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Carboxymethyl chitosan modified drug-carrying vesicle, and preparation method and application thereof

A technology of carboxymethyl chitosan and vesicles, which is applied in the field of carboxymethyl chitosan modified drug-loaded vesicles, can solve problems such as insolubility in water, and achieve the effect of increasing the amount of cell vesicles

Pending Publication Date: 2020-04-10
TIANJIN CITY THIRD CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the disadvantage is that it is insoluble in water under physiological conditions

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  • Carboxymethyl chitosan modified drug-carrying vesicle, and preparation method and application thereof
  • Carboxymethyl chitosan modified drug-carrying vesicle, and preparation method and application thereof
  • Carboxymethyl chitosan modified drug-carrying vesicle, and preparation method and application thereof

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Embodiment 1

[0031] A carboxymethyl chitosan modified drug-loaded vesicle is characterized in that the lipid bilayer membrane of the extracellular vesicle is coated or modified with carboxymethyl chitosan.

[0032] The carboxymethyl chitosan has a molecular weight of 165 to 119000 and a deacetylation degree of ≥50%.

[0033] The drug encapsulated by the carboxymethyl chitosan modified drug-loaded vesicle is one or more of drugs such as diclofenac sodium, insulin, paclitaxel, cisplatin, doxorubicin or sibeimine.

[0034] A carboxymethyl chitosan modified drug-loaded vesicle is used to make injections, freeze-dried powders for injections, eye drops, gels, suspensions, tablets, capsules, soft capsules, inhalation preparations, penetrating The use of one of the administration methods such as skin preparations or implants.

[0035] A preparation method of carboxymethyl chitosan modified drug-loaded vesicles, characterized in that it comprises the following steps:

[0036] 1) direct incubation...

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Abstract

The invention relates to a carboxymethyl chitosan modified drug-carrying vesicle. The drug-carrying vesicle is characterized in that a lipid bilayer membrane of an extracellular vesicle is coated or modified by carboxymethyl chitosan. The molecular weight of the carboxymethyl chitosan is from 165 to 119000, and the deacetylation degree is more than or equal to 50%. The drug-carrying vesicle comprises one or more medicines selected from diclofenac sodium, insulin, paclitaxel, cisplatin, doxorubicin, sipeimine and the like. According to the invention, the carboxymethyl chitosan is connected to the surface of the extracellular vesicle, and modification of the carboxymethyl chitosan changes the surface property of the extracellular vesicle and has profound influence on the drug delivery mechanism of the extracellular vesicle. Compared with a common extracellular vesicle, the drug-carrying vesicle is targeted to tumor cells. A preparation prepared from the carboxymethyl chitosan modified drug-carrying vesicle has more cell vesicles under a condition of ingestion in tumors.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a drug-loaded vesicle modified with carboxymethyl chitosan and its preparation and application. Background technique [0002] Chitosan is a basic amino polymer polysaccharide contained in natural organisms. It has low toxicity and a positive charge on the surface. It can be effectively absorbed by combining with negatively charged cells through the interaction between charges, and By opening cell channels, it can increase the instantaneous penetration of drugs between cells and prolong the retention time at the site of action to improve the bioavailability of drugs. But the disadvantage is that it is insoluble in water under physiological conditions. Now by modifying it to improve water solubility, low molecular weight chitosan mainly includes quaternized, carboxymethylated and sulfated derivatives. There are a large number of hydroxyl groups and amino groups on chitosan mole...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/196A61K31/337A61K31/58A61K31/704A61K33/243A61K38/28A61K47/61A61P35/00
CPCA61K47/61A61K47/6901A61K47/6911A61K31/196A61K38/28A61K31/337A61K33/243A61K31/704A61K31/58A61P35/00
Inventor 王毅军骆昱煜骆莹袁强高英堂
Owner TIANJIN CITY THIRD CENT HOSPITAL
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