High-stability nanoscale zirconium-based metal organic framework material and preparation method and application thereof

A high stability, organic framework technology, applied in the direction of organic active ingredients, medical preparations of non-active ingredients, wave energy or particle radiation treatment materials, etc., can solve problems such as difficult drug release control, and achieve good chemistry Stability and thermal stability, the effect of strong stability

Active Publication Date: 2017-12-08
ZHEJIANG UNIV
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Problems solved by technology

However, the latter is difficult to achieve controlled release of drugs in diseased tissues

Method used

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  • High-stability nanoscale zirconium-based metal organic framework material and preparation method and application thereof
  • High-stability nanoscale zirconium-based metal organic framework material and preparation method and application thereof
  • High-stability nanoscale zirconium-based metal organic framework material and preparation method and application thereof

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[0029] Example: (1) Using Suzuki coupling reaction, 11g, 38.46mmol of 1,4-dibromonaphthalene, 9mL, 84.6mmol of ethyl acrylate, 6.63g, 48mmol of anhydrous potassium carbonate, 2.06g, 6.4mmol of Tetrabutylammonium bromide and palladium acetate (catalyst) of 1.122g, 5mmol are uniformly dissolved in the DMF of 100mL according to the stoichiometric ratio of setting, react 1~2 days under 130 ℃ of stirring conditions, pass ethyl acetate and water The organic ligand 1,4-naphthalene diacrylic acid with high chemical purity is obtained through multiple extractions, drying with anhydrous magnesium sulfate, purification by chromatography and subsequent hydrolysis reaction.

[0030] (2) Using solvothermal method, 54 mg, 0.201 mmol of organic ligand 1,4-naphthalene diacrylic acid and 60 mg, 0.186 mmol of metal salt ZrOCl 2 ·8H 2 O was ultrasonically oscillated for five minutes in a solvent (DMF: formic acid, 5 mL / 0.22 mL) environment until it was uniformly dissolved, and reacted at 70° C. ...

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Abstract

The invention discloses a high-stability nanoscale zirconium-based metal organic framework material (Zr-MOFs) and a preparation method of the high-stability nanoscale zirconium-based metal organic framework material. Firstly, a specific organic ligand 1,4-naphthalenedi acrylic acid is obtained through a Suzuki coupling reaction; and secondly, a pure phase nanocrystal material is obtained through a solvothermal method. An anti-inflammatory drug, that is, diclofenac sodium (DS), is loaded in a hole of the activated nanocrystal material, and a drug loading system achieves the effect of controlling the release of the drug through heat. The pore diameter of the synthesized nanoscale zirconium-based metal organic framework material is well matched with the size of the diclofenac sodium (DS), so that a higher loading capacity is achieved. The material is higher in chemical stability and heat stability, and the requirements of the practical application field on local thermal therapy of cancers and inflammation tissues are greatly met. Therefore, the nanoscale metal organic framework material has a potential application prospect on the local thermal therapy and chemotherapy of the inflammation and cancer tissues.

Description

technical field [0001] The invention belongs to the preparation of a drug controlled release system, and in particular relates to a preparation method of a highly stable nano-scale metal organic framework material, which can be used to prepare medicines for combining hyperthermia and chemotherapy to treat inflammatory tissues and cancer tissues. Background technique [0002] In the field of pharmacy, diclofenac sodium is a non-steroidal anti-inflammatory analgesic drug with excellent efficacy, which can relieve rheumatoid arthritis, osteoarthritis, spondyloarthropathy, gouty arthritis, rheumatoid arthritis, etc. The curative effect of various chronic arthritis in the acute attack stage or persistent joint swelling and pain symptoms. However, the half-life of diclofenac sodium in the body is only 1 to 2 hours, and diclofenac sodium is more hydrophilic and cannot penetrate the cell membrane, which greatly affects the therapeutic effect of the drug. Therefore, it is particular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K41/00A61K31/196A61K47/69A61P29/00A61P35/00
CPCA61K31/196A61K41/0052C08G83/008A61K2300/00
Inventor 钱国栋姜珂张玲杨雨崔元靖
Owner ZHEJIANG UNIV
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