally therapeutically active concentrations for 24 hours, as well as an adhesive polymeric matrix (PSA) for use in a medical plaster based on diclofenac sodium salt.

The invention discloses a Jinhuang powder external application paste and application thereof in preparation of drugs for treating gonitis synovitis, the external application paste is prepared from ten traditional Chinese medicines including turmeric, rheum officinale, golden cypress, radix angelicae, rhizoma arisaematis, pericarpium citri reticulatae, rhizoma atractylodis, mangnolia officinalis, liquorice and radices trichosanthis, honey, edible vegetable oil, paraffin oil and water through a specific emulsification process, the pH value is 6.0-7.0, and the viscosity is 3000-5000 mPa.s; standard random control clinical tests prove that the total effective rate of the external application ointment for treating gonarthromeningitis reaches 99.04%, the Lyshilm score is improved by 30.2 score, the VAS score is reduced by 5.39 score and is greatly superior to that of a diclofenac sodium control group, the adverse reaction occurrence rate is only 3.85%, the levels of serum TNF-alpha, IL-1beta and IL-6 and the synovial thickness can be greatly reduced, and the external application ointment has a good clinical application prospect. The method is suitable for K-L grading I-II and postoperative rehabilitation patients.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

The invention discloses a ZnS / ZnO nano photocatalyst, concrete containing the ZnS / ZnO nano photocatalyst and application of the ZnS / ZnO nano photocatalyst. The ZnS / ZnO nano photocatalyst is constructed by performing high-temperature calcination on ZnS in air; the method is applied to concrete. The nano photocatalyst designed by the invention not only has excellent photocatalytic performance, but also is simpler and more efficient in preparation method, and pervious concrete with excellent photocatalytic performance can be prepared within a shorter time; meanwhile, the adopted ZnS / ZnO nano photocatalytic material is low in price and environment-friendly, has better capability of degrading an anti-inflammatory drug pollutant diclofenac sodium, has excellent sunlight activity and pollutant removal capability after being used for the pervious concrete, is particularly suitable for the field of sponge cities, effectively reduces refractory organic pollutants in rainwater runoff, and has a good application prospect. The method is of great significance to improvement of urban water environment.

The invention relates to the field of medicine detection, in particular to a method for detecting related substances of diclofenac sodium and chlorpheniramine maleate in a lofenac tablet. According to the method, impurities of diclofenac sodium and chlorpheniramine maleate in the lofenac sodium and chlorpheniramine maleate tablet are detected through high performance liquid chromatography (HPLC), the method for detecting related substances in the lofenac sodium and chlorpheniramine maleate tablet can conduct integrated quality control on a compound preparation, the method is better in separation efficiency, higher in sensitivity and higher in durability, and the method is suitable for large-scale popularization and application. The method can ensure that all known impurities are completely separated and accurately quantified, and has enough detection capability on unknown impurities, thereby providing more reliable technical support for ensuring the safety, effectiveness and quality consistency of the medicine.

The invention belongs to the technical field of pharmaceutical preparation analysis and detection, and particularly relates to a determination method of a dissolution curve of diclofenac sodium sustained release tablets. According to the method, a sample dissolution method is optimized, and a reciprocating cylinder method is used for dissolving out the sample, so that the determination method is not influenced by the release speed of the diclofenac sodium sustained release tablet in an acid medium and the degradation degree of the released raw material medicine, the in-vivo release environment of the medicine is better simulated, the accuracy is high, the reliability and the repeatability are good, and the method is suitable for industrial production. The method can be used for judging whether a self-made preparation of a BE test is equivalent to a reference or not, and the method for determining the dissolution curve established by the invention can provide guidance for the process research of a preparation prescription required by the declaration of a generic drug.

This invention belongs to the field of biomedical materials technology, specifically relating to an in-situ drug-loaded hydrogel based on nanobottle encapsulation technology, its preparation method, and its application. The in-situ drug-loaded hydrogel is formed by cross-linking copper chloride and reduced thiourea groups grafted onto hyaluronic acid within drug-loaded polydopamine nanobottles under near-infrared light irradiation. Diclofenac sodium is dispersed on the periphery and within the pores of the in-situ drug-loaded hydrogel; Kartogenin is encapsulated within the drug-loaded polydopamine nanobottles. Compared with existing technologies, this invention utilizes nanobottle encapsulation technology to achieve in-situ gelation and time-controlled drug release, solving the problems of non-in-situ hydrogels failing to adhere to irregular tissues and in-situ hydrogels struggling to simultaneously possess controllable time-controlled drug release capabilities. This solution achieves perfect adhesion of the hydrogel to the joint cavity through controllable in-situ gelation to protect the joint; simultaneously, it enables rapid release of diclofenac sodium and sustained release of Kartogenin, thereby achieving staged treatment of osteoarthritis.

The invention relates to a powder mixing device and method for a diclofenac sodium enteric-coated tablet preparation process. The powder mixing device for the diclofenac sodium enteric-coated tablet preparation process comprises an outer cylinder, a powder mixing device and a powder mixing device, the top of the outer cylinder is provided with a feed hopper, and the bottom of the outer cylinder is provided with a plurality of discharge ports; the inner cylinder is arranged on the inner side of the outer cylinder, a rotating shaft is arranged in the middle of the inner cylinder, and the rotating shaft is connected with a cylinder body of the inner cylinder; the driving device is connected with the rotating shaft; the upper end of the circulating pipe is connected with the feeding hopper of the outer cylinder, and the lower end of the circulating pipe is connected with the discharging opening of the outer cylinder; and at least one vacuum pump, wherein each vacuum pump is connected with one circulating pipe. Compared with the prior art, the fluidity of powder can be improved, and the powder can be mixed more uniformly.

The invention discloses a method for determining related substances in diclofenac sodium gel, which comprises the following steps: (1) preparing: preparing a test solution, a contrast solution, a system applicability solution and a sensitivity solution by taking methanol as a solvent; (2) determination: determining the content of diclofenac sodium and related substances in the diclofenac sodium gel by adopting a high performance liquid chromatography, and respectively feeding a test solution, a contrast solution, a system applicability solution and a sensitivity solution; chromatographic conditions are as follows: a chromatographic column takes octadecylsilane chemically bonded silica as a filler, the column temperature is 25-45 DEG C, the detection wavelength is 254 nm, the feeding amount is 10 [mu] L, the flow velocity is 0.8-1.2 mL / min, a glacial acetic acid solution is taken as a mobile phase A, and methanol is taken as a mobile phase B for gradient elution. The method solves the technical problems of precipitation after preparation of the test solution, poor impurity peak separation degree, detection interference by the chromatographic peak of the bacteriostatic agent, impurity peak cracking and the like.

The invention relates to the technical field of medicinal preparations, and provides a diclofenac sodium medicinal preparation as well as a preparation method and application thereof. The diclofenac sodium pharmaceutical preparation is prepared from the following components in parts by weight: 1 to 10 parts of diclofenac sodium, 5 to 10 parts of cationic lipid, 1 to 5 parts of PEGylated lipid and 0.1 to 5 parts of a surfactant. The active component diclofenac sodium in the pharmaceutical preparation is delivered through liposome, so that the preparation is endowed with a better transdermal absorption effect; meanwhile, an excellent controlled release effect is achieved, so that the blood concentration is more stable, and the liposome microcapsule is encapsulated, so that the stimulation to the stomach and intestine is effectively reduced, and the compliance of a patient can be effectively improved; the pharmaceutical preparation not only can be prepared into an external transdermal patch, but also can be prepared into an oral controlled-release preparation, and is wide in application.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a full-continuous chemical synthesis method of diclofenac sodium. According to the method, aniline and chloroacetyl chloride are taken as starting raw materials, a fully continuous device consisting of a plurality of micro-mixers, micro-reactors, online solvent recovery equipment and the like which are sequentially communicated and are subjected to improved design is adopted, a high-purity (the purity is greater than 98.5%) diclofenac sodium product is synthesized through six-step chemical reaction and continuous operation, the recovery and reuse of the solvent are realized, and the method is suitable for industrial production. The problems of hydrochloride blockage and the like are solved, and three-waste discharge is obviously reduced. And through continuous synthesis, the production efficiency and the process control accuracy are greatly improved, and the stable product quality is ensured. In addition, the use amount of aluminum trichloride is reduced by more than 30%, the material loss caused by solvent switching is effectively reduced, and the production cost is reduced.

The invention relates to diquafosol sodium eye drops. Specifically, the invention provides the diquafosol sodium eye drops, and the diquafosol sodium eye drops comprise diquafosol sodium, propylene glycol, sorbitol, hydroxypropyl methylcellulose, glycine, sodium chloride, sodium dihydrogen phosphate and water. The diquafosol sodium eye drops disclosed by the invention have excellent illumination and high-temperature stability, so that excellent stability can be maintained in the transportation and storage processes, the transportation and storage cost is reduced, the quality safety of the diquafosol sodium eye drops is improved, and the diquafosol sodium eye drops are free of eye irritation and can be used for preparing eye drops. Therefore, the composition has excellent medication safety, and the eye administration compliance of a patient is high.

The invention discloses a triboelectric response DNA hydrogel dressing for promoting wound healing as well as a preparation method and application of the triboelectric response DNA hydrogel dressing. The hydrogel can simultaneously load a silver nano-cluster, VEGF and diclofenac sodium through a DNA three-way junction structure containing a cytosine ring, a DNA connecting chain containing a VEGF aptamer sequence and a cross-linked skeleton deposited by polypyrrole. The DNA hydrogel dressing prepared by the invention can realize on-demand administration by utilizing the triboelectric response characteristic, promotes healing of bacterial infected diabetic wounds, has the characteristics of good biocompatibility, excellent antibacterial property, high response speed, remarkable healing effect and the like, and is simple in preparation process, low in cost and easy for large-scale production. Therefore, the problems that an existing wound dressing is insufficient in antibacterial performance, poor in conductivity and low in healing efficiency are solved, the application of the wound dressing in chronic wound and diabetes wound treatment can be further expanded, and an important solution is provided for wound nursing and infection control.

The invention relates to the technical field of covalent organic framework materials and sample pretreatment, in particular to a cation covalent organic framework and a preparation method and application thereof.The preparation method of the cation covalent organic framework comprises the following steps that triaminoguanidine hydrochloride and 2, 6-dialdehyde-1, 5-dihydroxy naphthalene are dissolved in a reaction solvent, stirring is carried out, and the cation covalent organic framework is obtained; performing ultrasonic dispersion; vacuumizing the system after liquid nitrogen freezing, repeating for three times after unfreezing at room temperature, finally adding a catalyst, introducing nitrogen, and carrying out polymerization reaction, so as to obtain a dark brown precipitate. The prepared cation covalent organic framework has the advantages of being good in chemical stability, high in ion density, high in diclofenac sodium adsorption capacity and fast in adsorption kinetics, is far superior to a traditional adsorbent, is used as a dispersive solid-phase extraction adsorbent to be combined with HPLC-PDA to detect diclofenac sodium in food, and is simple in operation steps, short in extraction time and high in efficiency. The linear range is wide, the detection limit is low, and the accuracy and precision are high.

The invention discloses a diclofenac sodium sustained-release tablet and a preparation method thereof, the sustained-release tablet takes diclofenac sodium as an active ingredient, a waxy sustained-release framework material, a filler, an adhesive, a glidant, a lubricant and a coating material are supplemented, and 12-24 hours of stable release is realized by optimizing a hot melting granulation process; by expanding the selection range of auxiliary materials and simplifying the production steps, the product has good compressibility, hardness of 60-100N, friability of less than 0.6%, excellent dissolution performance, release of 25%-30% in one hour and release of more than or equal to 90% in 24 hours in a phosphate buffer solution with pH of 6.8, stability, acceleration of 6 months at 40 DEG C / 75% RH and long-term storage of 12 months at 25 DEG C / 60% RH, is consistent with in-vitro pharmaceutical characteristics of a control preparation, and is suitable for industrial production.

The present invention provides a patch for relieving lumbago, the patch comprising a backing and an adhesive layer laminated on the backing, wherein the adhesive layer comprises an adhesive base and 0.70 to 1.50 mg of diclofenac sodium per cm2 of application area, and the patch is used by applying the patch once a day to the chest region, the abdominal region, the dorsal region, the brachial region, or the femoral region of a human.

A method of compounding a topical cream includes combining ingredients including lidocaine hydrochloride, 4%, topical solution, diclofenac sodium, 1.5%, topical solution, lidocaine hydrochloride USP powder, and diclofenac sodium powder.

The invention discloses a diclofenac sodium transdermal microneedle patch for treating motor system diseases and a preparation method of the diclofenac sodium transdermal microneedle patch. The patch comprises a backing layer, a solid insoluble microneedle array and a drug coating positioned at the tip of a microneedle, the drug coating takes diclofenac sodium nanocrystals as an active ingredient and contains a stabilizer, a film-forming agent, a plasticizer and other auxiliaries, and the limitation that diclofenac sodium is difficult to dissolve in water and the transdermal permeability of an external preparation is insufficient is overcome by combining nanocrystallization treatment with a mixed solvent system of PEG400, propylene glycol and ethanol and a mild drying process. And the microneedle matrix has high mechanical strength and can be completely recovered after administration, so that the untoward effects of the whole body are reduced while pain and inflammation are relieved, and the stability and the safety of the preparation are improved.

The invention relates to a cell sugar and lipid metabolism regulation type drug-loaded linoleic acid lipid hybrid vesicle as well as a preparation method and application thereof, and the cell sugar and lipid metabolism regulation type drug-loaded linoleic acid lipid hybrid vesicle comprises a linoleic acid lipid hybrid vesicle, a sugar metabolism drug and a lipid metabolism drug, the glycometabolism drug and the lipid metabolism drug are loaded in the linoleic acid lipid hybrid vesicles; wherein the glycometabolism medicine is prepared from alkannin, tripterine, scutellarin or luteolin, and the lipid metabolism medicine is prepared from cinnamyl aldehyde, curcumin, myricetin, squalene or diclofenac sodium. The drug-loaded linoleic acid lipid hybrid vesicles prepared by the invention have uniform particle size and very stable structure and property, are naturally targeted to macrophages, can enhance the ability of host cells to remove intracellular bacteria, and have a remarkable effect on treatment of staphylococcus aureus and escherichia coli drug-resistant bacterial infection.

This invention relates to the field of medical devices, specifically to a patch application, its preparation method, and its application. The patch comprises an immediate-release layer, a cross-linking layer, and a sustained-release layer; the cross-linking layer is placed between the immediate-release and sustained-release layers, with the immediate-release layer in contact with the skin; the immediate-release layer comprises a first microsphere, which has a polyvinyl alcohol coating and an ibuprofen core; the cross-linking layer is a calcium ion cross-linked membrane obtained by cross-linking sodium alginate and calcium chloride; the sustained-release layer comprises a second microsphere, which has a polylactic acid-glycolic acid copolymer coating and a diclofenac sodium core. The patch application provided by this invention can rapidly reduce inflammation and pain through the anti-inflammatory and analgesic microspheres and maintain the surgical patch for a certain period of time, while also providing local physical cooling. Compared with traditional patches, it alleviates postoperative pain to a certain extent and accelerates wound healing.

The invention relates to the field of pharmaceutical preparations, in particular to a diclofenac sodium pellet and a preparation method thereof, and the diclofenac sodium pellet comprises a pellet core, a diclofenac sodium medicine layer and a coating layer from inside to outside; wherein the diclofenac sodium medicine layer comprises 35%-50% of diclofenac sodium, 15%-30% of microcrystalline cellulose, 0.2%-2% of PVP (Polyvinyl Pyrrolidone) and 0.2%-2% of colloidal silicon dioxide. According to the diclofenac sodium pellet disclosed by the invention, organic solvents such as isopropanol, ethanol and the like are abandoned in the preparation process, the formula is more environment-friendly, the process is simpler, and more importantly, the technical threshold and the process requirements in the production process are remarkably reduced.

The present invention relates to the field of electrochemical analysis technology, and specifically discloses a method for simultaneously detecting baicalin and diclofenac sodium by an electrochemical sensor based on a Cu-TCPP / BN composite material, including: synthesizing a Cu-TCPP / BN composite material; the Cu-TCPP / BN composite material is dispersed in a solvent to obtain a Cu-TCPP / BN dispersion, which is drop-coated on the surface of a glassy carbon electrode, dried, and a Cu-TCPP / BN modified electrode is obtained; the Cu-TCPP / BN modified electrode is used as a working electrode, and a three-electrode system is formed with an auxiliary electrode and a reference electrode, and an electrochemical workstation is used to construct an electrochemical sensor. The method for simultaneously detecting baicalin and diclofenac sodium by an electrochemical sensor based on a Cu-TCPP / BN composite material of the present invention can quickly and easily perform quantitative detection of baicalin and diclofenac sodium at the same time. The electrochemical sensor based on a Cu-TCPP / BN composite material of the present invention has a low detection limit, high stability, good reproducibility and anti-interference ability.