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Extruded 3D printing coated sustained-release preparation and preparation method thereof

A slow-release preparation and 3D printing technology, applied in the field of medicine and medicine, can solve problems such as unstable production process, inability to quickly deposit, and poor print strength, and achieve stable and efficient production, no obvious changes in appearance and sustained release, extrusion Good printing effect

Active Publication Date: 2022-05-03
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large amount of ethanol not only needs to be produced for explosion protection; at the same time, the viscosity of the printing material changes with the volatilization of ethanol, and the production process is unstable; and the printed samples cannot be used directly, and need to be dried for 12-24 hours
To sum up, when using the existing slow-release materials for extrusion 3D printing, the amount of solvent added is small, the fluidity of the material is poor, and the material cannot be extruded smoothly; the amount of solvent added is large, the material is extruded smoothly, but it cannot be deposited quickly, and the printing poor body strength

Method used

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  • Extruded 3D printing coated sustained-release preparation and preparation method thereof
  • Extruded 3D printing coated sustained-release preparation and preparation method thereof
  • Extruded 3D printing coated sustained-release preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1: Preparation and Evaluation of Diclofenac Sodium Sustained Release Preparation

[0030] Weigh 4.5g of gelatin, 0.9g of glycerin and 9.6g of water, and place them in a water bath at 55°C to fully mix and swell. Add 6.4g of diclofenac sodium and mix well to prepare the inner core material. Weigh 4.5g of gelatin, 0.9g of glycerin and 9.6g of water, and place them in a water bath at 55°C to fully mix and swell. Add 5g of HPMC K4M and mix evenly to prepare the coating material. Add the above materials into the barrel of the extrusion printer.

[0031] A cylindrical coated sustained-release preparation model was established, with an inner core diameter of 8.8 mm, a height of 4.5 mm, a coating wall thickness of 1.6 mm, a bottom thickness of 2.0 mm, and a top thickness of 2.0 mm. Coating printing parameters are: extrusion port diameter 0.8mm, layer height 0.5mm, extrusion temperature 45°C, printing speed 5mm / s, deposition temperature 25°C. Extrude the bottom 4 lay...

Embodiment 2

[0034] Example 2: Preparation and evaluation of different drug-coated sustained-release tablets

[0035]Weigh 3g of gelatin, 0.6g of glycerol and 6.4g of water, and place them in a water bath at 55°C to fully mix and swell. Add different drugs such as 6.8g of aminophylline, 4g of metoprolol tartrate or 1.1g of acetylsalicylic acid and mix them uniformly to prepare the inner core material. Weigh 3g of gelatin, 0.6g of glycerol and 6.4g of water, and place them in a water bath at 55°C to fully mix and swell. Add 3.4g HPMC and mix evenly to prepare coating material. Add the above materials into the barrel of the extrusion printer.

[0036] A cylindrical coated sustained-release preparation model was established, with an inner core diameter of 7.5 mm, a height of 4.5 mm, a coating wall thickness of 1.8 mm, a bottom thickness of 1.8 mm, and a top thickness of 1.8 mm. Coating printing parameters are: extrusion port diameter 0.6mm, layer height 0.3mm, extrusion temperature 45°C, p...

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Abstract

The invention belongs to the field of pharmaceutical medicine, and relates to an extrusion 3D printing coating type sustained-release preparation and a preparation method thereof. The coated sustained-release preparation of the present invention is based on a mixture of gelatin, glycerin and water, adding drugs or HPMC to obtain an inner core or coating, and then extruding 3D printing in combination with model slices and printing parameters to obtain the target coating sustained-release preparations. The formula has good printability, taking into account "smooth extrusion" and "rapid deposition". Compared with the existing slow-release printing materials, the water content of the system is reduced, and the strength and elasticity of the sample are increased. The optimized coating model structure can solve the problems existing in the existing extrusion 3D printing sustained-release preparations, including: low drug loading, obvious early burst release and unsatisfactory 24h sustained-release behavior. The present invention is further represented by diclofenac sodium, aminophylline, metoprolol tartrate and acetylsalicylic acid, disclosing the application effect of coated sustained-release preparations, proving that by adjusting the drugs and models, the individualization of various drugs can be realized treat.

Description

technical field [0001] The invention belongs to the field of pharmaceutical medicine, and relates to a sustained-release pharmaceutical preparation, in particular to a coating-type sustained-release preparation and a preparation method for extrusion 3D printing. Background technique [0002] Different from fused deposition 3D printing, extrusion 3D printing based on semi-solid does not require high temperature operation, which is beneficial to the stability of drugs and the activity of biological protein drugs, and has great application prospects in the field of personalized pharmaceutical preparations. At present, there are mainly public studies on "extrusion 3D printing to prepare immediate-release preparations", and there are few studies on "extrusion 3D printing to prepare sustained-release preparations". The main reason is that the extrusion 3D printability of conventional pharmaceutical sustained-release materials is poor, and the sustained-release preparations prepare...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K9/36A61K9/40A61K47/38A61K47/42A61K47/10A61K31/196A61K31/522A61K31/138A61K31/616B33Y10/00B33Y70/10B33Y80/00
CPCA61K9/2013A61K9/2063A61K9/2072A61K9/282A61K9/2866A61K9/2873A61K9/2893A61K31/196A61K31/522A61K31/138A61K31/616B33Y10/00B33Y70/00B33Y80/00
Inventor 杨燕王晓月杨根生杨庆良
Owner ZHEJIANG UNIV OF TECH
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