8 results about "Sodium Diclofenac" patented technology

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

The application provides a drug-loaded acupuncture needle and a preparation method and application thereof, and belongs to the technical field of combination of traditional Chinese medicine and western medicine. The preparation method of the drug-loaded acupuncture needle comprises the following steps: after the surface of the acupuncture needle is modified by silanization, the acupuncture needle is repeatedly soaked in sodium polystyrene sulfonate solution and polyallyl ammonium chloride solution in sequence, a high-molecular drug-loaded film is formed on the surface of the acupuncture needle, and the acupuncture needle is loaded with target drugs in a diclofenac sodium solution, so that the drug-loaded acupuncture needle is obtained. The acupuncture needle is combined with drugs, so that the same-acupoint drug administration can be realized. On one hand, the acupoint is mechanically stimulated, and the internal regulation of the body is exerted; on the other hand, the drug efficacy is exerted. The acupoint stimulation and drug treatment play the same effect and are complementary to each other. Animal experiment results show that the acupuncture needle and the diclofenac sodium in the drug-loaded acupuncture needle have a synergistic effect, and the acupuncture-needle-drug combination treatment mode has obvious effects on the treatment of rheumatoid arthritis.

The invention discloses a Jinhuang powder external application paste and application thereof in preparation of drugs for treating gonitis synovitis, the external application paste is prepared from ten traditional Chinese medicines including turmeric, rheum officinale, golden cypress, radix angelicae, rhizoma arisaematis, pericarpium citri reticulatae, rhizoma atractylodis, mangnolia officinalis, liquorice and radices trichosanthis, honey, edible vegetable oil, paraffin oil and water through a specific emulsification process, the pH value is 6.0-7.0, and the viscosity is 3000-5000 mPa.s; standard random control clinical tests prove that the total effective rate of the external application ointment for treating gonarthromeningitis reaches 99.04%, the Lyshilm score is improved by 30.2 score, the VAS score is reduced by 5.39 score and is greatly superior to that of a diclofenac sodium control group, the adverse reaction occurrence rate is only 3.85%, the levels of serum TNF-alpha, IL-1beta and IL-6 and the synovial thickness can be greatly reduced, and the external application ointment has a good clinical application prospect. The method is suitable for K-L grading I-II and postoperative rehabilitation patients.

The invention relates to the field of medicine detection, in particular to a method for detecting related substances of diclofenac sodium and chlorpheniramine maleate in a lofenac tablet. According to the method, impurities of diclofenac sodium and chlorpheniramine maleate in the lofenac sodium and chlorpheniramine maleate tablet are detected through high performance liquid chromatography (HPLC), the method for detecting related substances in the lofenac sodium and chlorpheniramine maleate tablet can conduct integrated quality control on a compound preparation, the method is better in separation efficiency, higher in sensitivity and higher in durability, and the method is suitable for large-scale popularization and application. The method can ensure that all known impurities are completely separated and accurately quantified, and has enough detection capability on unknown impurities, thereby providing more reliable technical support for ensuring the safety, effectiveness and quality consistency of the medicine.

This invention belongs to the field of biomedical materials technology, specifically relating to an in-situ drug-loaded hydrogel based on nanobottle encapsulation technology, its preparation method, and its application. The in-situ drug-loaded hydrogel is formed by cross-linking copper chloride and reduced thiourea groups grafted onto hyaluronic acid within drug-loaded polydopamine nanobottles under near-infrared light irradiation. Diclofenac sodium is dispersed on the periphery and within the pores of the in-situ drug-loaded hydrogel; Kartogenin is encapsulated within the drug-loaded polydopamine nanobottles. Compared with existing technologies, this invention utilizes nanobottle encapsulation technology to achieve in-situ gelation and time-controlled drug release, solving the problems of non-in-situ hydrogels failing to adhere to irregular tissues and in-situ hydrogels struggling to simultaneously possess controllable time-controlled drug release capabilities. This solution achieves perfect adhesion of the hydrogel to the joint cavity through controllable in-situ gelation to protect the joint; simultaneously, it enables rapid release of diclofenac sodium and sustained release of Kartogenin, thereby achieving staged treatment of osteoarthritis.

This invention relates to the field of medical devices, specifically to a patch application, its preparation method, and its application. The patch comprises an immediate-release layer, a cross-linking layer, and a sustained-release layer; the cross-linking layer is placed between the immediate-release and sustained-release layers, with the immediate-release layer in contact with the skin; the immediate-release layer comprises a first microsphere, which has a polyvinyl alcohol coating and an ibuprofen core; the cross-linking layer is a calcium ion cross-linked membrane obtained by cross-linking sodium alginate and calcium chloride; the sustained-release layer comprises a second microsphere, which has a polylactic acid-glycolic acid copolymer coating and a diclofenac sodium core. The patch application provided by this invention can rapidly reduce inflammation and pain through the anti-inflammatory and analgesic microspheres and maintain the surgical patch for a certain period of time, while also providing local physical cooling. Compared with traditional patches, it alleviates postoperative pain to a certain extent and accelerates wound healing.

The invention discloses an external application preparation for treating meniscus sport injury and a preparation method, and relates to the technical field of external application preparations for meniscus. The medicine comprises diclofenac sodium gel paste, a Chinese patent medicine patch, an adjuvant A and an adjuvant B, the diclofenac sodium gel cream is prepared from the following raw materials: diclofenac sodium, propylene glycol, carbomer, triethanolamine, glycerol, absolute ethyl alcohol, menthol and water. The Chinese patent medicine patch comprises the following raw materials: frankincense, myrrh, angelica sinensis, ligusticum wallichii, borneol and menthol. The adjuvant A is prepared from the following raw materials: rhizoma cyperi, radix angelicae, ground beetle and radix puerariae; the adjuvant B is prepared from the following raw materials: flos carthami and rhizoma zingiberis. The traditional Chinese medicine plaster and the traditional Chinese medicine patch are prepared to achieve Chinese and western combined treatment, the traditional Chinese medicine ingredients are subpackaged according to the medicine effect, the traditional Chinese medicine ingredients can be used by different patients in different proportions, and the problems that an existing external application preparation is single in medicine effect, cannot be matched with different patients for ingredient matching application, cannot achieve Chinese and western combined application and the like are solved.

[Problem] To provide a pharmaceutical composition for external use, which comprises indomethacin, diclofenac sodium, biphenylacetic acid, a salicylic acid, or a heparin, and which alleviates irritation to a site to which the pharmaceutical composition is applied. [Solution] A pharmaceutical composition for external use, which is a composition that mitigates irritation to an application site, and which contains: one or more components (A) selected from the group consisting of the following components (A-1)-(A-5), and (B) one or more components (B) selected from the group consisting of the following components (A-1)-(A-5), the component (B) being one or more selected from the group consisting of the following components (A-1)-(A-5); component (A-1): indomethacin component (A-2): diclofenac sodium component (A-3): biphenylacetic acid component (A-4): salicylic acid component (A-5): heparin analogue component (B): one or more substances selected from the group consisting of loxoprofen, salts thereof, and hydrates thereof.