Felbinac acetaminopher ester and its preparation method

A technology of acetaminophen ester and felbinac, which is applied in the field of acetaminophen felbinac compound, can solve the problems affecting the popularization and use of drugs, low bioavailability, etc., and achieves simple and feasible synthesis process, good product purity, good analgesic effect
CN1962614AInactive Publication Date: 2007-05-16GUANGDONG ZHONGKE DRUG R&D
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG ZHONGKE DRUG R&D
Publication Date
2007-05-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a biphenyl acetate n-acetamido-phenolic ester compound and preparing method with active component as drug composition, which comprises the following steps: adopting biphenyl acetate and thionyl chloride as raw material to prepare biphenyl acetyl chloride; reacting biphenyl acetyl chloride and n-acetamido-phenolic ester to produce rough crystal of product; recrystallizing to obtain the product.
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Description

Technical field:

[0001] The invention belongs to the field of organic chemistry and relates to a felbinac acetaminophen ester compound. Background technique:

[0002] Antipyretic and analgesic drugs commonly used in clinical practice mainly include paracetamol, aspirin, ibuprofen, felbinac, etc. Traditional antipyretic and analgesic drugs such as analgin, antipyrine, phenacetin, and aminopyrine Drugs have been withdrawn from the market due to their toxic side effects. Because of its toxicity, phenacetin is rarely used in developed countries, and aminopyrines are used less and less because of their damage to hematopoietic granulocytes. Acetaminophen has good antipyretic and analgesic effects, but it has no anti-inflammatory effect, and other anti-inflammatory drugs are usually added when using pyretaminophen. Aspirin has strong digestive system and anticoagulant side effects, and is not an ideal antipyretic and analgesic drug.

[0003] As an anti-inflammatory and analgesic...

Claims

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