Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1- piperidinyl]-1-hydroxybutyl]-$g(a)-dimethylbenzene acetic acid and its hydrochloride

a technology of dimethylbenzene acetic acid and hydroxybutyl, which is applied in the direction of heterocyclic compound active ingredients, biocide, organic chemistry, etc., can solve the problems of increasing production costs, difficult to remove undesired impurities, and inability to obtain substantially pure regioisomers

Inactive Publication Date: 2004-04-22
DR REDDYS LAB LTD
View PDF2 Cites 24 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These components are referred to as inseparable and it is also stated that it is not possible to obtain either of the regioisomers in substantially pure form.
Purity of fexofenadine is critical when it is used for the conversion to its hydrochloride salt since it is very difficult to remove any undesired impurities, including regioisomers, from the desired compound in last late processing stage.
Removing the impurities increases the cost of production.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1- piperidinyl]-1-hydroxybutyl]-$g(a)-dimethylbenzene acetic acid and its hydrochloride
  • Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1- piperidinyl]-1-hydroxybutyl]-$g(a)-dimethylbenzene acetic acid and its hydrochloride
  • Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1- piperidinyl]-1-hydroxybutyl]-$g(a)-dimethylbenzene acetic acid and its hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Pure Fexofenadine

[0075] A solution of Fexofenadine crude (500 g; prepared as per reference example) in methanol (4000 ml) is refluxed for 1 hour and the reaction mixture is then cooled to room temperature. The precipitated pure Fexofenadine obtained was filtered and washed with methanol (250 ml). Repeated recrystallization in methanol afforded pure Fexofenadine of desired purity.

[0076] Purity by HPLC 99.85%; Meta isomer<0.1%

example 2

Step 1

Preparation of Form A from Pure Fexofenadine

[0077] A suspension of pure Fexofenadine (180 g) in toluene (1800 ml) is azeotropically refluxed for 2 and a half hours. The reaction mixture is then cooled to room temperature and stirred for about 40 minutes. After completion of this step the reaction mixture was filtered and washed with toluene (180 ml) and the obtained Form A of Fexofenadine is dried at 80-85.degree. C. under atmospheric pressure till constant weight.

[0078] Yield 179.2 g: M.R (melting range) 220-224.degree. C.

Step 2

Preparation of Form X of Fexofenadine Hydrochloride

[0079] To the Fexofenadine Form A (170 g; prepared as per procedure in step 1), toluene (1700 ml) is added followed by slow addition of isopropanol hydrogen chloride (prepared by purging hydrogen chloride to isopropyl alcohol) to pH 2. The reaction mass is then stirred for 10 hours 15 minutes. The solid obtained is filtered, washed with toluene (170 ml) and dried under vacuum at 75-80.degree. C. Solid ...

example 3

Preparation of Form X of Fexofenadine Hydrochloride

[0081] To the Fexofenadine Form A (95 g; prepared as per procedure under Example 2, step 1), toluene (950 ml) is added followed by slow addition of isopropanol hydrogen chloride (prepared by purging hydrogen chloride to isopropyl alcohol) to pH 2. The reaction mass is then stirred for 2 hours 45 minutes. The reaction mass is filtered and washed with toluene (95 ml) to isolate solid which is dried at 80-85.degree. C. under atmospheric pressure till constant weight.

[0082] Part of the above-obtained solid was kept in oven to remove residual organic solvents at 141-149.degree. C. at 100-mbar pressure, for 3 and half hours, to afford desired Form X of Fexofenadine Hydrochloride M.R 183-188.degree. C.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
temperatureaaaaaaaaaa
peak temperatureaaaaaaaaaa
melting pointaaaaaaaaaa
Login to view more

Abstract

The present invention is related to novel polymorph of Fexofenadine and Fexofenadine hydrochloride of formula 1 and process of preparation thereof. The present invention is also directed to provide pure novel polymorphs of Fexofenadine and its hydrochloride by a simple process which is cost effective, commercially viable and environment friendly.

Description

[0001] The present invention relates to a novel crystalline form of fexofenadine hydrochloride and to a process for the preparation thereof. More specifically, the present invention relates to a novel anhydrous crystalline Form X of fexofenadine hydrochloride. The present invention also relates to a novel crystalline form of fexofenadine, particularly Form A of fexofenadine and to a process for the preparation thereof.BACKGROUND OF INVENTION[0002] Chemically fexofenadine hydrochloride is 4-[4-[4-(hydroxydiphenylme-thyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.alpha.-dimethylbenzene acetic acid hydrochloride. It is also known as terfenadine carboxylic acid metabolite. It is represented by Formula 1. 1[0003] Fexofenadine hydrochloride is useful as an antihistamine, and does not cause the adverse effects associated with the administration of terfenadine including abnormal heart rhythms in some patients with liver disease or patients who also take the antifimgal drug ketoconazole or the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): C07D211/22
CPCC07D211/22
Inventor REDDY, M. SATYANARAYANARAJAN, S. THIRUMALAIRAO, U.V. BHASKARA
Owner DR REDDYS LAB LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap