93 results about "Phenyl acetic acid" patented technology

The invention discloses an enriching and thickening functional cluster substance preparation capable of obviously increasing richness and lumping of cigarette smoke, relates to a tobacco additive, and aims to provide the enriching and thickening functional cluster substance preparation capable of obviously increasing the richness and the lumping of the cigarette smoke, which has the capabilities of enriching, thickening and improving the cigarette aroma and richness. The preparation is characterized in that the raw materials for preparing the preparation comprise the following basic raw materials in percentage by weight: ethyl vanillin, ethyl maltol, pineapple ketone, dihydroactinidiolide, heliotropin, phenyl acetic acid, plum extract, raisin extract, fenugreek concrete, breadfruit concrete and the balance of 95 percent ethanol. The preparation can be widely used in all the cigarette factories throughout the country.

The invention provides a mutant of penicillin G acylase (PGA) and a preparation method and application of the mutant. The non-rationally and semi-rationally designed enzyme engineering reconstruction technology is adopted for mutation of penicillin G acylase obtained from Escherichia coli ATCC 11105, so that a PGA mutant with higher reactivity, higher reaction rate, better conversion rate, stronger in penicillihe concentration tolerance, less substrate residue, and higher in phenyl acetic acid concentration tolerance; meanwhile, the mutant is subjected to recombinant expression, bacteria strain construction, fermenting cultivation, immobilization and application to prepare 6-amino-penicillanic acid (6-APA). The activity of the PGA-6 mutant prepared by the invention is increased by 102 times, the substrate penicillihe concentration tolerance is increased to 30%, and the phenyl acetic acid concentration tolerance is increased to 20 mmol/L; meanwhile, the immobilized PGA-6 mutant is used to decompose penicillihe with a concentration of 25% under the condition of pH 8.0 and 25 DEG C so as to prepare 6-APA, and the reaction time is shortened to 55 minutes, the substrate conversion rate is 98% or above, and after being used for 600 batches and above, the activity is not lost obviously, therefore, good operation stability is achieved.

The invention discloses a 2- carbonyl- 2- phenyl acetic acid p-nitro benzoyl hydrazone 2-n-butyl tin complex in the following structural formula (I) of (img file='dest_path_image002. TIF'wi='363'he='181'/), wherein Ph is phenyl and R is normal-butyl. The invention also discloses the preparing method and application in preparing anti-cancer drugs for 2- carbonyl- 2- phenyl acetic acid p-nitro benzoyl hydrazone 2-n-butyl tin complex.

The invention relates to polymorph 1 of acid 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-il]-1-piperidinyl]ethyl-alpha, alpha-dimethyl-benzeneacetic having formula (I), preparation methods thereof, pharmaceutical formulations containing polymoph 1 and the use of polymorph 1 for the treatment of allergic reactions and pathological processes mediated by histamine in mammals such as humans.

The invention discloses building paint. The building paint is prepared from 3.5-7.5 parts by weight of methyl acetate, 2.3-4.5 parts by weight of hept-2-ene-2-methanol, 6.5-12.7 parts by weight of hydroxymethyl propyl cellulose, 10-15 parts by weight of titanium dioxide, 20-28 parts by weight of white emulsion, 1.2-3.5 parts by weight of perillaldehyde, 2.5-6.4 parts by weight of distyrylphenol polyoxyethylene ether and 3.5-6.8 parts by weight of (R)-(-)-alpha-methoxyphenylacetic acid. Compared with the existing exterior wall paint, the building paint improves an emulsion paint finished product covering capacity through use of a mixture of methyl acetate and white emulsion. Through mixing of hydroxymethyl propyl cellulose and titanium dioxide, latex finished product adhesion and water washing resistance are improved. Through the mixture of perillaldehyde, distyrylphenol polyoxyethylene ether and (R)-(-)-alpha-methoxyphenylacetic acid, the paint film has lasting and beautiful gloss and has lasting pollution resistance.

The invention discloses a low-tar cigarette flavoring essence with organic acids. The cigarette flavoring essence is a mixture of the following raw materials in percentage by weight: 1%-2% of 0.1% formic acid, 2%-4% of 0.1% acetic acid, 0.05%-0.2% of 0.1% benzoic acid, 0.2%-0.4% of 0.1% isobutyric acid, 0.05%-1.5% of 0.1% valeric acid, 0.1%-0.2% of 0.1% isovaleric acid, 0.1%-0.4% of 0.1% phenyl acetic acid, 1.0%-2.0% of 0.1% beta-mevalonic acid, 1.5%-2.5% of 0.1% alpha-methylbutyric acid, 0.2%-0.5% of 0.1% hexanoic acid, 1.0%-3.0% of DL-tartaric acid, 2.0%-6.0% of malic acid, 0.05%-1.5% of lactic acid, 0.5%-2.5% of citric acid, 0.5%-2.0% of 10% levulinic acid, 36.3%-69.75% of distilled water and 20%-35% of propylene glycol. Due to the use of organic acid raw materials, the effect of the blended essence is promoted greatly; the problems such as high irritation, rough smoke, uncomfortable aftertaste and insufficient aroma, existing in the existing low-tar cigarette, are covercome remarkably; the smoking quality of the low-tar cigarette is enhanced.

The invention relates to the technical field of paints, and specifically discloses an LED light cured aqueous woodenware paint and a preparation method thereof. The aqueous woodenware paint comprisesfollowing components in parts by weight: 95 to 110 pars of LED acrylic emulsion, 2 to 6 parts of carbon nanotube modified polyphosphazene-polyether sulfone segmented copolymer, 3 to 10 parts of photoinitiator, 1 to 3 parts of co-initiator, 1 to 5 parts of water soluble active monomer, 2 to 5 parts of silver nano particle, 0.1 to 0.5 part of Ag-diphenylpyrazolopyridine-p-phenyl acetic acid complex, 3 to 10 parts of delustering agent, 1 to 7 parts of antiseptic, 8 to 20 parts of wetting dispersant, 1 to 6 parts of antifoaming agent, 5 to 13 parts of thickening agent, 1 to 3 parts of film forming additive, 0.2 to 0.5 part of pH adjuster, 6 to 10 parts of filler, 5 to 10 parts of coloring agent, and 25 to 35 parts of deionized water. The prepared aqueous woodenware paint has the advantages ofhigh hardness, good acid-resistant, alkali-resistant, aging-resistant, and waterproof performance, high storage stability, quick drying speed, and low VOC content, and the environmentally friendly property, hardness, and corrosion resistant performance are all enhanced.

The invention relates to a synthetic method of Alpha-chloro-(2-chloro) methyl phenyl acetate, pertaining to the field of chemical synthesis. The technical problem to be solved by the invention is that a high-purity synthetic method of the Alpha-chloro-(2-chloro) methyl phenyl acetate with high purity is provided. The technical proposal comprises the steps as follows: pyridine is tanken as a solvent, and O-chloro mandelic acid methyl ester reacts with thionyl chloride under the condition of 25 DEG C to 80 DEG C for 0.5h to 5h, and then filtered. Filtrate is extracted by water for impurity removal, and anhydrous sodium sulfate is added for removing water. Filtering is carried out for removing solid sodium sulfate and the filtrate is depressurized for distilling off the solvent to obtain the Alpha-chloro-(2-chloro) methyl phenyl acetate. The reaction formula is shown as the formula in upper right side.

There is described a process for preparing a hybrid organic inorganic nano-composite used to prepare high (nD=1.52) refractive index (Rl) protective coatings for brightness enhancers for LCDs. The process comprising the steps of: a) diluting an aqueous solution of inorganic nano-particles (such as ZrO2) with a first solvent (such as acetic acid or methyl ethyl ketone (MEK)) to form a dispersion; b) adding surface modifiers (such as 1-benzoyl acetone, diphenyl acetic acid, diphenyl phosphonic acid, ethylene methacrylate phosphate; 2,2,6,6- tetramethyl-3,5-heptanedione or neopentyl(diallyl)oxy trimethacryl zirconate); c) removing the first solvent to enhance the interactions between the surface modifier and nano- particles; d) washing the resultant slurry of surface modified lipophilic nano particles by repeated dilution with an azeotropic solvent mixture (such as ethyl acetate, toluene and water) and distillation to remove low Rl impurities and/or OH groups, e) adding a radiation curable polymer precursor (such as an optionally brominated epoxy acrylate to the mixture opt with a photo initiator (Pl); and f) removing the remaining solvent to form a solid composite comprising an intimate mixture of surface modified inorganic nano-particles and uncured polymer precursor.

The invention provides a preparation method for resveratrol. The method comprises the following steps: with (3,5-dimethoxyphenyl)acetic acid as a raw material, subjecting (3,5-dimethoxyphenyl)acetic acid and methoxybenzaldehyde dimethyl acetal to a one-pot reaction so as to obtain a crude resveratrol product; and then carrying out neutralizing with alkali lye, decoloring in alcohol and recrystallization so as to prepare a refined resveratrol product. Compared with the prior art, the preparation method provided by the invention has the advantages of short process flow, simple operation and suitability for industrial production, and the prepared refined resveratrol product has yield of more than 93%, a melting point of 261 to 263 DEG C, HPLC of greater than 99%, a whitish color, good quality and low preparation cost.

The invention belongs to the field of nonaqueous phase enzymatic organic synthesis, in particular to an ester exchange method synthesizing process of aryl acetic acid (propionic acid) L-ascorbic acid ester. The process is applicable to synthesis of the aryl acetic acid (propionic acid) L-ascorbic acid ester under catalysis of a biocatalyst (such as Novozym 435). The synthesizing process provides a commonly-used synthesizing process of the aryl acetic acid (propionic acid) L-ascorbic acid ester, can move to a ester synthesizing direction in balance through decompression and continuous alcohol removal on premises of influencing no catalytic activity of the biocatalyst, accordingly improves conversion rate of the enzymatic organic synthesis and guarantees reaction to trend to completion. Through simulated moving bed chromatography separation, through separation of reaction products and excess reaction raw materials are guaranteed, circulation and reuse problems of the excess reaction raw materials are solved, the conversion rate, product yield and product purity of the raw materials are all improved to be close to 100%, cost of production is substantially lowered, zero discharge of waste water and waste residues of product production is achieved, and the synthesizing process has wide application prospects in fields such as medicines and fine chemical engineering.

The invention belongs to the field of medicine and pharmacology, and is Pharmaceuticals oral granule. The Aceclofenac granule is made by raw material drug aceclofenac, findings and disintegrant. The Aceclofenac granule is phenyl acetic acid non-steroidal anti-inflammatory agent. It has notable anti-inflammatory, analgesic and antipyretic effect. It applies to the treatment of various rheumatoid arthritis, atrophic arthritis, osteoarthritis and spondylitis. It is fit for pain and fever caused by various diseases, and the toxic and side effects is lower than other varieties. Aceclofenac has not granule in prior medicine market; it is innovative formula and benefit for absorbing drug to getting better curative effect and better taste. It is safe, reliable and new drug for treatment of acute, chronic pain and anti-inflammation.

The present invention provides process of preparing chloro phenyl acetic acid. The technological process includes the main steps of hydrolyzing corresponding o-chloro benzyl cyanide, p-chloro benzyl cyanide or m-chloro benzyl cyanide in sulfuric acid solution to obtain course chloro phenyl acetic acid product; steam stripping to eliminate organic impurities; water washing and drying. The technological process of the present invention is simple, stable, less pollutant and suitable for industrial production.

The invention provides a preparation method and application of repaglinide. The preparation method comprises the following steps of neutralizing repagamine.N-acetyl-L-glutamic acid and alkali to obtain repagamine, acylating repagamine, condensing acylated repagamine and ethoxy-4-ethoxycarbonyl phenyl acetic acid to obtain an intermediate and hydrolyzing the intermediate to obtain the repaglinide. The preparation method has the advantages of low cost, high yield, simple process and the like and is more suitable for industrial production.

The invention discloses a green synthesis method for high-yield preparation of trifloxystrobin. The method comprises the following steps that methyl 2-bromomethyl-(alpha E) methoxyiminobenzene acetateis condensed with m-trifluoromethyl acetophenone oxime under the dual catalytic action of a phosphine-containing ligand catalyst and DBU serving as alkali to generate the high-yield trifloxystrobin.The reaction conditions for preparing trifloxystrobin are milder, the reaction time is short, the use amount of the solvent is small, inorganic base is adopted, and the amount of waste salt is reduced. And the fully-dissolved state of the material can be used for a micro-channel reactor. The method has the advantages of simple steps, environmental protection, suitableness for industrial production, high yield and high content of the final product, and production cost reduction.

The invention discloses a 2-carbonyl-2-phenyl acetic acid p-nitrobenzoylhydrazone bis(2,4-dichlorobenzyl)tin complex, which is shown in a following structural formula (I), wherein Ph is phenyl, and R is 2,4-dichlorobenzyl. The invention also discloses a preparation method of the 2-carbonyl-2-phenyl acetic acid p-nitrobenzoylhydrazone bis(2,4-dichlorobenzyl)tin complex and an application of the complex in preparation of anticancer medicines.

The invention relates to a method for producing entacapone. The method comprises the following specific steps: dissolving 1.83g of 3,4-dihydroxy-5-nitrobenzaldehyde and 1.5g of N,N-diethyl cyanoacetamide and a catalytic amount of piperidine acetate in 40mL in dry ethanol, and stirring overnight to obtain 2.23g of a crude product; heating at 90 DEG, dissolving 3.0kg of the crude product in 8.0kg of acetic acid (or formic acid) containing 80g of HBr (or 40g of HCl), slowly cooling to 20 DEG C, and stirring at the temperature for 20 h, then stirring at 15 DEG C for 6 h, filtering, collecting precipitated crystal; and carefully washing the crystal with 1L of a cold mixed liquid (4 DEG C) of toluene-acetic acid (volume ratio of 1:1), then washing the crystal with 1L of cold toluene, and drying in vacuum at 45 DEG C to obtain 2.4kg of crystalline pure entacapone. The method for producing entacapone has the advantages of simple manufacture process, low production cost and high output.

The invention discloses a novel method for synthesizing a bisoprolol importance intermediate. The novel method has the following steps: carrying out a reaction between hydroxy benzaldehyde which is taken as a raw material and acetic anhydride to obtain 4-acetoxybenzaldehyde; conducting reduction on 4-acetoxybenzaldehyde with sodium borohydride to obtain 4-acetoxyl benzyl alcohol; carrying out a reaction between 4-acetoxyl benzyl alcohol and 2-isopropoxyethanol to obtain 4-[(2-isopropoxyethanol)methyl]phenyl acetic acid, thereby avoiding side reactions such as phenolic hydroxyl etherification; under an alkaline condition, directly hydrolyzing 4-[(2-isopropoxyethanol)methyl]phenyl acetic acid without separation to recover 2-isopropoxyethanol, thereby obtaining the required intermediate, namely 4-isopropoxyethoxymethylphenol. The novel method is mild in reaction and safe to operate; impurities generated due to self-polymerization of raw materials, phenolic hydroxyl etherification and the like are reduced; the product purity and yield are relatively high; as a novel way for obtaining the bisoprolol importance intermediate, the novel method can be applied to large-scale industrialized production.

The invention provides an improved production process for repaglinide. The process is characterized by comprising the following steps: with (S,S')-3-methyl-1-(2-(1-piperidinyl)phenyl)butylamine, N-acetyl-glutamate as a main material, adding ammonia water to prepare chiral amine (S)-(+)-3-methyl-1-(2-piperidinyl-phenyl)butyl amine; then adding triethylamine and adding a mixed liquid of pivaloyl chloride and toluene drop by drop; subjecting a product obtained in the previous step and 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid to a condensation reaction so as to prepare a compound (S)-2-ethoxy-4[2-[3-methyl-1-[2-(1-piperidinyl)-phenyl]-butyl]-amino]-2-carbonylehtyl ethyl benzoate; hydrolyzing the compound in ethanol and a sodium hydroxide solution so as to obtain a crude repaglinide product; and dissolving the obtained crude repaglinide product in a mixed solution of ethanol and water for purification so as to prepare a refined repaglinide product. The improved production process provided by the invention further simplifies synthesis and purification steps, has the advantages of high efficiency, low toxicity, low danger, easy operation, etc. and has the characteristics of simplicity and easiness in control and industrial production.