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Preparation method and application of typical acidic drug multi-template molecularly imprinted polymer

A molecular imprinting and template molecule technology, which is used in the testing of pharmaceutical preparations, alkali metal compounds, chemical instruments and methods, etc. It can solve the problem of ineffective removal of acidic drugs, achieve high sensitivity and regeneration and reuse performance, and expand the scope of application. Effect

Inactive Publication Date: 2012-10-03
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional sewage treatment plants cannot effectively remove acidic drugs. Molecular imprinting technology provides an effective way to solve this problem due to its unique selective adsorption. Studies have shown that MIPs are more suitable for removing large-volume and low-concentration pollutants in water bodies.

Method used

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  • Preparation method and application of typical acidic drug multi-template molecularly imprinted polymer
  • Preparation method and application of typical acidic drug multi-template molecularly imprinted polymer
  • Preparation method and application of typical acidic drug multi-template molecularly imprinted polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The synthesis method of the typical acidic drug multi-template molecularly imprinted polymer of the present invention is as follows:

[0029] (1) Weigh 20mg (0.12 mmol) of AIBN, 1.5mL of EGDMA, and 60mL of toluene into a 300mL hard screw-top glass bottle with a stopper, and mix well. In the state of ice bath, nitrogen gas was passed into the reaction solution for 10 minutes to remove dissolved oxygen and a trace amount of oxygen in the air above the glass bottle, and it was sealed under nitrogen state. The reaction vessel was placed in a water bath, and the temperature was slowly raised from room temperature to 50° C. within two hours, and the polymerization was carried out at constant temperature for 15 hours. The synthesis gave a monodisperse polymer.

[0030] (2) Weigh 140mgDFC, 100mgCA, 99mgIBP, 110mgNPX, 122mgKTP, 0.30mL2-VP, 1.22mLEGDMA, 20mgAIBN and dissolve them in 100mL toluene. After mixing evenly, transfer the mixed reaction solution to the reaction bottle...

Embodiment 2

[0038] The synthesis method of the typical acidic drug multi-template molecularly imprinted polymer of the present invention is as follows:

[0039] (1) Weigh 10 mg (0.06 mmol) of AIBN, 0.69 mL of DVB-80, and 60 mL of a mixed solution of toluene and acetonitrile (V / V 1:3) into a 300 mL hard screw-top glass bottle with a stopper, and mix well. In the state of ice bath, nitrogen gas was passed through the reaction solution for 10 minutes to remove dissolved oxygen and a trace amount of oxygen in the air above the glass bottle, and it was sealed under nitrogen state. The reaction vessel was placed in a water bath, and the temperature was slowly raised from room temperature to 50° C. within two hours, and the polymerization was carried out at constant temperature for 15 hours. The synthesis gave a monodisperse polymer.

[0040] (2) Weigh 70mgDFC, 50mgCA, 49.5mgIBP, 55mgNPX, 61mgKTP, 0.15mL2-VP, 0.56mLDVB-80, 10mgAIBN and dissolve them in 100mL of toluene and acetonitrile mixe...

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Abstract

The invention relates to a preparation method and application of a typical acidic drug multi-template molecularly imprinted polymer. The adopted template molecules are clofibric acid, diclofenac sodium, ibuprofen, naproxen and ketoprofen. The preparation method and the application of the molecularly imprinted polymer belong to the technical field of analysis, determination and removal of five typical acidic drugs in environmental samples. The preparation method is simple and reliable, and the prepared multi-template molecularly imprinted polymer has a uniform size, a large specific surface area and higher specific selectivity for acidic drugs. The five acidic drugs in the environmental samples can be separated and gathered rapidly and efficiently. The multi-template molecularly imprinted polymer can be directly applied in selective removal of the five acidic drugs in surface water and has better effects than other adsorption materials. The method is an effective method for specific separation of a series of substances with the same attributes and has broad application prospects.

Description

technical field [0001] The invention relates to a preparation method and application of a typical acid drug multi-template molecularly imprinted polymer. Background technique [0002] Biologically active pharmaceuticals and personal care products (PPCPs) and their metabolites have potential ecological risks to the environment. The behavior, risk research and removal mechanism of PPCPs in environmental media have increasingly become the focus of environmental researchers and the public. The current situation of extensive use of PPCPs and their special physical and chemical properties have brought certain potential risks to the ecological environment and human health. At present, more than 50 PPCPs substances have been found in the influent and effluent water of sewage plants, surface water, groundwater and drinking water, with concentrations as high as μg L -1 level. There are many kinds of PPCPs, low concentration, different physical and chemical properties, and the enviro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F236/20C08F216/04C08F222/20C08F220/06C08F226/06C08F220/56C08J9/28C08J9/26B01J20/26B01J20/28B01J20/30C02F1/28G01N33/15
Inventor 张亚雷代朝猛张娟周雪飞沈哲刘战广
Owner TONGJI UNIV
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