A kind of berberine hydrochloride oral pellet xerogel and its preparation method and application

Abstract

The invention provides berberine hydrochloride oral pill dried gel as well as a preparation method and applications of the berberine hydrochloride oral pill dried gel. According to the berberine hydrochloride oral pill dried gel as well as the preparation method and the applications of the berberine hydrochloride oral pill dried gel, firstly, the applications of berberine hydrochloride in preparing the medicines for treating heart diseases are defined, and secondly, the condition that the berberine hydrochloride oral pill dried gel comprises berberine hydrochloride pills uniformly distributed in gel matrix is defined, and the gel matrix comprises a gel forming agent, a curing agent, a corrigent, an aromatic, a preservative and a pH regulator. The berberine hydrochloride provided by the invention can be used for preparing the medicines for treating heart diseases, the treatment effects are obvious, and the side effects can be effectively reduced; for the berberine hydrochloride, through the pill coating technology, the stability of the medicine is improved, the bad smell of the medicine is masked, and the side effects are reduced; meanwhile, after the pill is added into the gel matrix, the slow release effect can be effectively achieved, so that the medicine taking times is reduced, the irritation to the gastrointestinal tract is reduced, the mouthfeel of the preparation is completely improved, the fearful mental state generated when children patients take the medicine is overcome, and the compliance is improved.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a dry gel of berberine hydrochloride oral pellets and a preparation method and application thereof. Background technique [0002] At present, heart disease has become one of the diseases with the highest morbidity, mortality and disability, seriously affecting human life and health. Statistics show that 17 million people die from heart disease every year in the world, and one out of every three deaths due to disease is a heart disease patient. Heart disease has become the number one killer of human health. [0003] At present, the drugs for treating heart diseases mainly include cardiotonic drugs, antiarrhythmic drugs and antianginal drugs. These three types of drugs are basically chemical drugs, and various adverse reactions may occur if they are used improperly or for a long time. For example, digitalis is the representative of cardiotonic drugs, and loss of appetite, nausea,...

AI Technical Summary

Problems solved by technology

[0006] In order to solve the application of berberine alone in the treatment of heart disease drugs in the prior art, in addition, most of the existing berberine hydrochloride is tablets, and berberine hydrochloride has a bitter taste, which is difficult to cover the bitter taste, resulting in Poor, at the same time, the fluidity of medicine tablet is poor, can't improve children's medication compliance, problems such as dysphagia, the present invention provides a kind of berberine hydrochloride oral pellet xerogel and its preparation method and application

Images