Method for preparing enteric composite microcapsules by utilizing spray drying technology

A composite microcapsule, enteric-coated technology, applied in the directions of microcapsules, capsule delivery, medical preparations with inactive ingredients, etc., can solve the problems of difficult to achieve large-scale production, difficult process control, complicated operation, etc., to mask bad odors. , Effective release, high stability effect

Active Publication Date: 2020-08-11
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the existing preparation methods of enteric-coated microcapsules include extrusion method, and sodium alginate is used as the most immobilized material, but it is generally only suitable for a small amount of preparation, and it is difficult to obtain dry microcapsule samples; there is interfacial polymerization method, but the operation is more complicated, the process is difficult to control, and it is difficult to achieve large-scale production; there is also a high-temperature spray drying method, which is suitable for large-scale production, but it cannot be applied to heat-sensitive substances and needs further improvement
In summary, there is no more general method in the prior art, which is suitable for the large-scale preparation of enteric-coated microcapsules that are irritating to the stomach, less stable, or heat-sensitive substances

Method used

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  • Method for preparing enteric composite microcapsules by utilizing spray drying technology
  • Method for preparing enteric composite microcapsules by utilizing spray drying technology

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of enteric-coated composite microcapsules

[0027] (1) Prepare 1 L of whey protein aqueous solution with a concentration of 20 g / L. After stirring continuously for 2 hours, centrifuge at 6000 rpm for 10 minutes, and keep the supernatant for later use.

[0028] (2) Prepare 1 L of gelatin aqueous solution with a concentration of 40 g / L, heat and stir until completely dissolved, cool to room temperature, and set aside.

[0029] (3) Bacillus subtilis is carried out strain activation, and after subculture twice, the concentration of Bacillus subtilis is about 10 9 CFU / mL, centrifuge 1L of Bacillus subtilis fermentation broth at 6000rpm for 10min, collect the bacterial sediment, disperse the bacterial sediment of Bacillus subtilis into the supernatant of whey protein, and slowly add gelatin aqueous solution , to mix the suspension.

[0030] (4) Spray-dry the suspension while stirring, the inlet air temperature is 105°C, the outlet air temperature i...

Embodiment 2

[0031] Embodiment 2: Preparation of enteric-coated composite microcapsules

[0032] (1) Prepare 2L of sodium caseinate aqueous solution with a concentration of 40g / L. After stirring continuously for 4h, centrifuge at 10000rpm for 10min, and keep the supernatant for later use.

[0033] (2) Prepare 2L of pectin aqueous solution with a concentration of 40g / L, stir until completely dissolved, and set aside.

[0034] (3) Lactobacillus plantarum was activated for strains. After two passages, the concentration of Lactobacillus plantarum was about 10 9 CFU / mL, centrifuge 4L of Lactobacillus plantarum fermentation broth at 6000rpm for 10min, collect the bacterial sediment, disperse the bacterial sediment of Lactobacillus plantarum into the supernatant of sodium caseinate, and slowly add pectin aqueous solution , to mix the suspension.

[0035] (4) Spray-dry the suspension while stirring, the inlet air temperature is 100°C, the outlet air temperature is 80°C, and the feed flow rate is...

Embodiment 3

[0036] Embodiment 3: Preparation of enteric-coated composite microcapsules

[0037] (1) Prepare 1 L of soybean protein aqueous solution with a concentration of 40 g / L, continue stirring for 2 hours, centrifuge at 6000 rpm for 10 minutes, and keep the supernatant for later use.

[0038] (2) Prepare 1 L of collagen aqueous solution with a concentration of 40 g / L, stir until completely dissolved, and set aside.

[0039] (3) Bacillus subtilis is carried out strain activation, and after subculture twice, the concentration of Bacillus subtilis is about 10 9 CFU / mL, centrifuge 1L of Bacillus subtilis fermentation broth at 6000rpm for 10min, collect the bacterial sediment, disperse the bacterial sediment of Bacillus subtilis into the supernatant of soybean protein, and slowly add it to the aqueous collagen solution , to mix the suspension.

[0040](4) Spray-dry the suspension while stirring, the inlet air temperature is 105°C, the outlet air temperature is 85°C, and the feed flow ra...

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Abstract

The invention discloses a method for preparing enteric composite microcapsules by utilizing a spray drying technology, and belongs to the technical field of a microcapsule preparation. The method is suitable for embedding solid medicine powder such as probiotics or diclofenac sodium and the like and uses natural macromolecular materials such as casein and collagen as enteric microcapsule wall materials, and utilizes a process of combining a complex coacervation method and spray drying at the normal temperature so as to prepare the enteric composite microcapsules which are uniform in size. According to the method, influence of a high temperature on core materials in the microcapsules in the spray drying process can be reduced, and the core materials are effectively embedded; stability of the product is improved; and the method is simple to operate and suitable for industrial production. The prepared enteric composite microcapsules are safe and non-toxic, cannot be disintegrated in 2h inartificial gastric juice, can avoid stimulus of an embedded medicine to the gastric mucosa and cover up objectionable odor, and can implement effective release in 0.5h in artificial intestinal juice.

Description

technical field [0001] The invention belongs to the technical field of microcapsule preparations, and in particular relates to a method for preparing oral enteric-coated composite microcapsules by using spray drying technology. Background technique [0002] Microcapsule technology is to use natural or synthetic polymer materials to encapsulate core substances such as solids, liquids and even gases into a semi-permeable or sealed capsule with a diameter of 1-5000 μm by chemical, physical or physicochemical methods. Capsule technology for tiny capsules. In recent years, microencapsulation technology has been widely used in different fields such as medicine, food, and agriculture. Microencapsulation can provide a physical barrier for the embedded core material, so that the core material is separated from the surrounding environment, and its advantages are: (1) It can improve the physical properties of the substance; (2) Control and adjust the release ability; ( 3) improve the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/36A61K31/196A61K35/742A61K35/747
CPCA61K9/5089A61K9/5052A61K9/5057A61K9/5036A61K31/196A61K35/742A61K35/747
Inventor 郭洪辉洪专陈晖张怡评
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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