16 results about "Phenyl acetic acid" patented technology

The application provides application of an acetyl dopamine compound in preparation of a medicine for improving insomnia, and belongs to the technical field of traditional Chinese medicine medicines, and the acetyl dopamine compound is acetyl dopamine dimer A extracted from cicada slough. Experiments prove that the acetyl dopamine dimer A can increase the content of brain-derived neurotrophic factor (BDNF) which plays an important role in the occurrence process of insomnia, reduce dopamine (DA) level, and has obvious effects on DA metabolites homovanillic acid (HVA) and dihydroxyphenyl acetic acid (DOPAC), thereby effectively improving insomnia. Through research on the effect of the acetyl dopamine dimer A on improving insomnia, the application obtains the basis of using the acetyl dopamine dimer A for improving insomnia, provides data support for research and development of the cicada slough as a medicine, and also provides a new medicinal source for improving insomnia.

The present application discloses a kind of 4-acetylamino butyric acid and 3,4-dihydroxyphenylacetic acid in Guizhou Kaili Hong acid soup, which can enhance intestinal microecological balance, promote intestinal motility, and improve constipation or inflammatory bowel disease. The principle is that 4-acetylamino butyric acid or 3,4-dihydroxyphenylacetic acid can significantly increase the expression of C-Kit in the intestine, and significantly inhibit the expression of macrophage inflammatory factors.

The invention discloses a method for detecting the content of p-aminophenylacetonitrile in felbinac, which adopts a triple quadrupole liquid chromatography-mass spectrometry method, takes formic acid-methanol-water with different volume ratios as a mobile phase, adopts a multi-reaction monitoring mass spectrometry mode, and researches liquid chromatography and mass spectrometry conditions to determine the content of p-aminophenylacetonitrile in felbinac. The detection of trace p-aminophenylacetonitrile impurities in the felbinac is realized. The method has good accuracy, precision, stability and specificity, and can effectively control the content of p-aminophenylacetonitrile in the biphenylacetic acid, thereby ensuring the quality of the ibuprofen product taking the biphenylacetic acid as the raw material.

The invention belongs to the technical field of carbon capture, and discloses an organic amine absorbent suitable for cement kiln flue gas carbon capture and a preparation method and application thereof.The organic amine absorbent is prepared from, by mass, 3.0-6.0 parts of a main agent, 1.0 part of an auxiliary agent, 0.1-0.5 part of an accelerant and 0.1-0.5 part of a stabilizer, the main agent comprises diamine, the auxiliary agent comprises tertiary amine, the accelerant is 1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1 the catalyst is one or more of 1, 3, 5-tri-tert-butylbenzene, tert-butyl acetate, triphenylcarbinol and triphenylphosphine. According to the invention, high-temperature degradation resistance and impurity selective adsorption can be considered, and the problems of insufficient high-temperature stability and lack of impurity interference resistance of an organic amine absorbent in the prior art are solved at the same time.

The application provides a preparation method of 2,4-difluorophenyl glycine and relates to the field of compound synthesis. The method uses 2,4-difluorophenyl acetic acid as raw material, and 2,4-difluorophenyl glycine is obtained through bromination reaction and ammoniation reaction; the temperature of the bromination reaction is 60-100 DEG C, and the bromination reaction also needs to add an initiator; the temperature of the ammoniation reaction is 0-50 DEG C, the reaction is carried out in the presence of a solvent, and the solvent is at least one selected from water, methanol, ethanol, acetone and acetonitrile. The target product is obtained through inexpensive and easily available raw materials and mild reaction. The method of the application avoids using a highly toxic reagent, the raw material is inexpensive and easily available, the steps are simple, the overall reaction yield is high, the cost is low, and the method is suitable for industrial production.

The invention discloses an MOF (Metal Organic Framework) capable of being used for preparing ammonia by electroreduction of a nitrate-containing solution and a preparation method, and belongs to the technical field of nano materials. Comprising the following steps: firstly, treating carbon cloth with a saturated potassium permanganate solution; then adding an organic ligand 2, 3, 6, 7, 10, 11-hexahydroxy triphenylene and cobalt acetate monohydrate into deionized water and N-methyl pyrrolidone, and carrying out ultrasonic treatment to fully disperse the solid medicine in the solution; obliquely putting the pretreated carbon cloth into the mixed solution, transferring into a reaction kettle, carrying out hydrothermal treatment, repeatedly cleaning the surface of the carbon cloth by using deionized water and absolute ethyl alcohol, and drying to obtain the MOF capable of being used for preparing ammonia by electroreduction of a nitrate-containing solution. According to the method, bismuth chloride can also be added into the organic ligand 2, 3, 6, 7, 10, 11-hexahydroxy triphenylene and cobalt acetate monohydrate to prepare Bi-doped MOF. The invention aims to provide the method for preparing the MOF which can be used for preparing the ammonia by electroreduction of the nitrate-containing solution, can be massively produced, has uniform morphology and can be used for preparing the ammonia by electroreduction of the nitrate-containing solution under a hydrothermal condition.

The application belongs to the technical field of carbon capture, and discloses an organic amine absorbent suitable for carbon capture of cement kiln flue gas, and a preparation method and application thereof. The organic amine absorbent comprises the following components in mass fraction: 3.0-6.0 parts of a main agent, 1.0 parts of an auxiliary agent, 0.1-0.5 parts of a promoter, and 0.1-0.5 parts of a stabilizer. The main agent comprises a binary amine, the auxiliary agent comprises a tertiary amine, and the promoter is one or more of 1,3,5-tri-tert-butylbenzene, tert-butyl acetate, triphenyl carbinol and triphenyl phosphine. The application can take into account high-temperature degradation resistance and selective adsorption of impurities, and simultaneously solves the problems of insufficient high-temperature stability and lack of anti-impurity interference ability of the organic amine absorbent in the prior art.

The invention is applicable to the technical field of biological medicines, and provides pH responsive tumor targeting nanogel based on dynamic borate bonds as well as a preparation method and application of the pH responsive tumor targeting nanogel. According to the invention, 3-aminophenylboronic acid and 3, 4-dihydroxyphenylacetic acid are used as key groups, in a PBS buffer solution or a Tris-HCl buffer solution with the pH value of 7.5-8.5, dynamic borate bonds are formed through boric acid groups of a polymer ligand 1 and a polymer ligand 2 and benzenediol groups, and the nanogel is constructed through crosslinking and is loaded with cytochrome C. The nanogel can specifically target CD44 high-expression tumor cells, drug accumulation in a tumor area is achieved by means of permeability enhancement and retention effect, pH-responsive drug release is achieved under the tumor microenvironment acidic condition, and the nanogel is good in stability and biocompatibility and remarkable in anti-tumor effect and has good application prospects. A new scheme is provided for delivery of protein drugs and application of the nanogel in cancer combined treatment, and development of cancer precise treatment is promoted.

The application relates to the technical field of thermal insulation materials, and discloses a flame-retardant modified thermal insulation foam material and a preparation process thereof. The flame-retardant modified thermal insulation foam material is prepared from low-density polyethylene as a main material and 3,5-di-tert-butyl-4-hydroxyphenyl acetic acid grafting material and the like as auxiliary materials. Silicon phosphorus boron in the hydroxyl-terminated polydimethylsiloxane grafting material serves as a flame-retardant element, a dense thermal insulation oxygen isolation silicon phosphorus boron composite carbon layer is constructed at high temperature, and the flame-retardant effect is achieved. After 3,5-di-tert-butyl-4-hydroxyphenyl acetic acid is grafted to carboxyl-terminated polybutadiene, the antioxidant unit is fixed on the flexible long chain of the carboxyl-terminated polybutadiene through chemical bonding, the antioxidant activity of the antioxidant unit is retained, and the agglomeration phenomenon is inhibited, so that the flame-retardant modified thermal insulation foam material prepared by the application has the flame-retardant, antioxidant and thermal insulation performances.

To provide a packaged black tea beverage having reduced and / or suppressed deterioration odor and taste caused by aging and / or light-induced deterioration of the black tea beverage, and also to provide a method for producing the same.SOLUTION: A method for producing a packaged black tea beverage having a tannin content of 10 mg / 100 mL or more, the packaged black tea beverage being prepared to meet at least one of the following conditions (a) and (b): (a) a content of isobutyl phenylacetate is 0.5 ppm or more; (b) a content of isoamyl phenylacetate is 0.5 ppm or more.SELECTED DRAWING: None

The application discloses a kind of polymethyl methacrylate macromolecular initiator / polymethyl methacrylate-block-polydimethylaminoethyl methacrylate copolymer / PVDF blend membrane and its preparation method in wastewater treatment application.Belongs to wastewater treatment adsorption material preparation technical field.Raw material includes: laboratory synthesis 3-(((2-cyanopropane-2-yl)oxy)(isopropyl)amino)-2,2-dimethyl-3-phenyl propionitrile (CPDMN) with methyl methacrylate, methyl methacrylate, methylbenzene, n-butyl acetate, polyvinylidene fluoride, N-N dimethylacetamide.Preparation includes polymethyl methacrylate macromolecular initiator preparation, polymethyl methacrylate-block-polydimethylaminoethyl methacrylate preparation, polymethyl methacrylate-block-polydimethylaminoethyl methacrylate and polyvinylidene fluoride blend preparation membrane.The block copolymer product prepared by nitrogen oxygen free radical stable polymerization has the advantages of pure, no color, reaction process is simple, etc., and the membrane prepared by blending with polyvinylidene fluoride has good performance, and wide application prospect.

The present invention relates to a continuous production method of isosorbide-5-mononitrate, belonging to the technical field of medicine. Sorbitol is added to deionized water, and a solid acid catalyst is added. After vacuum distillation, ethyl acetate and methanol are added, the pH is adjusted, dried, filtered under pressure, rinsed with ethyl acetate, and the solvent is removed by distillation; after the system is heated up, it is added to a mixed solution of toluene, acetic acid and acetic anhydride. After cooling, fuming nitric acid is slowly added dropwise. After the reaction, it is poured into ice water, the pH is adjusted, separated, and the organic phase is washed with water; the aqueous phase is taken and extracted 3 times with 2-butanone. The extracted organic phases are combined, the solvent is removed by distillation, added to deionized water, sodium hydroxide solution is added dropwise, after the reaction, it is filtered, added to water to form a suspension, the pH is adjusted, extracted with 2-butanone, the solvent of the organic phase is removed by distillation, and then recrystallized with chloroform to obtain isosorbide-5-mononitrate; the isosorbide-5-mononitrate prepared by the present invention has a high purity and yield.

Derivatives of polymethinium salts of the general formula I, where both terminal heteroaromatic groups of the methinium chain are identical or different and are benzothiazole, naphthothiazole, benzimidazole, naphthoimidazole, benzooxazole, naphthooxazole, benzoselenazole, naphthoselenazole, quinoline, benzoquinoline, indole or benzoindole, the particular structure of which is characterized by the groups A, B, X, Y, with one or more R groups on both terminal heteroaromatic groups of the methinium salt, where R is H, C1 to C12 alkyl, glycol chains with 1 to 8 glycol (OCH2CH2) repeating units terminating with an O—C1 to C12 alkyl substituent or OH group, alkyl C1 to C8 sulfonic acids or their corresponding lithium, sodium or potassium salts, allyl, propargyl, phenyl, benzyl, pyridyl, halogen, CH2OR′, OR′, CHF2, CF3, OCF, OCOR′, CN, CHO, COOR′, CONHR′, CONR′2, CONHOR′, CONHNHR′, CONHNR′2, N3, NO2, SR′, SCN, NHR′, NR′2, NHCOR′, NHCONHR′, NHCONR′2, NHCSNHR′, NHCSNR′2, NHSO2NHR′, NHSO2NR′2, NHCOOR′, N(COOR′)2, B(OR′)2, SO3R′, SO2NHR′, SO2NR′2, SO2R′, where R′ is H, alkyl C1 to C12, phenyl, p-tolyl, benzyl, allyl, propargyl, CF3; CH═CH—CH═CH (i.e. a fused benzene nucleus), where X is O, S, Se, CR′2, NR′, CH═CH, where R′ has the above meaning; where A is alkyl C1 to C12, benzyl, allyl, propargyl, a glycol chain with a number of 1 to 8 glycolic (CH2CH2O) repeating units terminating with the substituent R′, (CH2)jCOR′, (CH2)jCOOR′, (CH2)jSO3R′, (CH2)jSO3H, (CH2)jCONHR′, (CH2)jCONR′2, where j is in the range of 1 to 12 and R′ has the above meaning; where B is phenyl, pyridyl, pyrazinyl, quinolyl, quinoxalyl, furanyl, thienyl, benzoxazolyl, benzothiazolyl, which may be further substituted by one or more of the same or different substituents R, where R has the above meaning, where in the case of doubly charged salts the group B is formed by pyridyl or quinolyl quaternized on its nitrogen atom by A, where A is as defined above, where Y is acetate, acetylacetate, adipate, ascorbate, benzoate, besylate, borate, bromide, butanoate, citrate, deoxycholate, dihydrogen phosphate, phenylacetate, fluoride, phosphate, fumarate, gallate, glutarate, hexafluorophosphate, hippurate, hydrogen sulfate, chloride, perchlorate, cholate, isocyanate, isonicotinate, iodide, caprylate, cyanate, lactate, laurate, lithocholate, malate, maleate, malonate, mandelate, mesylate, monohydrogen phosphate, formate, myristate, napsylate, nicotinate, nitrate, nonafluorobutylsulfonate, oleate, oxalate, oxopropanoate, palmitate, picrate, pimelate, propionate, rhodanide, salicylate, sebacate, cinnamate, stearate, suberate, succinate, sulfate, tetrafluoroborate, tosylate, triflate, trifluoroacetate, trichloroacetate, carbonate, valerate, tartrate, and salts of natural amino acids, for the use as an inhibitor of dihydroorotate dehydrogenase.

The invention discloses a method for preparing a special-shaped hole structure covalent organic framework material suitable for a zinc ion battery electrode through a simple ultrasonic method. 5 ', 5'-bis (4-aminophenyl)-[1, 1 ': 3', 1 ': 3 '', 1'''-tetraphenyl]-4, 4 ''-diamine, 3, 3 ', 5, 5'-tetraformyl-4, 4 '-dihydroxybiphenyl and acetic acid are used as raw materials, benzyl alcohol, mesitylene and orthodichlorobenzene are used as solvents, and ultrasonic treatment is performed at a proper temperature to prepare the covalent organic framework material with the special-shaped pore structure. The composite material has a nitrogen-doped carbon chain with a high specific surface area and regular micropores capable of being used for diffusion, and can be used for storing zinc ions in a negative electrode of a zinc ion battery. The preparation method of the material is simple, low in preparation cost, green, environment-friendly and suitable for large-scale production.

Described herein are processes for the preparation of 2-(pyridin-2-yloxymethyl)-phenyl acetic acid esters that are useful as intermediates for agricultural products. These methods comprise reacting a substituted pyridine with a phenylacetic acid alcohol dianion derived from 3-isochromanone. The intermediate may be further reacted to form an agricultural product such as a fungicide.

The application discloses a preparation method of 5-cyanoindole, S1) o-chloroaniline and dimethyl malonate are dissolved and subjected to catalytic reaction to prepare dimethyl 2-(2-aminophenyl)malonate; S2) dimethyl 2-(2-aminophenyl)malonate is dissolved, hydrolysis reaction is carried out by adding alkali, and then high-temperature decarboxylation reaction is carried out by adding acid to prepare o-aminophenylacetic acid; S3) o-aminophenylacetic acid is dissolved and subjected to amino para-bromination to prepare 2-(2-amino-5-bromophenyl)acetic acid; S4) 2-(2-amino-5-bromophenyl)acetic acid is dissolved, and intramolecular condensation is carried out by adding a condensing agent to prepare 5-bromo-oxindole; S5) 5-bromo-oxindole is subjected to reduction reaction to prepare 5-bromoindoline; S6) 5-bromoindoline is subjected to oxidation reaction to prepare 5-bromoindole; and S7) substitution reaction is carried out on the bromine of 5-bromoindole by using cyano to prepare 5-cyanoindole. The application has the advantages of simple process, environmental protection, no pollution, low cost, safe operation, easy scale production, mild reaction condition, high conversion rate and good product quality.